Anuradha Bapsi Chakravarthy, M.D.

Faculty Appointments
Professor of Radiation Oncology
M.D., MEDICINE, George Washington University, Washington, District of ColumbiaB.S., Johns Hopkins University, Baltimore, Maryland
Office Address
B-1003 PRB
Nashville, TN 5671
Atuegwu NC, Li X, Arlinghaus LR, Abramson RG, Williams JM, Chakravarthy AB, Abramson VG, Yankeelov TE. Longitudinal, intermodality registration of quantitative breast PET and MRI data acquired before and during neoadjuvant chemotherapy: preliminary results. Med Phys. 2014 May; 41(5): 52302. PMID: 24784395, PMCID: PMC4000383, DOI: 10.1118/1.4870966, ISSN: 0094-2405.

Li X, Arlinghaus LR, Ayers GD, Chakravarthy AB, Abramson RG, Abramson VG, Atuegwu N, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Grau AM, Sanders M, Bhave SR, Yankeelov TE. DCE-MRI analysis methods for predicting the response of breast cancer to neoadjuvant chemotherapy: pilot study findings. Magn Reson Med [print-electronic]. 2014 Apr; 71(4): 1592-602. PMID: 23661583, PMCID: PMC3742614, DOI: 10.1002/mrm.24782, ISSN: 1522-2594.

FitzHenry F, Wells N, Slater V, Dietrich MS, Wisawatapnimit P, Chakravarthy AB. A randomized placebo-controlled pilot study of the impact of healing touch on fatigue in breast cancer patients undergoing radiation therapy. Integr Cancer Ther [print-electronic]. 2014 Mar; 13(2): 105-13. PMID: 24105358, PII: 1534735413503545, DOI: 10.1177/1534735413503545, ISSN: 1552-695X.

Li X, Kang H, Arlinghaus LR, Abramson RG, Chakravarthy AB, Abramson VG, Farley J, Sanders M, Yankeelov TE. Analyzing Spatial Heterogeneity in DCE- and DW-MRI Parametric Maps to Optimize Prediction of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer. Transl Oncol. 2014 Feb; 7(1): 14-22. PMID: 24772203, PMCID: PMC3998687, ISSN: 1936-5233.

Abramson RG, Li X, Hoyt TL, Su PF, Arlinghaus LR, Wilson KJ, Abramson VG, Chakravarthy AB, Yankeelov TE. Early assessment of breast cancer response to neoadjuvant chemotherapy by semi-quantitative analysis of high-temporal resolution DCE-MRI: preliminary results. Magn Reson Imaging [print-electronic]. 2013 Nov; 31(9): 1457-64. PMID: 23954320, PMCID: PMC3807825, PII: S0730-725X(13)00233-6, DOI: 10.1016/j.mri.2013.07.002, ISSN: 1873-5894.

Weis JA, Miga MI, Arlinghaus LR, Li X, Chakravarthy AB, Abramson V, Farley J, Yankeelov TE. A mechanically coupled reaction-diffusion model for predicting the response of breast tumors to neoadjuvant chemotherapy. Phys Med Biol [print-electronic]. 2013 Sep 9/7/2013; 58(17): 5851-66. PMID: 23920113, PMCID: PMC3791925, DOI: 10.1088/0031-9155/58/17/5851, ISSN: 1361-6560.

Wang T, Wentz SC, Ausborn NL, Washington MK, Merchant N, Zhao Z, Shyr Y, Chakravarthy AB, Xia F. Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma. Pancreas. 2013 Aug; 42(6): 977-82. PMID: 23851432, PMCID: PMC4026161, PII: 00006676-201308000-00013, DOI: 10.1097/MPA.0b013e318287885c, ISSN: 1536-4828.

Castel LD, Hartmann KE, Mayer IA, Saville BR, Alvarez J, Boomershine CS, Abramson VG, Chakravarthy AB, Friedman DL, Cella DF. Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort. Cancer [print-electronic]. 2013 Jul 7/1/2013; 119(13): 2375-82. PMID: 23575918, PMCID: PMC3687009, DOI: 10.1002/cncr.28016, ISSN: 1097-0142.

Atuegwu NC, Arlinghaus LR, Li X, Chakravarthy AB, Abramson VG, Sanders ME, Yankeelov TE. Parameterizing the Logistic Model of Tumor Growth by DW-MRI and DCE-MRI Data to Predict Treatment Response and Changes in Breast Cancer Cellularity during Neoadjuvant Chemotherapy. Transl Oncol [electronic-print]. 2013 Jun; 6(3): 256-64. PMID: 23730404, PMCID: PMC3660793, ISSN: 1936-5233.

Al-Greene NT, Means AL, Lu P, Jiang A, Schmidt CR, Chakravarthy AB, Merchant NB, Washington MK, Zhang B, Shyr Y, Deane NG, Beauchamp RD. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. PLoS ONE [electronic-print]. 2013; 8(7): e69660. PMID: 23922772, PMCID: PMC3726759, PII: PONE-D-13-05038, DOI: 10.1371/journal.pone.0069660, ISSN: 1932-6203.

Chan E, Wise PE, Chakravarthy AB. Controversies in radiation for upper rectal cancers. J Natl Compr Canc Netw. 2012 Dec 12/1/2012; 10(12): 1567-72. PMID: 23221791, PII: 10/12/1567, ISSN: 1540-1413.

Chakravarthy AB, Catalano PJ, Mondschein JK, Rosenthal DI, Haller DG, Whittington R, Spitz FR, Wagner H, Sigurdson ER, Tschetter LK, Bayer GK, Mulcahy MF, Benson AB. Phase II Trial of Paclitaxel/Cisplatin Followed by Surgery and Adjuvant Radiation Therapy and 5-Fluorouracil/Leucovorin for Gastric Cancer (ECOG E7296). Gastrointest Cancer Res. 2012 Nov; 5(6): 191-7. PMID: 23293700, PMCID: PMC3533847, ISSN: 1934-7820.

Li X, Welch EB, Chakravarthy AB, Xu L, Arlinghaus LR, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Abramson VG, Grau AM, Gore JC, Yankeelov TE. Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer. Magn Reson Med [print-electronic]. 2012 Jul; 68(1): 261-71. PMID: 22127821, PMCID: PMC3291742, DOI: 10.1002/mrm.23205, ISSN: 1522-2594.

Li X, Abramson RG, Arlinghaus LR, Chakravarthy AB, Abramson V, Mayer I, Farley J, Delbeke D, Yankeelov TE. An algorithm for longitudinal registration of PET/CT images acquired during neoadjuvant chemotherapy in breast cancer: preliminary results. EJNMMI Res. 2012; 2(1): 62. PMID: 23157877, PMCID: PMC3520720, PII: 2191-219X-2-62, DOI: 10.1186/2191-219X-2-62, ISSN: 2191-219X.

Snyder RA, Castaldo ET, Bailey CE, Phillips SE, Chakravarthy AB, Merchant NB. Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy. Int J Surg Oncol [print-electronic]. 2012; 2012: 307670. PMID: 22778937, PMCID: PMC3388431, DOI: 10.1155/2012/307670, ISSN: 2090-1410.

Atuegwu NC, Arlinghaus LR, Li X, Welch EB, Chakravarthy BA, Gore JC, Yankeelov TE. Integration of diffusion-weighted MRI data and a simple mathematical model to predict breast tumor cellularity during neoadjuvant chemotherapy. Magn Reson Med [print-electronic]. 2011 Dec; 66(6): 1689-96. PMID: 21956404, PMCID: PMC3218213, DOI: 10.1002/mrm.23203, ISSN: 1522-2594.

Chakravarthy AB, Catalano PJ, Martenson JA, Mondschein JK, Wagner H, Mansour EG, Talamonti MS, Benson AB. Long-term follow-up of a Phase II trial of high-dose radiation with concurrent 5-fluorouracil and cisplatin in patients with anal cancer (ECOG E4292). Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2011 Nov 11/15/2011; 81(4): e607-13. PMID: 21514072, PMCID: PMC3197794, PII: S0360-3016(11)00362-2, DOI: 10.1016/j.ijrobp.2011.02.042, ISSN: 1879-355X.

Li X, Welch EB, Arlinghaus LR, Chakravarthy AB, Xu L, Farley J, Loveless ME, Mayer IA, Kelley MC, Meszoely IM, Means-Powell JA, Abramson VG, Grau AM, Gore JC, Yankeelov TE. A novel AIF tracking method and comparison of DCE-MRI parameters using individual and population-based AIFs in human breast cancer. Phys Med Biol [print-electronic]. 2011 Sep 9/7/2011; 56(17): 5753-69. PMID: 21841212, PMCID: PMC3176673, PII: S0031-9155(11)87575-5, DOI: 10.1088/0031-9155/56/17/018, ISSN: 1361-6560.

Jiang J, Yang ES, Jiang G, Nowsheen S, Wang H, Wang T, Wang Y, Billheimer D, Chakravarthy AB, Brown M, Haffty B, Xia F. P53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage. Cancer Res [print-electronic]. 2011 Aug 8/15/2011; 71(16): 5546-57. PMID: 21742769, PII: 0008-5472.CAN-10-3423, DOI: 10.1158/0008-5472.CAN-10-3423, ISSN: 1538-7445.

Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest. 2011 Jul; 121(7): 2750-67. PMID: 21633166, PMCID: PMC3127435, PII: 45014, DOI: 10.1172/JCI45014, ISSN: 1558-8238.

Mani S, Chen Y, Arlinghaus LR, Li X, Chakravarthy AB, Bhave SR, Welch EB, Levy MA, Yankeelov TE. Early prediction of the response of breast tumors to neoadjuvant chemotherapy using quantitative MRI and machine learning. AMIA Annu Symp Proc [print-electronic]. 2011; 2011: 868-77. PMID: 22195145, PMCID: PMC3243164, ISSN: 1942-597X.

Li X, Dawant BM, Welch EB, Chakravarthy AB, Freehardt D, Mayer I, Kelley M, Meszoely I, Gore JC, Yankeelov TE. A nonrigid registration algorithm for longitudinal breast MR images and the analysis of breast tumor response. Magn Reson Imaging [print-electronic]. 2009 Nov; 27(9): 1258-70. PMID: 19525078, PMCID: PMC2763059, PII: S0730-725X(09)00086-1, DOI: 10.1016/j.mri.2009.05.007, ISSN: 1873-5894.

Cuneo KC, Geng L, Fu A, Orton D, Hallahan DE, Chakravarthy AB. SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys. 2008 Jul 7/1/2008; 71(3): 873-9. PMID: 18514780, PII: S0360-3016(08)00407-0, DOI: 10.1016/j.ijrobp.2008.02.062, ISSN: 0360-3016.

Kim DW, Blanke CD, Wu H, Shyr Y, Berlin J, Beauchamp RD, Chakravarthy B. Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer. Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2007 Feb 2/1/2007; 67(2): 397-404. PMID: 17097833, PII: S0360-3016(06)02837-9, DOI: 10.1016/j.ijrobp.2006.08.062, ISSN: 0360-3016.

Yankeelov TE, Lepage M, Chakravarthy A, Broome EE, Niermann KJ, Kelley MC, Meszoely I, Mayer IA, Herman CR, McManus K, Price RR, Gore JC. Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results. Magn Reson Imaging [print-electronic]. 2007 Jan; 25(1): 1-13. PMID: 17222711, PMCID: PMC2634832, PII: S0730-725X(06)00289-X, DOI: 10.1016/j.mri.2006.09.006, ISSN: 0730-725X.

Chakravarthy AB, Kelley MC, McLaren B, Truica CI, Billheimer D, Mayer IA, Grau AM, Johnson DH, Simpson JF, Beauchamp RD, Jones C, Pietenpol JA. Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer. Clin. Cancer Res. 2006 Mar 3/1/2006; 12(5): 1570-6. PMID: 16533783, PII: 12/5/1570, DOI: 10.1158/1078-0432.CCR-05-2304, ISSN: 1078-0432.

Tedesco KL, Berlin J, Rothenberg M, Choy H, Wyman K, Scott Pearson A, Daniel Beauchamp R, Merchant N, Lockhart AC, Shyr Y, Caillouette C, Chakravarthy B. A phase I study of concurrent 9-nitro-20(s)-camptothecin (9NC/Orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas. Radiother Oncol. 2005 Jul; 76(1): 54-8. PMID: 15921772, PII: S0167-8140(05)00169-6, DOI: 10.1016/j.radonc.2005.04.005, ISSN: 0167-8140.

Tedesco KL, Berlin J, Blanke CD, Teng M, Choy H, Roberts J, Beauchamp RD, Leach S, Wyman K, Tarpley J, Shyr Y, Caillouette C, Chakravarthy B. Phase I trial of Orzel (UFT plus leucovorin), cisplatin, and radiotherapy in the treatment of potentially resectable esophageal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2005 Apr 4/1/2005; 61(5): 1364-70. PMID: 15817338, PII: S0360-3016(04)02471-X, DOI: 10.1016/j.ijrobp.2004.08.050, ISSN: 0360-3016.

Chakravarthy B, Pietenpol JA. Combined modality management of breast cancer: development of predictive markers through proteomics. Semin. Oncol. 2003 Aug; 30(4 Suppl 9): 23-36. PMID: 12908134, PII: S0093775403002677, ISSN: 0093-7754.

Hallahan DE, Qu S, Geng L, Cmelak A, Chakravarthy A, Martin W, Scarfone C, Giorgio T. Radiation-mediated control of drug delivery. Am. J. Clin. Oncol. 2001 Oct; 24(5): 473-80. PMID: 11586099, ISSN: 0277-3732.

Hallahan DE, Geng L, Cmelak AJ, Chakravarthy AB, Martin W, Scarfone C, Gonzalez A. Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature. J Control Release. 2001 Jul 7/6/2001; 74(1-3): 183-91. PMID: 11489494, PII: S0168365901003352, ISSN: 0168-3659.

Choy H, Chakravarthy A, Kim JS. Radiation therapy for non-small cell lung cancer (NSCLC). Cancer Treat. Res. 2001; 105: 121-48. PMID: 11224985, ISSN: 0927-3042.

Choy H, Chakravarthy A, Devore RF, Jagasia M, Hande KR, Roberts JR, Johnson DH, Yunus F. Weekly irinotecan and concurrent radiation therapy for stage III unresectable NSCLC. Oncology (Williston Park, N.Y.). 2000 Jul; 14(7 Suppl 5): 43-6. PMID: 10981290, PII: 173444, ISSN: 0890-9091.

Chakravarthy A, Choy H. A phase I trial of outpatient weekly irinotecan/carboplatin and concurrent radiation for stage III unresectable non small-cell lung cancer: a Vanderbilt-Ingram Cancer Center Affiliate Network Trial. Clin Lung Cancer. 2000 May; 1(4): 310-1. PMID: 14733637, ISSN: 1525-7304.

Chakravarthy A, Nicholson B, Kelley M, Beauchamp D, Johnson D, Frexes-Steed M, Simpson J, Shyr Y, Pietenpol J. A pilot study of neoadjuvant paclitaxel and radiation with correlative molecular studies in stage II/III breast cancer. Clin. Breast Cancer. 2000 Apr; 1(1): 68-71. PMID: 11899393, PII: S1526-8209(11)70101-X, DOI: 10.3816/CBC.2000.n.007, ISSN: 1526-8209.

Chakravarthy, A, Choy H. A Phase I Trial of outpatient Weekly irinotecan/carboplatin and concurrent radiation for Stage III unresectable non-small-cell lung cancer. Vanderbilt-Ingram Cancer Center Affiliate Network Trial, Brief communication, Clinical Lung Cancer. 2000; 1((4)): 310-1.

Chakravarthy, A, Nicholson B, Kelley M, Beauchamp D, Johnson D, Frexes-Steed M, Simpson J, Shyr Y, Pietenpol J. A pilot study of neoadjuvant paclitaxel and radiation therapy with correlative molecular studies in Stage II/III breast cancer. Clinical Breast Cancer. 2000; 1((1)): 68-71.

Chakravarthy A, Johnson D, Choy H. The role of radiation, with or without chemotherapy, in the management of NSCLC. Oncology (Williston Park, N.Y.). 1999 Oct; 13(10 Suppl 5): 93-100. PMID: 10550832, PII: 162949, ISSN: 0890-9091.

Mignano, J.E., Zahurak, M.L., Chakravarthy, A., Piantadosi, S., Dooley, W.C., Gage,I. Significance of axillary nodal extranodal soft tissue extension and indications for post-mastectomy irradiation. Cancer. 1999; 86((7)): 1258-62.

Chakravarthy, A., Johnson, D., Choy, H. The Role of Radiation with or without Chemotherapy in the management of NSCLC. Oncology. 1999; 13: 10 (supp 5): 93-100.

Abrams RA, Grochow LB, Chakravarthy A, Sohn TA, Zahurek ML, Haulk TL, Ord S, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL, Yeo CJ. Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy and CA 19-9 levels. Int J Radiat Oncol Biol Phys. 1999; 44((5)): 151039-46.

Choy, H, Chakravarthy, A. Phase I trial of Irinotecan and concurrent radiation therapy for stage III non-small cell lung cancer. Cancer Conference Highlights. 1999; 4((6-7)): 12.