Holly M. Algood, Ph.D.

Assistant Professor

holly.m.algood@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Molecular Virology and Microbiology, University of Pittsburgh, Pittsburgh, PennsylvaniaB.S., Biology, Mount Union College, Alliance, Ohio
Office Address
AA-2200 MCN
1161 21st Ave South
Nashville, TN 37232
Research Description
Projects in Dr. Algood's lab focus on pathogen - host interactions in chronic infections and during chronic inflammation. Her main model system is <i>Helicobacter pylori</i> infection. <i>Helicobacter pylori</i> is a Gram-negative pathogen which can chronically colonize the human stomach and lead to adverse disease outcomes such as peptic ulcers or gastric cancer. Her projects investigate how T cell cytokines influence gastric epithelial cells responding to infection but also even more broadly how T cell cytokines activate other cells to protect the epithelial cells and the mucosal barrier they maintain. Dr. Algood's research utilizes <i>H. pylori</i> as a model mucosal pathogen, but her long-term research interests lie in understanding the balance between the mucosal immune responses, pathogens, and normal flora. While immune responses may be necessary to control bacterial colonization at the mucosal surfaces, the immune response must also be well controlled to maintain epithelial cell integrity and to control infiltration of other potentially damaging immune cells. Th17-driven immune responses have been implicated in pro-inflammatory activity and induction of chronic inflammation; she would like to better understand how the Th17 response is balanced. Moreover, since the inflammatory/immune response is not sufficient to clear the infection, Dr. Algood's laboratory is beginning studies to investigate how the bacteria persist while combated with the stresses of the immune response.
Research Keywords
Helicobacter pylori, inflammation, T lymphocytes, cytokines, bacterial pathogenesis, Th17, bacterial response, oxidative stress, host-pathogen interactions
Publications
Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HM. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. MBio. 2014; 5(4): e01243-14. PMID: 25053783, PMCID: PMC4120195, PII: mBio.01243-14, DOI: 10.1128/mBio.01243-14, ISSN: 2150-7511.

Radin JN, González-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS, Cover TL. Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect. Immun [print-electronic]. 2014 Jan; 82(1): 423-32. PMID: 24191302, PMCID: PMC3911829, PII: IAI.00827-13, DOI: 10.1128/IAI.00827-13, ISSN: 1098-5522.

Gaddy JA, Radin JN, Loh JT, Zhang F, Washington MK, Peek RM, Algood HM, Cover TL. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect. Immun [print-electronic]. 2013 Jun; 81(6): 2258-67. PMID: 23569116, PMCID: PMC3676043, PII: IAI.01271-12, DOI: 10.1128/IAI.01271-12, ISSN: 1098-5522.

Radin JN, Gaddy JA, González-Rivera C, Loh JT, Algood HM, Cover TL. Flagellar localization of a Helicobacter pylori autotransporter protein. MBio. 2013; 4(2): e00613-12. PMID: 23572556, PMCID: PMC3622936, PII: mBio.00613-12, DOI: 10.1128/mBio.00613-12, ISSN: 2150-7511.

Horvath DJ, Radin JN, Cho SH, Washington MK, Algood HM. The interleukin-17 receptor B subunit is essential for the Th2 response to Helicobacter pylori, but not for control of bacterial burden. PLoS ONE [print-electronic]. 2013; 8(3): e60363. PMID: 23533678, PMCID: PMC3606319, PII: PONE-D-12-40152, DOI: 10.1371/journal.pone.0060363, ISSN: 1932-6203.

González-Rivera C, Algood HM, Radin JN, McClain MS, Cover TL. The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay. Infect. Immun [print-electronic]. 2012 Aug; 80(8): 2578-88. PMID: 22585965, PMCID: PMC3434591, PII: IAI.00052-12, DOI: 10.1128/IAI.00052-12, ISSN: 1098-5522.

Horvath DJ, Washington MK, Cope VA, Algood HM. IL-23 Contributes to Control of Chronic Helicobacter Pylori Infection and the Development of T Helper Responses in a Mouse Model. Front Immunol. 2012; 3: 56. PMID: 22566937, PMCID: PMC3342083, DOI: 10.3389/fimmu.2012.00056, ISSN: 1664-3224.

Olivares-Villagómez D, Algood HM, Singh K, Parekh VV, Ryan KE, Piazuelo MB, Wilson KT, Van Kaer L. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J. Immunol [print-electronic]. 2011 Oct 10/15/2011; 187(8): 4051-60. PMID: 21900182, PMCID: PMC3186831, PII: jimmunol.1101052, DOI: 10.4049/jimmunol.1101052, ISSN: 1550-6606.

Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-¿ production. Gastroenterology [print-electronic]. 2011 Jan; 140(1): 265-74. PMID: 20875416, PMCID: PMC3008308, PII: S0016-5085(10)01421-6, DOI: 10.1053/j.gastro.2010.09.041, ISSN: 1528-0012.

Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K, Barry DP, Algood HS, de Sablet T, Gobert AP, Wilson KT. Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. J. Biol. Chem [print-electronic]. 2010 Jun 6/25/2010; 285(26): 20343-57. PMID: 20410304, PMCID: PMC2888446, PII: M110.116988, DOI: 10.1074/jbc.M110.116988, ISSN: 1083-351X.

Ivie SE, McClain MS, Algood HM, Lacy DB, Cover TL. Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin. BMC Microbiol. 2010; 10: 60. PMID: 20178613, PMCID: PMC2836311, PII: 1471-2180-10-60, DOI: 10.1186/1471-2180-10-60, ISSN: 1471-2180.

Algood HM, Allen SS, Washington MK, Peek RM, Miller GG, Cover TL. Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J. Immunol [print-electronic]. 2009 Nov 11/1/2009; 183(9): 5837-46. PMID: 19812196, PMCID: PMC2834183, PII: jimmunol.0901206, DOI: 10.4049/jimmunol.0901206, ISSN: 1550-6606.

Loh JT, Torres VJ, Algood HM, McClain MS, Cover TL. Helicobacter pylori HopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells. FEMS Microbiol. Lett. 2008 Dec; 289(1): 53-8. PMID: 19065710, PMCID: PMC2651568, ISSN: 0378-1097.

Ivie SE, McClain MS, Torres VJ, Algood HM, Lacy DB, Yang R, Blanke SR, Cover TL. Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes. Infect. Immun [print-electronic]. 2008 Jul; 76(7): 2843-51. PMID: 18443094, PMCID: PMC2446698, PII: IAI.01664-07, DOI: 10.1128/IAI.01664-07, ISSN: 1098-5522.

Algood HM, Gallo-Romero J, Wilson KT, Peek RM, Cover TL. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol. Med. Microbiol [print-electronic]. 2007 Dec; 51(3): 577-86. PMID: 17919297, PII: FIM338, DOI: 10.1111/j.1574-695X.2007.00338.x, ISSN: 0928-8244.

Chaturvedi R, Asim M, Lewis ND, Algood HM, Cover TL, Kim PY, Wilson KT. L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect. Immun [print-electronic]. 2007 Sep; 75(9): 4305-15. PMID: 17562760, PMCID: PMC1951193, PII: IAI.00578-07, DOI: 10.1128/IAI.00578-07, ISSN: 0019-9567.

Algood HM, Torres VJ, Unutmaz D, Cover TL. Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin. Infect. Immun [print-electronic]. 2007 Jan; 75(1): 334-41. PMID: 17074854, PMCID: PMC1828377, PII: IAI.01063-06, DOI: 10.1128/IAI.01063-06, ISSN: 0019-9567.

Algood HM, Cover TL. Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses. Clin. Microbiol. Rev. 2006 Oct; 19(4): 597-613. PMID: 17041136, PMCID: PMC1592695, PII: 19/4/597, DOI: 10.1128/CMR.00006-06, ISSN: 0893-8512.

Algood HM, Lin PL, Flynn JL. Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. Clin. Infect. Dis. 2005 Aug 8/1/2005; 41 Suppl 3: S189-93. PMID: 15983898, PII: CID35769, DOI: 10.1086/429994, ISSN: 1537-6591.

Algood HM, Flynn JL. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J. Immunol. 2004 Sep 9/1/2004; 173(5): 3287-96. PMID: 15322191, PII: 173/5/3287, ISSN: 0022-1767.

Algood HM, Lin PL, Yankura D, Jones A, Chan J, Flynn JL. TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection. J. Immunol. 2004 Jun 6/1/2004; 172(11): 6846-57. PMID: 15153503, ISSN: 0022-1767.

Algood HM, Chan J, Flynn JL. Chemokines and tuberculosis. Cytokine Growth Factor Rev. 2003 Dec; 14(6): 467-77. PMID: 14563349, PII: S1359610103000546, ISSN: 1359-6101.

Scott HM, Flynn JL. Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infect. Immun. 2002 Nov; 70(11): 5946-54. PMID: 12379669, PMCID: PMC130313, ISSN: 0019-9567.

Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2001 Jul 7/3/2001; 98(14): 7958-63. PMID: 11438742, PMCID: PMC35450, PII: 98/14/7958, DOI: 10.1073/pnas.131207398, ISSN: 0027-8424.

Mohan VP, Scanga CA, Yu K, Scott HM, Tanaka KE, Tsang E, Tsai MM, Flynn JL, Chan J. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect. Immun. 2001 Mar; 69(3): 1847-55. PMID: 11179363, PMCID: PMC98092, DOI: 10.1128/IAI.69.3.1847-1855.2001, ISSN: 0019-9567.