Jay H. Fowke, Ph.D.

Associate Professor

Faculty Appointments
Associate Professor of Medicine Associate Professor of Urologic Surgery
Ph.D., Epidemiology, University of Massachusetts, Boston, MassachusettsM.P.H., Epidemiology, State University of New York, Albany, New YorkM.S., Neuroscience, University of Michigan, Ann Arbor, MichiganB.A., Biology, Clark University, Worcester, Massachusetts
Office Address
Institute of Medicine and Public Health
12th floor
2525 West End Ave.
Nashville, TN 37232-8300
Research Description
We use epidemiologic methods to investigate the the causes of cancer. This includes several investigations to understand the relationship between diet or obesity affects the risk of breast or prostate cancer. Genetic markers of susceptibility to these cancers are also investigated. Addtionally, we have started work to understand racial disparities in cancer risk, including the possibility that differences in cancer screening practices by race affect disease outcomes.
Research Keywords
Epidemiology of prostate, breast, and colorectal cancers.
Barocas DA, Grubb R, Black A, Penson DF, Fowke JH, Andriole G, Crawford ED. Association between race and follow-up diagnostic care after a positive prostate cancer screening test in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer [print-electronic]. 2013 Jun 6/15/2013; 119(12): 2223-9. PMID: 23559420, DOI: 10.1002/cncr.28042, ISSN: 1097-0142.

Graff M, Gordon-Larsen P, Lim U, Fowke JH, Love SA, Fesinmeyer M, Wilkens LR, Vertilus S, Ritchie MD, Prentice RL, Pankow J, Monroe K, Manson JE, Le Marchand L, Kuller LH, Kolonel LN, Hong CP, Henderson BE, Haessler J, Gross MD, Goodloe R, Franceschini N, Carlson CS, Buyske S, Bužková P, Hindorff LA, Matise TC, Crawford DC, Haiman CA, Peters U, North KE. The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes [print-electronic]. 2013 May; 62(5): 1763-7. PMID: 23300277, PMCID: PMC3636619, PII: db12-0863, DOI: 10.2337/db12-0863, ISSN: 1939-327X.

Fowke JH, Motley S, Dai Q, Concepcion R, Barocas DA. Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size. Cancer Lett [print-electronic]. 2013 Jan 1/28/2013; 328(2): 345-52. PMID: 23079532, PMCID: PMC3513505, PII: S0304-3835(12)00598-8, DOI: 10.1016/j.canlet.2012.10.010, ISSN: 1872-7980.

Fesinmeyer MD, North KE, Lim U, Bužková P, Crawford DC, Haessler J, Gross MD, Fowke JH, Goodloe R, Love SA, Graff M, Carlson CS, Kuller LH, Matise TC, Hong CP, Henderson BE, Allen M, Rohde RR, Mayo P, Schnetz-Boutaud N, Monroe KR, Ritchie MD, Prentice RL, Kolonel LN, Manson JE, Pankow J, Hindorff LA, Franceschini N, Wilkens LR, Haiman CA, Le Marchand L, Peters U. Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. BMC Med. Genet. 2013; 14: 6. PMID: 23311614, PMCID: PMC3564691, PII: 1471-2350-14-6, DOI: 10.1186/1471-2350-14-6, ISSN: 1471-2350.

Dallal CM, Stone RA, Cauley JA, Ness RB, Vogel VG, Fentiman IS, Fowke JH, Krogh V, Loft S, Meilahn EN, Muti P, Olsen A, Overvad K, Sieri S, Tjønneland A, Ursin G, Wellejus A, Taioli E. Urinary estrogen metabolites and breast cancer: a combined analysis of individual level data. Int. J. Biol. Markers. 2013 Jan; 28(1): 3-16. PMID: 22865302, PII: E28F6DAA-B0E8-4134-9E15-F48EA663FEF5, DOI: 10.5301/JBM.2012.9353, ISSN: 1724-6008.

Fowke JH, Phillips S, Koyama T, Byerly S, Concepcion R, Motley SS, Clark PE. Association between physical activity, lower urinary tract symptoms (LUTS) and prostate volume. BJU Int [print-electronic]. 2013 Jan; 111(1): 122-8. PMID: 22726636, PMCID: PMC3460041, DOI: 10.1111/j.1464-410X.2012.11287.x, ISSN: 1464-410X.

Barocas DA, Gray DT, Fowke JH, Mercaldo ND, Blume JD, Chang SS, Cookson MS, Smith JA, Penson DF. Racial variation in the quality of surgical care for prostate cancer. J. Urol [print-electronic]. 2012 Oct; 188(4): 1279-85. PMID: 22902011, PMCID: PMC3770766, PII: S0022-5347(12)03947-X, DOI: 10.1016/j.juro.2012.06.037, ISSN: 1527-3792.

Buchowski MS, Matthews CE, Cohen SS, Signorello LB, Fowke JH, Hargreaves MK, Schlundt DG, Blot WJ. Evaluation of a questionnaire to assess sedentary and active behaviors in the Southern Community Cohort Study. J Phys Act Health [print-electronic]. 2012 Aug; 9(6): 765-75. PMID: 21952413, PMCID: PMC3527833, PII: 2010-0146, ISSN: 1543-5474.

Cohen SS, Fowke JH, Cai Q, Buchowski MS, Signorello LB, Hargreaves MK, Zheng W, Blot WJ, Matthews CE. Differences in the association between serum leptin levels and body mass index in black and white women: a report from the Southern Community Cohort Study. Ann. Nutr. Metab [print-electronic]. 2012; 60(2): 90-7. PMID: 22353927, PMCID: PMC3710998, PII: 000336180, DOI: 10.1159/000336180, ISSN: 1421-9697.

Fowke JH, Motley SS, Concepcion RS, Penson DF, Barocas DA. Obesity, body composition, and prostate cancer. BMC Cancer. 2012; 12: 23. PMID: 22257467, PMCID: PMC3292483, PII: 1471-2407-12-23, DOI: 10.1186/1471-2407-12-23, ISSN: 1471-2407.

Edwards TL, Velez Edwards DR, Villegas R, Cohen SS, Buchowski MS, Fowke JH, Schlundt D, Long J, Cai Q, Zheng W, Shu XO, Hargreaves MK, Smith J, Williams SM, Signorello LB, Blot WJ, Matthews CE. HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am. J. Epidemiol [print-electronic]. 2012 Jan 1/1/2012; 175(1): 11-21. PMID: 22106445, PMCID: PMC3244609, PII: kwr272, DOI: 10.1093/aje/kwr272, ISSN: 1476-6256.

Penson DF, Munro HM, Signorello LB, Blot WJ, Fowke JH, . Obesity, physical activity and lower urinary tract symptoms: results from the Southern Community Cohort Study. J. Urol [print-electronic]. 2011 Dec; 186(6): 2316-22. PMID: 22014824, PMCID: PMC3327364, PII: S0022-5347(11)04497-1, DOI: 10.1016/j.juro.2011.07.067, ISSN: 1527-3792.

Fowke JH, Munro H, Signorello LB, Blot WJ, Penson DF, . Association between socioeconomic status (SES) and lower urinary tract symptom (LUTS) severity among black and white men. J Gen Intern Med [print-electronic]. 2011 Nov; 26(11): 1305-10. PMID: 21720905, PMCID: PMC3208454, DOI: 10.1007/s11606-011-1776-8, ISSN: 1525-1497.

Fowke JH, Gao YT, Chow WH, Cai Q, Shu XO, Li HL, Ji BT, Rothman N, Yang G, Chung FL, Zheng W. Urinary isothiocyanate levels and lung cancer risk among non-smoking women: a prospective investigation. Lung Cancer [print-electronic]. 2011 Jul; 73(1): 18-24. PMID: 21122939, PMCID: PMC3072449, PII: S0169-5002(10)00537-4, DOI: 10.1016/j.lungcan.2010.10.024, ISSN: 1872-8332.

Barocas DA, Motley S, Cookson MS, Chang SS, Penson DF, Dai Q, Milne G, Roberts LJ, Morrow J, Concepcion RS, Smith JA, Fowke JH. Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. J. Urol [print-electronic]. 2011 Jun; 185(6): 2102-7. PMID: 21496850, PMCID: PMC3093434, PII: S0022-5347(11)00255-2, DOI: 10.1016/j.juro.2011.02.020, ISSN: 1527-3792.

Epplein M, Signorello LB, Zheng W, Cai Q, Hargreaves MK, Michel A, Pawlita M, Fowke JH, Correa P, Blot WJ. Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. Cancer Prev Res (Phila) [print-electronic]. 2011 Jun; 4(6): 871-8. PMID: 21436385, PMCID: PMC3107911, PII: 1940-6207.CAPR-10-0398, DOI: 10.1158/1940-6207.CAPR-10-0398, ISSN: 1940-6215.

Fowke JH, Motley SS, Barocas DA, Cookson MS, Concepcion R, Byerly S, Smith JA. The associations between statin use and prostate cancer screening, prostate size, high-grade prostatic intraepithelial neoplasia (PIN), and prostate cancer. Cancer Causes Control [print-electronic]. 2011 Mar; 22(3): 417-26. PMID: 21170754, PMCID: PMC3042514, DOI: 10.1007/s10552-010-9713-4, ISSN: 1573-7225.

Cohen SS, Gammon MD, Signorello LB, North KE, Lange EM, Fowke JH, Hargreaves MK, Cai Q, Zheng W, Blot WJ, Matthews CE. Serum adiponectin in relation to body mass index and other correlates in black and white women. Ann Epidemiol [print-electronic]. 2011 Feb; 21(2): 86-94. PMID: 21109453, PMCID: PMC3018848, PII: S1047-2797(10)00367-4, DOI: 10.1016/j.annepidem.2010.10.011, ISSN: 1873-2585.

Dai Q, Motley SS, Smith JA, Concepcion R, Barocas D, Byerly S, Fowke JH. Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer. PLoS ONE. 2011; 6(4): e18237. PMID: 21541018, PMCID: PMC3081812, DOI: 10.1371/journal.pone.0018237, ISSN: 1932-6203.

Fowke JH. Head and neck cancer: a case for inhibition by isothiocyanates and indoles from cruciferous vegetables. Eur. J. Cancer Prev. 2007 Aug; 16(4): 348-56. PMID: 17554208, PII: 00008469-200708000-00009, DOI: 10.1097/01.cej.0000236258.80522.fb, ISSN: 0959-8278.

Fowke JH, Motley SS, Wills M, Cookson MS, Concepcion RS, Eckstein CW, Chang SS, Smith JA. Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia. Cancer Causes Control [print-electronic]. 2007 May; 18(4): 375-84. PMID: 17334811, DOI: 10.1007/s10552-007-0119-x, ISSN: 0957-5243.

M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem. Biophys. Res. Commun [print-electronic]. 2007 Feb 2/16/2007; 353(3): 829-34. PMID: 17194448, PMCID: PMC2562600, PII: S0006-291X(06)02787-2, DOI: 10.1016/j.bbrc.2006.12.111, ISSN: 0006-291X.

Fowke JH, Motley SS, Cookson MS, Concepcion R, Chang SS, Wills ML, Smith JA. The association between body size, prostate volume and prostate-specific antigen. Prostate Cancer Prostatic Dis [print-electronic]. 2007; 10(2): 137-42. PMID: 17179979, PII: 4500924, DOI: 10.1038/sj.pcan.4500924, ISSN: 1365-7852.

Fowke JH, Signorello LB, Chang SS, Matthews CE, Buchowski MS, Cookson MS, Ukoli FM, Blot WJ. Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men. Cancer. 2006 Nov 11/15/2006; 107(10): 2361-7. PMID: 17031814, DOI: 10.1002/cncr.22249, ISSN: 0008-543X.

Canter JA, Kallianpur AR, Fowke JH. Re: North American white mitochondrial haplogroups in prostate and renal cancer [letter]. J. Urol. 2006 Nov; 176(5): 2308-9; author reply 2309. PMID: 17070319, PII: S0022-5347(06)01744-7, DOI: 10.1016/j.juro.2006.07.067, ISSN: 0022-5347.

Fowke JH, Morrow JD, Motley S, Bostick RM, Ness RM. Brassica vegetable consumption reduces urinary F2-isoprostane levels independent of micronutrient intake. Carcinogenesis [print-electronic]. 2006 Oct; 27(10): 2096-102. PMID: 16704986, PII: bgl065, DOI: 10.1093/carcin/bgl065, ISSN: 0143-3334.

Fowke JH, Signorello LB, Underwood W, Ukoli FA, Blot WJ. Obesity and prostate cancer screening among African-American and Caucasian men. Prostate. 2006 Sep 9/15/2006; 66(13): 1371-80. PMID: 16752375, DOI: 10.1002/pros.20377, ISSN: 0270-4137.

Fowke JH, Schlundt D, Signorello LB, Ukoli FA, Blot WJ. Prostate cancer screening between low-income African-American and Caucasian men. Urol. Oncol. 2005 Sep; 23(5): 333-40. PMID: 16144667, PII: S1078-1439(05)00004-9, DOI: 10.1016/j.urolonc.2005.01.002, ISSN: 1078-1439.

Teas J, Cunningham JE, Fowke JH, Nitcheva D, Kanwat CP, Boulware RJ, Sepkovic DW, Hurley TG, Hebert JR. Urinary estrogen metabolites, prostate specific antigen, and body mass index among African-American men in South Carolina. Cancer Detect. Prev [print-electronic]. 2005; 29(6): 494-500. PMID: 16289388, PII: S0361-090X(05)00121-2, DOI: 10.1016/j.cdp.2005.08.004, ISSN: 0361-090X.

Fowke JH, Schlundt D, Gong Y, Jin F, Shu XO, Wen W, Liu DK, Gao YT, Zheng W. Impact of season of food frequency questionnaire administration on dietary reporting. Ann Epidemiol. 2004 Nov; 14(10): 778-85. PMID: 15519900, PII: S1047-2797(04)00061-4, DOI: 10.1016/j.annepidem.2004.02.002, ISSN: 1047-2797.

Fowke JH, Shu XO, Dai Q, Jin F, Cai Q, Gao YT, Zheng W. Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms. Cancer Epidemiol. Biomarkers Prev. 2004 Aug; 13(8): 1308-15. PMID: 15298951, PII: 13/8/1308, ISSN: 1055-9965.

Matthews CE, Fowke JH, Dai Q, Leon Bradlow H, Jin F, Shu XO, Gao YT, Longcope C, Hebert JR, Zheng W. Physical activity, body size, and estrogen metabolism in women. Cancer Causes Control. 2004 Jun; 15(5): 473-81. PMID: 15286467, PII: 5271905, DOI: 10.1023/B:CACO.0000036445.04238.87, ISSN: 0957-5243.

Fowke JH, Shu XO, Dai Q, Shintani A, Conaway CC, Chung FL, Cai Q, Gao YT, Zheng W. Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China. Cancer Epidemiol. Biomarkers Prev. 2003 Dec; 12(12): 1536-9. PMID: 14693750, ISSN: 1055-9965.

Fowke JH, Chung FL, Jin F, Qi D, Cai Q, Conaway C, Cheng JR, Shu XO, Gao YT, Zheng W. Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res. 2003 Jul 7/15/2003; 63(14): 3980-6. PMID: 12873994, ISSN: 0008-5472.

Fowke JH, Qi D, Bradlow HL, Shu XO, Gao YT, Cheng JR, Jin F, Zheng W. Urinary estrogen metabolites and breast cancer: differential pattern of risk found with pre- versus post-treatment collection. Steroids. 2003 Jan; 68(1): 65-72. PMID: 12475724, PII: S0039128X02001162, ISSN: 0039-128X.

Fowke JH, Hebert JR, Fahey JW. Urinary excretion of dithiocarbamates and self-reported Cruciferous vegetable intake: application of the 'method of triads' to a food-specific biomarker. Public Health Nutr. 2002 Dec; 5(6): 791-9. PMID: 12570887, PII: S1368980002001052, DOI: 10.1079/PHN2002345, ISSN: 1368-9800.

Fowke JH, Fahey JW, Stephenson KK, Hebert JR. Using isothiocyanate excretion as a biological marker of Brassica vegetable consumption in epidemiological studies: evaluating the sources of variability. Public Health Nutr. 2001 Jun; 4(3): 837-46. PMID: 11415492, PII: S1368980001000805, ISSN: 1368-9800.

Fowke JH, Longcope C, Hebert JR. Macronutrient intake and estrogen metabolism in healthy postmenopausal women. Breast Cancer Res. Treat. 2001 Jan; 65(1): 1-10. PMID: 11245334, ISSN: 0167-6806.

Fowke JH, Longcope C, Hebert JR. Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidemiol. Biomarkers Prev. 2000 Aug; 9(8): 773-9. PMID: 10952093, ISSN: 1055-9965.

DeCaprio AP, Kinney EA, Fowke JH. Regioselective binding of 2,5-hexanedione to high-molecular-weight rat neurofilament proteins in vitro. Toxicol. Appl. Pharmacol. 1997 Jul; 145(1): 211-7. PMID: 9221839, PII: S0041-008X(97)98181-3, DOI: 10.1006/taap.1997.8181, ISSN: 0041-008X.

Richardson RJ, Moore TB, Kayyali US, Fowke JH, Randall JC. Inhibition of hen brain acetylcholinesterase and neurotoxic esterase by chlorpyrifos in vivo and kinetics of inhibition by chlorpyrifos oxon in vitro: application to assessment of neuropathic risk. Fundam Appl Toxicol. 1993 Apr; 20(3): 273-9. PMID: 7684990, PII: S0272059083710365, ISSN: 0272-0590.

DeCaprio AP, Fowke JH. Limited and selective adduction of carboxyl-terminal lysines in the high molecular weight neurofilament proteins by 2,5-hexanedione in vitro. Brain Res. 1992 Jul 7/24/1992; 586(2): 219-28. PMID: 1521155, PII: 0006-8993(92)91630-W, ISSN: 0006-8993.

DeCaprio AP, Spink DC, Chen X, Fowke JH, Zhu M, Bank S. Characterization of isothiocyanates, thioureas, and other lysine adduction products in carbon disulfide-treated peptides and protein. Chem. Res. Toxicol. 1992 Jul; 5(4): 496-504. PMID: 1391615, ISSN: 0893-228X.