Jeffrey M. Davidson, Ph.D.

Professor

jeff.davidson@vanderbilt.edu

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Faculty Appointments
Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Biological Sciences, Stanford University, Stanford, CaliforniaM.S., Biological Sciences, Stanford University, Stanford, CaliforniaB.S., Biology, Tufts University, Medford, Massachusetts
Office Address
C-3321A MCN
21st Avenue
Nashville, TN 37232-2562
Research Description
Elastin is a highly insoluble matrix protein with very low turnover. We study elastin gene expression in several biological systems. cDNA and antibody probes are used, respectively, to study regulation of elastin mRNA and protein synthesis, particularly related to modulation of elastin metabolism in diseases of human connective tissues such as blood vessels, lung and skin. Transcriptional and post-transcriptional regulation of matrix synthesis is evident in this system The role of mRNA stability, cis-acting mutations, and trans-acting factors are being evaluated in the context of elastic tissue diseases and growth factor responses. Cytokine effects are tested on cells from vascular smooth muscle, skin, and vocal fold. Several human diseases involve loss or excessive accumulation of elastic tissue, including an unusual aging syndrome, Hutchinson-Gilford progeria, and recessive and acquired forms of cutis laxa.. The consequences of elastin mutations that we discovered in cutis laxa is under intense examination

Connective tissue production and remodeling are also critical to proper wound repair. We have been examining the mechanisms of collagen and elastin turnover in pulmonary fibrosis and related diseases. We also use animal models to explore how addition or local inactivation of growth factors such as basic fibroblast growth factor, keratinocyte growth factor, transforming growth factor-? superfamily members, platelet derived growth factor and connective tissue growth affect the process and outcome of wound healing. Defective wound healing is an important clinical problem that is under study in fibrotic, aging and diabetic animal populations. Cellular and tissue-equivalent models are used where they appear to accurately reflect tissue behavior. Evaluation of gene expression by in situ and filter hybridization reveals diverse mechanisms, including the influence of metalloproteinases involved in reorganization of fibrous connective tissue.

We have used a novel form of gene therapy to express various factors in wounds with clear effects on the rate of healing. This technique offers the possibility of manipulating the healing process in a new and precise way, since recombinant expression vectors can be readily modified to understand structure-function relationships in an authentic biological context. Gene therapy of wounds also offers a rapid way to screen for wound healing functions of newly discovered cDNAs.

The laboratory is also part of the Vanderbilt Free-Electron Laser Center. This is a multidisciplinary program in which this laboratory is examining how tissues respond and heal after irradiation from the most powerful source of pulsed, infrared light energy in the country. .
Research Keywords
Connective tissue research; Wound healing; Gene therapy
Publications
Wilmink GJ, Opalenik SR, Beckham JT, Abraham AA, Nanney LB, Mahadevan-Jansen A, Davidson JM, Jansen ED. Molecular imaging-assisted optimization of hsp70 expression during laser-induced thermal preconditioning for wound repair enhancement. J. Invest. Dermatol [print-electronic]. 2009 Jan; 129(1): 205-16. PMID: 18580963, PMCID: PMC3846389, PII: jid2008175, DOI: 10.1038/jid.2008.175, ISSN: 1523-1747.

Hafeman AE, Li B, Yoshii T, Zienkiewicz K, Davidson JM, Guelcher SA. Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration. Pharm. Res [print-electronic]. 2008 Oct; 25(10): 2387-99. PMID: 18516665, PMCID: PMC3842433, DOI: 10.1007/s11095-008-9618-z, ISSN: 0724-8741.

Prokop A, Davidson JM. Nanovehicular intracellular delivery systems. J Pharm Sci. 2008 Sep; 97(9): 3518-90. PMID: 18200527, PMCID: PMC3747665, DOI: 10.1002/jps.21270, ISSN: 1520-6017.

Davidson JM. First-class delivery: getting growth factors to their destination. J. Invest. Dermatol. 2008 Jun; 128(6): 1360-2. PMID: 18478013, PII: jid2008128, DOI: 10.1038/jid.2008.128, ISSN: 1523-1747.

Caldwell RL, Opalenik SR, Davidson JM, Caprioli RM, Nanney LB. Tissue profiling MALDI mass spectrometry reveals prominent calcium-binding proteins in the proteome of regenerative MRL mouse wounds. Wound Repair Regen [print-electronic]. 2008 May; 16(3): 442-9. PMID: 18282264, PMCID: PMC2891803, PII: WRR351, DOI: 10.1111/j.1524-475X.2007.00351.x, ISSN: 1524-475X.

Hartig SM, Greene RR, Carlesso G, Higginbotham JN, Khan WN, Prokop A, Davidson JM. Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells. Biomaterials [print-electronic]. 2007 Sep; 28(26): 3843-55. PMID: 17560645, PMCID: PMC2000344, PII: S0142-9612(07)00346-8, DOI: 10.1016/j.biomaterials.2007.04.027, ISSN: 0142-9612.

Rauth TP, Poulose BK, Davidson JM, Nanney LB, Holzman MD. Mechanical abrasion improves early incorporation of small intestinal submucosa. Am Surg. 2007 Jul; 73(7): 647-51; discussion 651. PMID: 17674934, ISSN: 0003-1348.

Hartig SM, Carlesso G, Davidson JM, Prokop A. Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights. Biomacromolecules. 2007 Jan; 8(1): 265-72. PMID: 17206816, DOI: 10.1021/bm0604754, ISSN: 1525-7797.

Davidson JM, Giro M. Healing slack skin. J. Invest. Dermatol. 2006 Dec; 126(12): 2563-4. PMID: 17108902, PII: 5700608, DOI: 10.1038/sj.jid.5700608, ISSN: 1523-1747.

Nanney LB, Caldwell RL, Pollins AC, Cardwell NL, Opalenik SR, Davidson JM. Novel approaches for understanding the mechanisms of wound repair. J. Investig. Dermatol. Symp. Proc. 2006 Sep; 11(1): 132-9. PMID: 17069021, ISSN: 1087-0024.

Samaras SE, Shi Y, Davidson JM. CARP: fishing for novel mechanisms of neovascularization. J. Investig. Dermatol. Symp. Proc. 2006 Sep; 11(1): 124-31. PMID: 17069020, ISSN: 1087-0024.

Tang T, Shi Y, Opalenik SR, Brantley-Sieders DM, Chen J, Davidson JM, Brandt SJ. Expression of the TAL1/SCL transcription factor in physiological and pathological vascular processes. J. Pathol. 2006 Sep; 210(1): 121-9. PMID: 16841371, DOI: 10.1002/path.2028, ISSN: 0022-3417.

Wilmink GJ, Opalenik SR, Beckham JT, Davidson JM, Jansen ED. Assessing laser-tissue damage with bioluminescent imaging. J Biomed Opt. 2006 Jul; 11(4): 41114. PMID: 16965142, DOI: 10.1117/1.2339012, ISSN: 1083-3668.

Spindler KP, Murray MM, Devin C, Nanney LB, Davidson JM. The central ACL defect as a model for failure of intra-articular healing. J. Orthop. Res. 2006 Mar; 24(3): 401-6. PMID: 16479574, DOI: 10.1002/jor.20074, ISSN: 0736-0266.

Opalenik SR, Davidson JM. Fibroblast differentiation of bone marrow-derived cells during wound repair. FASEB J [print-electronic]. 2005 Sep; 19(11): 1561-3. PMID: 16014399, PII: 04-2978fje, DOI: 10.1096/fj.04-2978fje, ISSN: 1530-6860.

Carlesso G, Kozlov E, Prokop A, Unutmaz D, Davidson JM. Nanoparticulate system for efficient gene transfer into refractory cell targets. Biomacromolecules. 2005 May; 6(3): 1185-92. PMID: 15877332, DOI: 10.1021/bm0492531, ISSN: 1525-7797.

Shi Y, Reitmaier B, Regenbogen J, Slowey RM, Opalenik SR, Wolf E, Goppelt A, Davidson JM. CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue. Am. J. Pathol. 2005 Jan; 166(1): 303-12. PMID: 15632022, PMCID: PMC1602297, PII: S0002-9440(10)62254-7, DOI: 10.1016/S0002-9440(10)62254-7, ISSN: 0002-9440.

Wu N, Davidson JM. Migration inhibitory factor-related protein (MRP)8 and MRP14 are differentially expressed in free-electron laser and scalpel incisions. Wound Repair Regen. 2004 May; 12(3): 327-36. PMID: 15225211, PII: WRR12313, DOI: 10.1111/j.1067-1927.2004.012313.x, ISSN: 1067-1927.

Wu N, Jansen ED, Davidson JM. Comparison of mouse matrix metalloproteinase 13 expression in free-electron laser and scalpel incisions during wound healing. J. Invest. Dermatol. 2003 Oct; 121(4): 926-32. PMID: 14632214, DOI: 10.1046/j.1523-1747.2003.12497.x, ISSN: 0022-202X.

Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am. J. Pathol. 2003 Oct; 163(4): 1261-73. PMID: 14507636, PMCID: PMC1868298, PII: S0002-9440(10)63486-4, ISSN: 0002-9440.

Riordan CL, McDonough M, Davidson JM, Corley R, Perlov C, Barton R, Guy J, Nanney LB. Noncontact laser Doppler imaging in burn depth analysis of the extremities. J Burn Care Rehabil. 2003 Jul; 24(4): 177-86. PMID: 14501410, DOI: 10.1097/01.BCR.0000075966.50533.B0, ISSN: 0273-8481.

Davidson JM, Breyer MD. Inflammatory modulation and wound repair. J. Invest. Dermatol. 2003 May; 120(5): xi-xii. PMID: 12713603, PII: 12154, DOI: 10.1046/j.1523-1747.2003.12154.x, ISSN: 0022-202X.

Spindler KP, Murray MM, Detwiler KB, Tarter JT, Dawson JM, Nanney LB, Davidson JM. The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J. Orthop. Res. 2003 Mar; 21(2): 245-9. PMID: 12568955, PII: S0736026602001456, DOI: 10.1016/S0736-0266(02)00145-6, ISSN: 0736-0266.

Davidson JM, Eming SA, Dasgupta J. Particle-mediated gene therapy of wounds. Methods Mol. Med. 2003; 78: 433-52. PMID: 12825291, DOI: 10.1385/1-59259-332-1:433, ISSN: 1543-1894.

Nishida M, Fujinaka H, Matsusaka T, Price J, Kon V, Fogo AB, Davidson JM, Linton MF, Fazio S, Homma T, Yoshida H, Ichikawa I. Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J. Clin. Invest. 2002 Dec; 110(12): 1859-68. PMID: 12488436, PMCID: PMC151648, DOI: 10.1172/JCI15045, ISSN: 0021-9738.

Spindler KP, Dawson JM, Stahlman GC, Davidson JM, Nanney LB. Collagen expression and biomechanical response to human recombinant transforming growth factor beta (rhTGF-beta2) in the healing rabbit MCL. J. Orthop. Res. 2002 Mar; 20(2): 318-24. PMID: 11918312, DOI: 10.1016/S0736-0266(01)00107-3, ISSN: 0736-0266.

Wu N, Opalenik S, Liu J, Jansen ED, Giro MG, Davidson JM. Real-time visualization of MMP-13 promoter activity in transgenic mice. Matrix Biol. 2002 Mar; 21(2): 149-61. PMID: 11852231, PII: S0945053X01001925, ISSN: 0945-053X.

Davidson JM. Smad about elastin regulation. Am. J. Respir. Cell Mol. Biol. 2002 Feb; 26(2): 164-6. PMID: 11804864, DOI: 10.1165/ajrcmb.26.2.f228, ISSN: 1044-1549.

Prokop A, Kozlov E, Moore W, Davidson JM. Maximizing the in vivo efficiency of gene transfer by means of nonviral polymeric gene delivery vehicles. J Pharm Sci. 2002 Jan; 91(1): 67-76. PMID: 11782898, PII: 10.1002/jps.1171, ISSN: 0022-3549.

Bennett LL, Rosenblum RS, Perlov C, Davidson JM, Barton RM, Nanney LB. An in vivo comparison of topical agents on wound repair. Plast. Reconstr. Surg. 2001 Sep 9/1/2001; 108(3): 675-87. PMID: 11698839, ISSN: 0032-1052.

Ballas CB, Davidson JM. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Repair Regen. 2001 May; 9(3): 223-37. PMID: 11472619, PII: wrr223, ISSN: 1067-1927.

Nanney LB, Wamil BD, Whitsitt J, Cardwell NL, Davidson JM, Yan HP, Hellerqvist CG. CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism. Angiogenesis. 2001; 4(1): 61-70. PMID: 11824380, ISSN: 0969-6970.

Prokop A, Kozlov E, Nun Non S, Dikov MM, Sephel GC, Whitsitt JS, Davidson JM. Towards retrievable vascularized bioartificial pancreas: induction and long-lasting stability of polymeric mesh implant vascularized with the help of acidic and basic fibroblast growth factors and hydrogel coating. Diabetes Technol. Ther. 2001; 3(2): 245-61. PMID: 11478332, ISSN: 1520-9156.

Davidson, J.M. Experimental animal wound models. Wounds. 2001; 13: 9-23.

Ballas, C.B., Davidson, J.M. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Rep. Regen. 2001; 9: 223-7.

Drew, A.F., Liu, H., Davidson, J.M., Daugherty, C.C., Degen, J.L. Wound healing defects in mice lacking fibrinogen. Blood. 2001; 97: 3691-98.

Prokop, A., Kozlov, E., Nun Non, Shuhaida, Dikov, M.M., Sephel, G.C., Davidson, J.M. Towards retrievable vascularized bioartificial pancreas (vbap): induction and long-lasting stability of polymeric mesh implant vascularized with help of acidic and basic fibroblast growth factors and hydrogel coating. Diab Technol Therap. 2001; 3: 245-61.

Nanney LB, Wamil BD, Whitsitt J, Cardwell JL, Davidson JM, Yan, H.P., Hellerqvist CG. CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism. Angiogenesis. 2001; 4: 61-70.

Ma LJ, Nakamura S, Whitsitt JS, Marcantoni C, Davidson JM, Fogo AB. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int. 2000 Dec; 58(6): 2425-36. PMID: 11115076, PII: kid426, DOI: 10.1046/j.1523-1755.2000.00426.x, ISSN: 0085-2538.

Davidson JM, Krieg T, Eming SA. Particle-mediated gene therapy of wounds. Wound Repair Regen. 2000 Nov; 8(6): 452-9. PMID: 11208172, PII: wrr452, ISSN: 1067-1927.

Nanney LB, Paulsen S, Davidson MK, Cardwell NL, Whitsitt JS, Davidson JM. Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair Regen. 2000 Mar; 8(2): 117-27. PMID: 10810038, PII: wrr117, ISSN: 1067-1927.

Light, R.W., Cheng, D-S., Lee, Y.C., Rogers, J., Davidson, J.M., Lane, K.B. A single intrapleural injection of transforming growth factor ?2 produces an excellent pleurodesis in rats. Am J Respir Crit Care Med. 2000; 162: 98-104.

Nanney, L.B., Paulsen, S., Davidson, M.K., Cardwell, N.L., Whitsitt, J.S., Davidson, J.M. Boosting EGF receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Rep. Reg. 2000; 8: 117-27.

Ma, L.-J., Nakamura, S., Whitsitt, J.S., Marcantoni, C., Davidson, J.M., Fogo, A.B. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int. 2000; 56: 2425-36.

Davidson JM, Aquino AM, Woodward SC, Wilfinger WW. Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. FASEB J. 1999 Feb; 13(2): 325-9. PMID: 9973320, ISSN: 0892-6638.

Zhang MC, He L, Giro M, Yong SL, Tiller GE, Davidson JM. Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN). J. Biol. Chem. 1999 Jan 1/8/1999; 274(2): 981-6. PMID: 9873040, ISSN: 0021-9258.

Hoff CR, Perkins DR, Davidson JM. Elastin gene expression is upregulated during pulmonary fibrosis. Connect. Tissue Res. 1999; 40(2): 145-53. PMID: 10761639, ISSN: 0300-8207.

Davidson JM, Whitsitt JS, Pennington B, Ballas CB, Eming S, Benn SI. Gene therapy of wounds with growth factors. Curr Top Pathol. 1999; 93: 111-21. PMID: 10339904, ISSN: 0070-2188.

Garrard CL, Clements RH, Nanney L, Davidson JM, Richards WO. Adhesion formation is reduced after laparoscopic surgery. Surg Endosc. 1999 Jan; 13(1): 10-3. PMID: 9869679, ISSN: 0930-2794.

Hoff, C.R. and Davidson, J.M. Elastin expression in murine pulmonary fibrosis. Connect. Tiss. Res. 1999; 40: 145-53.

Zhang, M.C., He L., Giro M, Yong S-L, Tiller G.E., and Davidson J.M. Cutis laxa arising from frame shift mutations in the elastin gene (ELN). J. Biol. Chem. 1999; 274: 981-6.

Davidson, J.M., Aquino, A.M., Woodward, S.C., Wilfinger, W.W. Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat. FASEB J. 1999; 13: 325-9.

Eming, S.A., Whitsitt, J.S., He, L., Krieg, T., Morgan, J.R., Davidson, J.M. Particle-mediated gene transfer of PDGF isoforms promotes wound repair. J. Invest. Dermatol. 1999; 112: 297-302.

Davidson JM. Animal models for wound repair. Arch. Dermatol. Res. 1998 Jul; 290 Suppl: S1-11. PMID: 9710378, ISSN: 0340-3696.

Davidson JM. Wound repair. J Hand Ther. 1998 Apr; 11(2): 80-94. PMID: 9602964, ISSN: 0894-1130.

Liaw L, Birk DE, Ballas CB, Whitsitt JS, Davidson JM, Hogan BL. Altered wound healing in mice lacking a functional osteopontin gene (spp1). J. Clin. Invest. 1998 Apr 4/1/1998; 101(7): 1468-78. PMID: 9525990, PMCID: PMC508725, DOI: 10.1172/JCI2131, ISSN: 0021-9738.

Bryant GL, Davidson JM, Ossoff RH, Garrett CG, Reinisch L. Histologic study of oral mucosa wound healing: a comparison of a 6.0- to 6.8-micrometer pulsed laser and a carbon dioxide laser. Laryngoscope. 1998 Jan; 108(1 Pt 1): 13-7. PMID: 9432060, ISSN: 0023-852X.

Bryant, G.L., Davidson, J.M., Ossoff, R.H., Garrett, G. and Reinisch, L. Histologic study of oral mucosa wound healing: A comparison of a 6.0- to 6.8-?m pulsed laser and a carbon dioxide laser. Laryngoscope. 1998; 108: 13-7.

Liaw, L., Birk, D.E., Whitsitt, J.S., Ballas, C.B., Davidson, J.M., Hogan, B.L.M. Altered wound healing in mice lacking a functional osteopontin gene (spp1). J. Clin. Invest. 1998; 101: 1468-78.

Davidson, J.M. Animal models for wound repair. Arch. Dermatol Res. 1998; 290: S1-S11.

Davidson JM, LuValle PA, Zoia O, Quaglino D, Giro M. Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms. J. Biol. Chem. 1997 Jan 1/3/1997; 272(1): 345-52. PMID: 8995268, ISSN: 0021-9258.

Davidson, J.M., Broadley, K.N., Quaglino Jr., D. Reversal of the wound healing deficit in diabetic rats by combined basic fibroblast growth factor and transforming growth factor-? therapy. Wound Rep. Regen. 1997; 5: 77-88.

Davidson, J.M., LuValle, P.A., Zoia, O., Quaglino, Jr., D., Giro, M.G. Ascorbate down regulates collagen and elastin biosynthesis in vascular smooth muscle cells and skin fibroblasts by a pretranslational mechanism. J. Biol. Chem. 1997; 272: 345-52.

Benn SI, Whitsitt JS, Broadley KN, Nanney LB, Perkins D, He L, Patel M, Morgan JR, Swain WF, Davidson JM. Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. J. Clin. Invest. 1996 Dec 12/15/1996; 98(12): 2894-902. PMID: 8981938, PMCID: PMC507757, DOI: 10.1172/JCI119118, ISSN: 0021-9738.

Spindler KP, Clark SW, Nanney LB, Davidson JM. Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study. J. Orthop. Res. 1996 Nov; 14(6): 857-61. PMID: 8982126, DOI: 10.1002/jor.1100140603, ISSN: 0736-0266.

Charous SJ, Ossoff RH, Reinisch L, Davidson JM. Canine subglottic stenosis as a model for excessive fibrosis: a pilot histologic and immunohistochemical analysis. Wound Repair Regen. 1996 Oct; 4(4): 444-53. PMID: 17309695, PII: WRRwrr_040408, DOI: 10.1046/j.1524-475X.1996.40408.x, ISSN: 1067-1927.

Spindler KP, Imro AK, Mayes CE, Davidson JM. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor beta. J. Orthop. Res. 1996 Jul; 14(4): 542-6. PMID: 8764862, DOI: 10.1002/jor.1100140407, ISSN: 0736-0266.

Speyer M, Joe J, Davidson JM, Ossoff RH, Reinisch L. Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions. Laryngoscope. 1996 Jul; 106(7): 845-50. PMID: 8667981, ISSN: 0023-852X.

Clymer MA, Schwaber MK, Davidson JM. The effects of keratinocyte growth factor on healing of tympanic membrane perforations. Laryngoscope. 1996 Mar; 106(3 Pt 1): 280-5. PMID: 8614189, ISSN: 0023-852X.

Benn, S.I., Whitsitt, J.S., Broadley, K.N., He, L.,Nanney, L.B., Perkins, D, Patel, M., Swain, W.F.,Davidson, J.M. Particle mediated gene transfer with TGF-?1 cDNAs enhances wound repair in rat skin. J. Clin. Invest. 1996; 98((12)): 2894-902.

Spindler, K.P., Imro, A.K., Mayes, C.E., Davidson, J.M. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor ?. J. Orth. Res. 1996; 14: 542-6.

Speyer, M., Joe, J., Davidson, J.M., Ossoff, R.H., Reinisch, L. Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions. Laryngoscope. 1996; 106: 845-50.

Spindler, K.P., Clark, S.W., Nanney, L.B., Davidson, J.M. Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study. J. Orth. Res. 1996; 14: 857-61.

McCarthy, M.J., Davidson, J.M., Cardone, J.S., Anderson, L.L. Cutis laxa aquisita associated with multiple myeloma: A case report and review of the literature. Cutis. 1996; 57((4)): 267-70.

Clymer, M., Reinisch, L., Ossoff, R., Davidson, J.M. Effects of keratinocyte growth factor on healing of tympanic membrane perforations. Laryngoscope. 1996; 106: 280-5.

Charous, S.J., Ossoff, R.H., Davidson, J.M. Canine subglottic stenosis as a model for hypertrophic scarring: histological and immunochemical analysis. Wound Repair Regen. 1996; 4: 444-53.

Gossage JR, Perkett EA, Davidson JM, Starcher BC, Carmichael D, Brigham KL, Meyrick B. Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep. J. Appl. Physiol. 1995 Oct; 79(4): 1163-72. PMID: 8567558, ISSN: 8750-7587.

Broadley C, Broadley KN, Disimone G, Riensch L, Davidson JM. Low-energy helium-neon laser irradiation and the tensile strength of incisional wounds in the rat. Wound Repair Regen. 1995 Oct; 3(4): 512-7. PMID: 17147664, PII: WRRwrr_030417, DOI: 10.1046/j.1524-475X.1995.30417.x, ISSN: 1067-1927.

Zhang MC, Giro M, Quaglino D, Davidson JM. Transforming growth factor-beta reverses a posttranscriptional defect in elastin synthesis in a cutis laxa skin fibroblast strain. J. Clin. Invest. 1995 Mar; 95(3): 986-94. PMID: 7884000, PMCID: PMC441431, DOI: 10.1172/JCI117808, ISSN: 0021-9738.

Spindler KP, Mayes CE, Miller RR, Imro AK, Davidson JM. Regional mitogenic response of the meniscus to platelet-derived growth factor (PDGF-AB). J. Orthop. Res. 1995 Mar; 13(2): 201-7. PMID: 7722757, DOI: 10.1002/jor.1100130208, ISSN: 0736-0266.

Davidson JM, Zang MC, Zoia O, Giro MG. Regulation of elastin synthesis in pathological states. Ciba Found. Symp. 1995; 192: 81-94; discussion 94. PMID: 8575269, ISSN: 0300-5208.

Broadley C, Gonzalez DA, Nair R, Koriwchak MJ, Ossoff RH, Davidson JM. A tissue-culture model for the study of canine vocal fold fibroblasts. Laryngoscope. 1995 Jan; 105(1): 23-7. PMID: 7837909, DOI: 10.1288/00005537-199501000-00008, ISSN: 0023-852X.

Spindler KP, Nanney LB, Davidson JM. Proliferative responses to platelet-derived growth factor in young and old rat patellar tendon. Connect. Tissue Res. 1995; 31(2): 171-7. PMID: 15612333, ISSN: 0300-8207.

TGF-? reverses a post-transcriptional defect of elastin synthesis in two cutis laxa skin fibroblast strains. Zhang, M.C., Giro, M.G., Quaglino, D., Jr., Davidson, J.M. J. Clin. Invest. 1995; 95: 986-94.

Vrabec JT, Schwaber MK, Davidson JM, Clymer MA. Evaluation of basic fibroblast growth factor in tympanic membrane repair. Laryngoscope. 1994 Sep; 104(9): 1059-64. PMID: 8072349, DOI: 10.1288/00005537-199409000-00002, ISSN: 0023-852X.

Tissue ablation by a free-electron laser tuned to the amide II band. Edwards, G., Logan, R., Copeland, M., Reinisch, L., Davidson, J.M., Johnson, B., Maciunas, R., Mendenhall, M., Ossoff, R., Tribble, J., Werkhaven, J., O'Day, D. Nature. 1994; 371: 416-9.

Giro M, Davidson JM. Familial co-segregation of the elastin phenotype in skin fibroblasts from Hutchinson-Gilford progeria. Mech. Ageing Dev. 1993 Aug 8/15/1993; 70(3): 163-36. PMID: 8246632, ISSN: 0047-6374.

Gossage JR, Kuratomi Y, Davidson JM, Lefferts PL, Snapper JR. Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep. Am. Rev. Respir. Dis. 1993 Jun; 147(6 Pt 1): 1371-9. PMID: 8503548, DOI: 10.1164/ajrccm/147.6_Pt_1.1371, ISSN: 0003-0805.

Kyzer MD, Aly AS, Davidson JM, Reinisch L, Ossoff RH. Sub ablation effects of the KTP laser on wound healing. Lasers Surg Med. 1993; 13(1): 62-71. PMID: 8426529, ISSN: 0196-8092.

Giro MG, Duvic M, Smith LT, Kennedy R, Rapini R, Arnett FC, Davidson JM. Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture. J. Invest. Dermatol. 1992 Aug; 99(2): 129-37. PMID: 1629625, ISSN: 0022-202X.

Schriver EE, Davidson JM, Sutcliffe MC, Swindell BB, Bernard GR. Comparison of elastin peptide concentrations in body fluids from healthy volunteers, smokers, and patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1992 Apr; 145(4 Pt 1): 762-6. PMID: 1554198, DOI: 10.1164/ajrccm/145.4_Pt_1.762, ISSN: 0003-0805.

Lane KB, Zoia O, Davidson JM. Semidry electrophoretic transfer of RNA to membranes. BioTechniques. 1992 Mar; 12(3): 340-2, 346. PMID: 1373942, ISSN: 0736-6205.

Perkett EA, Davidson JM, Meyrick B. Sequence of structural changes and elastin peptide release during vascular remodelling in sheep with chronic pulmonary hypertension induced by air embolization. Am. J. Pathol. 1991 Dec; 139(6): 1319-32. PMID: 1836307, PMCID: PMC1886467, ISSN: 0002-9440.

Quaglino D, Nanney LB, Ditesheim JA, Davidson JM. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin: incisional wound model. J. Invest. Dermatol. 1991 Jul; 97(1): 34-42. PMID: 2056191, ISSN: 0022-202X.

Fava RA, Olsen NJ, Postlethwaite AE, Broadley KN, Davidson JM, Nanney LB, Lucas C, Townes AS. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. J. Exp. Med. 1991 May 5/1/1991; 173(5): 1121-32. PMID: 2022923, PMCID: PMC2118851, ISSN: 0022-1007.

Henderson GS, Conary JT, Davidson JM, Stewart SJ, House FS, McCurley TL. A reliable method for northern blot analysis using synthetic oligonucleotide probes. BioTechniques. 1991 Feb; 10(2): 190-7. PMID: 1711871, ISSN: 0736-6205.

Davidson JM, Broadley KN. Manipulation of the wound-healing process with basic fibroblast growth factor. Ann. N. Y. Acad. Sci. 1991; 638: 306-15. PMID: 1785808, ISSN: 0077-8923.

Davidson JM, Nanney LB, Broadley KN, Whitsett JS, Aquino AM, Beccaro M, Rastrelli A. Hyaluronate derivatives and their application to wound healing: preliminary observations. Clin Mater. 1991; 8(1-2): 171-7. PMID: 10149164, ISSN: 0267-6605.

Davidson JM. Biochemistry and turnover of lung interstitium. Eur. Respir. J. 1990 Oct; 3(9): 1048-63. PMID: 2289553, ISSN: 0903-1936.

Quaglino D, Nanney LB, Kennedy R, Davidson JM. Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model. Lab. Invest. 1990 Sep; 63(3): 307-19. PMID: 2395327, ISSN: 0023-6837.

Garcia FU, Wojta J, Broadley KN, Davidson JM, Hoover RL. Bartonella bacilliformis stimulates endothelial cells in vitro and is angiogenic in vivo. Am. J. Pathol. 1990 May; 136(5): 1125-35. PMID: 1693472, PMCID: PMC1877437, ISSN: 0002-9440.

Broadley KN, Aquino AM, Woodward SC, Buckley-Sturrock A, Sato Y, Rifkin DB, Davidson JM. Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair. Lab. Invest. 1989 Nov; 61(5): 571-5. PMID: 2811305, ISSN: 0023-6837.

Broadley KN, Aquino AM, Hicks B, Ditesheim JA, McGee GS, Demetriou AA, Woodward SC, Davidson JM. The diabetic rat as an impaired wound healing model: stimulatory effects of transforming growth factor-beta and basic fibroblast growth factor. Biotechnol Ther. 1989; 1(1): 55-68. PMID: 2562644, ISSN: 0898-2848.

Buckley-Sturrock A, Woodward SC, Senior RM, Griffin GL, Klagsbrun M, Davidson JM. Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors. J. Cell. Physiol. 1989 Jan; 138(1): 70-8. PMID: 2536037, DOI: 10.1002/jcp.1041380111, ISSN: 0021-9541.

Liu JM, Davidson JM. The elastogenic effect of recombinant transforming growth factor-beta on porcine aortic smooth muscle cells. Biochem. Biophys. Res. Commun. 1988 Aug 8/15/1988; 154(3): 895-901. PMID: 3165637, PII: 0006-291X(88)90224-0, ISSN: 0006-291X.

McGee GS, Davidson JM, Buckley A, Sommer A, Woodward SC, Aquino AM, Barbour R, Demetriou AA. Recombinant basic fibroblast growth factor accelerates wound healing. J. Surg. Res. 1988 Jul; 45(1): 145-53. PMID: 3392988, PII: 0022-4804(88)90034-0, ISSN: 0022-4804.

Sephel GC, Sturrock A, Giro MG, Davidson JM. Increased elastin production by progeria skin fibroblasts is controlled by the steady-state levels of elastin mRNA. J. Invest. Dermatol. 1988 May; 90(5): 643-7. PMID: 3361140, ISSN: 0022-202X.

Broadley KN, Aquino AM, Hicks B, Ditesheim JA, McGee GS, Demetriou AA, Woodward SC, Davidson JM. Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats. Int J Tissue React. 1988; 10(6): 345-53. PMID: 3255729, ISSN: 0250-0868.

Buckley A, Davidson JM, Kamerath CD, Woodward SC. Epidermal growth factor increases granulation tissue formation dose dependently. J. Surg. Res. 1987 Oct; 43(4): 322-8. PMID: 3498859, ISSN: 0022-4804.