Roy Zent, M.B.B.Ch., Ph.D.

Professor

roy.zent@vanderbilt.edu
Faculty Appointments
Professor of Medicine Thomas F. Frist Sr. Chair in MedicineProfessor of Cancer BiologyProfessor of Cell and Developmental Biology
Education
Ph.D., Cell Biology, University of Toronto, TorontoM.Med., Medicine, University of Cape TownM.B.B.Ch., Medicine, University of Witwatersrand, Johannesburg
Office Address
C-3210 MCN
TN 2372
Research Description
The laboratory works on the basic role of integrins in epithelial cell biology. We utilize the kidney as a model system and perform biochemical techniques, cell biology and transgenic mice to understand the basic mechanisms whereby integrin-ECM interactions modify cell function. In addition, in collaboration with Dr. Charles Sanders, we perform structural functions on integrins utilizing NMR.

Research Keywords
Integrin biology, Kidney, Signal transduction, Branching morphogenesis,Kidney,Mouse
Publications
Yi Y, Polosukhina D, Love HD, Hembd A, Pickup M, Moses HL, Lovvorn HN, Zent R, Clark PE. A Murine Model of K-RAS and ß-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor. J. Urol [print-electronic]. 2015 Dec; 194(6): 1762-70. PMID: 25934441, PII: S0022-5347(15)03890-2, DOI: 10.1016/j.juro.2015.04.090, ISSN: 1527-3792.

Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, Fogo AB, Hao CM, Harris RC, Zent R, Gewin L. Renal fibrosis is not reduced by blocking transforming growth factor-ß signaling in matrix-producing interstitial cells. Kidney Int [print-electronic]. 2015 Sep; 88(3): 503-14. PMID: 25760325, PMCID: PMC4556568, PII: ki201551, DOI: 10.1038/ki.2015.51, ISSN: 1523-1755.

Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jiménez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E. Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell. Microbiol [print-electronic]. 2015 Aug; 17(8): 1179-204. PMID: 25678064, DOI: 10.1111/cmi.12429, ISSN: 1462-5822.

Yazlovitskaya EM, Tseng HY, Viquez O, Tu T, Mernaugh G, McKee KK, Riggins K, Quaranta V, Pathak A, Carter BD, Yurchenco P, Sonnenberg A, Böttcher RT, Pozzi A, Zent R. Integrin a3ß1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol. Biol. Cell [print-electronic]. 2015 May 5/15/2015; 26(10): 1857-74. PMID: 25808491, PMCID: PMC4436831, PII: mbc.E14-07-1203, DOI: 10.1091/mbc.E14-07-1203, ISSN: 1939-4586.

Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A. P47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int [print-electronic]. 2015 May; 87(5): 948-62. PMID: 25565313, PMCID: PMC4425591, PII: ki2014386, DOI: 10.1038/ki.2014.386, ISSN: 1523-1755.

Karaköse E, Geiger T, Flynn K, Lorenz-Baath K, Zent R, Mann M, Fässler R. The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites. J. Cell. Sci [print-electronic]. 2015 Mar 3/1/2015; 128(5): 1023-33. PMID: 25609703, PMCID: PMC4342583, PII: jcs.162545, DOI: 10.1242/jcs.162545, ISSN: 1477-9137.

Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. J. Am. Soc. Nephrol [print-electronic]. 2015 Mar; 26(3): 597-610. PMID: 25071086, PMCID: PMC4341468, PII: ASN.2013090980, DOI: 10.1681/ASN.2013090980, ISSN: 1533-3450.

Cleghorn WM, Branch KM, Kook S, Arnette C, Bulus N, Zent R, Kaverina I, Gurevich EV, Weaver AM, Gurevich VV. Arrestins regulate cell spreading and motility via focal adhesion dynamics. Mol. Biol. Cell [print-electronic]. 2015 Feb 2/15/2015; 26(4): 622-35. PMID: 25540425, PMCID: PMC4325834, PII: mbc.E14-02-0740, DOI: 10.1091/mbc.E14-02-0740, ISSN: 1939-4586.

Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R. Epithelial ß1 integrin is required for lung branching morphogenesis and alveolarization. Development [print-electronic]. 2014 Dec; 141(24): 4751-62. PMID: 25395457, PMCID: PMC4299273, PII: dev.117200, DOI: 10.1242/dev.117200, ISSN: 1477-9129.

Miller CG, Pozzi A, Zent R, Schwarzbauer JE. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol. Biol. Cell [print-electronic]. 2014 Aug 8/15/2014; 25(16): 2342-50. PMID: 24943838, PMCID: PMC4142608, PII: mbc.E14-03-0800, DOI: 10.1091/mbc.E14-03-0800, ISSN: 1939-4586.

Bryan L, Ibrahim T, Zent R, Fischer MJ. The kidney research predicament. J. Am. Soc. Nephrol [print-electronic]. 2014 May; 25(5): 898-903. PMID: 24652790, PMCID: PMC4005318, PII: ASN.2013121313, DOI: 10.1681/ASN.2013121313, ISSN: 1533-3450.

Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J. Am. Soc. Nephrol [print-electronic]. 2014 May; 25(5): 953-66. PMID: 24436469, PMCID: PMC4005312, PII: ASN.2013070795, DOI: 10.1681/ASN.2013070795, ISSN: 1533-3450.

Lennon R, Byron A, Humphries JD, Randles MJ, Carisey A, Murphy S, Knight D, Brenchley PE, Zent R, Humphries MJ. Global analysis reveals the complexity of the human glomerular extracellular matrix. J. Am. Soc. Nephrol [print-electronic]. 2014 May; 25(5): 939-51. PMID: 24436468, PMCID: PMC4005295, PII: ASN.2013030233, DOI: 10.1681/ASN.2013030233, ISSN: 1533-3450.

Skrypnyk N, Chen X, Hu W, Su Y, Mont S, Yang S, Gangadhariah M, Wei S, Falck JR, Jat JL, Zent R, Capdevila JH, Pozzi A. PPARa activation can help prevent and treat non-small cell lung cancer. Cancer Res [print-electronic]. 2014 Jan 1/15/2014; 74(2): 621-31. PMID: 24302581, PMCID: PMC3902646, PII: 0008-5472.CAN-13-1928, DOI: 10.1158/0008-5472.CAN-13-1928, ISSN: 1538-7445.

Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R. Cdc42 promotes host defenses against fatal infection. Infect. Immun [print-electronic]. 2013 Aug; 81(8): 2714-23. PMID: 23690402, PMCID: PMC3719566, PII: IAI.01114-12, DOI: 10.1128/IAI.01114-12, ISSN: 1098-5522.

Moik D, Böttcher A, Makhina T, Grashoff C, Bulus N, Zent R, Fässler R. Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice. J. Biol. Chem [print-electronic]. 2013 Jun 6/28/2013; 288(26): 18863-71. PMID: 23658024, PMCID: PMC3696662, PII: M113.470476, DOI: 10.1074/jbc.M113.470476, ISSN: 1083-351X.

Pozzi A, Zent R. Integrins in kidney disease. J. Am. Soc. Nephrol [print-electronic]. 2013 Jun; 24(7): 1034-9. PMID: 23641054, PMCID: PMC3699832, PII: ASN.2013010012, DOI: 10.1681/ASN.2013010012, ISSN: 1533-3450.

Natarajan C, Hata AN, Hamm HE, Zent R, Breyer RM. Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor. Mol. Pharmacol [print-electronic]. 2013 Jan; 83(1): 206-16. PMID: 23087260, PMCID: PMC3533480, PII: mol.112.080473, DOI: 10.1124/mol.112.080473, ISSN: 1521-0111.

Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R. Deleting the TGF-ß receptor attenuates acute proximal tubule injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Dec; 23(12): 2001-11. PMID: 23160515, PMCID: PMC3507360, PII: ASN.2012020139, DOI: 10.1681/ASN.2012020139, ISSN: 1533-3450.

Bartlett CS, Boyd KL, Harris RC, Zent R, Breyer RM. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Hypertension [print-electronic]. 2012 Nov; 60(5): 1184-91. PMID: 23006735, PMCID: PMC3478772, PII: HYPERTENSIONAHA.112.199026, DOI: 10.1161/HYPERTENSIONAHA.112.199026, ISSN: 1524-4563.

Plosa EJ, Gooding KA, Zent R, Prince LS. Nonmuscle myosin II regulation of lung epithelial morphology. Dev. Dyn [print-electronic]. 2012 Nov; 241(11): 1770-81. PMID: 22972683, PMCID: PMC3484380, DOI: 10.1002/dvdy.23866, ISSN: 1097-0177.

Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A. Enhancing integrin a1 inserted (I) domain affinity to ligand potentiates integrin a1ß1-mediated down-regulation of collagen synthesis. J. Biol. Chem [print-electronic]. 2012 Oct 10/12/2012; 287(42): 35139-52. PMID: 22888006, PMCID: PMC3471707, PII: M112.358648, DOI: 10.1074/jbc.M112.358648, ISSN: 1083-351X.

Mathew S, Lu Z, Palamuttam RJ, Mernaugh G, Hadziselimovic A, Chen J, Bulus N, Gewin LS, Voehler M, Meves A, Ballestrem C, Fässler R, Pozzi A, Sanders CR, Zent R. ß1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mol. Cell. Biol [print-electronic]. 2012 Oct; 32(20): 4080-91. PMID: 22869523, PMCID: PMC3457338, PII: MCB.00568-12, DOI: 10.1128/MCB.00568-12, ISSN: 1098-5549.

Zent R, Pozzi A. Connecting the segments [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2012 Oct; 23(10): 1603-5. PMID: 22975669, PII: ASN.2012080850, DOI: 10.1681/ASN.2012080850, ISSN: 1533-3450.

Mathew S, Chen X, Pozzi A, Zent R. Integrins in renal development. Pediatr. Nephrol [print-electronic]. 2012 Jun; 27(6): 891-900. PMID: 21603909, DOI: 10.1007/s00467-011-1890-1, ISSN: 1432-198X.

Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, Harris RC, Zent R, Pozzi A. Integrin a1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int [print-electronic]. 2012 Jun; 81(11): 1086-97. PMID: 22297672, PMCID: PMC3345314, PII: ki2011474, DOI: 10.1038/ki.2011.474, ISSN: 1523-1755.

Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. Inhibition of integrin a2ß1 ameliorates glomerular injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Jun; 23(6): 1027-38. PMID: 22440900, PMCID: PMC3358756, PII: ASN.2011040367, DOI: 10.1681/ASN.2011040367, ISSN: 1533-3450.

Zent R, Harris R. The mammalian kidney [editorial]. Exp. Cell Res. 2012 May 5/15/2012; 318(9): v. PMID: 22520051, PII: S0014-4827(12)00185-1, DOI: 10.1016/S0014-4827(12)00185-1, ISSN: 1090-2422.

Gewin L, Zent R. How does TGF-ß mediate tubulointerstitial fibrosis?. Semin. Nephrol. 2012 May; 32(3): 228-35. PMID: 22835453, PII: S0270-9295(12)00061-7, DOI: 10.1016/j.semnephrol.2012.04.001, ISSN: 1558-4488.

Lu Z, Van Horn WD, Chen J, Mathew S, Zent R, Sanders CR. Bicelles at low concentrations. Mol. Pharm [print-electronic]. 2012 Apr 4/2/2012; 9(4): 752-61. PMID: 22221179, PMCID: PMC3319193, DOI: 10.1021/mp2004687, ISSN: 1543-8392.

Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur. J. Cell Biol [print-electronic]. 2012 Mar; 91(3): 180-91. PMID: 22306379, PMCID: PMC3629562, PII: S0171-9335(11)00235-4, DOI: 10.1016/j.ejcb.2011.12.003, ISSN: 1618-1298.

Pozzi A, Zent R. Hold tight or you'll fall off: CD151 helps podocytes stick in high-pressure situations. J. Clin. Invest [print-electronic]. 2012 Jan; 122(1): 13-6. PMID: 22201676, PMCID: PMC3248315, PII: 61858, DOI: 10.1172/JCI61858, ISSN: 1558-8238.

Bulus N, Feral C, Pozzi A, Zent R. CD98 increases renal epithelial cell proliferation by activating MAPKs. PLoS ONE [print-electronic]. 2012; 7(6): e40026. PMID: 22768207, PMCID: PMC3386947, PII: PONE-D-11-23182, DOI: 10.1371/journal.pone.0040026, ISSN: 1932-6203.

Clark PE, Polosukhina D, Love H, Correa H, Coffin C, Perlman EJ, de Caestecker M, Moses HL, Zent R. ß-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors. Am. J. Pathol [print-electronic]. 2011 Dec; 179(6): 3045-55. PMID: 21983638, PMCID: PMC3260797, PII: S0002-9440(11)00808-X, DOI: 10.1016/j.ajpath.2011.08.006, ISSN: 1525-2191.

Pozzi A, Zent R. Extracellular matrix receptors in branched organs. Curr. Opin. Cell Biol [print-electronic]. 2011 Oct; 23(5): 547-53. PMID: 21561755, PMCID: PMC3181278, PII: S0955-0674(11)00051-2, DOI: 10.1016/j.ceb.2011.04.003, ISSN: 1879-0410.

Pozzi A, Zent R. TGF-ß sequestration by mesangial cell integrin avß8: A novel mechanism of glomerular endothelial cell regulation. Am. J. Pathol. 2011 Feb; 178(2): 485-9. PMID: 21281780, PMCID: PMC3069894, PII: S0002-9440(10)00134-3, DOI: 10.1016/j.ajpath.2010.10.038, ISSN: 1525-2191.

Borza CM, Chen X, Mathew S, Mont S, Sanders CR, Zent R, Pozzi A. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J. Biol. Chem [print-electronic]. 2010 Dec 12/17/2010; 285(51): 40114-24. PMID: 20940300, PMCID: PMC3000994, PII: M110.156729, DOI: 10.1074/jbc.M110.156729, ISSN: 1083-351X.

Riggins KS, Mernaugh G, Su Y, Quaranta V, Koshikawa N, Seiki M, Pozzi A, Zent R. MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp. Cell Res [print-electronic]. 2010 Oct 10/15/2010; 316(17): 2993-3005. PMID: 20727881, PMCID: PMC2945451, PII: S0014-4827(10)00397-6, DOI: 10.1016/j.yexcr.2010.08.003, ISSN: 1090-2422.

Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R. Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development. 2010 Oct; 137(19): 3233-43. PMID: 20823064, PMCID: PMC2934735, PII: 137/19/3233, DOI: 10.1242/dev.052845, ISSN: 1477-9129.

Clark PE, Polosukhina DA, Gyabaah K, Moses HL, Thorburn A, Zent R. TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis. J. Urol [print-electronic]. 2010 Sep; 184(3): 1166-74. PMID: 20663526, PMCID: PMC2963111, PII: S0022-5347(10)03492-0, DOI: 10.1016/j.juro.2010.04.064, ISSN: 1527-3792.

Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J. Am. Soc. Nephrol [print-electronic]. 2010 Aug; 21(8): 1334-43. PMID: 20576806, PMCID: PMC2938601, PII: ASN.2010020147, DOI: 10.1681/ASN.2010020147, ISSN: 1533-3450.

Yamashita H, Tripathi M, Harris MP, Liu S, Weidow B, Zent R, Quaranta V. The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration. Biomaterials [print-electronic]. 2010 Jul; 31(19): 5110-21. PMID: 20347131, PMCID: PMC2861493, PII: S0142-9612(10)00343-1, DOI: 10.1016/j.biomaterials.2010.03.003, ISSN: 1878-5905.

Wang SE, Yu Y, Criswell TL, Debusk LM, Lin PC, Zent R, Johnson DH, Ren X, Arteaga CL. Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Oncogene [print-electronic]. 2010 Jun 6/10/2010; 29(23): 3335-48. PMID: 20383197, PMCID: PMC2883631, PII: onc2010112, DOI: 10.1038/onc.2010.112, ISSN: 1476-5594.

Chen X, Whiting C, Borza C, Hu W, Mont S, Bulus N, Zhang MZ, Harris RC, Zent R, Pozzi A. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol. Cell. Biol [print-electronic]. 2010 Jun; 30(12): 3048-58. PMID: 20368353, PMCID: PMC2876688, PII: MCB.00892-09, DOI: 10.1128/MCB.00892-09, ISSN: 1098-5549.

He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J. Clin. Invest [print-electronic]. 2010 Apr; 120(4): 1056-68. PMID: 20335659, PMCID: PMC2846063, PII: 41563, DOI: 10.1172/JCI41563, ISSN: 1558-8238.

Pozzi A, Zent R. ZO-1 and ZONAB interact to regulate proximal tubular cell differentiation [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2010 Mar; 21(3): 388-90. PMID: 20133486, PMCID: PMC4473249, PII: ASN.2010010061, DOI: 10.1681/ASN.2010010061, ISSN: 1533-3450.

Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood [print-electronic]. 2009 Nov 11/26/2009; 114(23): 4897-906. PMID: 19789387, PMCID: PMC2786295, PII: blood-2009-02-207134, DOI: 10.1182/blood-2009-02-207134, ISSN: 1528-0020.

Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev. Biol [print-electronic]. 2009 Nov 11/15/2009; 335(2): 407-17. PMID: 19769957, PMCID: PMC2783258, PII: S0012-1606(09)01206-8, DOI: 10.1016/j.ydbio.2009.09.021, ISSN: 1095-564X.

Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature. 2009 Oct 10/15/2009; 461(7266): 1002-6. PMID: 19829382, PII: nature08468, DOI: 10.1038/nature08468, ISSN: 1476-4687.

Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R. Beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development [print-electronic]. 2009 Oct; 136(19): 3357-66. PMID: 19710172, PMCID: PMC2739149, PII: dev.036269, DOI: 10.1242/dev.036269, ISSN: 1477-9129.

Pozzi A, Zent R, Chetyrkin S, Borza C, Bulus N, Chuang P, Chen D, Hudson B, Voziyan P. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. J. Am. Soc. Nephrol [print-electronic]. 2009 Oct; 20(10): 2119-25. PMID: 19608705, PMCID: PMC2754111, PII: ASN.2008080900, DOI: 10.1681/ASN.2008080900, ISSN: 1533-3450.

Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC. Distinct roles for basal and induced COX-2 in podocyte injury. J. Am. Soc. Nephrol [print-electronic]. 2009 Sep; 20(9): 1953-62. PMID: 19643929, PMCID: PMC2736764, PII: ASN.2009010039, DOI: 10.1681/ASN.2009010039, ISSN: 1533-3450.

Pozzi A, Zent R. Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med. 2009 Sep; 1(2): 254-72. PMID: 20835995, PMCID: PMC3789245, DOI: 10.1002/wsbm.7, ISSN: 1939-005X.

Moser M, Legate KR, Zent R, Fässler R. The tail of integrins, talin, and kindlins. Science. 2009 May 5/15/2009; 324(5929): 895-9. PMID: 19443776, PII: 324/5929/895, DOI: 10.1126/science.1163865, ISSN: 1095-9203.

Wang SE, Xiang B, Zent R, Quaranta V, Pozzi A, Arteaga CL. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res. 2009 Jan 1/15/2009; 69(2): 475-82. PMID: 19147560, PMCID: PMC2629389, PII: 69/2/475, DOI: 10.1158/0008-5472.CAN-08-2649, ISSN: 1538-7445.

Pozzi A, Voziyan PA, Hudson BG, Zent R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr. Pharm. Des. 2009; 15(12): 1318-33. PMID: 19355971, ISSN: 1873-4286.

Moser M, Legate KR, Zent R, Fassler R.. The tail of integrins, talin, and kindlins. Science. 2009; 15((324)): 895-9.

Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A, Zent R. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp. Cell Res [print-electronic]. 2008 Nov 11/15/2008; 314(19): 3593-604. PMID: 18809396, PMCID: PMC2729514, PII: S0014-4827(08)00328-5, DOI: 10.1016/j.yexcr.2008.08.014, ISSN: 1090-2422.

Abair TD, Bulus N, Borza C, Sundaramoorthy M, Zent R, Pozzi A. Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood [print-electronic]. 2008 Oct 10/15/2008; 112(8): 3242-54. PMID: 18647959, PMCID: PMC2569176, PII: blood-2007-12-126433, DOI: 10.1182/blood-2007-12-126433, ISSN: 1528-0020.

Srichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD. Apoptosis of the thick ascending limb results in acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2008 Aug; 19(8): 1538-46. PMID: 18495962, PMCID: PMC2488270, PII: ASN.2007101101, DOI: 10.1681/ASN.2007101101, ISSN: 1533-3450.

Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res. 2008 Aug 8/1/2008; 68(15): 6224-31. PMID: 18676846, PII: 68/15/6224, DOI: 10.1158/0008-5472.CAN-08-0513, ISSN: 1538-7445.

Macias-Perez I, Borza C, Chen X, Yan X, Ibanez R, Mernaugh G, Matrisian LM, Zent R, Pozzi A. Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res. 2008 Aug 8/1/2008; 68(15): 6127-35. PMID: 18676835, PMCID: PMC2801028, PII: 68/15/6127, DOI: 10.1158/0008-5472.CAN-08-1395, ISSN: 1538-7445.

Montanez E, Ussar S, Schifferer M, Bösl M, Zent R, Moser M, Fässler R. Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 2008 May 5/15/2008; 22(10): 1325-30. PMID: 18483218, PMCID: PMC2377186, PII: 22/10/1325, DOI: 10.1101/gad.469408, ISSN: 0890-9369.

Macias-Perez IM, Zent R, Carmosino M, Breyer MD, Breyer RM, Pozzi A. Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J. Biol. Chem [print-electronic]. 2008 May 5/2/2008; 283(18): 12538-45. PMID: 18230618, PMCID: PMC2335350, PII: M800105200, DOI: 10.1074/jbc.M800105200, ISSN: 0021-9258.

Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev. Biol [print-electronic]. 2008 Apr 4/15/2008; 316(2): 288-301. PMID: 18328474, PMCID: PMC2396524, PII: S0012-1606(08)00039-0, DOI: 10.1016/j.ydbio.2008.01.022, ISSN: 1095-564X.

Borza CM, Borza DB, Pedchenko V, Saleem MA, Mathieson PW, Sado Y, Hudson HM, Pozzi A, Saus J, Abrahamson DR, Zent R, Hudson BG. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J. Am. Soc. Nephrol [print-electronic]. 2008 Apr; 19(4): 677-84. PMID: 18235087, PMCID: PMC2390958, PII: ASN.2007070793, DOI: 10.1681/ASN.2007070793, ISSN: 1533-3450.

Maginnis MS, Mainou BA, Derdowski A, Johnson EM, Zent R, Dermody TS. NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J. Virol [print-electronic]. 2008 Apr; 82(7): 3181-91. PMID: 18216114, PMCID: PMC2268482, PII: JVI.01612-07, DOI: 10.1128/JVI.01612-07, ISSN: 1098-5514.

Zeng F, Zhang MZ, Singh AB, Zent R, Harris RC. ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol. Biol. Cell [print-electronic]. 2007 Nov; 18(11): 4446-56. PMID: 17761534, PMCID: PMC2043549, PII: E07-03-0223, DOI: 10.1091/mbc.E07-03-0223, ISSN: 1059-1524.

Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R. Signaling pathways regulating TC21-induced tumorigenesis. J. Biol. Chem [print-electronic]. 2007 Sep 9/21/2007; 282(38): 27713-20. PMID: 17656362, PII: M703037200, DOI: 10.1074/jbc.M703037200, ISSN: 0021-9258.

Rao R, Redha R, Macias-Perez I, Su Y, Hao C, Zent R, Breyer MD, Pozzi A. Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J. Biol. Chem [print-electronic]. 2007 Jun 6/8/2007; 282(23): 16959-68. PMID: 17401137, PII: M701214200, DOI: 10.1074/jbc.M701214200, ISSN: 0021-9258.

Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk DB, Singh AB, Harris RC, Zent R, Pozzi A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol. Cell. Biol [print-electronic]. 2007 May; 27(9): 3313-26. PMID: 17339338, PMCID: PMC1899972, PII: MCB.01476-06, DOI: 10.1128/MCB.01476-06, ISSN: 0270-7306.

Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE. PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol. Pharmacol [print-electronic]. 2007 May; 71(5): 1399-406. PMID: 17303701, PII: mol.106.033365, DOI: 10.1124/mol.106.033365, ISSN: 0026-895X.

Zent R, Pozzi A. Angiogenesis in diabetic nephropathy. Semin. Nephrol. 2007 Mar; 27(2): 161-71. PMID: 17418685, PII: S0270-9295(07)00008-3, DOI: 10.1016/j.semnephrol.2007.01.007, ISSN: 0270-9295.

Dwyer JP, Yates KM, Sumner EL, Stone WJ, Wang Y, Koury MJ, Fogo AB, Zent R. Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. Clin. Nephrol. 2007 Mar; 67(3): 176-81. PMID: 17390742, ISSN: 0301-0430.

Zent R, Yan X, Su Y, Hudson BG, Borza DB, Moeckel GW, Qi Z, Sado Y, Breyer MD, Voziyan P, Pozzi A. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice. Kidney Int [print-electronic]. 2006 Aug; 70(3): 460-70. PMID: 16775606, PII: 5000359, DOI: 10.1038/sj.ki.5000359, ISSN: 0085-2538.

Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J. Biol. Chem [print-electronic]. 2006 Jul 7/28/2006; 281(30): 20932-9. PMID: 16731529, PII: M601147200, DOI: 10.1074/jbc.M601147200, ISSN: 0021-9258.

Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A, Fogo AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J. Am. Soc. Nephrol [print-electronic]. 2006 Jul; 17(7): 1886-95. PMID: 16790514, PII: ASN.2005020205, DOI: 10.1681/ASN.2005020205, ISSN: 1046-6673.

Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL. Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene [print-electronic]. 2006 Jun 6/8/2006; 25(24): 3408-23. PMID: 16186809, PII: 1208964, DOI: 10.1038/sj.onc.1208964, ISSN: 0950-9232.

Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J. Clin. Invest [print-electronic]. 2006 Jun; 116(6): 1696-702. PMID: 16691295, PMCID: PMC1459070, DOI: 10.1172/JCI27546, ISSN: 0021-9738.

Pozzi A, Coffa S, Bulus N, Zhu W, Chen D, Chen X, Mernaugh G, Su Y, Cai S, Singh A, Brissova M, Zent R. H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis. Mol. Biol. Cell [print-electronic]. 2006 Apr; 17(4): 2046-56. PMID: 16467383, PMCID: PMC1415315, PII: E05-08-0800, DOI: 10.1091/mbc.E05-08-0800, ISSN: 1059-1524.

Zent R, Pozzi A. Antiangiogenic therapy in diabetic nephropathy [editorial]. J. Am. Soc. Nephrol. 2006 Feb; 17(2): 325-7. PMID: 16434503, PII: 17/2/325, DOI: 10.1681/ASN.2005121290, ISSN: 1046-6673.

Moeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Am. J. Physiol. Renal Physiol [print-electronic]. 2006 Jan; 290(1): F223-31. PMID: 16106035, PII: 00371.2004, DOI: 10.1152/ajprenal.00371.2004, ISSN: 1931-857X.

Mernaugh RL, Yan H, Chen D, Edl J, Hanley G, Pozzi A, Zent R. Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. J. Immunol. Methods [print-electronic]. 2005 Nov 11/30/2005; 306(1-2): 115-27. PMID: 16212977, PII: S0022-1759(05)00257-7, DOI: 10.1016/j.jim.2005.08.006, ISSN: 0022-1759.

Mai W, Chen D, Ding T, Kim I, Park S, Cho SY, Chu JS, Liang D, Wang N, Wu D, Li S, Zhao P, Zent R, Wu G. Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Mol. Biol. Cell [print-electronic]. 2005 Sep; 16(9): 4398-409. PMID: 15975909, PMCID: PMC1196347, PII: E04-11-1019, DOI: 10.1091/mbc.E04-11-1019, ISSN: 1059-1524.

Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int. J. Cancer. 2005 Aug 8/10/2005; 116(1): 52-61. PMID: 15756690, DOI: 10.1002/ijc.20997, ISSN: 0020-7136.

Pozzi A, Macias-Perez I, Abair T, Wei S, Su Y, Zent R, Falck JR, Capdevila JH. Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. J. Biol. Chem [print-electronic]. 2005 Jul 7/22/2005; 280(29): 27138-46. PMID: 15917237, PII: M501730200, DOI: 10.1074/jbc.M501730200, ISSN: 0021-9258.

Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R. CD98 modulates integrin beta1 function in polarized epithelial cells. J. Cell. Sci [print-electronic]. 2005 Mar 3/1/2005; 118(Pt 5): 889-99. PMID: 15713750, PII: jcs.01674, DOI: 10.1242/jcs.01674, ISSN: 0021-9533.

Tvorogov D, Wang XJ, Zent R, Carpenter G. Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J. Cell. Sci [print-electronic]. 2005 Feb 2/1/2005; 118(Pt 3): 601-10. PMID: 15657076, PII: jcs.01643, DOI: 10.1242/jcs.01643, ISSN: 0021-9533.

Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin. Exp. Metastasis. 2005; 22(2): 185-93. PMID: 16086239, DOI: 10.1007/s10585-005-7453-8, ISSN: 0262-0898.

Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, Ginsberg M, Sethi T. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J. Biol. Chem [print-electronic]. 2004 Dec 12/24/2004; 279(52): 54731-41. PMID: 15485886, PII: M408700200, DOI: 10.1074/jbc.M408700200, ISSN: 0021-9258.

Zent RM, Cothren CC, Moore EE. Gastric trichobezoar and Rapunzel syndrome. J. Am. Coll. Surg. 2004 Dec; 199(6): 990. PMID: 15555984, PII: S1072-7515(04)01049-X, DOI: 10.1016/j.jamcollsurg.2004.03.030, ISSN: 1072-7515.

Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris RC, Pozzi A, Zent R. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am. J. Physiol. Renal Physiol [print-electronic]. 2004 Oct; 287(4): F602-11. PMID: 15187002, PII: 00015.2004, DOI: 10.1152/ajprenal.00015.2004, ISSN: 1931-857X.

Fisher ME, Rossini M, Simmons E, Harris RC, Moeckel G, Zent R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. Am. J. Kidney Dis. 2004 Sep; 44(3): 567-73. PMID: 15332232, PII: S0272638604008285, ISSN: 1523-6838.

Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am. J. Pathol. 2004 Aug; 165(2): 617-30. PMID: 15277235, PMCID: PMC1618576, PII: S0002-9440(10)63326-3, ISSN: 0002-9440.

Singh AB, Tsukada T, Zent R, Harris RC. Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J. Cell. Sci [print-electronic]. 2004 Mar 3/15/2004; 117(Pt 8): 1365-79. PMID: 14996914, PII: jcs.01037, DOI: 10.1242/jcs.01037, ISSN: 0021-9533.

Koshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB J [print-electronic]. 2004 Feb; 18(2): 364-6. PMID: 14688206, PII: 03-0584fje, DOI: 10.1096/fj.03-0584fje, ISSN: 1530-6860.

Pedchenko V, Zent R, Hudson BG. Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion. J. Biol. Chem [print-electronic]. 2004 Jan 1/23/2004; 279(4): 2772-80. PMID: 14610079, PII: M311901200, DOI: 10.1074/jbc.M311901200, ISSN: 0021-9258.

Hata AN, Zent R, Breyer MD, Breyer RM. Expression and molecular pharmacology of the mouse CRTH2 receptor. J. Pharmacol. Exp. Ther [print-electronic]. 2003 Aug; 306(2): 463-70. PMID: 12721327, PII: jpet.103.050955, DOI: 10.1124/jpet.103.050955, ISSN: 0022-3565.

Pozzi A, Zent R. Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp. Nephrol. 2003; 94(3): e77-84. PMID: 12902617, PII: 72025, DOI: 72025, ISSN: 1660-2129.

Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J. Biol. Chem [print-electronic]. 2001 Dec 12/14/2001; 276(50): 46707-13. PMID: 11590169, PII: M106176200, DOI: 10.1074/jbc.M106176200, ISSN: 0021-9258.

Zent R, Bush KT, Pohl ML, Quaranta V, Koshikawa N, Wang Z, Kreidberg JA, Sakurai H, Stuart RO, Nigám SK. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev. Biol. 2001 Oct 10/15/2001; 238(2): 289-302. PMID: 11784011, PII: S0012-1606(01)90391-4, DOI: 10.1006/dbio.2001.0391, ISSN: 0012-1606.

Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C, Ginsberg MH. Distinct domains of CD98hc regulate integrins and amino acid transport. J. Biol. Chem [print-electronic]. 2001 Mar 3/23/2001; 276(12): 8746-52. PMID: 11121428, PII: M011239200, DOI: 10.1074/jbc.M011239200, ISSN: 0021-9258.

Zent R, Fenczik CA, Calderwood DA, Liu S, Dellos M, Ginsberg MH. Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains. J. Biol. Chem. 2000 Feb 2/18/2000; 275(7): 5059-64. PMID: 10671548, ISSN: 0021-9258.

Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J. Biol. Chem. 1999 Oct 10/1/1999; 274(40): 28071-4. PMID: 10497155, ISSN: 0021-9258.

Zent R, Ailenberg M, Downey GP, Silverman M. ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling. Am. J. Physiol. 1999 Feb; 276(2 Pt 2): F278-87. PMID: 9950959, ISSN: 0002-9513.

Zent R, Ailenberg M, Silverman M. Tyrosine kinase cell signaling pathways of rat mesangial cells in 3-dimensional cultures: response to fetal bovine serum and platelet-derived growth factor-BB. Exp. Cell Res. 1998 Apr 4/10/1998; 240(1): 134-43. PMID: 9570928, PII: S0014-4827(98)94008-3, DOI: 10.1006/excr.1998.4008, ISSN: 0014-4827.

Zent R, Katz A, Quaggin S, Cattran D, Wade J, Cardella C, Zaltzman J, Fenton S, Cole E. Thrombotic microangiopathy in renal transplant recipients treated with cyclosporin A. Clin. Nephrol. 1997 Mar; 47(3): 181-6. PMID: 9105765, ISSN: 0301-0430.

Zent R, Nagai R, Cattran DC. Idiopathic membranous nephropathy in the elderly: a comparative study. Am. J. Kidney Dis. 1997 Feb; 29(2): 200-6. PMID: 9016890, PII: S0272-6386(97)90030-5, ISSN: 0272-6386.

De Villiers C, Zent R, Eastman RW, Swingler D. A flight of fantasy: false memories in frontal lobe disease [letter]. J. Neurol. Neurosurg. Psychiatr. 1996 Dec; 61(6): 652-3. PMID: 8971120, PMCID: PMC486667, ISSN: 0022-3050.

Zent R, Ailenberg M, Waddell TK, Downey GP, Silverman M. Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species. Kidney Int. 1995 Mar; 47(3): 811-7. PMID: 7752581, ISSN: 0085-2538.

Katz A, Zent R, Bargman JM. IgG heavy-chain deposition disease. Mod. Pathol. 1994 Oct; 7(8): 874-8. PMID: 7838842, ISSN: 0893-3952.

Zent R, Van Zyl Smit R, Duffield M, Cassidy MJ. Crescentic nephritis at Groote Schuur Hospital, South Africa--not a benign disease. Clin. Nephrol. 1994 Jul; 42(1): 22-9. PMID: 7923962, ISSN: 0301-0430.

Bargman JM, Zent R, Ellis P, Auger M, Wilson S. Diagnosis of lymphoma in a continuous ambulatory peritoneal dialysis patient by peritoneal fluid cytology. Am. J. Kidney Dis. 1994 May; 23(5): 747-50. PMID: 8172221, PII: S0272638694001010, ISSN: 0272-6386.

Zent R, Myers JE, Donald D, Rayner BL. Continuous ambulatory peritoneal dialysis: an option in the developing world?. Perit Dial Int. 1994; 14(1): 48-51. PMID: 8312414, ISSN: 0896-8608.

Morton LP, Reynolds L, Zent R, Rayner BL. Hearing thresholds in CAPD patients. Adv Perit Dial. 1992; 8: 150-2. PMID: 1361774, ISSN: 1197-8554.