John Robert Koethe, M.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Medicine
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseeM.D., Yale University, New Haven, ConnecticutB.A., Oberlin College, Oberlin, Ohio
Office Address
1161 21st Avenue South
Nashville, TN 37232-2582
Clinical Research Keywords
HIV, obesity, nutrition, inflammation, immunology
Koethe JR, Jenkins CA, Lau B, Shepherd BE, Wester W, Rebeiro PF, Silverberg MJ, Thorne JE, Gill J, Mayor AM, Willig A, Bosch R, Horberg MA, Justice AC, Sterling TR, Moore RD. Higher Time-updated Body Mass Index: Association with Improved CD4+ Cell Recovery on HIV Treatment. J. Acquir. Immune Defic. Syndr [print-electronic]. 2016 Apr 4/21/2016; PMID: 27116044, DOI: 10.1097/QAI.0000000000001035, ISSN: 1944-7884.

PrayGod G, Blevins M, Woodd S, Rehman AM, Jeremiah K, Friis H, Kelly P, Changalucha J, Heimburger DC, Filteau S, Koethe JR. A longitudinal study of systemic inflammation and recovery of lean body mass among malnourished HIV-infected adults starting antiretroviral therapy in Tanzania and Zambia. Eur J Clin Nutr [print-electronic]. 2016 Apr; 70(4): 499-504. PMID: 26785764, PII: ejcn2015221, DOI: 10.1038/ejcn.2015.221, ISSN: 1476-5640.

Tirivayi N, Koethe JR. The economic benefits of high CD4 counts among people living with HIV/AIDS in Zambia. J Public Health (Oxf) [print-electronic]. 2016 Jan 1/19/2016; PMID: 26791910, PII: fdv199, DOI: 10.1093/pubmed/fdv199, ISSN: 1741-3850.

Koethe JR, Grome H, Jenkins CA, Kalams SA, Sterling TR. The metabolic and cardiovascular consequences of obesity in persons with HIV on long-term antiretroviral therapy. AIDS. 2016 Jan 1/2/2016; 30(1): 83-91. PMID: 26418084, PMCID: PMC4703444, DOI: 10.1097/QAD.0000000000000893, ISSN: 1473-5571.

Koethe JR, Jenkins CA, Lau B, Shepherd BE, Justice AC, Tate JP, Buchacz K, Napravnik S, Mayor AM, Horberg MA, Blashill AJ, Willig A, Wester CW, Silverberg MJ, Gill J, Thorne JE, Klein M, Eron JJ, Kitahata MM, Sterling TR, Moore RD, . Rising Obesity Prevalence and Weight Gain Among Adults Starting Antiretroviral Therapy in the United States and Canada. AIDS Res. Hum. Retroviruses [print-electronic]. 2016 Jan; 32(1): 50-8. PMID: 26352511, PMCID: PMC4692122, DOI: 10.1089/aid.2015.0147, ISSN: 1931-8405.

Koethe JR, Jenkins CA, Lau B, Shepherd BE, Silverberg MJ, Brown TT, Blashill AJ, Anema A, Willig A, Stinnette S, Napravnik S, Gill J, Crane HM, Sterling TR, . Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010. HIV Med [print-electronic]. 2015 Oct; 16(9): 572-7. PMID: 25960080, PMCID: PMC4558259, DOI: 10.1111/hiv.12259, ISSN: 1468-1293.

Bestawros M, Chidumayo T, Blevins M, Canipe A, Bala J, Kelly P, Filteau S, Shepherd BE, Heimburger DC, Koethe JR. Increased systemic inflammation is associated with cardiac and vascular dysfunction over the first 12 weeks of antiretroviral therapy among undernourished, HIV-infected adults in Southern Africa. J AIDS Clin Res. 2015 Mar; 6(3): PMID: 26038711, PMCID: PMC4450092, DOI: 10.4172/2155-6113.1000431, ISSN: 2155-6113.

Koethe JR, Jenkins CA, Turner M, Bebawy S, Shepherd BE, Wester CW, Sterling TR. Body mass index and the risk of incident noncommunicable diseases after starting antiretroviral therapy. HIV Med [print-electronic]. 2015 Jan; 16(1): 67-72. PMID: 25230709, PMCID: PMC4268383, DOI: 10.1111/hiv.12178, ISSN: 1468-1293.

Canipe A, Chidumayo T, Blevins M, Bestawros M, Bala J, Kelly P, Filteau S, Shepherd BE, Heimburger DC, Koethe JR. A 12 week longitudinal study of microbial translocation and systemic inflammation in undernourished HIV-infected Zambians initiating antiretroviral therapy. BMC Infect. Dis. 2014; 14: 521. PMID: 25266928, PMCID: PMC4261887, PII: 1471-2334-14-521, DOI: 10.1186/1471-2334-14-521, ISSN: 1471-2334.

Koethe JR, Marseille E, Giganti MJ, Chi BH, Heimburger D, Stringer JS. Estimating the cost-effectiveness of nutrition supplementation for malnourished, HIV-infected adults starting antiretroviral therapy in a resource-constrained setting. Cost Eff Resour Alloc. 2014; 12: 10. PMID: 24839400, PMCID: PMC4024113, PII: 1478-7547-12-10, DOI: 10.1186/1478-7547-12-10, ISSN: 1478-7547.

Koethe JR, Hulgan T, Niswender K. Adipose tissue and immune function: a review of evidence relevant to HIV infection. J. Infect. Dis [print-electronic]. 2013 Oct 10/15/2013; 208(8): 1194-201. PMID: 23878320, PMCID: PMC3778969, PII: jit324, DOI: 10.1093/infdis/jit324, ISSN: 1537-6613.

Koethe JR, Dee K, Bian A, Shintani A, Turner M, Bebawy S, Sterling TR, Hulgan T. Circulating interleukin-6, soluble CD14, and other inflammation biomarker levels differ between obese and nonobese HIV-infected adults on antiretroviral therapy. AIDS Res. Hum. Retroviruses [print-electronic]. 2013 Jul; 29(7): 1019-25. PMID: 23469772, PMCID: PMC3685684, DOI: 10.1089/aid.2013.0016, ISSN: 1931-8405.

Koethe JR, Blevins M, Bosire C, Nyirenda C, Kabagambe EK, Mwango A, Kasongo W, Zulu I, Shepherd BE, Heimburger DC. Self-reported dietary intake and appetite predict early treatment outcome among low-BMI adults initiating HIV treatment in sub-Saharan Africa. Public Health Nutr [print-electronic]. 2013 Mar; 16(3): 549-58. PMID: 22691872, PMCID: PMC3772135, PII: S1368980012002960, DOI: 10.1017/S1368980012002960, ISSN: 1475-2727.

Koethe JR, Bian A, Shintani AK, Wester CW, Erdem H, Hulgan T. An association between adiposity and serum levels of macrophage inflammatory protein-1a and soluble CD14 in HIV-infected adults: results from a cross-sectional study. Antivir. Ther. (Lond.) [print-electronic]. 2013; 18(5): 729-33. PMID: 23748193, PMCID: PMC3923367, DOI: 10.3851/IMP2645, ISSN: 2040-2058.

Koethe JR, Blevins M, Nyirenda CK, Kabagambe EK, Chiasera JM, Shepherd BE, Zulu I, Heimburger DC. Serum Phosphate Predicts Early Mortality among Underweight Adults Starting ART in Zambia: A Novel Context for Refeeding Syndrome?. J Nutr Metab [print-electronic]. 2013; 2013: 545439. PMID: 23691292, PMCID: PMC3652146, DOI: 10.1155/2013/545439, ISSN: 2090-0724.

Menge TJ, Koethe JR, Jenkins CA, Wright PW, Shinar AA, Miller GG, Holt GE. Acute kidney injury after placement of an antibiotic-impregnated cement spacer during revision total knee arthroplasty. J Arthroplasty [print-electronic]. 2012 Jun; 27(6): 1221-7.e1. PMID: 22321301, PII: S0883-5403(11)00683-8, DOI: 10.1016/j.arth.2011.12.005, ISSN: 1532-8406.

Koethe JR, Bian A, Shintani AK, Boger MS, Mitchell VJ, Erdem H, Hulgan T. Serum leptin level mediates the association of body composition and serum C-reactive protein in HIV-infected persons on antiretroviral therapy. AIDS Res. Hum. Retroviruses [print-electronic]. 2012 Jun; 28(6): 552-7. PMID: 22145933, PMCID: PMC3358098, DOI: 10.1089/AID.2011.0232, ISSN: 1931-8405.

Koethe JR, Jenkins CA, Shepherd BE, Stinnette SE, Sterling TR. An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy. Clin. Infect. Dis [print-electronic]. 2011 Nov; 53(9): 952-60. PMID: 21946189, PMCID: PMC3189168, PII: cir606, DOI: 10.1093/cid/cir606, ISSN: 1537-6591.

Wester CW, Koethe JR, Shepherd BE, Stinnette SE, Rebeiro PF, Kipp AM, Hong H, Bussmann H, Gaolathe T, McGowan CC, Sterling TR, Marlink RG. Non-AIDS-defining events among HIV-1-infected adults receiving combination antiretroviral therapy in resource-replete versus resource-limited urban setting. AIDS. 2011 Jul 7/31/2011; 25(12): 1471-9. PMID: 21572309, PMCID: PMC3188442, DOI: 10.1097/QAD.0b013e328347f9d4, ISSN: 1473-5571.

Koethe JR, Blevins M, Nyirenda C, Kabagambe EK, Shepherd BE, Wester CW, Zulu I, Chiasera JM, Mulenga LB, Mwango A, Heimburger DC. Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia. J Int AIDS Soc. 2011; 14: 19. PMID: 21477359, PMCID: PMC3094357, PII: 1758-2652-14-19, DOI: 10.1186/1758-2652-14-19, ISSN: 1758-2652.

Koethe JR, Limbada MI, Giganti MJ, Nyirenda CK, Mulenga L, Wester CW, Chi BH, Stringer JS. Early immunologic response and subsequent survival among malnourished adults receiving antiretroviral therapy in Urban Zambia. AIDS. 2010 Aug 8/24/2010; 24(13): 2117-21. PMID: 20543657, PMCID: PMC2919155, DOI: 10.1097/QAD.0b013e32833b784a, ISSN: 1473-5571.

Koethe JR, Heimburger DC. Nutritional aspects of HIV-associated wasting in sub-Saharan Africa. Am. J. Clin. Nutr [print-electronic]. 2010 Apr; 91(4): 1138S-1142S. PMID: 20147470, PMCID: PMC2844686, PII: ajcn.2010.28608D, DOI: 10.3945/ajcn.2010.28608D, ISSN: 1938-3207.

Koethe JR, Lukusa A, Giganti MJ, Chi BH, Nyirenda CK, Limbada MI, Banda Y, Stringer JS. Association between weight gain and clinical outcomes among malnourished adults initiating antiretroviral therapy in Lusaka, Zambia. J. Acquir. Immune Defic. Syndr. 2010 Apr 4/1/2010; 53(4): 507-13. PMID: 19730111, PMCID: PMC3749827, DOI: 10.1097/QAI.0b013e3181b32baf, ISSN: 1944-7884.

Heimburger DC, Koethe JR, Nyirenda C, Bosire C, Chiasera JM, Blevins M, Munoz AJ, Shepherd BE, Potter D, Zulu I, Chisembele-Taylor A, Chi BH, Stringer JS, Kabagambe EK. Serum phosphate predicts early mortality in adults starting antiretroviral therapy in Lusaka, Zambia: a prospective cohort study. PLoS ONE. 2010; 5(5): e10687. PMID: 20502700, PMCID: PMC2872675, DOI: 10.1371/journal.pone.0010687, ISSN: 1932-6203.

Koethe JR, Westfall AO, Luhanga DK, Clark GM, Goldman JD, Mulenga PL, Cantrell RA, Chi BH, Zulu I, Saag MS, Stringer JS. A cluster randomized trial of routine HIV-1 viral load monitoring in Zambia: study design, implementation, and baseline cohort characteristics. PLoS ONE. 2010; 5(3): e9680. PMID: 20300631, PMCID: PMC2837376, DOI: 10.1371/journal.pone.0009680, ISSN: 1932-6203.

Koethe JR, Chi BH, Megazzini KM, Heimburger DC, Stringer JS. Macronutrient supplementation for malnourished HIV-infected adults: a review of the evidence in resource-adequate and resource-constrained settings. Clin. Infect. Dis. 2009 Sep 9/1/2009; 49(5): 787-98. PMID: 19624276, PMCID: PMC3092426, DOI: 10.1086/605285, ISSN: 1537-6591.

Koethe JR, Moore RD, Wagner KR. Physician specialization and women's primary care services in an urban HIV clinic. AIDS Patient Care STDS. 2008 May; 22(5): 373-80. PMID: 18373414, PMCID: PMC2597508, DOI: 10.1089/apc.2007.0032, ISSN: 1557-7449.

Koethe JR, Chang AY. Dyspnea and hemoptysis in a 53-year-old woman with a history of breast cancer. Chest. 2008 May; 133(5): 1248-51. PMID: 18460525, PII: 133/5/1248, DOI: 10.1378/chest.07-2188, ISSN: 0012-3692.

Koethe J, Kulesza P. Hypercalcemia and lymphadenopathy. Am. J. Med. 2006 Nov; 119(11): 920-2. PMID: 17071155, PII: S0002-9343(06)01129-6, DOI: 10.1016/j.amjmed.2006.09.004, ISSN: 1555-7162.