David W. Haas, M.D.


Faculty Appointments
Professor of Medicine Professor of Pathology, Microbiology and ImmunologyProfessor of Pharmacology
M.D., Medicine , Vanderbilt University, Nashville, TennesseeA.B., Indiana University, Bloomington, Indiana
Office Address
Vanderbilt Health - One Hundred Oaks
719 Thompson Lane, Suite 47183
Nashville, TN 37204
Research Description
David Haas is an accomplished HIV clinical trialist and leader in human pharmacogenomic research relevant to HIV infection and its therapy. He has led the design and implementation of dozens of HIV clinical trials since 1994, both single site studies and multicenter projects. He established and has led the AIDS Clinical Trials Group (ACTG) Clinical Research Site at Vanderbilt since its inception. He previously chaired the Pharmacology Committee for the AIDS Clinical Trials Group (ACTG), has led the ACTG’s pharmacogenomics program since 2000, and in 2011 was elected to serve on the ACTG Executive Committee. He oversaw the establishment of the ACTG Human DNA Repository, and is now extending DNA banking to non-US ACTG sites in resource-limited countries in worldwide. His work with the ACTG led to the seminal observation that a frequent CYP2B6 polymorphism predicts delayed clearance of efavirenz, which largely explains increased plasma exposure among individuals of African descent, and may help predict CNS side effects and virologic response. He is PI of a substantial, collaborative, multidisciplinary R01 entitled “Pharmacogenomics of HIV Therapy”. He is highly engaged in collaborative, multidisciplinary research with an emphasis on the importance of human genomics for antiretroviral disposition, efficacy, and toxicity. This is complemented on his extensive work on designing and implementing prospective clinical trials.
Research Keywords
AIDS, HIV, Pharmacogenomics, Tuberculosis
McLaren PJ, Ripke S, Pelak K, Weintrob AC, Patsopoulos NA, Jia X, Erlich RL, Lennon NJ, Kadie CM, Heckerman D, Gupta N, Haas DW, Deeks SG, Pereyra F, Walker BD, de Bakker PI, . Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans. Hum. Mol. Genet [print-electronic]. 2012 Oct 10/1/2012; 21(19): 4334-47. PMID: 22718199, PMCID: PMC3441117, PII: dds226, DOI: 10.1093/hmg/dds226, ISSN: 1460-2083.

Boger MS, Hulgan T, Haas DW, Mitchell V, Smith AG, Singleton JR, Peltier AC. Measures of small-fiber neuropathy in HIV infection. Auton Neurosci [print-electronic]. 2012 Jul 7/2/2012; 169(1): 56-61. PMID: 22542355, PMCID: PMC3372978, PII: S1566-0702(12)00067-7, DOI: 10.1016/j.autneu.2012.04.001, ISSN: 1872-7484.

Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Purcell SM, Haas DW, Liang L, Sunyaev S, Patterson N, de Bakker PI, Reich D, Price AL. Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nat. Genet. 2012 Jun; 44(6): 631-5. PMID: 22610117, PMCID: PMC3400344, PII: ng.2283, DOI: 10.1038/ng.2283, ISSN: 1546-1718.

Dooley KE, Park JG, Swindells S, Allen R, Haas DW, Cramer Y, Aweeka F, Wiggins I, Gupta A, Lizak P, Qasba S, van Heeswijk R, Flexner C, . Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267. J. Acquir. Immune Defic. Syndr. 2012 Apr 4/15/2012; 59(5): 455-62. PMID: 22126739, PMCID: PMC3302922, DOI: 10.1097/QAI.0b013e3182410503, ISSN: 1944-7884.

Martin MA, Klein TE, Dong BJ, Pirmohamed M, Haas DW, Kroetz DL, . Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing. Clin. Pharmacol. Ther [print-electronic]. 2012 Apr; 91(4): 734-8. PMID: 22378157, PMCID: PMC3374459, PII: clpt2011355, DOI: 10.1038/clpt.2011.355.

Clifford DB, Simpson DM, Brown S, Moyle G, Brew BJ, Conway B, Tobias JK, Vanhove GF, . A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy. J. Acquir. Immune Defic. Syndr. 2012 Feb 2/1/2012; 59(2): 126-33. PMID: 22067661, DOI: 10.1097/QAI.0b013e31823e31f7, ISSN: 1944-7884.

Birdwell KA, Grady B, Choi L, Xu H, Bian A, Denny JC, Jiang M, Vranic G, Basford M, Cowan JD, Richardson DM, Robinson MP, Ikizler TA, Ritchie MD, Stein CM, Haas DW. The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet. Genomics. 2012 Jan; 22(1): 32-42. PMID: 22108237, PMCID: PMC3237759, DOI: 10.1097/FPC.0b013e32834e1641, ISSN: 1744-6880.

Boger MS, Bian A, Shintani A, Milne GL, Morrow JD, Erdem H, Mitchell V, Haas DW, Hulgan T. Sex differences in urinary biomarkers of vascular and endothelial function in HIV-infected persons receiving antiretroviral therapy. Antivir. Ther. (Lond.) [print-electronic]. 2012; 17(3): 485-93. PMID: 22293574, PMCID: PMC3766979, DOI: 10.3851/IMP1990, ISSN: 2040-2058.

Grady BJ, Samuels DC, Robbins GK, Selph D, Canter JA, Pollard RB, Haas DW, Shafer R, Kalams SA, Murdock DG, Ritchie MD, Hulgan T, . Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384. J. Acquir. Immune Defic. Syndr. 2011 Dec 12/1/2011; 58(4): 363-70. PMID: 21792066, PMCID: PMC3204178, DOI: 10.1097/QAI.0b013e31822c688b, ISSN: 1944-7884.

Haas DW, Kuritzkes DR, Ritchie MD, Amur S, Gage BF, Maartens G, Masys D, Fellay J, Phillips E, Ribaudo HJ, Freedberg KA, Petropoulos C, Manolio TA, Gulick RM, Haubrich R, Kim P, Dehlinger M, Abebe R, Telenti A, . Pharmacogenomics of HIV therapy: summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases. HIV Clin Trials. 2011 Sep; 12(5): 277-85. PMID: 22180526, PMCID: PMC3322423, PII: H4HV83200516XH08, DOI: 10.1310/hct1205-277, ISSN: 1528-4336.

Almeida CA, Bronke C, Roberts SG, McKinnon E, Keane NM, Chopra A, Kadie C, Carlson J, Haas DW, Riddler SA, Haubrich R, Heckerman D, Mallal S, John M. Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes. J. Immunol [print-electronic]. 2011 Sep 9/1/2011; 187(5): 2502-13. PMID: 21821798, PMCID: PMC3183574, PII: jimmunol.1100691, DOI: 10.4049/jimmunol.1100691, ISSN: 1550-6606.

Yuan J, Guo S, Hall D, Cammett AM, Jayadev S, Distel M, Storfer S, Huang Z, Mootsikapun P, Ruxrungtham K, Podzamczer D, Haas DW, . Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent. AIDS. 2011 Jun 6/19/2011; 25(10): 1271-80. PMID: 21505298, PMCID: PMC3387531, DOI: 10.1097/QAD.0b013e32834779df, ISSN: 1473-5571.

Hulgan T, Haubrich R, Riddler SA, Tebas P, Ritchie MD, McComsey GA, Haas DW, Canter JA. European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142. AIDS. 2011 Jan 1/2/2011; 25(1): 37-47. PMID: 20871389, PMCID: PMC2995830, DOI: 10.1097/QAD.0b013e32833f9d02, ISSN: 1473-5571.

Grady BJ, Torstenson ES, McLaren PJ, DE Bakker PI, Haas DW, Robbins GK, Gulick RM, Haubrich R, Ribaudo H, Ritchie MD. Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pac Symp Biocomput. 2011; 253-64. PMID: 21121053, PMCID: PMC3094912, PII: 9789814335058_0027, ISSN: 2335-6936.

Currier J, Averitt Bridge D, Hagins D, Zorrilla CD, Feinberg J, Ryan R, Falcon R, Tennenberg A, Mrus J, Squires K, . Sex-based outcomes of darunavir-ritonavir therapy: a single-group trial. Ann. Intern. Med. 2010 Sep 9/21/2010; 153(6): 349-57. PMID: 20855799, PMCID: PMC3056066, PII: 153/6/349, DOI: 10.7326/0003-4819-153-6-201009210-00002, ISSN: 1539-3704.

Ribaudo HJ, Liu H, Schwab M, Schaeffeler E, Eichelbaum M, Motsinger-Reif AA, Ritchie MD, Zanger UM, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford D, Haas DW. Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. J. Infect. Dis. 2010 Sep 9/1/2010; 202(5): 717-22. PMID: 20662624, PMCID: PMC2919241, DOI: 10.1086/655470, ISSN: 1537-6613.

Canter JA, Robbins GK, Selph D, Clifford DB, Kallianpur AR, Shafer R, Levy S, Murdock DG, Ritchie MD, Haas DW, Hulgan T, , . African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy. J. Infect. Dis. 2010 Jun 6/1/2010; 201(11): 1703-7. PMID: 20402593, PMCID: PMC2862090, DOI: 10.1086/652419, ISSN: 1537-6613.

John M, Heckerman D, James I, Park LP, Carlson JM, Chopra A, Gaudieri S, Nolan D, Haas DW, Riddler SA, Haubrich R, Mallal S. Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. J. Immunol [print-electronic]. 2010 Apr 4/15/2010; 184(8): 4368-77. PMID: 20231689, PMCID: PMC3011274, PII: jimmunol.0903745, DOI: 10.4049/jimmunol.0903745, ISSN: 1550-6606.

Smith JP, Weller S, Johnson B, Nicotera J, Luther JM, Haas DW. Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function. Antimicrob. Agents Chemother [print-electronic]. 2010 Mar; 54(3): 1146-51. PMID: 20038622, PMCID: PMC2825963, PII: AAC.00729-09, DOI: 10.1128/AAC.00729-09, ISSN: 1098-6596.

Sadagopal S, Lorey SL, Barnett L, Sutherland D, Basham R, Erdem H, Kalams SA, Haas DW. Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection. J. Virol [print-electronic]. 2010 Jan; 84(1): 131-40. PMID: 19828602, PMCID: PMC2798447, PII: JVI.01181-09, DOI: 10.1128/JVI.01181-09, ISSN: 1098-5514.

Xu H, Doan S, Birdwell KA, Cowan JD, Vincz AJ, Haas DW, Basford MA, Denny JC. An automated approach to calculating the daily dose of tacrolimus in electronic health records. AMIA Jt Summits Transl Sci Proc. 2010; 2010: 71-5. PMID: 21347153, PMCID: PMC3041548, ISSN: 2153-4063.

Boger MS, Shintani A, Redhage LA, Mitchell V, Haas DW, Morrow JD, Hulgan T. Highly sensitive C-reactive protein, body mass index, and serum lipids in HIV-infected persons receiving antiretroviral therapy: a longitudinal study. J. Acquir. Immune Defic. Syndr. 2009 Dec 12/1/2009; 52(4): 480-7. PMID: 19911471, PMCID: PMC2794651, ISSN: 1944-7884.

Hulgan T, Donahue JP, Smeaton L, Pu M, Wang H, Lederman MM, Smith K, Valdez H, Pilcher C, Haas DW, . Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors. Eur. J. Clin. Pharmacol. 2009 Nov; 65(11): 1081-8. PMID: 19779705, PMCID: PMC2873632, DOI: 10.1007/s00228-009-0725-5, ISSN: 1432-1041.

Basham RJ, Richardson DM, Sutcliffe CB, Haas DW. Effect of HIV-1 infection on human DNA yield from saliva. HIV Clin Trials. 2009 Jul; 10(4): 282-5. PMID: 19723616, PMCID: PMC2761620, PII: Y65W64K36346NK41, DOI: 10.1310/hct1004-282, ISSN: 1528-4336.

Redhage LA, Shintani A, Haas DW, Emeagwali N, Markovic M, Oboho I, Mwenya C, Erdem H, Acosta EP, Morrow JD, Hulgan T. Clinical factors associated with plasma F2-isoprostane levels in HIV-infected adults. HIV Clin Trials. 2009 May; 10(3): 181-92. PMID: 19632957, PMCID: PMC2891063, PII: BG421Q1XL1393227, DOI: 10.1310/hct1003-181, ISSN: 1528-4336.

Haas DW, Gebretsadik T, Mayo G, Menon UN, Acosta EP, Shintani A, Floyd M, Stein CM, Wilkinson GR. Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans. J. Infect. Dis. 2009 Mar 3/15/2009; 199(6): 872-80. PMID: 19239339, PMCID: PMC2784690, DOI: 10.1086/597125, ISSN: 0022-1899.

Haas DW, Koletar SL, Laughlin L, Kendall MA, Suckow C, Gerber JG, Zolopa AR, Bertz R, Child MJ, Hosey L, Alston-Smith B, Acosta EP, . Hepatotoxicity and gastrointestinal intolerance when healthy volunteers taking rifampin add twice-daily atazanavir and ritonavir. J. Acquir. Immune Defic. Syndr. 2009 Mar 3/1/2009; 50(3): 290-3. PMID: 19194314, PMCID: PMC2653210, DOI: 10.1097/QAI.0b013e318189a7df, ISSN: 1525-4135.

Sadagopal S, Lorey SL, Barnett L, Basham R, Lebo L, Erdem H, Haman K, Avison M, Waddell K, Haas DW, Kalams SA. Enhancement of human immunodeficiency virus (HIV)-specific CD8+ T cells in cerebrospinal fluid compared to those in blood among antiretroviral therapy-naive HIV-positive subjects. J. Virol [print-electronic]. 2008 Nov; 82(21): 10418-28. PMID: 18715919, PMCID: PMC2573184, PII: JVI.01190-08, DOI: 10.1128/JVI.01190-08, ISSN: 1098-5514.

Pepper T, Joseph P, Mwenya C, McKee GS, Haushalter A, Carter A, Warkentin J, Haas DW, Sterling TR. Normal chest radiography in pulmonary tuberculosis: implications for obtaining respiratory specimen cultures. Int. J. Tuberc. Lung Dis. 2008 Apr; 12(4): 397-403. PMID: 18371265, ISSN: 1027-3719.

Hulgan T, Tebas P, Canter JA, Mulligan K, Haas DW, Dubé M, Grinspoon S, Robbins GK, Motsinger AA, Kallianpur AR, . Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy. J. Infect. Dis. 2008 Mar 3/15/2008; 197(6): 858-66. PMID: 18419350, DOI: 10.1086/528697, ISSN: 0022-1899.

Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Murdock DG, Hulgan T. The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenomics J [print-electronic]. 2008 Feb; 8(1): 71-7. PMID: 17684475, PII: 6500470, DOI: 10.1038/sj.tpj.6500470, ISSN: 1470-269X.

Motsinger AA, Haas DW, Hulgan T, Ritchie MD. Human genomic association studies: a primer for the infectious diseases specialist. J. Infect. Dis [print-electronic]. 2007 Jun 6/15/2007; 195(12): 1737-44. PMID: 17492588, PII: JID37481, DOI: 10.1086/518247, ISSN: 0022-1899.

Oswald-Richter K, Grill SM, Leelawong M, Tseng M, Kalams SA, Hulgan T, Haas DW, Unutmaz D. Identification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection. PLoS Pathog. 2007 Apr; 3(4): e58. PMID: 17465678, PMCID: PMC1857714, PII: 06-PLPA-RA-0420R2, DOI: 10.1371/journal.ppat.0030058, ISSN: 1553-7374.