Keith T. Wilson, M.D.

Professor

keith.wilson@vanderbilt.edu
Faculty Appointments
Professor of Medicine Professor of Pathology, Microbiology and ImmunologyProfessor of Cancer BiologyThomas F. Frist Sr. Chair in Medicine
Education
M.D., Medicine, Harvard Medical School, Boston, MassachusettsB.A., Biology/Anthropolopy, Cornell University, Ithaca, New York
Office Address
1030C MRB IV
2215 Garland Avenue
Nashville, TN 37232-0252
Research Description
My laboratory is focused on gastrointestinal mucosal inflammation and carcinogenesis. We study the host immune response to the gastric pathogen Helicobacter pylori that causes peptic ulcer disease and gastric cancer. This includes the innate immune response in macrophages and the identification of ways that this response is ineffective. We have also elucidated mechanisms whereby epithelial responses are inappropriate, leading to risk for cancer development. We study novel mechanisms for inflammation and cellular/DNA damage, which leads to increased cancer risk.

We have reported that H. pylori induces the enzyme spermine oxidase (SMOX), originally known as polyamine oxidase 1, which utilizes the polyamine spermine as substrate. Generation of H2O2 by SMOX results in mitochondrial membrane depolarization, cytochrome c release, and apoptosis. Spermine itself contributes to the inadequacy of the host response, by blocking translation of inducible nitric oxide (NO) synthase (iNOS) and hence NO production that is needed for the killing of H. pylori. Upregulation of SMOX causes oxidative stress in gastric epithelial cells that leads to both apoptosis and DNA damage. Induction of ornithine decarboxylase (ODC) that generates polyamines also leads to apoptosis of macrophages, contributing to loss of host innate immunity to H. pylori. We have shown that induction of the transcription factor c-Myc by H. pylori enhances ODC transcription and has a causal role in macrophage apoptosis. We have also implicated formation of a specific AP-1 complex in the activation of c-Myc.

We are utilizing clinical material from a large cohort of human subjects from Colombia, South America where H. pylori infection prevalence is very high, but gastric cancer risk is 25-fold higher in the Andean mountains when compared to the coastal region. We have found that SMOX-dependent oxidative stress is increased in gastric epithelial cells in vivo in the subjects at high risk for gastric cancer and that H. pylori clinical strains from these subjects induce more SMOX and oxidative DNA damage both in vitro and in vivo in a gerbil model. Furthermore, inhibition of ODC or SMOX reduces gastric cancer in the gerbil model. Studies are ongoing to pursue the mechanisms involved in the differential induction of SMOX and DNA damage.

We are also pursuing studies on immune dysregulation in inflammatory bowel disease. This includes work on arginine availability/transport, polyamines, and nitric oxide. We have reported that levels of the amino acid L-arginine are increased in the serum of humans with ulcerative colitis. Because L-arginine is important in regulation of epithelial integrity and immune function a defect in the utilization of L-arginine could contribute to the disease pathogenesis. Consistent with this, we have shown that treatment with L-arginine improves colitis in mouse models and that mice lacking an inducible L-arginine transporter have increased disease activity.

Our funded studies are focused on:
1) Mechanisms of H. pylori induced DNA damage and immune dysregulation, with an emphasis on the effects of polyamines and their oxidation (PI, R01 grant)
2) The role oxidative and nitrosative stress in the development of gastric cancer in Colombia, and the importance of H. pylori strains from regions of low and high gastric cancer risk in modulation of host responses (PI, P01 grant)
3) Importance of arginine metabolism in the immune response to H. pylori (PI, VA Merit Review Grant)
4) Role of EGFR signaling and polyamines in epithelial dysfunction in H. pylori infection and carcinogenesis (PI, project on P01)
5) Inhibition of polyamine synthesis with difluoromethylornithine in human subjects in Colombia and Honduras with precancerous gastric lesions (PI, R01 grant).
6) Arginine and other amino acids as immunomodulatory agents and potential therapies in colitis and colitis-associated cancer (PI, R01 grant)
7) Clinical study on amino acids in ulcerative colitis (PI- R01 supplement; funding completed, analysis ongoing)

Research Keywords
Mucosal immunology, mechanisms of inflammation, oxidative stress and gastrointestinal carcinogenesis, host-pathogen interactions, inflammatory bowel disease, Helicobacter pylori infection
Publications
Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Oncogene [print-electronic]. 2016 May 5/9/2016; PMID: 27157617, PII: onc2016158, DOI: 10.1038/onc.2016.158, ISSN: 1476-5594.

Gobert AP, Wilson KT. The Immune Battle against Helicobacter pylori Infection: NO Offense. Trends Microbiol [print-electronic]. 2016 May; 24(5): 366-76. PMID: 26916789, PMCID: PMC4841705, PII: S0966-842X(16)00041-X, DOI: 10.1016/j.tim.2016.02.005, ISSN: 1878-4380.

Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT. L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Inflamm. Bowel Dis [print-electronic]. 2016 Apr 4/21/2016; PMID: 27104830, DOI: 10.1097/MIB.0000000000000790, ISSN: 1536-4844.

Hardbower DM, Asim M, Murray-Stewart T, Casero RA, Verriere T, Lewis ND, Chaturvedi R, Piazuelo MB, Wilson KT. Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. Amino Acids [print-electronic]. 2016 Apr 4/13/2016; PMID: 27074721, PII: 10.1007/s00726-016-2231-2, DOI: 10.1007/s00726-016-2231-2, ISSN: 1438-2199.

Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA. Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. Oncogene [print-electronic]. 2016 Apr 4/4/2016; PMID: 27041578, PII: onc201691, DOI: 10.1038/onc.2016.91, ISSN: 1476-5594.

Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA. Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. Oncogene [print-electronic]. 2016 Apr 4/4/2016; PMID: 27041578, PII: onc201691, DOI: 10.1038/onc.2016.91, ISSN: 1476-5594.

Gobert AP, Wilson KT. The Immune Battle against Helicobacter pylori Infection: NO Offense. Trends Microbiol [print-electronic]. 2016 Feb 2/22/2016; PMID: 26916789, PII: S0966-842X(16)00041-X, DOI: 10.1016/j.tim.2016.02.005, ISSN: 1878-4380.

Garay J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, Zabaleta J. The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice. Cancer Lett [print-electronic]. 2016 Feb 2/1/2016; 371(1): 90-8. PMID: 26639196, PII: S0304-3835(15)00705-3, DOI: 10.1016/j.canlet.2015.10.037, ISSN: 1872-7980.

Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Sci Rep. 2016; 6: 18594. PMID: 26729566, PMCID: PMC4700446, PII: srep18594, DOI: 10.1038/srep18594, ISSN: 2045-2322.

Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Sci Rep. 2016; 6: 18594. PMID: 26729566, PMCID: PMC4700446, PII: srep18594, DOI: 10.1038/srep18594, ISSN: 2045-2322.

Waddell A, Vallance JE, Moore PD, Hummel AT, Wu D, Shanmukhappa SK, Fei L, Washington MK, Minar P, Coburn LA, Nakae S, Wilson KT, Denson LA, Hogan SP, Rosen MJ. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function. Inflamm. Bowel Dis. 2015 Dec; 21(12): 2737-46. PMID: 26313694, PMCID: PMC4654638, DOI: 10.1097/MIB.0000000000000532, ISSN: 1536-4844.

Gogoi M, Datey A, Wilson KT, Chakravortty D. Dual role of arginine metabolism in establishing pathogenesis. Curr. Opin. Microbiol [print-electronic]. 2015 Nov 11/20/2015; 29: 43-8. PMID: 26610300, PII: S1369-5274(15)00153-8, DOI: 10.1016/j.mib.2015.10.005, ISSN: 1879-0364.

Schneider BG, Mera R, Piazuelo MB, Bravo JC, Zabaleta J, Delgado AG, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P. DNA Methylation Predicts Progression of Human Gastric Lesions. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2015 Oct; 24(10): 1607-13. PMID: 26269563, PMCID: PMC4592454, PII: 1055-9965.EPI-15-0388, DOI: 10.1158/1055-9965.EPI-15-0388, ISSN: 1538-7755.

Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR. Hepatic TLR4 signaling in obese NAFLD. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Aug 8/15/2015; 309(4): G270-8. PMID: 26113297, PMCID: PMC4537925, PII: ajpgi.00304.2014, DOI: 10.1152/ajpgi.00304.2014, ISSN: 1522-1547.

Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J. Clin. Invest [print-electronic]. 2015 Jul 7/1/2015; 125(7): 2646-60. PMID: 26053663, PMCID: PMC4563672, PII: 76099, DOI: 10.1172/JCI76099, ISSN: 1558-8238.

Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene [print-electronic]. 2015 Jun; 34(26): 3429-40. PMID: 25174398, PMCID: PMC4345146, PII: onc2014273, DOI: 10.1038/onc.2014.273, ISSN: 1476-5594.

Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut [print-electronic]. 2015 May; 64(5): 720-30. PMID: 25123931, PMCID: PMC4329117, PII: gutjnl-2014-307650, DOI: 10.1136/gutjnl-2014-307650, ISSN: 1468-3288.

Krakowiak MS, Noto JM, Piazuelo MB, Hardbower DM, Romero-Gallo J, Delgado A, Chaturvedi R, Correa P, Wilson KT, Peek RM. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene [print-electronic]. 2015 Apr 4/2/2015; 34(14): 1865-71. PMID: 24837365, PMCID: PMC4237684, PII: onc2014135, DOI: 10.1038/onc.2014.135, ISSN: 1476-5594.

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS. Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Mar 3/15/2015; 308(6): G562-71. PMID: 25573176, PMCID: PMC4360050, PII: ajpgi.00253.2014, DOI: 10.1152/ajpgi.00253.2014, ISSN: 1522-1547.

Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Genome Announc. 2015; 3(3): PMID: 26067974, PMCID: PMC4463538, PII: 3/3/e00641-15, DOI: 10.1128/genomeA.00641-15, ISSN: 2169-8287.

Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Mucosal Immunol [print-electronic]. 2014 Nov; 7(6): 1340-53. PMID: 24670427, PMCID: PMC4221190, PII: mi201421, DOI: 10.1038/mi.2014.21, ISSN: 1935-3456.

Van Kaer L, Algood HM, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D. CD8aa¿ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity [print-electronic]. 2014 Sep 9/18/2014; 41(3): 451-64. PMID: 25220211, PMCID: PMC4169715, PII: S1074-7613(14)00304-5, DOI: 10.1016/j.immuni.2014.08.010, ISSN: 1097-4180.

Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM, Chaturvedi R, Wilson KT. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. J. Immunol [print-electronic]. 2014 Sep 9/15/2014; 193(6): 3013-22. PMID: 25108023, PMCID: PMC4171064, PII: jimmunol.1401075, DOI: 10.4049/jimmunol.1401075, ISSN: 1550-6606.

Hardbower DM, Peek RM, Wilson KT. At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J. Leukoc. Biol [print-electronic]. 2014 Aug; 96(2): 201-12. PMID: 24868089, PMCID: PMC4101087, PII: jlb.4BT0214-099R, DOI: 10.1189/jlb.4BT0214-099R, ISSN: 1938-3673.

Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology [print-electronic]. 2014 Jun; 146(7): 1739-51.e14. PMID: 24530706, PMCID: PMC4035375, PII: S0016-5085(14)00192-9, DOI: 10.1053/j.gastro.2014.02.005, ISSN: 1528-0012.

Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN. Peroxisome proliferator-activated receptor d promotes colonic inflammation and tumor growth. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 May 5/13/2014; 111(19): 7084-9. PMID: 24763687, PMCID: PMC4024916, PII: 1324233111, DOI: 10.1073/pnas.1324233111, ISSN: 1091-6490.

Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab. Invest [print-electronic]. 2014 Apr; 94(4): 409-21. PMID: 24535260, PMCID: PMC3992484, PII: labinvest201410, DOI: 10.1038/labinvest.2014.10, ISSN: 1530-0307.

Chaturvedi R, Asim M, Barry DP, Frye JW, Casero RA, Wilson KT. Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Amino Acids [print-electronic]. 2014 Mar; 46(3): 531-42. PMID: 23820617, PMCID: PMC3812355, DOI: 10.1007/s00726-013-1531-z, ISSN: 1438-2199.

Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F. Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. J. Immunol [print-electronic]. 2014 Feb 2/1/2014; 192(3): 1013-23. PMID: 24391216, PMCID: PMC4006992, PII: jimmunol.1300133, DOI: 10.4049/jimmunol.1300133, ISSN: 1550-6606.

Falaiye TO, Mitchell KR, Lu Z, Saville BR, Horst SN, Moulton DE, Schwartz DA, Wilson KT, Rosen MJ. Outcomes following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant IBD. J. Pediatr. Gastroenterol. Nutr. 2014 Feb; 58(2): 213-9. PMID: 24048170, PMCID: PMC3946904, DOI: 10.1097/MPG.0b013e3182a98df2, ISSN: 1536-4801.

Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jan 1/28/2014; 111(4): 1455-60. PMID: 24474772, PMCID: PMC3910595, PII: 1318093111, DOI: 10.1073/pnas.1318093111, ISSN: 1091-6490.

Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HM. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. MBio. 2014; 5(4): e01243-14. PMID: 25053783, PMCID: PMC4120195, PII: mBio.01243-14, DOI: 10.1128/mBio.01243-14, ISSN: 2150-7511.

Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Dec; 305(11): G786-96. PMID: 24136787, PMCID: PMC3882435, PII: ajpgi.00279.2013, DOI: 10.1152/ajpgi.00279.2013, ISSN: 1522-1547.

Hardbower DM, de Sablet T, Chaturvedi R, Wilson KT. Chronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer?. Gut Microbes [print-electronic]. 2013 Nov; 4(6): 475-81. PMID: 23811829, PMCID: PMC3928159, PII: 25583, DOI: 10.4161/gmic.25583, ISSN: 1949-0984.

Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics [print-electronic]. 2013 Nov; 8(11): 1153-61. PMID: 24128875, PMCID: PMC3927747, PII: 26072, DOI: 10.4161/epi.26072, ISSN: 1559-2308.

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut [print-electronic]. 2013 Oct; 62(10): 1446-55. PMID: 22833394, PMCID: PMC3663894, PII: gutjnl-2011-301439, DOI: 10.1136/gutjnl-2011-301439, ISSN: 1468-3288.

Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KT. Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Aug 8/1/2013; 305(3): G225-40. PMID: 23703655, PMCID: PMC3742860, PII: ajpgi.00091.2013, DOI: 10.1152/ajpgi.00091.2013, ISSN: 1522-1547.

Sierra JC, Hobbs S, Chaturvedi R, Yan F, Wilson KT, Peek RM, Polk DB. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Jul 7/15/2013; 305(2): G196-203. PMID: 23681474, PMCID: PMC3725681, PII: ajpgi.00495.2012, DOI: 10.1152/ajpgi.00495.2012, ISSN: 1522-1547.

Sheh A, Chaturvedi R, Merrell DS, Correa P, Wilson KT, Fox JG. Phylogeographic origin of Helicobacter pylori determines host-adaptive responses upon coculture with gastric epithelial cells. Infect. Immun [print-electronic]. 2013 Jul; 81(7): 2468-77. PMID: 23630959, PMCID: PMC3697613, PII: IAI.01182-12, DOI: 10.1128/IAI.01182-12, ISSN: 1098-5522.

Parekh VV, Wu L, Olivares-Villagómez D, Wilson KT, Van Kaer L. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. J. Immunol [print-electronic]. 2013 Mar 3/1/2013; 190(5): 1948-60. PMID: 23345328, PMCID: PMC3577977, PII: jimmunol.1201718, DOI: 10.4049/jimmunol.1201718, ISSN: 1550-6606.

Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1849-58. PMID: 23303670, PMCID: PMC3563924, PII: jimmunol.1201373, DOI: 10.4049/jimmunol.1201373, ISSN: 1550-6606.

Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res [print-electronic]. 2013 Feb 2/1/2013; 73(3): 1245-55. PMID: 23221387, PMCID: PMC3563732, PII: 0008-5472.CAN-12-3150, DOI: 10.1158/0008-5472.CAN-12-3150, ISSN: 1538-7445.

Peek RM, Bimczok D, Wilson KT. Helicobacter pylori infection. In: Principles of Mucosal Immunology. Smith PD, MacDonald TT, Blumberg RS. Garland Science: New York. 2013.

Gobert AP, Verriere T, de Sablet T, Peek RM, Chaturvedi R, Wilson KT. Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells. Cell. Microbiol [print-electronic]. 2013 Jan; 15(1): 145-56. PMID: 23051580, PMCID: PMC3524338, DOI: 10.1111/cmi.12039, ISSN: 1462-5822.

Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM. Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS ONE [print-electronic]. 2013; 8(1): e54344. PMID: 23372710, PMCID: PMC3553174, PII: PONE-D-12-20127, DOI: 10.1371/journal.pone.0054344, ISSN: 1932-6203.

Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J. Clin. Invest [print-electronic]. 2013 Jan; 123(1): 479-92. PMID: 23257361, PMCID: PMC3533289, PII: 64373, DOI: 10.1172/JCI64373, ISSN: 1558-8238.

Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS ONE [electronic-print]. 2013; 8(7): e67845. PMID: 23861820, PMCID: PMC3701622, PII: PONE-D-13-14817, DOI: 10.1371/journal.pone.0067845, ISSN: 1932-6203.

Sheh A, Piazuelo MB, Wilson KT, Correa P, Fox JG. Draft Genome Sequences of Helicobacter pylori Strains Isolated from Regions of Low and High Gastric Cancer Risk in Colombia. Genome Announc. 2013; 1(5): PMID: 24051318, PMCID: PMC3778201, PII: 1/5/e00736-13, DOI: 10.1128/genomeA.00736-13, ISSN: 2169-8287.

Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS ONE. 2013; 8(12): e82300. PMID: 24367513, PMCID: PMC3867379, PII: PONE-D-13-38373, DOI: 10.1371/journal.pone.0082300, ISSN: 1932-6203.

Loh JT, Friedman DB, Piazuelo MB, Bravo LE, Wilson KT, Peek RM, Correa P, Cover TL. Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression. Infect. Immun [print-electronic]. 2012 Sep; 80(9): 3094-106. PMID: 22710874, PMCID: PMC3418733, PII: IAI.00232-12, DOI: 10.1128/IAI.00232-12, ISSN: 1098-5522.

Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut [print-electronic]. 2012 Sep; 61(9): 1250-60. PMID: 22157330, PMCID: PMC3419307, PII: gutjnl-2011-301078, DOI: 10.1136/gutjnl-2011-301078, ISSN: 1468-3288.

Singh K, Coburn LA, Barry DP, Boucher JL, Chaturvedi R, Wilson KT. L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 May 5/1/2012; 302(9): G1061-73. PMID: 22361732, PMCID: PMC3362080, PII: ajpgi.00544.2011, DOI: 10.1152/ajpgi.00544.2011, ISSN: 1522-1547.

Gobert AP, Wilson KT. Editorial: Orchestration of macrophage polarization by polyamines [editorial]. J. Leukoc. Biol. 2012 May; 91(5): 677-9. PMID: 22547131, PMCID: PMC3336771, PII: 91/5/677, DOI: 10.1189/jlb.0112047, ISSN: 1938-3673.

Sicinschi LA, Correa P, Bravo LE, Peek RM, Wilson KT, Loh JT, Yepez MC, Gold BD, Thompson DT, Cover TL, Schneider BG. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Helicobacter. 2012 Apr; 17(2): 96-106. PMID: 22404439, PMCID: PMC3305281, DOI: 10.1111/j.1523-5378.2011.00919.x, ISSN: 1523-5378.

Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): G504-14. PMID: 22173918, PMCID: PMC3311435, PII: ajpgi.00312.2011, DOI: 10.1152/ajpgi.00312.2011, ISSN: 1522-1547.

Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KT. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino Acids [print-electronic]. 2012 Feb; 42(2-3): 627-40. PMID: 21874531, PMCID: PMC3258477, DOI: 10.1007/s00726-011-1038-4, ISSN: 1438-2199.

Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Chaturvedi R, Zhao Z, Wilson KT. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS ONE [print-electronic]. 2012; 7(3): e33546. PMID: 22428068, PMCID: PMC3299802, PII: PONE-D-12-00729, DOI: 10.1371/journal.pone.0033546, ISSN: 1932-6203.

Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, Hu T, Ren X, Wilson KT, Polk DB, Yan F. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS ONE [print-electronic]. 2012; 7(5): e36418. PMID: 22574158, PMCID: PMC3344856, PII: PONE-D-11-19780, DOI: 10.1371/journal.pone.0036418, ISSN: 1932-6203.

Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS ONE [print-electronic]. 2012; 7(12): e51205. PMID: 23251453, PMCID: PMC3521008, PII: PONE-D-12-22965, DOI: 10.1371/journal.pone.0051205, ISSN: 1932-6203.

Chaturvedi R, de Sablet T, Peek RM, Wilson KT. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut Microbes. 2012 Jan; 3(1): 48-56. PMID: 22555547, PMCID: PMC3337125, PII: 19345, DOI: 10.4161/gmic.19345, ISSN: 1949-0984.

Gobert AP, Asim M, Piazuelo MB, Verriere T, Scull BP, de Sablet T, Glumac A, Lewis ND, Correa P, Peek RM, Chaturvedi R, Wilson KT. Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. J. Immunol [print-electronic]. 2011 Nov 11/15/2011; 187(10): 5370-9. PMID: 21987660, PMCID: PMC3208050, PII: jimmunol.1102111, DOI: 10.4049/jimmunol.1102111, ISSN: 1550-6606.

Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology [print-electronic]. 2011 Nov; 141(5): 1696-708.e1. PMID: 21839041, PMCID: PMC3202654, PII: S0016-5085(11)01080-8, DOI: 10.1053/j.gastro.2011.07.045, ISSN: 1528-0012.

Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk DB. STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm. Bowel Dis [print-electronic]. 2011 Nov; 17(11): 2224-34. PMID: 21308881, PMCID: PMC3120916, DOI: 10.1002/ibd.21628, ISSN: 1536-4844.

Olivares-Villagómez D, Algood HM, Singh K, Parekh VV, Ryan KE, Piazuelo MB, Wilson KT, Van Kaer L. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J. Immunol [print-electronic]. 2011 Oct 10/15/2011; 187(8): 4051-60. PMID: 21900182, PMCID: PMC3186831, PII: jimmunol.1101052, DOI: 10.4049/jimmunol.1101052, ISSN: 1550-6606.

de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Bravo LE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM, Cover TL, Correa P, Wilson KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut [print-electronic]. 2011 Sep; 60(9): 1189-95. PMID: 21357593, PMCID: PMC3133872, PII: gut.2010.234468, DOI: 10.1136/gut.2010.234468, ISSN: 1468-3288.

Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene [print-electronic]. 2011 Jul 7/21/2011; 30(29): 3234-47. PMID: 21383692, PMCID: PMC3591522, PII: onc201143, DOI: 10.1038/onc.2011.43, ISSN: 1476-5594.

Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J. Clin. Invest [print-electronic]. 2011 Jun; 121(6): 2242-53. PMID: 21606592, PMCID: PMC3104743, PII: 44031, DOI: 10.1172/JCI44031, ISSN: 1558-8238.

Lewis ND, Asim M, Barry DP, de Sablet T, Singh K, Piazuelo MB, Gobert AP, Chaturvedi R, Wilson KT. Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II. J. Immunol [print-electronic]. 2011 Mar 3/15/2011; 186(6): 3632-41. PMID: 21296975, PMCID: PMC3069806, PII: jimmunol.1003431, DOI: 10.4049/jimmunol.1003431, ISSN: 1550-6606.

Rana T, Misra S, Mittal MK, Farrow AL, Wilson KT, Linton MF, Fazio S, Willis IM, Chaudhuri G. Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania. J. Biol. Chem [print-electronic]. 2011 Feb 2/25/2011; 286(8): 6614-26. PMID: 21149457, PMCID: PMC3057815, PII: M110.181735, DOI: 10.1074/jbc.M110.181735, ISSN: 1083-351X.

Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer Res [print-electronic]. 2011 Feb 2/15/2011; 71(4): 1302-12. PMID: 21303973, PMCID: PMC3150168, PII: 0008-5472.CAN-10-3317, DOI: 10.1158/0008-5472.CAN-10-3317, ISSN: 1538-7445.

Singh K, Chaturvedi R, Barry DP, Coburn LA, Asim M, Lewis ND, Piazuelo MB, Washington MK, Vitek MP, Wilson KT. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J. Biol. Chem [print-electronic]. 2011 Feb 2/4/2011; 286(5): 3839-50. PMID: 21115487, PMCID: PMC3030385, PII: M110.176719, DOI: 10.1074/jbc.M110.176719, ISSN: 1083-351X.

Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-¿ production. Gastroenterology [print-electronic]. 2011 Jan; 140(1): 265-74. PMID: 20875416, PMCID: PMC3008308, PII: S0016-5085(10)01421-6, DOI: 10.1053/j.gastro.2010.09.041, ISSN: 1528-0012.

Barry DP, Asim M, Leiman DA, de Sablet T, Singh K, Casero RA, Chaturvedi R, Wilson KT. Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. PLoS ONE. 2011; 6(2): e17510. PMID: 21386987, PMCID: PMC3046249, DOI: 10.1371/journal.pone.0017510, ISSN: 1932-6203.

Gobert AP, Chaturvedi R, Wilson KT. Methods to evaluate alterations in polyamine metabolism caused by Helicobacter pylori infection. Methods Mol. Biol. 2011; 720: 409-25. PMID: 21318889, PMCID: PMC3069756, DOI: 10.1007/978-1-61779-034-8_26, ISSN: 1940-6029.

Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT. Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. PLoS ONE [print-electronic]. 2011; 6(12): e29046. PMID: 22194986, PMCID: PMC3237590, PII: PONE-D-11-18825, DOI: 10.1371/journal.pone.0029046, ISSN: 1932-6203.

Schneider BG, Peng DF, Camargo MC, Piazuelo MB, Sicinschi LA, Mera R, Romero-Gallo J, Delgado AG, Bravo LE, Wilson KT, Peek RM, Correa P, El-Rifai W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int. J. Cancer. 2010 Dec 12/1/2010; 127(11): 2588-97. PMID: 20178103, PMCID: PMC2916942, DOI: 10.1002/ijc.25274, ISSN: 1097-0215.

Chaturvedi R, Asim M, Hoge S, Lewis ND, Singh K, Barry DP, de Sablet T, Piazuelo MB, Sarvaria AR, Cheng Y, Closs EI, Casero RA, Gobert AP, Wilson KT. Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Gastroenterology [print-electronic]. 2010 Nov; 139(5): 1686-98, 1698.e1. PMID: 20600019, PMCID: PMC2967614, PII: S0016-5085(10)01003-6, DOI: 10.1053/j.gastro.2010.06.060, ISSN: 1528-0012.

Wroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin. Microbiol. Rev. 2010 Oct; 23(4): 713-39. PMID: 20930071, PMCID: PMC2952980, PII: 23/4/713, DOI: 10.1128/CMR.00011-10, ISSN: 1098-6618.

Hong SK, Chaturvedi R, Piazuelo MB, Coburn LA, Williams CS, Delgado AG, Casero RA, Schwartz DA, Wilson KT. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Inflamm. Bowel Dis. 2010 Sep; 16(9): 1557-66. PMID: 20127992, PMCID: PMC2894261, DOI: 10.1002/ibd.21224, ISSN: 1536-4844.

Peek RM, Fiske C, Wilson KT. Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiol. Rev. 2010 Jul; 90(3): 831-58. PMID: 20664074, PMCID: PMC2990353, PII: 90/3/831, DOI: 10.1152/physrev.00039.2009, ISSN: 1522-1210.

Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K, Barry DP, Algood HS, de Sablet T, Gobert AP, Wilson KT. Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. J. Biol. Chem [print-electronic]. 2010 Jun 6/25/2010; 285(26): 20343-57. PMID: 20410304, PMCID: PMC2888446, PII: M110.116988, DOI: 10.1074/jbc.M110.116988, ISSN: 1083-351X.

Lewis ND, Asim M, Barry DP, Singh K, de Sablet T, Boucher JL, Gobert AP, Chaturvedi R, Wilson KT. Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages. J. Immunol [print-electronic]. 2010 Mar 3/1/2010; 184(5): 2572-82. PMID: 20097867, PMCID: PMC2841360, PII: jimmunol.0902436, DOI: 10.4049/jimmunol.0902436, ISSN: 1550-6606.

Correa P, Piazuelo MB, Wilson KT. Pathology of gastric intestinal metaplasia: clinical implications. Am. J. Gastroenterol. 2010 Mar; 105(3): 493-8. PMID: 20203636, PMCID: PMC2895407, PII: ajg2009728, DOI: 10.1038/ajg.2009.728, ISSN: 1572-0241.

Correa P, Piazuelo MB, Wilson KT. Pathology of gastric intestinal metaplasia: clinical implications. Am. J. Gastroenterol. 2010 Mar; 105(3): 493-8. PMID: 20203636, PMCID: PMC2895407, PII: ajg2009728, DOI: 10.1038/ajg.2009.728, ISSN: 1572-0241.

Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res. 2010 Jan 1/1/2010; 70(1): 30-5. PMID: 20048070, PMCID: PMC2804939, PII: 0008-5472.CAN-09-2899, DOI: 10.1158/0008-5472.CAN-09-2899, ISSN: 1538-7445.

Hong SK, Maltz BE, Coburn LA, Slaughter JC, Chaturvedi R, Schwartz DA, Wilson KT. Increased serum levels of L-arginine in ulcerative colitis and correlation with disease severity. Inflamm. Bowel Dis. 2010 Jan; 16(1): 105-11. PMID: 19637336, PMCID: PMC2795785, DOI: 10.1002/ibd.21035, ISSN: 1536-4844.

Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology [print-electronic]. 2009 Apr; 136(4): 1297-1307, e1. PMID: 19250983, PMCID: PMC2878739, PII: S0016-5085(08)02317-2, DOI: 10.1053/j.gastro.2008.12.059, ISSN: 1528-0012.

O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J. Biol. Chem [print-electronic]. 2008 Aug 8/29/2008; 283(35): 23922-30. PMID: 18579524, PMCID: PMC2527108, PII: M801144200, DOI: 10.1074/jbc.M801144200, ISSN: 0021-9258.

Singh K, Chaturvedi R, Asim M, Barry DP, Lewis ND, Vitek MP, Wilson KT. The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. J. Biol. Chem [print-electronic]. 2008 Jun 6/13/2008; 283(24): 16752-61. PMID: 18417477, PMCID: PMC2423260, PII: M710530200, DOI: 10.1074/jbc.M710530200, ISSN: 0021-9258.

Algood HM, Gallo-Romero J, Wilson KT, Peek RM, Cover TL. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol. Med. Microbiol [print-electronic]. 2007 Dec; 51(3): 577-86. PMID: 17919297, PII: FIM338, DOI: 10.1111/j.1574-695X.2007.00338.x, ISSN: 0928-8244.

Chaturvedi R, Asim M, Lewis ND, Algood HM, Cover TL, Kim PY, Wilson KT. L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect. Immun [print-electronic]. 2007 Sep; 75(9): 4305-15. PMID: 17562760, PMCID: PMC1951193, PII: IAI.00578-07, DOI: 10.1128/IAI.00578-07, ISSN: 0019-9567.

Wilson KT, Crabtree JE. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology. 2007 Jul; 133(1): 288-308. PMID: 17631150, PII: S0016-5085(07)00990-0, DOI: 10.1053/j.gastro.2007.05.008, ISSN: 0016-5085.

Bussiere FI, Chaturvedi R, Asim M, Hoek KL, Cheng Y, Gainor J, Scholz A, Khan WN, Wilson KT. Low multiplicity of infection of Helicobacter pylori suppresses apoptosis of B lymphocytes. Cancer Res. 2006 Jul 7/1/2006; 66(13): 6834-42. PMID: 16818661, PII: 66/13/6834, DOI: 10.1158/0008-5472.CAN-05-4197, ISSN: 0008-5472.

Chaturvedi, R, Wilson, KT. In Wang, JY, Casero, RA, Jr., eds., Polyamine Cell Signalling: Physiology, Pharmacology, and Cancer Research. Totowa, NJ: Human Press. [place unknown: publisher unknown]; 2006.

Cross RK, Wilson KT, Binion DG. Narcotic use in patients with Crohn's disease. Am. J. Gastroenterol. 2005 Oct; 100(10): 2225-9. PMID: 16181373, PII: AJG256, DOI: 10.1111/j.1572-0241.2005.00256.x, ISSN: 0002-9270.

Cheng Y, Chaturvedi R, Asim M, Bussière FI, Scholz A, Xu H, Casero RA, Wilson KT. Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. J. Biol. Chem [print-electronic]. 2005 Jun 6/10/2005; 280(23): 22492-6. PMID: 15843384, PII: C500122200, DOI: 10.1074/jbc.C500122200, ISSN: 0021-9258.

Cross RK, Wilson KT, Binion DG. Polypharmacy and Crohn's disease. Aliment. Pharmacol. Ther. 2005 May 5/15/2005; 21(10): 1211-6. PMID: 15882241, PII: APT2429, DOI: 10.1111/j.1365-2036.2005.02429.x, ISSN: 0269-2813.

Gobert AP, Wilson KT, Martin C. Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system. Arch. Immunol. Ther. Exp. (Warsz.). 2005 May; 53(3): 234-44. PMID: 15995584, PII: 7450, ISSN: 0004-069X.

Bussière FI, Chaturvedi R, Cheng Y, Gobert AP, Asim M, Blumberg DR, Xu H, Kim PY, Hacker A, Casero RA, Wilson KT. Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation. J. Biol. Chem [print-electronic]. 2005 Jan 1/28/2005; 280(4): 2409-12. PMID: 15548540, PII: C400498200, DOI: 10.1074/jbc.C400498200, ISSN: 0021-9258.

Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero RA, Wilson KT. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res. 2004 Dec 12/1/2004; 64(23): 8521-5. PMID: 15574757, PII: 64/23/8521, DOI: 10.1158/0008-5472.CAN-04-3511, ISSN: 0008-5472.

Chaturvedi R, Cheng Y, Asim M, Bussière FI, Xu H, Gobert AP, Hacker A, Casero RA, Wilson KT. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J. Biol. Chem [print-electronic]. 2004 Sep 9/17/2004; 279(38): 40161-73. PMID: 15247269, PII: M401370200, DOI: 10.1074/jbc.M401370200, ISSN: 0021-9258.

Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA, Wilson KT. Protective role of arginase in a mouse model of colitis. J. Immunol. 2004 Aug 8/1/2004; 173(3): 2109-17. PMID: 15265947, PII: 173/3/2109, ISSN: 0022-1767.

Duleu S, Vincendeau P, Courtois P, Semballa S, Lagroye I, Daulouède S, Boucher JL, Wilson KT, Veyret B, Gobert AP. Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect. J. Immunol. 2004 May 5/15/2004; 172(10): 6298-303. PMID: 15128819, ISSN: 0022-1767.

Ma X, Yang Q, Wilson KT, Kundu N, Meltzer SJ, Fulton AM. Promoter methylation regulates cyclooxygenase expression in breast cancer. Breast Cancer Res [print-electronic]. 2004; 6(4): R316-21. PMID: 15217498, PMCID: PMC468630, PII: bcr793, DOI: 10.1186/bcr793, ISSN: 1465-542X.

Meyer F, Ramanujam KS, Gobert AP, James SP, Wilson KT. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. J. Immunol. 2003 Oct 10/15/2003; 171(8): 3913-7. PMID: 14530307, ISSN: 0022-1767.

Cross RK, Wilson KT. Nitric oxide in inflammatory bowel disease. Inflamm. Bowel Dis. 2003 May; 9(3): 179-89. PMID: 12792224, ISSN: 1078-0998.

Panchal PC, Forman JS, Blumberg DR, Wilson KT. Helicobacter pylori infection: pathogenesis. Curr. Opin. Gastroenterol. 2003 Jan; 19(1): 4-10. PMID: 15699887, PII: 00001574-200301000-00002, ISSN: 0267-1379.

Rafiee P, Johnson CP, Li MS, Ogawa H, Heidemann J, Fisher PJ, Lamirand TH, Otterson MF, Wilson KT, Binion DG. Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. J. Biol. Chem [print-electronic]. 2002 Sep 9/20/2002; 277(38): 35605-15. PMID: 12110686, PII: M205826200, DOI: 10.1074/jbc.M205826200, ISSN: 0021-9258.

Gobert AP, Mersey BD, Cheng Y, Blumberg DR, Newton JC, Wilson KT. Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase. J. Immunol. 2002 Jun 6/15/2002; 168(12): 6002-6. PMID: 12055207, ISSN: 0022-1767.

Gobert AP, Cheng Y, Wang JY, Boucher JL, Iyer RK, Cederbaum SD, Casero RA, Newton JC, Wilson KT. Helicobacter pylori induces macrophage apoptosis by activation of arginase II. J. Immunol. 2002 May 5/1/2002; 168(9): 4692-700. PMID: 11971019, ISSN: 0022-1767.

Wilson KT. Angiogenic markers, neovascularization and malignant deformation of Barrett's esophagus. Dis. Esophagus. 2002; 15(1): 16-21. PMID: 12060038, PII: 212, ISSN: 1120-8694.

Gobert AP, McGee DJ, Akhtar M, Mendz GL, Newton JC, Cheng Y, Mobley HL, Wilson KT. Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival. Proc. Natl. Acad. Sci. U.S.A. 2001 Nov 11/20/2001; 98(24): 13844-9. PMID: 11717441, PMCID: PMC61129, PII: 98/24/13844, DOI: 10.1073/pnas.241443798, ISSN: 0027-8424.

Akhtar M, Cheng Y, Magno RM, Ashktorab H, Smoot DT, Meltzer SJ, Wilson KT. Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. Cancer Res. 2001 Mar 3/15/2001; 61(6): 2399-403. PMID: 11289104, ISSN: 0008-5472.

Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Nishizuka S, James SP, Wilson KT, Herman JG, Meltzer SJ. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. Oncogene. 2001 Jan 1/18/2001; 20(3): 329-35. PMID: 11313962, DOI: 10.1038/sj.onc.1204104, ISSN: 0950-9232.

Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KT. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic. Biol. Med. 2000 Nov 11/1/2000; 29(9): 881-8. PMID: 11063913, PII: S0891-5849(00)00391-9, ISSN: 0891-5849.

Meyer F, Wilson KT, James SP. Modulation of innate cytokine responses by products of Helicobacter pylori. Infect. Immun. 2000 Nov; 68(11): 6265-72. PMID: 11035734, PMCID: PMC97708, ISSN: 0019-9567.

Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res. 2000 Sep 9/1/2000; 60(17): 4864-8. PMID: 10987299, ISSN: 0008-5472.

Tsuchiya T, Tamura G, Sato K, Endoh Y, Sakata K, Jin Z, Motoyama T, Usuba O, Kimura W, Nishizuka S, Wilson KT, James SP, Yin J, Fleisher AS, Zou T, Silverberg SG, Kong D, Meltzer SJ. Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia. Oncogene. 2000 Jul 7/27/2000; 19(32): 3642-6. PMID: 10951570, DOI: 10.1038/sj.onc.1203704, ISSN: 0950-9232.

Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J. Natl. Cancer Inst. 2000 Apr 4/5/2000; 92(7): 569-73. PMID: 10749913, ISSN: 0027-8874.

Malamud A, Wilson KT. Treatment of gastrointestinal infections. Curr. Opin. Gastroenterol. 2000 Jan; 16(1): 51-5. PMID: 17024016, PII: 00001574-200001000-00009, ISSN: 0267-1379.

Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, Meltzer SJ, Wilson KT. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology. 1999 Jun; 116(6): 1319-29. PMID: 10348815, PII: S0016508599005442, ISSN: 0016-5085.

Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res. 1999 Mar 3/1/1999; 59(5): 1090-5. PMID: 10070967, ISSN: 0008-5472.

Wilson KT, Fantry GT. Pathogenesis of Helicobacter pylori infection. Curr. Opin. Gastroenterol. 1999 Jan; 15(1): 66-71. PMID: 17023920, PII: 00001574-199901000-00012, ISSN: 0267-1379.

Varanasi RV, Fantry GT, Wilson KT. Decreased prevalence of Helicobacter pylori infection in gastroesophageal reflux disease. Helicobacter. 1998 Sep; 3(3): 188-94. PMID: 9731990, ISSN: 1083-4389.

Binion DG, Fu S, Ramanujam KS, Chai YC, Dweik RA, Drazba JA, Wade JG, Ziats NP, Erzurum SC, Wilson KT. INOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am. J. Physiol. 1998 Sep; 275(3 Pt 1): G592-603. PMID: 9724273, ISSN: 0002-9513.

Wilson KT, Fu S, Ramanujam KS, Meltzer SJ. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res. 1998 Jul 7/15/1998; 58(14): 2929-34. PMID: 9679948, ISSN: 0008-5472.

Kundu N, Dorsey R, Jackson MJ, Guiterrez P, Wilson K, Fu S, Ramanujam K, Thomas E, Fulton AM. Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxide. Int. J. Cancer. 1998 May 5/29/1998; 76(5): 713-9. PMID: 9610731, PII: 10.1002/(SICI)1097-0215(19980529)76:5<713::AID-IJC17>3.0.CO;2-4, ISSN: 0020-7136.

Wilson KT, Ramanujam KS, Mobley HL, Musselman RF, James SP, Meltzer SJ. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Gastroenterology. 1996 Dec; 111(6): 1524-33. PMID: 8942731, PII: S0016-5085(96)70014-8, ISSN: 0016-5085.

Wilson KT, Vaandrager AB, De Vente J, Musch MW, De Jonge HR, Chang EB. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport. Am. J. Physiol. 1996 Mar; 270(3 Pt 1): C832-40. PMID: 8638664, ISSN: 0002-9513.

Wilson, KT, Chang, EB. Immune regulation of intestinal secretion. Practical Gastroenterol. 1994; 3: 22J-22Q.

Wilson KT, Xie Y, Musch MW, Chang EB. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J. Pharmacol. Exp. Ther. 1993 Jul; 266(1): 224-30. PMID: 8331560, ISSN: 0022-3565.

Wilson, KT, Musch, MW, Chang, EB. In MacDermott, R, Stenson, W, eds., Inflammatory Bowel Disease. New York: Elsevier. [place unknown: publisher unknown]; 1992.

Available Postdoctoral Position Details
Posted: 8/20/2015
Postdoctoral position available to study mucosal immunology, inflammation, and carcinogenesis. Expertise in molecular biology, immunology, microbiology, and/or biochemistry is highly desirable.