Luc Van Kaer, Ph.D.


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Faculty Appointments
Professor of Pathology, Microbiology and Immunology Elizabeth and John Shapiro Chair
Ph.D., Molecular Biology, University of Ghent, Ghent, FranceM.S., Biotechnology, University of Ghent, Ghent, FranceB.S., Chemistry, University of Ghent, Ghent, France
Research Description
We are interested in the basic mechanisms employed by the immune system to fight infection. Our work focuses on the function of a set of molecules encoded within a region of the genome referred to as the major histocompatibility complex (MHC). The MHC products bind with pathogen-derived peptides and present these peptides to T lymphocytes. Two classes of MHC molecule can be distinguished, MHC class I and class II, which present antigens to CD8+ cytotoxic T lymphocytes and CD4+ helper T lymphocytes, respectively.

Current projects in the laboratory include: 1) determine how antigenic peptides are generated and combined with MHC molecules; 2) understand the role of MHC molecules and their natural peptide ligands in the intrathymic selection of a complete repertoire of T lymphocytes; 3) study how the type of MHC molecule that presents a given antigen can influence the type of immune response that is generated against this antigen; and 4) investigate the importance of MHC products for the target cell specificity of natural killer cells, a poorly defined class of lymphocyte that is involved in the immune response against viruses and tumors.

Our general approach to study the immune system is to use mouse genetics. Genetic engineering techniques are now available that allow one to introduce or delete specific genes in a whole mice. Such mice provide unique models to study various aspects of a gene product. Using this technology, our laboratory has generated several new mouse strains which exhibit a variety of immune defects.
Research Keywords
Antigen presentation and lymphocyte development
Van Kaer L, Parekh VV, Wu L. Invariant natural killer T cells: bridging innate and adaptive immunity. Cell Tissue Res [print-electronic]. 2011 Jan; 343(1): 43-55. PMID: 20734065, PMCID: PMC3616393, DOI: 10.1007/s00441-010-1023-3, ISSN: 1432-0878.

Braun NA, Mendez-Fernandez YV, Covarrubias R, Porcelli SA, Savage PB, Yagita H, Van Kaer L, Major AS. Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2010 Sep; 30(9): 1758-65. PMID: 20539017, PMCID: PMC2963029, PII: ATVBAHA.110.206045, DOI: 10.1161/ATVBAHA.110.206045, ISSN: 1524-4636.

Hao J, Liu R, Piao W, Zhou Q, Vollmer TL, Campagnolo DI, Xiang R, La Cava A, Van Kaer L, Shi FD. Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology. J. Exp. Med [print-electronic]. 2010 Aug 8/30/2010; 207(9): 1907-21. PMID: 20696699, PMCID: PMC2931174, PII: jem.20092749, DOI: 10.1084/jem.20092749, ISSN: 1540-9538.

Van Kaer L, Joyce S. The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue?. Immunity. 2010 Aug 8/27/2010; 33(2): 143-5. PMID: 20732635, PII: S1074-7613(10)00292-X, DOI: 10.1016/j.immuni.2010.08.009, ISSN: 1097-4180.

Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity [print-electronic]. 2010 Aug 8/27/2010; 33(2): 254-65. PMID: 20691614, PMCID: PMC2929658, PII: S1074-7613(10)00281-5, DOI: 10.1016/j.immuni.2010.07.016, ISSN: 1097-4180.

Zu L, Bedja D, Fox-Talbot K, Gabrielson KL, Van Kaer L, Becker LC, Cai ZP. Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice. J. Mol. Cell. Cardiol [print-electronic]. 2010 Jul; 49(1): 5-15. PMID: 20153750, PMCID: PMC2883685, PII: S0022-2828(10)00042-8, DOI: 10.1016/j.yjmcc.2010.02.007, ISSN: 1095-8584.

Liu R, Zhou Q, La Cava A, Campagnolo DI, Van Kaer L, Shi FD. Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur. J. Immunol. 2010 Jun; 40(6): 1577-89. PMID: 20352624, PMCID: PMC3600978, DOI: 10.1002/eji.200939792, ISSN: 1521-4141.

Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J. Exp. Med [print-electronic]. 2009 Oct 10/26/2009; 206(11): 2407-16. PMID: 19808254, PMCID: PMC2768861, PII: jem.20082286, DOI: 10.1084/jem.20082286, ISSN: 1540-9538.

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J. Immunol [print-electronic]. 2009 Aug 8/1/2009; 183(3): 2016-26. PMID: 19587017, PMCID: PMC3755459, PII: jimmunol.0803167, DOI: 10.4049/jimmunol.0803167, ISSN: 1550-6606.

Wu L, Gabriel CL, Parekh VV, Van Kaer L. Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities. Tissue Antigens [print-electronic]. 2009 Jun; 73(6): 535-45. PMID: 19392798, PII: TAN1256, DOI: 10.1111/j.1399-0039.2009.01256.x, ISSN: 1399-0039.

Moens L, Jeurissen A, Nierkens S, Boon L, Van Kaer L, Kasran A, Wuyts G, Ceuppens JL, Bossuyt X. Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice. Infect. Immun [print-electronic]. 2009 May; 77(5): 1976-80. PMID: 19188354, PMCID: PMC2681747, PII: IAI.01091-08, DOI: 10.1128/IAI.01091-08, ISSN: 1098-5522.

Parekh VV, Lalani S, Kim S, Halder R, Azuma M, Yagita H, Kumar V, Wu L, Kaer LV. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J. Immunol. 2009 Mar 3/1/2009; 182(5): 2816-26. PMID: 19234176, PMCID: PMC2709814, PII: 182/5/2816, DOI: 10.4049/jimmunol.0803648, ISSN: 1550-6606.

Wu L, Van Kaer L. Natural killer T cells and autoimmune disease. Curr. Mol. Med. 2009 Feb; 9(1): 4-14. PMID: 19199937, ISSN: 1566-5240.

Sadagopal S, Braunstein M, Hager CC, Wei J, Daniel AK, Bochan MR, Crozier I, Smith NE, Gates HO, Barnett L, Van Kaer L, Price JO, Blackwell TS, Kalams SA, Kernodle DS. Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS ONE [print-electronic]. 2009; 4(5): e5531. PMID: 19436730, PMCID: PMC2677452, DOI: 10.1371/journal.pone.0005531, ISSN: 1932-6203.

Kim S, Lalani S, Parekh VV, Wu L, Van Kaer L. Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines. 2008 Dec; 7(10): 1519-32. PMID: 19053208, PMCID: PMC2680388, DOI: 10.1586/14760584.7.10.1519, ISSN: 1744-8395.

Cai ZP, Shen Z, Van Kaer L, Becker LC. Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J [print-electronic]. 2008 Dec; 22(12): 4248-57. PMID: 18728217, PMCID: PMC2614607, PII: fj.08-105940, DOI: 10.1096/fj.08-105940, ISSN: 1530-6860.

Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L. Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Nov 11/18/2008; 105(46): 17931-6. PMID: 19004778, PMCID: PMC2584730, PII: 0808242105, DOI: 10.1073/pnas.0808242105, ISSN: 1091-6490.

Diao H, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T. Osteopontin regulates development and function of invariant natural killer T cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Oct 10/14/2008; 105(41): 15884-9. PMID: 18836077, PMCID: PMC2560993, PII: 0806089105, DOI: 10.1073/pnas.0806089105, ISSN: 1091-6490.

Adeeku E, Gudapati P, Mendez-Fernandez Y, Van Kaer L, Boothby M. Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Jul 7/8/2008; 105(27): 9307-12. PMID: 18591677, PMCID: PMC2453725, PII: 0704807105, DOI: 10.1073/pnas.0704807105, ISSN: 1091-6490.

Ni CY, Wu ZH, Florence WC, Parekh VV, Arrate MP, Pierce S, Schweitzer B, Van Kaer L, Joyce S, Miyamoto S, Ballard DW, Oltz EM. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J. Immunol. 2008 Jun 6/1/2008; 180(11): 7107-11. PMID: 18490708, PMCID: PMC2601684, PII: 180/11/7107, ISSN: 0022-1767.

Kim S, Lalani S, Parekh VV, Vincent TL, Wu L, Van Kaer L. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J. Clin. Invest. 2008 Jun; 118(6): 2301-15. PMID: 18451996, PMCID: PMC2350429, DOI: 10.1172/JCI33071, ISSN: 0021-9738.

Joyce S, Van Kaer L. Lung NKT cell commotion takes your breath away. Nature medicine. 2008 Jun; 14(6) Sect. 609,10.

Joyce S, Van Kaer L. Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile. Cell Host Microbe. 2008 May 5/15/2008; 3(5): 275-7. PMID: 18474352, PII: S1931-3128(08)00125-X, DOI: 10.1016/j.chom.2008.04.007, ISSN: 1934-6069.

Van Kaer L. Pillars article: antigen presentation: discovery of the peptide TAP. J. Immunol. 2008 Mar 3/1/2008; 180(5): 2723-4. PMID: 18292486, PII: 180/5/2723, ISSN: 0022-1767.

Wu L, Van Kaer L. Role of NKT cells in the digestive system. II. NKT cells and diabetes. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2007 Nov; 293(5): G919-22. PMID: 17600041, PII: 00242.2007, DOI: 10.1152/ajpgi.00242.2007, ISSN: 0193-1857.

Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonça-Previato L, Nobrega A, Bellio M. Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J. Leukoc. Biol [print-electronic]. 2007 Sep; 82(3): 488-96. PMID: 17540734, PII: jlb.0706478, DOI: 10.1189/jlb.0706478, ISSN: 0741-5400.

Puttaparthi K, Van Kaer L, Elliott JL. Assessing the role of immuno-proteasomes in a mouse model of familial ALS. Exp. Neurol [print-electronic]. 2007 Jul; 206(1): 53-8. PMID: 17482163, PMCID: PMC2692686, PII: S0014-4886(07)00135-5, DOI: 10.1016/j.expneurol.2007.03.024, ISSN: 0014-4886.

Van Kaer L. NKT cells: T lymphocytes with innate effector functions. Curr. Opin. Immunol [print-electronic]. 2007 Jun; 19(3): 354-64. PMID: 17428648, PII: S0952-7915(07)00052-0, DOI: 10.1016/j.coi.2007.03.001, ISSN: 0952-7915.

Yang JQ, Wen X, Liu H, Folayan G, Dong X, Zhou M, Van Kaer L, Singh RR. Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum. 2007 Apr; 56(4): 1219-33. PMID: 17393451, PMCID: PMC2291538, DOI: 10.1002/art.22490, ISSN: 0004-3591.

Parekh VV, Lalani S, Van Kaer L. The in vivo response of invariant natural killer T cells to glycolipid antigens. Int. Rev. Immunol. 2007 Jan; 26(1-2): 31-48. PMID: 17454263, PII: 776080054, DOI: 10.1080/08830180601070179, ISSN: 0883-0185.

Das J, Eynott P, Jupp R, Bothwell A, Van Kaer L, Shi Y, Das G. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation [letter]. Nat. Med. 2006 Dec; 12(12): 1345-6; author reply 1347. PMID: 17151684, PII: nm1206-1345, DOI: 10.1038/nm1206-1345, ISSN: 1078-8956.

Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J. Exp. Med [print-electronic]. 2006 Nov 11/27/2006; 203(12): 2603-11. PMID: 17088432, PMCID: PMC2118151, PII: jem.20060936, DOI: 10.1084/jem.20060936, ISSN: 0022-1007.

Takagi D, Iwabuchi K, Maeda M, Nakamaru Y, Furuta Y, Fukuda S, Van Kaer L, Nishihira J, Onoé K. Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. Int. J. Mol. Med. 2006 Nov; 18(5): 829-36. PMID: 17016612, ISSN: 1107-3756.

Shi FD, Van Kaer L. Reciprocal regulation between natural killer cells and autoreactive T cells. Nat. Rev. Immunol. 2006 Oct; 6(10): 751-60. PMID: 16998508, PII: nri1935, DOI: 10.1038/nri1935, ISSN: 1474-1733.

Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity [print-electronic]. 2006 Sep; 25(3): 487-97. PMID: 16949316, PII: S1074-7613(06)00376-1, DOI: 10.1016/j.immuni.2006.06.017, ISSN: 1074-7613.

Van Kaer L, Joyce S. Viral evasion of antigen presentation: not just for peptides anymore. Nature immunology. 2006 Aug; 7(8) Sect. 795,7.

La Cava A, Van Kaer L, Fu-Dong-Shi. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol [print-electronic]. 2006 Jul; 27(7): 322-7. PMID: 16735139, PII: S1471-4906(06)00145-1, DOI: 10.1016/, ISSN: 1471-4906.

Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Van Kaer L, Brutkiewicz RR. Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo. Int. J. Cancer. 2006 Jun 6/15/2006; 118(12): 3045-53. PMID: 16395717, DOI: 10.1002/ijc.21764, ISSN: 0020-7136.

Major AS, Joyce S, Van Kaer L. Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Trends Mol Med [print-electronic]. 2006 Jun; 12(6): 270-8. PMID: 16651026, PII: S1471-4914(06)00071-2, DOI: 10.1016/j.molmed.2006.04.004, ISSN: 1471-4914.

Liu R, Van Kaer L, La Cava A, Price M, Campagnolo DI, Collins M, Young DA, Vollmer TL, Shi FD. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J. Immunol. 2006 May 5/1/2006; 176(9): 5247-54. PMID: 16621990, PII: 176/9/5247, ISSN: 0022-1767.

Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagómez D, Dragovic S, Hill T, Roopenian DC, Joyce S, Van Kaer L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J. Exp. Med [print-electronic]. 2006 Mar 3/20/2006; 203(3): 647-59. PMID: 16505142, PMCID: PMC2118255, PII: jem.20052271, DOI: 10.1084/jem.20052271, ISSN: 0022-1007.

Eger KA, Sundrud MS, Motsinger AA, Tseng M, Van Kaer L, Unutmaz D. Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. PLoS ONE. 2006; 1: e50. PMID: 17183680, PMCID: PMC1762372, DOI: 10.1371/journal.pone.0000050, ISSN: 1932-6203.

Major AS, Singh RR, Joyce S, Van Kaer L. The role of invariant natural killer T cells in lupus and atherogenesis. Immunol. Res. 2006; 34(1): 49-66. PMID: 16720898, PMCID: PMC2291524, PII: IR:34:1:49, ISSN: 0257-277X.

Liu R, La Cava A, Bai XF, Jee Y, Price M, Campagnolo DI, Christadoss P, Vollmer TL, Van Kaer L, Shi FD. Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J. Immunol. 2005 Dec 12/15/2005; 175(12): 7898-904. PMID: 16339525, PII: 175/12/7898, ISSN: 0022-1767.

Beilke JN, Kuhl NR, Van Kaer L, Gill RG. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat. Med [print-electronic]. 2005 Oct; 11(10): 1059-65. PMID: 16155578, PII: nm1296, DOI: 10.1038/nm1296, ISSN: 1078-8956.

Parekh VV, Wilson MT, Olivares-Villagómez D, Singh AK, Wu L, Wang CR, Joyce S, Van Kaer L. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J. Clin. Invest. 2005 Sep; 115(9): 2572-83. PMID: 16138194, PMCID: PMC1193878, DOI: 10.1172/JCI24762, ISSN: 0021-9738.

Chen M, Tabaczewski P, Truscott SM, Van Kaer L, Stroynowski I. Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J. Immunol. 2005 Jul 7/15/2005; 175(2): 1047-55. PMID: 16002705, PII: 175/2/1047, ISSN: 0022-1767.

Van Kaer L, Joyce S. Innate immunity: NKT cells in the spotlight. Curr. Biol. 2005 Jun 6/7/2005; 15(11): R429-31. PMID: 15936267, PII: S0960-9822(05)00547-6, DOI: 10.1016/j.cub.2005.05.032, ISSN: 0960-9822.

Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J. Immunol. 2005 Apr 4/15/2005; 174(8): 4696-705. PMID: 15814694, PII: 174/8/4696, ISSN: 0022-1767.

Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S. Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Apr 4/5/2005; 102(14): 5114-9. PMID: 15792999, PMCID: PMC555981, PII: 0408449102, DOI: 10.1073/pnas.0408449102, ISSN: 0027-8424.

Singh AK, Yang JQ, Parekh VV, Wei J, Wang CR, Joyce S, Singh RR, Van Kaer L. The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. Eur. J. Immunol. 2005 Apr; 35(4): 1143-54. PMID: 15761849, PMCID: PMC2291523, DOI: 10.1002/eji.200425861, ISSN: 0014-2980.

Robbins SH, Tessmer MS, Van Kaer L, Brossay L. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur. J. Immunol. 2005 Mar; 35(3): 757-65. PMID: 15719366, DOI: 10.1002/eji.200425797, ISSN: 0014-2980.

Van Kaer L. Alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat. Rev. Immunol. 2005 Jan; 5(1): 31-42. PMID: 15630427, PII: nri1531, DOI: 10.1038/nri1531, ISSN: 1474-1733.

Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T. Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. J. Immunol. 2005 Jan 1/1/2005; 174(1): 551-6. PMID: 15611282, PII: 174/1/551, ISSN: 0022-1767.

Parekh VV, Wilson MT, Van Kaer L. INKT-cell responses to glycolipids. Crit. Rev. Immunol. 2005; 25(3): 183-213. PMID: 16048435, PII: 2a1e865d14be9dc2,64f376715f2cfa97, ISSN: 1040-8401.

Major AS, Wilson MT, McCaleb JL, Ru Su Y, Stanic AK, Joyce S, Van Kaer L, Fazio S, Linton MF. Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2004 Dec; 24(12): 2351-7. PMID: 15472130, PII: 01.ATV.0000147112.84168.87, DOI: 10.1161/01.ATV.0000147112.84168.87, ISSN: 1524-4636.

Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito D, Segawa T, Maeda M, Hamuro J, Nakayama T, Taniguchi M, Yagita H, Van Kaer L, Onóe K, Denhardt D, Rittling S, Uede T. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity. 2004 Oct; 21(4): 539-50. PMID: 15485631, PII: S1074761304002481, DOI: 10.1016/j.immuni.2004.08.012, ISSN: 1074-7613.

Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Tanaka S, Bezbradica JS, Nakayama T, Taniguchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoé K. Natural killer T cells accelerate atherogenesis in mice. Blood [print-electronic]. 2004 Oct 10/1/2004; 104(7): 2051-9. PMID: 15113755, PII: 2003-10-3485, DOI: 10.1182/blood-2003-10-3485, ISSN: 0006-4971.

Li L, Sullivan BA, Aldrich CJ, Soloski MJ, Forman J, Grandea AG, Jensen PE, Van Kaer L. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J. Immunol. 2004 Sep 9/15/2004; 173(6): 3707-15. PMID: 15356116, PII: 173/6/3707, ISSN: 0022-1767.

Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J. Immunol. 2004 Sep 9/15/2004; 173(6): 3693-706. PMID: 15356115, PII: 173/6/3693, ISSN: 0022-1767.

Van Kaer L. Natural killer T cells as targets for immunotherapy of autoimmune diseases. Immunol. Cell Biol. 2004 Jun; 82(3): 315-22. PMID: 15186263, PII: ICB1252, DOI: 10.1111/j.0818-9641.2004.01252.x, ISSN: 0818-9641.

Yang JQ, Chun T, Liu H, Hong S, Bui H, Van Kaer L, Wang CR, Singh RR. CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur. J. Immunol. 2004 Jun; 34(6): 1723-32. PMID: 15162443, PMCID: PMC2291526, DOI: 10.1002/eji.200324099, ISSN: 0014-2980.

Adachi K, Tsutsui H, Seki E, Nakano H, Takeda K, Okumura K, Van Kaer L, Nakanishi K. Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int. Immunol [print-electronic]. 2004 Jun; 16(6): 787-98. PMID: 15096477, PII: dxh080, DOI: 10.1093/intimm/dxh080, ISSN: 0953-8178.

Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S. Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. J. Immunol. 2004 Apr 4/15/2004; 172(8): 4667-71. PMID: 15067039, ISSN: 0022-1767.

Roberts TJ, Lin Y, Spence PM, Van Kaer L, Brutkiewicz RR. CD1d1-dependent control of the magnitude of an acute antiviral immune response. J. Immunol. 2004 Mar 3/15/2004; 172(6): 3454-61. PMID: 15004145, ISSN: 0022-1767.

Mühlen KA, Schümann J, Wittke F, Stenger S, Van Rooijen N, Van Kaer L, Tiegs G. NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice. J. Immunol. 2004 Mar 3/1/2004; 172(5): 3034-41. PMID: 14978108, ISSN: 0022-1767.

Turnquist HR, Petersen JL, Vargas SE, McIlhaney MM, Bedows E, Mayer WE, Grandea AG, Van Kaer L, Solheim JC. The Ig-like domain of tapasin influences intermolecular interactions. J. Immunol. 2004 Mar 3/1/2004; 172(5): 2976-84. PMID: 14978101, ISSN: 0022-1767.

Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L. NKT cells: what's in a name?. Nat. Rev. Immunol. 2004 Mar; 4(3): 231-7. PMID: 15039760, PII: nri1309, DOI: 10.1038/nri1309, ISSN: 1474-1733.

Stanic AK, Bezbradica JS, Park JJ, Matsuki N, Mora AL, Van Kaer L, Boothby MR, Joyce S. NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J. Immunol. 2004 Feb 2/15/2004; 172(4): 2265-73. PMID: 14764695, ISSN: 0022-1767.

Van Kaer L. Regulation of immune responses by CD1d-restricted natural killer T cells. Immunol. Res. 2004; 30(2): 139-53. PMID: 15477656, PII: IR:30:2:139, DOI: 10.1385/IR:30:2:139, ISSN: 0257-277X.

Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Olivares-Villagómez D, Van Kaer L, Wang X, Xu M. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Dec 12/23/2003; 100(26): 15782-7. PMID: 14663139, PMCID: PMC307645, PII: 2636393100, DOI: 10.1073/pnas.2636393100, ISSN: 0027-8424.

Liang H, VanValkenburgh C, Chen X, Mullins C, Van Kaer L, Green N, Fang H. Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex. J. Biol. Chem [print-electronic]. 2003 Dec 12/19/2003; 278(51): 50932-9. PMID: 14559916, PII: M307542200, DOI: 10.1074/jbc.M307542200, ISSN: 0021-9258.

Zhang F, Liang Z, Matsuki N, Van Kaer L, Joyce S, Wakeland EK, Aune TM. A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. J. Immunol. 2003 Nov 11/1/2003; 171(9): 4613-20. PMID: 14568935, ISSN: 0022-1767.

Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. J. Immunol. 2003 Nov 11/1/2003; 171(9): 4539-51. PMID: 14568927, ISSN: 0022-1767.

Yang JQ, Saxena V, Xu H, Van Kaer L, Wang CR, Singh RR. Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol. 2003 Oct 10/15/2003; 171(8): 4439-46. PMID: 14530371, ISSN: 0022-1767.

Wilson MT, Johansson C, Olivares-Villagómez D, Singh AK, Stanic AK, Wang CR, Joyce S, Wick MJ, Van Kaer L. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Sep 9/16/2003; 100(19): 10913-8. PMID: 12960397, PMCID: PMC196902, PII: 1833166100, DOI: 10.1073/pnas.1833166100, ISSN: 0027-8424.

Yang JQ, Singh AK, Wilson MT, Satoh M, Stanic AK, Park JJ, Hong S, Gadola SD, Mizutani A, Kakumanu SR, Reeves WH, Cerundolo V, Joyce S, Van Kaer L, Singh RR. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J. Immunol. 2003 Aug 8/15/2003; 171(4): 2142-53. PMID: 12902521, ISSN: 0022-1767.

Shao H, Van Kaer L, Sun SL, Kaplan HJ, Sun D. Infiltration of the inflamed eye by NKT cells in a rat model of experimental autoimmune uveitis. J. Autoimmun. 2003 Aug; 21(1): 37-45. PMID: 12892734, PII: S0896841103000490, ISSN: 0896-8411.

Motsinger A, Azimzadeh A, Stanic AK, Johnson RP, Van Kaer L, Joyce S, Unutmaz D. Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. J. Virol. 2003 Jul; 77(14): 8153-8. PMID: 12829854, PMCID: PMC161937, ISSN: 0022-538X.

Chefalo PJ, Grandea AG, Van Kaer L, Harding CV. Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH. J. Immunol. 2003 Jun 6/15/2003; 170(12): 5825-33. PMID: 12794107, ISSN: 0022-1767.

Matsuki N, Stanic AK, Embers ME, Van Kaer L, Morel L, Joyce S. Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J. Immunol. 2003 Jun 6/1/2003; 170(11): 5429-37. PMID: 12759418, ISSN: 0022-1767.

Yoshimoto T, Min B, Sugimoto T, Hayashi N, Ishikawa Y, Sasaki Y, Hata H, Takeda K, Okumura K, Van Kaer L, Paul WE, Nakanishi K. Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J. Exp. Med [print-electronic]. 2003 Apr 4/21/2003; 197(8): 997-1005. PMID: 12695491, PMCID: PMC2193873, PII: jem.20021701, DOI: 10.1084/jem.20021701, ISSN: 0022-1007.

Stanic AK, De Silva AD, Park JJ, Sriram V, Ichikawa S, Hirabyashi Y, Hayakawa K, Van Kaer L, Brutkiewicz RR, Joyce S. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Feb 2/18/2003; 100(4): 1849-54. PMID: 12576547, PMCID: PMC149922, PII: 0430327100, DOI: 10.1073/pnas.0430327100, ISSN: 0027-8424.

Joyce S, Van Kaer L. CD1-restricted antigen presentation: an oily matter. Curr. Opin. Immunol. 2003 Feb; 15(1): 95-104. PMID: 12495740, PII: S0952791502000122, ISSN: 0952-7915.

Wilson MT, Van Kaer L. Natural killer T cells as targets for therapeutic intervention in autoimmune diseases. Curr. Pharm. Des. 2003; 9(3): 201-20. PMID: 12570826, ISSN: 1381-6128.

Yang, J.-Q., Saxena, V., Xu, H., Van Kaer, L., Wang, C.-R., and Singh, R.R. Repeated -galactosylceramide administration results in expansion of NKT cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol. 2003; 171: 4439-46.

Hayakawa Y, Takeda K, Yagita H, Smyth MJ, Van Kaer L, Okumura K, Saiki I. IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide. Blood. 2002 Sep 9/1/2002; 100(5): 1728-33. PMID: 12176894, ISSN: 0006-4971.

Faveeuw C, Angeli V, Fontaine J, Maliszewski C, Capron A, Van Kaer L, Moser M, Capron M, Trottein F. Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice. J. Immunol. 2002 Jul 7/15/2002; 169(2): 906-12. PMID: 12097395, ISSN: 0022-1767.

Van Kaer L. Major histocompatibility complex class I-restricted antigen processing and presentation. Tissue Antigens. 2002 Jul; 60(1): 1-9. PMID: 12366777, PII: tan600101, ISSN: 0001-2815.

Mars LT, Laloux V, Goude K, Desbois S, Saoudi A, Van Kaer L, Lassmann H, Herbelin A, Lehuen A, Liblau RS. Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J. Immunol. 2002 Jun 6/15/2002; 168(12): 6007-11. PMID: 12055208, ISSN: 0022-1767.

Suárez IM, Benvenutti LA, Noronh I, Van Kaer L, Kalil J, Coelho V. Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target. Transpl. Immunol. 2002 May; 9(2-4): 101-10. PMID: 12180815, ISSN: 0966-3274.

Wilson MT, Singh AK, Van Kaer L. Immunotherapy with ligands of natural killer T cells. Trends Mol Med. 2002 May; 8(5): 225-31. PMID: 12067632, PII: S1471491402023250, ISSN: 1471-4914.

Johnson TR, Hong S, Van Kaer L, Koezuka Y, Graham BS. NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus. J. Virol. 2002 May; 76(9): 4294-303. PMID: 11932395, PMCID: PMC155085, ISSN: 0022-538X.

Tompkins SM, Padilla J, Dal Canto MC, Ting JP, Van Kaer L, Miller SD. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J. Immunol. 2002 Apr 4/15/2002; 168(8): 4173-83. PMID: 11937578, ISSN: 0022-1767.

Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J. Exp. Med. 2002 Apr 4/1/2002; 195(7): 869-79. PMID: 11927631, PMCID: PMC2193731, ISSN: 0022-1007.

Gonzalez-Aseguinolaza G, Van Kaer L, Bergmann CC, Wilson JM, Schmieg J, Kronenberg M, Nakayama T, Taniguchi M, Koezuka Y, Tsuji M. Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 2002 Mar 3/4/2002; 195(5): 617-24. PMID: 11877484, PMCID: PMC2193764, ISSN: 0022-1007.

Mempel M, Ronet C, Suarez F, Gilleron M, Puzo G, Van Kaer L, Lehuen A, Kourilsky P, Gachelin G. Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells. J. Immunol. 2002 Jan 1/1/2002; 168(1): 365-71. PMID: 11751982, ISSN: 0022-1767.

Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, Joyce S, Sriram S, Koezuka Y, Van Kaer L. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 2001 Dec 12/17/2001; 194(12): 1801-11. PMID: 11748281, PMCID: PMC2193577, ISSN: 0022-1007.

Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J. Immunol. 2001 Nov 11/15/2001; 167(10): 5928-34. PMID: 11698470, ISSN: 0022-1767.

Van Kaer L. Drugs from the sea: a marine sponge-derived compound prevents Type 1 diabetes. ScientificWorldJournal. 2001 Nov 11/6/2001; 1: 630-2. PMID: 12805764, DOI: 10.1100/tsw.2001.357, ISSN: 1537-744X.

Spence PM, Sriram V, Van Kaer L, Hobbs JA, Brutkiewicz RR. Generation of cellular immunity to lymphocytic choriomeningitis virus is independent of CD1d1 expression. Immunology. 2001 Oct; 104(2): 168-74. PMID: 11683957, PMCID: PMC1783302, PII: 1302, ISSN: 0019-2805.

Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, Miura T, Haba T, Scherer DC, Wei J, Kronenberg M, Koezuka Y, Van Kaer L. The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 2001 Sep; 7(9): 1052-6. PMID: 11533710, PII: nm0901-1052, DOI: 10.1038/nm0901-1052, ISSN: 1078-8956.

Lybarger L, Yu YY, Chun T, Wang CR, Grandea AG, Van Kaer L, Hansen TH. Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers. J. Immunol. 2001 Aug 8/15/2001; 167(4): 2097-105. PMID: 11489993, ISSN: 0022-1767.

Chun T, Grandea AG, Lybarger L, Forman J, Van Kaer L, Wang CR. Functional roles of TAP and tapasin in the assembly of M3-N-formylated peptide complexes. J. Immunol. 2001 Aug 8/1/2001; 167(3): 1507-14. PMID: 11466371, ISSN: 0022-1767.

Hayakawa Y, Takeda K, Yagita H, Kakuta S, Iwakura Y, Van Kaer L, Saiki I, Okumura K. Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur. J. Immunol. 2001 Jun; 31(6): 1720-7. PMID: 11385616, PII: 10.1002/1521-4141(200106)31:6<1720::AID-IMMU1720>3.0.CO;2-U, ISSN: 0014-2980.

Hayakawa Y, Takeda K, Yagita H, Van Kaer L, Saiki I, Okumura K. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J. Immunol. 2001 May 5/15/2001; 166(10): 6012-8. PMID: 11342617, ISSN: 0022-1767.

Grandea AG, Van Kaer L. Tapasin: an ER chaperone that controls MHC class I assembly with peptide. Trends Immunol. 2001 Apr; 22(4): 194-9. PMID: 11274924, PII: S1471-4906(01)01861-0, ISSN: 1471-4906.

Seino KI, Fukao K, Muramoto K, Yanagisawa K, Takada Y, Kakuta S, Iwakura Y, Van Kaer L, Takeda K, Nakayama T, Taniguchi M, Bashuda H, Yagita H, Okumura K. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Feb 2/27/2001; 98(5): 2577-81. PMID: 11226281, PMCID: PMC30180, PII: 041608298, DOI: 10.1073/pnas.041608298, ISSN: 0027-8424.

Leite-De-Moraes MC, Hameg A, Pacilio M, Koezuka Y, Taniguchi M, Van Kaer L, Schneider E, Dy M, Herbelin A. IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. J. Immunol. 2001 Jan 1/15/2001; 166(2): 945-51. PMID: 11145671, ISSN: 0022-1767.

Van Kaer L. Accessory proteins that control the assembly of MHC molecules with peptides. Immunol. Res. 2001; 23(2-3): 205-14. PMID: 11444385, PII: IR:23:2-3:205, DOI: 10.1385/IR:23:2-3:205, ISSN: 0257-277X.

Das G, Gould DS, Augustine MM, Fragoso G, Sciutto E, Stroynowski I, Van Kaer L, Schust DJ, Ploegh H, Janeway CA. Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes. J. Exp. Med. 2000 Nov 11/20/2000; 192(10): 1521-8. PMID: 11085754, PMCID: PMC2193183, ISSN: 0022-1007.

Chen CL, Singh N, Yull FE, Strayhorn D, Van Kaer L, Kerr LD. Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function. J. Immunol. 2000 Nov 11/15/2000; 165(10): 5418-27. PMID: 11067893, ISSN: 0022-1767.

Assarsson E, Kambayashi T, Sandberg JK, Hong S, Taniguchi M, Van Kaer L, Ljunggren HG, Chambers BJ. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J. Immunol. 2000 Oct 10/1/2000; 165(7): 3673-9. PMID: 11034371, ISSN: 0022-1767.

Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat. Immunol. 2000 Sep; 1(3): 245-51. PMID: 10973283, DOI: 10.1038/79792, ISSN: 1529-2908.

Grandea AG, Golovina TN, Hamilton SE, Sriram V, Spies T, Brutkiewicz RR, Harty JT, Eisenlohr LC, Van Kaer L. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice. Immunity. 2000 Aug; 13(2): 213-22. PMID: 10981964, PII: S1074-7613(00)00021-2, ISSN: 1074-7613.

Kovalik JP, Singh N, Mendiratta SK, Martin WD, Ignatowicz L, Van Kaer L. The alloreactive and self-restricted CD4+ T cell response directed against a single MHC class II/peptide combination. J. Immunol. 2000 Aug 8/1/2000; 165(3): 1285-93. PMID: 10903728, PII: ji_v165n3p1285, ISSN: 0022-1767.

Gonzalez-Aseguinolaza G, de Oliveira C, Tomaska M, Hong S, Bruna-Romero O, Nakayama T, Taniguchi M, Bendelac A, Van Kaer L, Koezuka Y, Tsuji M. Alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria. Proc. Natl. Acad. Sci. U.S.A. 2000 Jul 7/18/2000; 97(15): 8461-6. PMID: 10900007, PMCID: PMC26970, PII: 97/15/8461, ISSN: 0027-8424.

Felix NJ, Brickey WJ, Griffiths R, Zhang J, Van Kaer L, Coffman T, Ting JP. H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J. Exp. Med. 2000 Jul 7/3/2000; 192(1): 31-40. PMID: 10880524, PMCID: PMC1887714, ISSN: 0022-1007.

Osman Y, Kawamura T, Naito T, Takeda K, Van Kaer L, Okumura K, Abo T. Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur. J. Immunol. 2000 Jul; 30(7): 1919-28. PMID: 10940881, PII: 10.1002/1521-4141(200007)30:7<1919::AID-IMMU1919>3.0.CO;2-3, DOI: 10.1002/1521-4141(200007)30:7<1919::AID-IMMU1919>3.0.CO;2-3, ISSN: 0014-2980.

Nishimura T, Kitamura H, Iwakabe K, Yahata T, Ohta A, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nakui M, Sekimoto M, Koda T. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int. Immunol. 2000 Jul; 12(7): 987-94. PMID: 10882410, ISSN: 0953-8178.

Takeda K, Hayakawa Y, Atsuta M, Hong S, Van Kaer L, Kobayashi K, Ito M, Yagita H, Okumura K. Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12. Int. Immunol. 2000 Jun; 12(6): 909-14. PMID: 10837418, ISSN: 0953-8178.

Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. U.S.A. 2000 May 5/9/2000; 97(10): 5498-503. PMID: 10792025, PMCID: PMC25857, PII: 040566697, DOI: 10.1073/pnas.040566697, ISSN: 0027-8424.

Sousa AO, Mazzaccaro RJ, Russell RG, Lee FK, Turner OC, Hong S, Van Kaer L, Bloom BR. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc. Natl. Acad. Sci. U.S.A. 2000 Apr 4/11/2000; 97(8): 4204-8. PMID: 10760288, PMCID: PMC18197, PII: 97/8/4204, ISSN: 0027-8424.

Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE. Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat. Genet. 2000 Feb; 24(2): 175-9. PMID: 10655065, DOI: 10.1038/72842, ISSN: 1061-4036.

Hong S, Van Kaer L. Immune privilege: keeping an eye on natural killer T cells. J. Exp. Med. 1999 Nov 11/1/1999; 190(9): 1197-200. PMID: 10544192, PMCID: PMC2195673, ISSN: 0022-1007.

Singh N, Van Kaer L. Unexpected reactivities of T cells selected by a single MHC-peptide ligand. J. Immunol. 1999 Oct 10/1/1999; 163(7): 3583-91. PMID: 10490950, PII: ji_v163n7p3583, ISSN: 0022-1767.

Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, Kronenberg M, Koezuka Y, Van Kaer L. Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J. Immunol. 1999 Sep 9/1/1999; 163(5): 2373-7. PMID: 10452969, PII: ji_v163n5p2373, ISSN: 0022-1767.

Hameg A, Gouarin C, Gombert JM, Hong S, Van Kaer L, Bach JF, Herbelin A. IL-7 up-regulates IL-4 production by splenic NK1.1+ and NK1.1- MHC class I-like/CD1-dependent CD4+ T cells. J. Immunol. 1999 Jun 6/15/1999; 162(12): 7067-74. PMID: 10358149, ISSN: 0022-1767.

Hong S, Scherer DC, Singh N, Mendiratta SK, Serizawa I, Koezuka Y, Van Kaer L. Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice. Immunol. Rev. 1999 Jun; 169: 31-44. PMID: 10450506, ISSN: 0105-2896.

Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, Ohmi Y, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nishimura T. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 1999 Apr 4/5/1999; 189(7): 1121-8. PMID: 10190903, PMCID: PMC2193012, ISSN: 0022-1007.

Mendiratta SK, Kovalik JP, Hong S, Singh N, Martin WD, Van Kaer L. Peptide dependency of alloreactive CD4+ T cell responses. Int. Immunol. 1999 Mar; 11(3): 351-60. PMID: 10221647, ISSN: 0953-8178.

Coelho V, Marrero I, Noronha I, Benvenuti LA, Van Kaer L, Kalil J. TAP1 mutant mice reject heart grafts from donors with no MHC disparity. Transplant. Proc. 1999 Feb; 31(1-2): 900-1. PMID: 10083397, PII: S0041-1345(98)01828-4, ISSN: 0041-1345.

Korsgren M, Persson CG, Sundler F, Bjerke T, Hansson T, Chambers BJ, Hong S, Van Kaer L, Ljunggren HG, Korsgren O. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J. Exp. Med. 1999 Feb 2/1/1999; 189(3): 553-62. PMID: 9927517, PMCID: PMC2192913, ISSN: 0022-1007.

Dabhi VM, Hovik R, Van Kaer L, Lindahl KF. The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides. J. Immunol. 1998 Nov 11/15/1998; 161(10): 5171-8. PMID: 9820487, ISSN: 0022-1767.

Zhang J, Liu X, Scherer DC, van Kaer L, Wang X, Xu M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc. Natl. Acad. Sci. U.S.A. 1998 Oct 10/13/1998; 95(21): 12480-5. PMID: 9770511, PMCID: PMC22856, ISSN: 0027-8424.

Salcedo M, Andersson M, Lemieux S, Van Kaer L, Chambers BJ, Ljunggren HG. Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice. Eur. J. Immunol. 1998 Apr; 28(4): 1315-21. PMID: 9565371, PII: 10.1002/(SICI)1521-4141(199804)28:04<1315::AID-IMMU1315>3.0.CO;2-2, DOI: 10.1002/(SICI)1521-4141(199804)28:04<1315::AID-IMMU1315>3.0.CO;2-2, ISSN: 0014-2980.

Bikoff EK, Kenty G, Van Kaer L. Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms. J. Immunol. 1998 Apr 4/1/1998; 160(7): 3101-10. PMID: 9531264, ISSN: 0022-1767.

Kovats S, Grubin CE, Eastman S, deRoos P, Dongre A, Van Kaer L, Rudensky AY. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J. Exp. Med. 1998 Jan 1/19/1998; 187(2): 245-51. PMID: 9432982, PMCID: PMC2212101, ISSN: 0022-1007.

Kenty G, Martin WD, Van Kaer L, Bikoff EK. MHC class II expression in double mutant mice lacking invariant chain and DM functions. J. Immunol. 1998 Jan 1/15/1998; 160(2): 606-14. PMID: 9551894, ISSN: 0022-1767.

Freland S, Chambers BJ, Andersson M, Van Kaer L, Ljunggren HG. Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice. J. Immunol. 1998 Jan 1/15/1998; 160(2): 572-9. PMID: 9551890, ISSN: 0022-1767.

Swier K, Brown DR, Bird JJ, Martin WD, Van Kaer L, Reiner SL. A critical, invariant chain-independent role for H2-M in antigen presentation. J. Immunol. 1998 Jan 1/15/1998; 160(2): 540-4. PMID: 9551884, ISSN: 0022-1767.

Griffin TA, Nandi D, Cruz M, Fehling HJ, Kaer LV, Monaco JJ, Colbert RA. Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits. J. Exp. Med. 1998 Jan 1/5/1998; 187(1): 97-104. PMID: 9419215, PMCID: PMC2199179, ISSN: 0022-1007.

Kawamura T, Takeda K, Mendiratta SK, Kawamura H, Van Kaer L, Yagita H, Abo T, Okumura K. Critical role of NK1+ T cells in IL-12-induced immune responses in vivo. J. Immunol. 1998 Jan 1/1/1998; 160(1): 16-9. PMID: 9551949, ISSN: 0022-1767.

Griffin, T.A., Nandi, D., Cruz, M., Fehling, H.J., Van Kaer, L., Monaco, J.J., and Colbert, R.A. Immunoproteasome assembly: cooperative incorporation of interferon g (IFN-g)-inducible subunits. J. Exp. Med. 1998; 187: 97-104.

Liu T, Chambers B, Diehl AD, Van Kaer L, Jondal M, Ljunggren HG. TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells. J. Immunol. 1997 Dec 12/1/1997; 159(11): 5364-71. PMID: 9548476, ISSN: 0022-1767.

Sant'Angelo DB, Waterbury PG, Cohen BE, Martin WD, Van Kaer L, Hayday AC, Janeway CA. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity. 1997 Oct; 7(4): 517-24. PMID: 9354472, PII: S1074-7613(00)80373-8, ISSN: 1074-7613.

Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997 Apr; 6(4): 469-77. PMID: 9133426, PII: S1074-7613(00)80290-3, ISSN: 1074-7613.

Salcedo M, Diehl AD, Olsson-Alheim MY, Sundbäck J, Van Kaer L, Kärre K, Ljunggren HG. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J. Immunol. 1997 Apr 4/1/1997; 158(7): 3174-80. PMID: 9120271, ISSN: 0022-1767.

Joyce S, Negishi I, Boesteanu A, DeSilva AD, Sharma P, Chorney MJ, Loh DY, Van Kaer L. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J. Exp. Med. 1996 Oct 10/1/1996; 184(4): 1579-84. PMID: 8879233, PMCID: PMC2192848, ISSN: 0022-1007.

Martin WD, Hicks GG, Mendiratta SK, Leva HI, Ruley HE, Van Kaer L. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell. 1996 Feb 2/23/1996; 84(4): 543-50. PMID: 8598041, PII: S0092-8674(00)81030-2, ISSN: 0092-8674.

Sandberg JK, Chambers BJ, Van Kaer L, Kärre K, Ljunggren HG. TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity. Eur. J. Immunol. 1996 Feb; 26(2): 288-93. PMID: 8617293, DOI: 10.1002/eji.1830260203, ISSN: 0014-2980.

Ljunggren HG, Van Kaer L, Sabatine MS, Auchincloss H, Tonegawa S, Ploegh HL. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int. Immunol. 1995 Jun; 7(6): 975-84. PMID: 7577806, ISSN: 0953-8178.

Machold RP, Andrée S, Van Kaer L, Ljunggren HG, Ploegh HL. Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains. J. Exp. Med. 1995 Mar 3/1/1995; 181(3): 1111-22. PMID: 7869032, PMCID: PMC2191915, ISSN: 0022-1007.

Martien van Santen H, Woolsey A, Rickardt PG, Van Kaer L, Baas EJ, Berns A, Tonegawa S, Ploegh HL. Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. J. Exp. Med. 1995 Feb 2/1/1995; 181(2): 787-92. PMID: 7836931, PMCID: PMC2191882, ISSN: 0022-1007.

Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Ploegh HL. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. Eur. J. Immunol. 1995 Jan; 25(1): 174-8. PMID: 7843229, DOI: 10.1002/eji.1830250129, ISSN: 0014-2980.

Ljunggren, H.G., and Van Kaer, L. Antigen presentation and T cell development in TAP1 deficient mice. Immunologist. 1995; 3: 136-40.

Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1994 Oct; 1(7): 533-41. PMID: 7600282, PII: 1074-7613(94)90043-4, ISSN: 1074-7613.

Aldrich CJ, Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Forman J. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 1994 Jul 7/5/1994; 91(14): 6525-8. PMID: 8022816, PMCID: PMC44235, ISSN: 0027-8424.

Ljunggren HG, Van Kaer L, Ploegh HL, Tonegawa S. Altered natural killer cell repertoire in Tap-1 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 1994 Jul 7/5/1994; 91(14): 6520-4. PMID: 8022815, PMCID: PMC44234, ISSN: 0027-8424.

Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM, Tonegawa S. Evidence for a differential avidity model of T cell selection in the thymus. Cell. 1994 Feb 2/25/1994; 76(4): 651-63. PMID: 8124708, PII: 0092-8674(94)90505-3, ISSN: 0092-8674.

Moriwaki S, Korn BS, Ichikawa Y, van Kaer L, Tonegawa S. Amino acid substitutions in the floor of the putative antigen-binding site of H-2T22 affect recognition by a gamma delta T-cell receptor. Proc. Natl. Acad. Sci. U.S.A. 1993 Dec 12/1/1993; 90(23): 11396-400. PMID: 8248260, PMCID: PMC47989, ISSN: 0027-8424.

Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Repertoire-determining role of peptide in the positive selection of CD8+ T cells. Immunol. Rev. 1993 Oct; 135: 157-82. PMID: 8282312, ISSN: 0105-2896.

Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell. 1993 Jun 6/4/1993; 73(5): 1041-9. PMID: 8500174, PII: 0092-8674(93)90281-T, ISSN: 0092-8674.

Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 1992 Dec 12/24/1992; 71(7): 1205-14. PMID: 1473153, PII: S0092-8674(05)80068-6, ISSN: 0092-8674.

Wu M, van Kaer L, Itohara S, Tonegawa S. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. J. Exp. Med. 1991 Jul 7/1/1991; 174(1): 213-8. PMID: 1711563, PMCID: PMC2118879, ISSN: 0022-1007.

Van Kaer L, Wu M, Ichikawa Y, Ito K, Bonneville M, Ostrand-Rosenberg S, Murphy DB, Tonegawa S. Recognition of MHC TL gene products by gamma delta T cells. Immunol. Rev. 1991 Apr; 120: 89-115. PMID: 1830863, ISSN: 0105-2896.

Ito K, Van Kaer L, Bonneville M, Hsu S, Murphy DB, Tonegawa S. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell. 1990 Aug 8/10/1990; 62(3): 549-61. PMID: 2379238, PII: 0092-8674(90)90019-B, ISSN: 0092-8674.

Bowler C, Van Kaer L, Van Camp W, Van Montagu M, Inzé D, Dhaese P. Characterization of the Bacillus stearothermophilus manganese superoxide dismutase gene and its ability to complement copper/zinc superoxide dismutase deficiency in Saccharomyces cerevisiae. J. Bacteriol. 1990 Mar; 172(3): 1539-46. PMID: 2407726, PMCID: PMC208630, ISSN: 0021-9193.

Van Kaer L, Van Montagu M, Dhaese P. Purification and in vitro DNA-binding specificity of the Bacillus subtilis phage phi 105 repressor. J. Biol. Chem. 1989 Sep 9/5/1989; 264(25): 14784-91. PMID: 2549036, ISSN: 0021-9258.

Van Kaer L, Gansemans Y, Van Montagu M, Dhaese P. Interaction of the Bacillus subtilis phage phi 105 repressor DNA: a genetic analysis. EMBO J. 1988 Mar; 7(3): 859-66. PMID: 3135184, PMCID: PMC454403, ISSN: 0261-4189.

Van Kaer L, Van Montagu M, Dhaese P. Transcriptional control in the EcoRI-F immunity region of Bacillus subtilis phage phi 105. Identification and unusual structure of the operator. J. Mol. Biol. 1987 Sep 9/5/1987; 197(1): 55-67. PMID: 3119860, PII: 0022-2836(87)90609-7, ISSN: 0022-2836.

Available Postdoctoral Position Details
Posted: 1/20/2012
A postdoctoral position is available immediately to perform research in the areas of antigen presentation, lymphocyte development and/or autoimmunity. We employ transgenic and knockout approaches to answer important questions in these areas. Relevant publications include: Martin et al. 1996. Cell 84:543-550; Mendiratta et al. 1997. Immunity 6:469-477; Grandea et al. 2000. Immunity 13:213-222; Hong et al. 2001. Nat. Med. 7:1052-1056. Applicants should have a Ph.D. or M.D. and a strong background in molecular biology and cellular immunology.

Interested individuals should send their CV, bibliography, and the names of three references by email . luc.van.kaer@Vanderbilt.Edu

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