Timothy Scott Blackwell, M.D.

Professor

timothy.blackwell@vanderbilt.edu
Faculty Appointments
Director, Division of Allergy, Pulmonary & Critical Care Professor of Medicine Professor of Cell and Developmental BiologyProfessor of Cancer BiologyProfessor of Cell and Developmental BiologyProfessor of Cancer BiologyRalph and Lulu Owen Chair in Medicine
Education
M.D., MEDICINE, University of Alabama, Birmingham, AlabamaB.A., Molecular Biology, Vanderbilt University, Nashville, Tennessee
Office Address
Division of Allergy, Pulmonary and Critical Care Medicine
T-1217 MCN
1161 21st Ave. S.
Nashville, TN 37272-2650
Research Description
My laboratory investigates lung inflamamtion/injury, remodeling, fibrosis, and development of lung cancer. Lung inflammation is important for host defense functions but can contribute to tissue injury when the inflammation is excessive or dysregulated. By studying the NF-kB transcription pathway, we hope to better understand factors that control lung inflammation, injury, and host defense. We are also interested in the basic mechanisms that lead to normal lung repair or fibrosis following injury and mechanisms by which chronic inflammation alters the lung microenvironment in a pro-tumorigenic manner.
Research Keywords
NF-kappaB,Lung,Inflammation,Fibrosis,Transgenic,Epithelial cells,Macrophages
Publications
Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. Molecular imaging of folate receptor ß-positive macrophages during acute lung inflammation. Am. J. Respir. Cell Mol. Biol. 2015 Jul; 53(1): 50-9. PMID: 25375039, PMCID: PMC4566110, DOI: 10.1165/rcmb.2014-0289OC, ISSN: 1535-4989.

Kropski JA, Blackwell TS, Loyd JE. The genetic basis of idiopathic pulmonary fibrosis. Eur. Respir. J [print-electronic]. 2015 Jun; 45(6): 1717-27. PMID: 25837031, PII: 09031936.00163814, DOI: 10.1183/09031936.00163814, ISSN: 1399-3003.

Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A. P47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int [print-electronic]. 2015 May; 87(5): 948-62. PMID: 25565313, PMCID: PMC4425591, PII: ki2014386, DOI: 10.1038/ki.2014.386, ISSN: 1523-1755.

Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res [print-electronic]. 2015 Apr 4/15/2015; 75(8): 1624-34. PMID: 25691457, PMCID: PMC4401663, PII: 0008-5472.CAN-14-2379, DOI: 10.1158/0008-5472.CAN-14-2379, ISSN: 1538-7445.

Aldrich MC, Munro HM, Mumma M, Grogan EL, Massion PP, Blackwell TS, Blot WJ. Chronic obstructive pulmonary disease and subsequent overall and lung cancer mortality in low-income adults. PLoS ONE. 2015; 10(3): e0121805. PMID: 25811837, PMCID: PMC4374870, PII: PONE-D-14-50985, DOI: 10.1371/journal.pone.0121805, ISSN: 1932-6203.

Buckman LB, Thompson MM, Lippert RN, Blackwell TS, Yull FE, Ellacott KL. Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Mol Metab. 2015 Jan; 4(1): 58-63. PMID: 25685690, PMCID: PMC4314532, PII: S2212-8778(14)00174-4, DOI: 10.1016/j.molmet.2014.10.001, ISSN: 2212-8778.

Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R. Epithelial ß1 integrin is required for lung branching morphogenesis and alveolarization. Development [print-electronic]. 2014 Dec; 141(24): 4751-62. PMID: 25395457, PMCID: PMC4299273, PII: dev.117200, DOI: 10.1242/dev.117200, ISSN: 1477-9129.

Polosukhin VV, Polosukhin IV, Hoskins A, Han W, Abdolrasulnia R, Blackwell TS, Dworski R. Glutathione S-transferase M1 modulates allergen-induced NF-¿B activation in asthmatic airway epithelium. Allergy [print-electronic]. 2014 Dec; 69(12): 1666-72. PMID: 25118837, PMCID: PMC4317365, DOI: 10.1111/all.12506, ISSN: 1398-9995.

Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect. Immun [print-electronic]. 2014 Sep; 82(9): 3723-39. PMID: 24958709, PMCID: PMC4187810, PII: IAI.00035-14, DOI: 10.1128/IAI.00035-14, ISSN: 1098-5522.

Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS. I¿B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J. Immunol [print-electronic]. 2014 Aug 8/1/2014; 193(3): 1184-93. PMID: 24981452, PMCID: PMC4108541, PII: jimmunol.1302516, DOI: 10.4049/jimmunol.1302516, ISSN: 1550-6606.

Jin R, Yi Y, Yull FE, Blackwell TS, Clark PE, Koyama T, Smith JA, Matusik RJ. NF-¿B gene signature predicts prostate cancer progression. Cancer Res [print-electronic]. 2014 May 5/15/2014; 74(10): 2763-72. PMID: 24686169, PMCID: PMC4024337, PII: 0008-5472.CAN-13-2543, DOI: 10.1158/0008-5472.CAN-13-2543, ISSN: 1538-7445.

Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab. Invest [print-electronic]. 2014 Apr; 94(4): 409-21. PMID: 24535260, PMCID: PMC3992484, PII: labinvest201410, DOI: 10.1038/labinvest.2014.10, ISSN: 1530-0307.

He W, Zhang M, Zhao M, Davis LS, Blackwell TS, Yull F, Breyer MD, Hao CM. Increased dietary sodium induces COX2 expression by activating NF¿B in renal medullary interstitial cells. Pflugers Arch [print-electronic]. 2014 Feb; 466(2): 357-67. PMID: 23900806, PMCID: PMC3946848, DOI: 10.1007/s00424-013-1328-7, ISSN: 1432-2013.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am. J. Respir. Crit. Care Med. 2014 Jan 1/15/2014; 189(2): 214-22. PMID: 24160862, PMCID: PMC3983890, DOI: 10.1164/rccm.201306-1141WS, ISSN: 1535-4970.

Sun X, He S, Wara AK, Icli B, Shvartz E, Tesmenitsky Y, Belkin N, Li D, Blackwell TS, Sukhova GK, Croce K, Feinberg MW. Systemic delivery of microRNA-181b inhibits nuclear factor-¿B activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ. Res [print-electronic]. 2014 Jan 1/3/2014; 114(1): 32-40. PMID: 24084690, PMCID: PMC4051320, PII: CIRCRESAHA.113.302089, DOI: 10.1161/CIRCRESAHA.113.302089, ISSN: 1524-4571.

Paulson NB, Gilbertsen AJ, Dalluge JJ, Welchlin CW, Hughes J, Han W, Blackwell TS, Laguna TA, Williams BJ. The arginine decarboxylase pathways of host and pathogen interact to impact inflammatory pathways in the lung. PLoS ONE. 2014; 9(10): e111441. PMID: 25350753, PMCID: PMC4211729, PII: PONE-D-14-32277, DOI: 10.1371/journal.pone.0111441, ISSN: 1932-6203.

Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K. BMP pathway regulation of and by macrophages. PLoS ONE. 2014; 9(4): e94119. PMID: 24713633, PMCID: PMC3979749, PII: PONE-D-12-05427, DOI: 10.1371/journal.pone.0094119, ISSN: 1932-6203.

Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE. Targeting the Wnt pathway in synovial sarcoma models. Cancer Discov [print-electronic]. 2013 Nov; 3(11): 1286-301. PMID: 23921231, PMCID: PMC3823757, PII: 2159-8290.CD-13-0138, DOI: 10.1158/2159-8290.CD-13-0138, ISSN: 2159-8290.

Tanjore H, Lawson WE, Blackwell TS. Endoplasmic reticulum stress as a pro-fibrotic stimulus. Biochim. Biophys. Acta [print-electronic]. 2013 Jul; 1832(7): 940-7. PMID: 23201247, PMCID: PMC3641173, PII: S0925-4439(12)00270-0, DOI: 10.1016/j.bbadis.2012.11.011, ISSN: 0006-3002.

Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. ß-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. Am. J. Respir. Crit. Care Med [print-electronic]. 2013 Mar 3/15/2013; 187(6): 630-9. PMID: 23306543, PMCID: PMC3733436, PII: rccm.201205-0972OC, DOI: 10.1164/rccm.201205-0972OC, ISSN: 1535-4970.

Kropski JA, Lawson WE, Young LR, Blackwell TS. Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis. Dis Model Mech. 2013 Jan; 6(1): 9-17. PMID: 23268535, PMCID: PMC3529334, PII: 6/1/9, DOI: 10.1242/dmm.010736, ISSN: 1754-8411.

Li H, Han W, Polosukhin V, Yull FE, Segal BH, Xie CM, Blackwell TS. NF-¿B inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Mediators Inflamm [print-electronic]. 2013; 2013: 503213. PMID: 24347827, PMCID: PMC3852536, DOI: 10.1155/2013/503213, ISSN: 1466-1861.

Kropski JA, Pritchett JM, Mason WR, Sivarajan L, Gleaves LA, Johnson JE, Lancaster LH, Lawson WE, Blackwell TS, Steele MP, Loyd JE, Rickman OB. Bronchoscopic cryobiopsy for the diagnosis of diffuse parenchymal lung disease. PLoS ONE. 2013; 8(11): e78674. PMID: 24265706, PMCID: PMC3827078, PII: PONE-D-13-31364, DOI: 10.1371/journal.pone.0078674, ISSN: 1932-6203.

Young LR, Gulleman PM, Bridges JP, Weaver TE, Deutsch GH, Blackwell TS, McCormack FX. The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/15/2012; 186(10): 1014-24. PMID: 23043085, PMCID: PMC3530211, PII: rccm.201207-1206OC, DOI: 10.1164/rccm.201207-1206OC, ISSN: 1535-4970.

Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-¿B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene [print-electronic]. 2012 Jun 6/28/2012; 31(26): 3164-76. PMID: 22002309, PMCID: PMC3266969, PII: onc2011480, DOI: 10.1038/onc.2011.480, ISSN: 1476-5594.

Tanjore H, Blackwell TS, Lawson WE. Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Apr 4/15/2012; 302(8): L721-9. PMID: 22287606, PMCID: PMC3331582, PII: ajplung.00410.2011, DOI: 10.1152/ajplung.00410.2011, ISSN: 1522-1504.

Polosukhin VV, Degryse AL, Newcomb DC, Jones BR, Ware LB, Lee JW, Loyd JE, Blackwell TS, Lawson WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp. Lung Res. 2012 Apr; 38(3): 135-46. PMID: 22394287, PMCID: PMC4046254, DOI: 10.3109/01902148.2012.658595, ISSN: 1521-0499.

Degryse AL, Xu XC, Newman JL, Mitchell DB, Tanjore H, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Phillips JA, Cogan JD, Blackwell TS, Lawson WE. Telomerase deficiency does not alter bleomycin-induced fibrosis in mice. Exp. Lung Res. 2012 Apr; 38(3): 124-34. PMID: 22394286, PMCID: PMC4046256, DOI: 10.3109/01902148.2012.658148, ISSN: 1521-0499.

Kropski JA, Lawson WE, Blackwell TS. Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): L441-4. PMID: 22180659, PMCID: PMC3311513, PII: ajplung.00335.2011, DOI: 10.1152/ajplung.00335.2011, ISSN: 1522-1504.

Han W, Li H, Segal BH, Blackwell TS. Bioluminescence imaging of NADPH oxidase activity in different animal models. J Vis Exp. 2012; (68): PMID: 23117583, PMCID: PMC3490291, PII: 3925, DOI: 10.3791/3925, ISSN: 1940-087X.

Barham W, Sherrill T, Connelly L, Blackwell TS, Yull FE. Intraductal injection of LPS as a mouse model of mastitis: signaling visualized via an NF-¿B reporter transgenic. J Vis Exp. 2012; (67): e4030. PMID: 22971993, PMCID: PMC3490260, PII: 4030, DOI: 10.3791/4030, ISSN: 1940-087X.

Zaynagetdinov R, Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, McMahon FB, Gleaves LA, Degryse AL, Stathopoulos GT, Yull FE, Blackwell TS. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J. Immunol [print-electronic]. 2011 Dec 12/1/2011; 187(11): 5703-11. PMID: 22048774, PMCID: PMC3221921, PII: jimmunol.1100558, DOI: 10.4049/jimmunol.1100558, ISSN: 1550-6606.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Oct; 301(4): L615-22. PMID: 21764988, PMCID: PMC3774255, PII: ajplung.00224.2010, DOI: 10.1152/ajplung.00224.2010, ISSN: 1522-1504.

Tanjore H, Cheng DS, Degryse AL, Zoz DF, Abdolrasulnia R, Lawson WE, Blackwell TS. Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J. Biol. Chem [print-electronic]. 2011 Sep 9/2/2011; 286(35): 30972-80. PMID: 21757695, PMCID: PMC3162456, PII: M110.181164, DOI: 10.1074/jbc.M110.181164, ISSN: 1083-351X.

Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LS. NF-¿B signaling in fetal lung macrophages disrupts airway morphogenesis. J. Immunol [print-electronic]. 2011 Sep 9/1/2011; 187(5): 2740-7. PMID: 21775686, PMCID: PMC3159744, PII: jimmunol.1101495, DOI: 10.4049/jimmunol.1101495, ISSN: 1550-6606.

Polosukhin VV, Cates JM, Lawson WE, Zaynagetdinov R, Milstone AP, Massion PP, Ocak S, Ware LB, Lee JW, Bowler RP, Kononov AV, Randell SH, Blackwell TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med [print-electronic]. 2011 Aug 8/1/2011; 184(3): 317-27. PMID: 21512171, PMCID: PMC3265275, PII: 201010-1629OC, DOI: 10.1164/rccm.201010-1629OC, ISSN: 1535-4970.

Dworski R, Han W, Blackwell TS, Hoskins A, Freeman ML. Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic. Biol. Med [print-electronic]. 2011 Jul 7/15/2011; 51(2): 516-21. PMID: 21605660, PMCID: PMC3439844, PII: S0891-5849(11)00281-4, DOI: 10.1016/j.freeradbiomed.2011.04.040, ISSN: 1873-4596.

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Jun 6/28/2011; 108(26): 10562-7. PMID: 21670280, PMCID: PMC3127925, PII: 1107559108, DOI: 10.1073/pnas.1107559108, ISSN: 1091-6490.

Zoz DF, Lawson WE, Blackwell TS. Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction. Am. J. Med. Sci. 2011 Jun; 341(6): 435-8. PMID: 21613930, PMCID: PMC3103044, PII: 00000441-201106000-00004, DOI: 10.1097/MAJ.0b013e31821a9d8e, ISSN: 1538-2990.

Polosukhin VV, Cates JM, Lawson WE, Milstone AP, Matafonov AG, Massion PP, Lee JW, Randell SH, Blackwell TS. Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. J. Pathol. 2011 Jun; 224(2): 203-11. PMID: 21557221, DOI: 10.1002/path.2863, ISSN: 1096-9896.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. TGFß signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Jun; 300(6): L887-97. PMID: 21441353, PMCID: PMC3119129, PII: ajplung.00397.2010, DOI: 10.1152/ajplung.00397.2010, ISSN: 1522-1504.

Grimm MJ, Vethanayagam RR, Almyroudis NG, Lewandowski D, Rall N, Blackwell TS, Segal BH. Role of NADPH oxidase in host defense against aspergillosis. Med. Mycol [print-electronic]. 2011 Apr; 49 Suppl 1: S144-9. PMID: 20560866, DOI: 10.3109/13693786.2010.487077, ISSN: 1460-2709.

Connelly L, Barham W, Onishko HM, Sherrill T, Chodosh LA, Blackwell TS, Yull FE. Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene [print-electronic]. 2011 Mar 3/24/2011; 30(12): 1402-12. PMID: 21076466, PMCID: PMC3063854, PII: onc2010521, DOI: 10.1038/onc.2010.521, ISSN: 1476-5594.

Lawson WE, Blackwell TS, Gauldie J. Let It Be: microRNAs impact interstitial lung disease [editorial]. Am. J. Respir. Crit. Care Med. 2011 Jan 1/1/2011; 183(1): 1-2. PMID: 21193781, PII: 183/1/1, DOI: 10.1164/rccm.201009-1482ED, ISSN: 1535-4970.

Connelly L, Barham W, Onishko HM, Chen L, Sherrill TP, Zabuawala T, Ostrowski MC, Blackwell TS, Yull FE. NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast Cancer Res. 2011; 13(4): R83. PMID: 21884585, PMCID: PMC3236346, PII: bcr2935, DOI: 10.1186/bcr2935, ISSN: 1465-542X.

Lee HJ, Joo M, Abdolrasulnia R, Young DG, Choi I, Ware LB, Blackwell TS, Christman BW. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Biol. Chem [print-electronic]. 2010 Dec 12/17/2010; 285(51): 39655-62. PMID: 20937835, PMCID: PMC3000946, PII: M110.170290, DOI: 10.1074/jbc.M110.170290, ISSN: 1083-351X.

Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS, Blackwell TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am. J. Respir. Crit. Care Med [print-electronic]. 2010 Nov 11/15/2010; 182(10): 1273-81. PMID: 20595227, PMCID: PMC3001265, PII: 201001-0001OC, DOI: 10.1164/rccm.201001-0001OC, ISSN: 1535-4970.

Benjamin JT, Carver BJ, Plosa EJ, Yamamoto Y, Miller JD, Liu JH, van der Meer R, Blackwell TS, Prince LS. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J. Immunol [print-electronic]. 2010 Oct 10/15/2010; 185(8): 4896-903. PMID: 20861353, PMCID: PMC4399641, PII: jimmunol.1001857, DOI: 10.4049/jimmunol.1001857, ISSN: 1550-6606.

Williams BJ, Dehnbostel J, Blackwell TS. Pseudomonas aeruginosa: host defence in lung diseases. Respirology [print-electronic]. 2010 Oct; 15(7): 1037-56. PMID: 20723140, PII: RES1819, DOI: 10.1111/j.1440-1843.2010.01819.x, ISSN: 1440-1843.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2010 Oct; 299(4): L442-52. PMID: 20562227, PMCID: PMC2957416, PII: ajplung.00026.2010, DOI: 10.1152/ajplung.00026.2010, ISSN: 1522-1504.

Crossno PF, Polosukhin VV, Blackwell TS, Johnson JE, Markin C, Moore PE, Worrell JA, Stahlman MT, Phillips JA, Loyd JE, Cogan JD, Lawson WE. Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest. 2010 Apr; 137(4): 969-73. PMID: 20371530, PMCID: PMC2851554, PII: 137/4/969, DOI: 10.1378/chest.09-0790, ISSN: 1931-3543.

Kobayashi H, Huang J, Ye F, Shyr Y, Blackwell TS, Lin PC. Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model. PLoS ONE. 2010; 5(3): e9458. PMID: 20221440, PMCID: PMC2832764, DOI: 10.1371/journal.pone.0009458, ISSN: 1932-6203.

Connelly L, Barham W, Pigg R, Saint-Jean L, Sherrill T, Cheng DS, Chodosh LA, Blackwell TS, Yull FE. Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection. J. Cell. Physiol. 2010 Jan; 222(1): 73-81. PMID: 19746431, PMCID: PMC2783968, DOI: 10.1002/jcp.21922, ISSN: 1097-4652.

Doris K, Karabela SP, Kairi CA, Simoes DC, Roussos C, Zakynthinos SG, Kalomenidis I, Blackwell TS, Stathopoulos GT. Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice. Respir. Res. 2010; 11: 118. PMID: 20796309, PMCID: PMC2936383, PII: 1465-9921-11-118, DOI: 10.1186/1465-9921-11-118, ISSN: 1465-993X.

Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS ONE. 2010; 5(3): e9631. PMID: 20300512, PMCID: PMC2838778, DOI: 10.1371/journal.pone.0009631, ISSN: 1932-6203.

Psallidas I, Karabela SP, Moschos C, Sherrill TP, Kollintza A, Magkouta S, Theodoropoulou P, Roussos C, Blackwell TS, Kalomenidis I, Stathopoulos GT. Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study. Mol. Cancer. 2010; 9: 56. PMID: 20219102, PMCID: PMC2841124, PII: 1476-4598-9-56, DOI: 10.1186/1476-4598-9-56, ISSN: 1476-4598.

Williams, B.J., Du, R.-H., Calcull, W., Abdolrasulnia, R., Christman, B.W., Blackwell, T.S.. Discovery of an operon that participates in agmatine metabolism and regulates biofilm formation in Pseudomonas aeruginosa. Mol. Microbiol. 2010.

Segal, B.H., Han, W., Bushey, J.J., Joo, M., Bhatti, Z., Feminella, J., Dennis, C.G., Vethanayagam, R.R., Yull, F.E., Capitano, M., Wallace, P.K., Minderman, H., Christman, J.W., Sporn, M.B., Chan, J., Vinh, D.C., Holland, S.M., Romani, L.R., Gaffen, S.L., Freeman, M.L., Blackwell, T.S.. NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice. PLoS One. 2010; 5(3): e9631.

Psallidas, I., Karabela, S.P., Moschos, C., Sherrill, T.P., Kollintza, A., Magkouta, S., Theodoropoulou, P., Roussos, C., Blackwell, T.S., Kalomenidis, I., Stathopoulos, G.T.. Speficic effects of bortezomib against experimental malignant pleural effusion: a preclinical study. Mol. Cancer. 2010; 9: 56.

Role of NADPH oxidase in host defense against Aspergillus.. Grimm, M.J., Vethanayagam, R.R., Almyroudis, N.G., Lewandowski, D., Rall, N., Blackwell, T.S., Segal, B.H. Medical Mycology. 2010.

Stathopoulos, G.T., Sherrill, T.P., Karabela, S.P., Goleniewska, K., Kalomenidis, I., Roussos, C., Fingleton, B., Yull, F.E., Peebles, R.S., Blackwell, T.S.. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am. J. Respir. Crit. Care Med. 2010.

Sheller JR, Polosukhin VV, Mitchell D, Cheng DS, Peebles RS, Blackwell TS. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp. Lung Res. 2009 Dec; 35(10): 883-95. PMID: 19995280, PMCID: PMC3419942, DOI: 10.3109/01902140903019710, ISSN: 1521-0499.

Tanjore H, Xu XC, Polosukhin VV, Degryse AL, Li B, Han W, Sherrill TP, Plieth D, Neilson EG, Blackwell TS, Lawson WE. Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am. J. Respir. Crit. Care Med [print-electronic]. 2009 Oct 10/1/2009; 180(7): 657-65. PMID: 19556518, PMCID: PMC2753790, PII: 200903-0322OC, DOI: 10.1164/rccm.200903-0322OC, ISSN: 1535-4970.

Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut [print-electronic]. 2009 Sep; 58(9): 1267-74. PMID: 19625278, PMCID: PMC2719085, PII: gut.2008.170779, DOI: 10.1136/gut.2008.170779, ISSN: 1468-3288.

Ma LL, Gao X, Liu L, Xiang Z, Blackwell TS, Williams P, Chari RS, Yin DP. CpG oligodeoxynucleotide triggers the liver inflammatory reaction and abrogates spontaneous tolerance. Liver Transpl. 2009 Aug; 15(8): 915-23. PMID: 19642135, PMCID: PMC2817947, DOI: 10.1002/lt.21771, ISSN: 1527-6473.

Bastarache JA, Blackwell TS. Development of animal models for the acute respiratory distress syndrome. Dis Model Mech. 2009 May; 2(5-6): 218-23. PMID: 19407329, PMCID: PMC2675821, PII: 2/5-6/218, DOI: 10.1242/dmm.001677, ISSN: 1754-8411.

Han W, Joo M, Everhart MB, Christman JW, Yull FE, Blackwell TS. Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Mar; 296(3): L320-7. PMID: 19098124, PMCID: PMC2660215, PII: 90485.2008, DOI: 10.1152/ajplung.90485.2008, ISSN: 1040-0605.

Sadagopal S, Braunstein M, Hager CC, Wei J, Daniel AK, Bochan MR, Crozier I, Smith NE, Gates HO, Barnett L, Van Kaer L, Price JO, Blackwell TS, Kalams SA, Kernodle DS. Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS ONE [print-electronic]. 2009; 4(5): e5531. PMID: 19436730, PMCID: PMC2677452, DOI: 10.1371/journal.pone.0005531, ISSN: 1932-6203.

Chen SM, Cheng DS, Williams BJ, Sherrill TP, Han W, Chont M, Saint-Jean L, Christman JW, Sadikot RT, Yull FE, Blackwell TS. The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin. Exp. Immunol [print-electronic]. 2008 Sep; 153(3): 420-8. PMID: 18647324, PMCID: PMC2527362, PII: CEI3707, DOI: 10.1111/j.1365-2249.2008.03707.x, ISSN: 1365-2249.

Jin RJ, Lho Y, Connelly L, Wang Y, Yu X, Saint Jean L, Case TC, Ellwood-Yen K, Sawyers CL, Bhowmick NA, Blackwell TS, Yull FE, Matusik RJ. The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res. 2008 Aug 8/15/2008; 68(16): 6762-9. PMID: 18701501, PMCID: PMC2840631, PII: 68/16/6762, DOI: 10.1158/0008-5472.CAN-08-0107, ISSN: 1538-7445.

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem [print-electronic]. 2008 Jul 7/18/2008; 283(29): 19927-35. PMID: 18490445, PMCID: PMC2459280, PII: M803625200, DOI: 10.1074/jbc.M803625200, ISSN: 0021-9258.

Joo M, Kwon M, Azim AC, Sadikot RT, Blackwell TS, Christman JW. Genetic determination of the role of PU.1 in macrophage gene expression. Biochem. Biophys. Res. Commun [print-electronic]. 2008 Jul 7/18/2008; 372(1): 97-102. PMID: 18485892, PMCID: PMC2494535, PII: S0006-291X(08)00873-5, DOI: 10.1016/j.bbrc.2008.04.189, ISSN: 1090-2104.

Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, Miller GG, Loyd JE, Blackwell TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Jun; 294(6): L1119-26. PMID: 18390830, PII: 00382.2007, DOI: 10.1152/ajplung.00382.2007, ISSN: 1040-0605.

Ma L, Xiang Z, Sherrill TP, Wang L, Blackwell TS, Williams P, Chong A, Chari R, Yin DP. Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation. Transplantation. 2008 Mar 3/27/2008; 85(6): 903-10. PMID: 18360274, PMCID: PMC2632578, PII: 00007890-200803270-00019, DOI: 10.1097/TP.0b013e318166cde1, ISSN: 0041-1337.

Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Yull FE, Blackwell TS, Fingleton B. Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol. Cancer Res. 2008 Mar; 6(3): 364-71. PMID: 18337446, PII: 6/3/364, DOI: 10.1158/1541-7786.MCR-07-0309, ISSN: 1541-7786.

Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ. Disease-specific gene expression profiling in multiple models of lung disease. Am. J. Respir. Crit. Care Med [print-electronic]. 2008 Feb 2/15/2008; 177(4): 376-87. PMID: 18029791, PMCID: PMC2258439, PII: 200702-333OC, DOI: 10.1164/rccm.200702-333OC, ISSN: 1535-4970.

Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Polosukhin VV, Fingleton B, Yull FE, Blackwell TS. Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clin. Exp. Metastasis [print-electronic]. 2008; 25(1): 43-51. PMID: 18008176, DOI: 10.1007/s10585-007-9100-z, ISSN: 0262-0898.

Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat. Med [print-electronic]. 2008 Jan; 14(1): 45-54. PMID: 18066075, PII: nm1685, DOI: 10.1038/nm1685, ISSN: 1546-170X.

Stathopoulos GT, Sherrill TP, Cheng DS, Scoggins RM, Han W, Polosukhin VV, Connelly L, Yull FE, Fingleton B, Blackwell TS. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Nov 11/20/2007; 104(47): 18514-9. PMID: 18000061, PMCID: PMC2141808, PII: 0705316104, DOI: 10.1073/pnas.0705316104, ISSN: 1091-6490.

Park GY, Hu N, Wang X, Sadikot RT, Yull FE, Joo M, Peebles RS, Blackwell TS, Christman JW. Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity. Clin. Exp. Immunol [print-electronic]. 2007 Nov; 150(2): 245-54. PMID: 17672868, PMCID: PMC2219354, PII: CEI3478, DOI: 10.1111/j.1365-2249.2007.03478.x, ISSN: 1365-2249.

Stathopoulos GT, Kollintza A, Moschos C, Psallidas I, Sherrill TP, Pitsinos EN, Vassiliou S, Karatza M, Papiris SA, Graf D, Orphanidou D, Light RW, Roussos C, Blackwell TS, Kalomenidis I. Tumor necrosis factor-alpha promotes malignant pleural effusion. Cancer Res. 2007 Oct 10/15/2007; 67(20): 9825-34. PMID: 17942913, PII: 67/20/9825, DOI: 10.1158/0008-5472.CAN-07-1064, ISSN: 0008-5472.

Zhang H, Lawson WE, Polosukhin VV, Pozzi A, Blackwell TS, Litingtung Y, Chiang C. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am. J. Pathol [print-electronic]. 2007 Oct; 171(4): 1113-26. PMID: 17717145, PMCID: PMC1988863, PII: S0002-9440(10)62377-2, DOI: 10.2353/ajpath.2007.070226, ISSN: 0002-9440.

Polosukhin VV, Lawson WE, Milstone AP, Egunova SM, Kulipanov AG, Tchuvakin SG, Massion PP, Blackwell TS. Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Arch [print-electronic]. 2007 Oct; 451(4): 793-803. PMID: 17674038, DOI: 10.1007/s00428-007-0469-5, ISSN: 0945-6317.

Joo M, Kwon M, Sadikot RT, Kingsley PJ, Marnett LJ, Blackwell TS, Peebles RS, Urade Y, Christman JW. Induction and function of lipocalin prostaglandin D synthase in host immunity. J. Immunol. 2007 Aug 8/15/2007; 179(4): 2565-75. PMID: 17675519, PII: 179/4/2565, ISSN: 0022-1767.

Glasgow SC, Ramachandran S, Blackwell TS, Mohanakumar T, Chapman WC. Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2007 Aug; 293(2): L491-6. PMID: 17545492, PII: 00009.2007, DOI: 10.1152/ajplung.00009.2007, ISSN: 1040-0605.

Cheng DS, Han W, Chen SM, Sherrill TP, Chont M, Park GY, Sheller JR, Polosukhin VV, Christman JW, Yull FE, Blackwell TS. Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. J. Immunol. 2007 May 5/15/2007; 178(10): 6504-13. PMID: 17475880, PII: 178/10/6504, ISSN: 0022-1767.

Joo M, Wright JG, Hu NN, Sadikot RT, Park GY, Blackwell TS, Christman JW. Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2007 May; 292(5): L1219-26. PMID: 17220375, PII: 00474.2006, DOI: 10.1152/ajplung.00474.2006, ISSN: 1040-0605.

Sadikot RT, Zeng H, Azim AC, Joo M, Dey SK, Breyer RM, Peebles RS, Blackwell TS, Christman JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur. J. Immunol. 2007 Apr; 37(4): 1001-9. PMID: 17330822, DOI: 10.1002/eji.200636636, ISSN: 0014-2980.

Connelly L, Robinson-Benion C, Chont M, Saint-Jean L, Li H, Polosukhin VV, Blackwell TS, Yull FE. A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. J. Biol. Chem [print-electronic]. 2007 Mar 3/30/2007; 282(13): 10028-35. PMID: 17261585, PII: M611300200, DOI: 10.1074/jbc.M611300200, ISSN: 0021-9258.

Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J. Leukoc. Biol [print-electronic]. 2007 Mar; 81(3): 809-17. PMID: 17135575, PII: jlb.0606375, DOI: 10.1189/jlb.0606375, ISSN: 0741-5400.

Kalomenidis I, Stathopoulos GT, Barnette R, Papiris S, Blackwell TS, Roussos C, Light RW. Vascular endothelial growth factor levels in post-CABG pleural effusions are associated with pleural inflammation and permeability. Respir Med [print-electronic]. 2007 Feb; 101(2): 223-9. PMID: 16854577, PII: S0954-6111(06)00281-2, DOI: 10.1016/j.rmed.2006.05.018, ISSN: 0954-6111.

Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J. Immunol. 2007 Jan 1/15/2007; 178(2): 702-10. PMID: 17202330, PII: 178/2/702, ISSN: 0022-1767.

Gray KD, Simovic MO, Blackwell TS, Christman JW, May AK, Parman KS, Chapman WC, Stain SC. Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis. Pancreas. 2006 Oct; 33(3): 260-7. PMID: 17003648, PII: 00006676-200610000-00009, DOI: 10.1097/01.mpa.0000240599.95817.34, ISSN: 1536-4828.

Chen JX, Zeng H, Lawrence ML, Blackwell TS, Meyrick B. Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2006 Oct; 291(4): H1563-72. PMID: 16679392, PII: 01081.2005, DOI: 10.1152/ajpheart.01081.2005, ISSN: 0363-6135.

Maus UA, Janzen S, Wall G, Srivastava M, Blackwell TS, Christman JW, Seeger W, Welte T, Lohmeyer J. Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Aug; 35(2): 227-35. PMID: 16543608, PII: 2005-0241OC, DOI: 10.1165/rcmb.2005-0241OC, ISSN: 1044-1549.

Park GY, Wang X, Hu N, Pedchenko TV, Blackwell TS, Christman JW. NIK is involved in nucleosomal regulation by enhancing histone H3 phosphorylation by IKKalpha. J. Biol. Chem [print-electronic]. 2006 Jul 7/7/2006; 281(27): 18684-90. PMID: 16675465, PMCID: PMC4360958, PII: M600733200, DOI: 10.1074/jbc.M600733200, ISSN: 0021-9258.

Everhart MB, Han W, Sherrill TP, Arutiunov M, Polosukhin VV, Burke JR, Sadikot RT, Christman JW, Yull FE, Blackwell TS. Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J. Immunol. 2006 Apr 4/15/2006; 176(8): 4995-5005. PMID: 16585596, PII: 176/8/4995, ISSN: 0022-1767.

Sadikot RT, Zeng H, Joo M, Everhart MB, Sherrill TP, Li B, Cheng DS, Yull FE, Christman JW, Blackwell TS. Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J. Immunol. 2006 Apr 4/15/2006; 176(8): 4923-30. PMID: 16585588, PII: 176/8/4923, ISSN: 0022-1767.

Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ. Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J. Biol. Chem [print-electronic]. 2006 Feb 2/24/2006; 281(8): 4616-23. PMID: 16371369, PII: M507340200, DOI: 10.1074/jbc.M507340200, ISSN: 0021-9258.

Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull FE, Light RW, Blackwell TS. Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Feb; 34(2): 142-50. PMID: 16210694, PMCID: PMC2644178, PII: 2005-0130OC, DOI: 10.1165/rcmb.2005-0130OC, ISSN: 1044-1549.

Dieperink HI, Blackwell TS, Prince LS. Hyperoxia and apoptosis in developing mouse lung mesenchyme. Pediatr. Res. 2006 Feb; 59(2): 185-90. PMID: 16439576, PII: 59/2/185, DOI: 10.1203/01.pdr.0000196371.85945.3a, ISSN: 0031-3998.

Cheng Q, Zhao Y, Lawson WE, Polosukhin VV, Johnson JE, Blackwell TS, Gailani D. The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice. Blood [print-electronic]. 2005 Nov 11/1/2005; 106(9): 3055-7. PMID: 15985536, PMCID: PMC1895339, PII: 2005-02-0577, DOI: 10.1182/blood-2005-02-0577, ISSN: 0006-4971.

Lawson WE, Polosukhin VV, Stathopoulos GT, Zoia O, Han W, Lane KB, Li B, Donnelly EF, Holburn GE, Lewis KG, Collins RD, Hull WM, Glasser SW, Whitsett JA, Blackwell TS. Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am. J. Pathol. 2005 Nov; 167(5): 1267-77. PMID: 16251411, PMCID: PMC1603790, PII: S0002-9440(10)61214-X, DOI: 10.1016/S0002-9440(10)61214-X, ISSN: 0002-9440.

Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, Backlund MG, DuBois RN, Zanoni G, Vidari G, Blackwell TS, Morrow JD. Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. J. Biol. Chem [print-electronic]. 2005 Oct 10/21/2005; 280(42): 35562-70. PMID: 16100121, PII: M504785200, DOI: 10.1074/jbc.M504785200, ISSN: 0021-9258.

O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valyi-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J. Clin. Invest [print-electronic]. 2005 Sep; 115(9): 2341-50. PMID: 16100570, PMCID: PMC1184036, DOI: 10.1172/JCI22428, ISSN: 0021-9738.

Pedchenko TV, Park GY, Joo M, Blackwell TS, Christman JW. Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia. Am. J. Physiol. Lung Cell Mol. Physiol. 2005 Sep; 289(3): L429-37. PMID: 16093364, PII: 289/3/L429, DOI: 10.1152/ajplung.00046.2005, ISSN: 1040-0605.

Joo M, Hahn YS, Kwon M, Sadikot RT, Blackwell TS, Christman JW. Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. J. Virol. 2005 Jun; 79(12): 7648-57. PMID: 15919917, PMCID: PMC1143634, PII: 79/12/7648, DOI: 10.1128/JVI.79.12.7648-7657.2005, ISSN: 0022-538X.

Sadikot RT, Blackwell TS, Christman JW, Prince AS. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am. J. Respir. Crit. Care Med [print-electronic]. 2005 Jun 6/1/2005; 171(11): 1209-23. PMID: 15695491, PMCID: PMC2718459, PII: 200408-1044SO, DOI: 10.1164/rccm.200408-1044SO, ISSN: 1073-449X.

Kalomenidis I, Stathopoulos GT, Barnette R, Guo Y, Peebles RS, Blackwell TS, Light RW. Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions. Chest. 2005 Jun; 127(6): 2094-100. PMID: 15947325, PII: 127/6/2094, DOI: 10.1378/chest.127.6.2094, ISSN: 0012-3692.

Lawson WE, Polosukhin VV, Zoia O, Stathopoulos GT, Han W, Plieth D, Loyd JE, Neilson EG, Blackwell TS. Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. Am. J. Respir. Crit. Care Med [print-electronic]. 2005 Apr 4/15/2005; 171(8): 899-907. PMID: 15618458, PII: 200311-1535OC, DOI: 10.1164/rccm.200311-1535OC, ISSN: 1073-449X.

Everhart MB, Han W, Parman KS, Polosukhin VV, Zeng H, Sadikot RT, Li B, Yull FE, Christman JW, Blackwell TS. Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. J. Leukoc. Biol [print-electronic]. 2005 Feb; 77(2): 173-80. PMID: 15563581, PII: jlb.1203647, DOI: 10.1189/jlb.1203647, ISSN: 0741-5400.

Maus UA, Wellmann S, Hampl C, Kuziel WA, Srivastava M, Mack M, Everhart MB, Blackwell TS, Christman JW, Schlöndorff D, Bohle RM, Seeger W, Lohmeyer J. CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2005 Feb; 288(2): L350-8. PMID: 15516494, PII: 00061.2004, DOI: 10.1152/ajplung.00061.2004, ISSN: 1040-0605.

Polosukhin VV, Stathopoulos GT, Lawson WE, Blackwell TS. Variability of interalveolar septal remodeling after bleomycin treatment in mice. Ultrastruct Pathol. 2005 Jan; 29(1): 53-64. PMID: 15934165, ISSN: 0191-3123.

Sadikot RT, Blackwell TS. Bioluminescence imaging. Proc Am Thorac Soc. 2005; 2(6): 537-40, 511. PMID: 16352761, PMCID: PMC2713342, PII: 2/6/537, DOI: 10.1513/pats.200507-067DS, ISSN: 1546-3222.

Lawson WE, Grant SW, Ambrosini V, Womble KE, Dawson EP, Lane KB, Markin C, Renzoni E, Lympany P, Thomas AQ, Roldan J, Scott TA, Blackwell TS, Phillips JA, Loyd JE, du Bois RM. Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. Thorax. 2004 Nov; 59(11): 977-80. PMID: 15516475, PMCID: PMC1746860, PII: 59/11/977, DOI: 10.1136/thx.2004.026336, ISSN: 0040-6376.

Tager AM, Kradin RL, LaCamera P, Bercury SD, Campanella GS, Leary CP, Polosukhin V, Zhao LH, Sakamoto H, Blackwell TS, Luster AD. Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2004 Oct; 31(4): 395-404. PMID: 15205180, PII: 2004-0175OC, DOI: 10.1165/rcmb.2004-0175OC, ISSN: 1044-1549.

Sadikot RT, Christman JW, Blackwell TS. Molecular targets for modulating lung inflammation and injury. Curr Drug Targets. 2004 Aug; 5(6): 581-8. PMID: 15270205, ISSN: 1389-4501.

Maus UA, Srivastava M, Paton JC, Mack M, Everhart MB, Blackwell TS, Christman JW, Schlöndorff D, Seeger W, Lohmeyer J. Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. J. Immunol. 2004 Jul 7/15/2004; 173(2): 1307-12. PMID: 15240724, ISSN: 0022-1767.

Park GY, Joo M, Pedchenko T, Blackwell TS, Christman JW. Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2004 May; 286(5): L956-62. PMID: 14672923, PII: 00338.2003, DOI: 10.1152/ajplung.00338.2003, ISSN: 1040-0605.

Joo M, Park GY, Wright JG, Blackwell TS, Atchison ML, Christman JW. Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1. J. Biol. Chem [print-electronic]. 2004 Feb 2/20/2004; 279(8): 6658-65. PMID: 14966110, PII: M306267200, DOI: 10.1074/jbc.M306267200, ISSN: 0021-9258.

Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW. P47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J. Immunol. 2004 Feb 2/1/2004; 172(3): 1801-8. PMID: 14734763, ISSN: 0022-1767.

Kalomenidis I, Lane K, Blackwell TS, Guo Y, Light RW. Mice are resistant to the induction of a pleurodesis [letter]. Chest. 2003 Dec; 124(6): 2407-8. PMID: 14665535, ISSN: 0012-3692.

Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, May AK, Parman KS, Stain SC. Endotoxin potentiates lung injury in cerulein-induced pancreatitis. Am. J. Surg. 2003 Nov; 186(5): 526-30. PMID: 14599619, PII: S0002961003003337, ISSN: 0002-9610.

Lee YC, Lane KB, Zoia O, Thompson PJ, Light RW, Blackwell TS. Transforming growth factor-beta induces collagen synthesis without inducing IL-8 production in mesothelial cells. Eur. Respir. J. 2003 Aug; 22(2): 197-202. PMID: 12952247, ISSN: 0903-1936.

Yull FE, Han W, Jansen ED, Everhart MB, Sadikot RT, Christman JW, Blackwell TS. Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo. J. Histochem. Cytochem. 2003 Jun; 51(6): 741-9. PMID: 12754285, ISSN: 0022-1554.

Maus UA, Waelsch K, Kuziel WA, Delbeck T, Mack M, Blackwell TS, Christman JW, Schlöndorff D, Seeger W, Lohmeyer J. Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. J. Immunol. 2003 Mar 3/15/2003; 170(6): 3273-8. PMID: 12626586, ISSN: 0022-1767.

Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, Washington MK, Yull FE, Jaffal N, Jansen ED, Gautman S, Stain SC. Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis. J. Surg. Res. 2003 Mar; 110(1): 310-4. PMID: 12697416, PII: S0022480403000246, ISSN: 0022-4804.

Sadikot RT, Han W, Everhart MB, Zoia O, Peebles RS, Jansen ED, Yull FE, Christman JW, Blackwell TS. Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. J. Immunol. 2003 Jan 1/15/2003; 170(2): 1091-8. PMID: 12517978, ISSN: 0022-1767.

Koay MA, Christman JW, Wudel LJ, Allos T, Cheng DS, Chapman WC, Blackwell TS. Modulation of endotoxin-induced NF-kappa B activation in lung and liver through TNF type 1 and IL-1 receptors. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2002 Dec; 283(6): L1247-54. PMID: 12388356, PII: 00036.2002, DOI: 10.1152/ajplung.00036.2002, ISSN: 1040-0605.

Maus UA, Koay MA, Delbeck T, Mack M, Ermert M, Ermert L, Blackwell TS, Christman JW, Schlöndorff D, Seeger W, Lohmeyer J. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am. J. Physiol. Lung Cell Mol. Physiol. 2002 Jun; 282(6): L1245-52. PMID: 12003780, DOI: 10.1152/ajplung.00453.2001, ISSN: 1040-0605.

Koay MA, Gao X, Washington MK, Parman KS, Sadikot RT, Blackwell TS, Christman JW. Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin. Am. J. Respir. Cell Mol. Biol. 2002 May; 26(5): 572-8. PMID: 11970909, DOI: 10.1165/ajrcmb.26.5.4748, ISSN: 1044-1549.

Sadikot RT, Wudel LJ, Jansen DE, Debelak JP, Yull FE, Christman JW, Blackwell TS, Chapman WC. Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kappaB activation in a transgenic mouse model. J. Gastrointest. Surg. 2002 Mar; 6(2): 264-70. PMID: 11992813, PII: S1091255X01000646, ISSN: 1091-255X.

Koay, M.A., Gao, X., Washington, M.K., Blackwell, T.S., Christman, J.W. Macrophages are necessary for maximal NF- B activation and generation of lung inflammation in response to inhaled and systemic endotoxin. Am. J. Respir. Cell Mol. Biol. 2002; 26: 572-8.

Koay MA, Christman JW, Segal BH, Venkatakrishnan A, Blackwell TR, Holland SM, Blackwell TS. Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Infect. Immun. 2001 Oct; 69(10): 5991-6. PMID: 11553535, PMCID: PMC98726, DOI: 10.1128/IAI.69.10.5991-5996.2001, ISSN: 0019-9567.

Sadikot RT, Jansen ED, Blackwell TR, Zoia O, Yull F, Christman JW, Blackwell TS. High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice. Am. J. Respir. Crit. Care Med. 2001 Sep 9/1/2001; 164(5): 873-8. PMID: 11549548, DOI: 10.1164/ajrccm.164.5.2008059, ISSN: 1073-449X.

Blackwell TS, Stecenko AA, Christman JW. Dysregulated NF-kappaB activation in cystic fibrosis: evidence for a primary inflammatory disorder [editorial]. Am. J. Physiol. Lung Cell Mol. Physiol. 2001 Jul; 281(1): L69-70. PMID: 11404247, ISSN: 1040-0605.

Stecenko AA, King G, Torii K, Breyer RM, Dworski R, Blackwell TS, Christman JW, Brigham KL. Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation. 2001 Jun; 25(3): 145-55. PMID: 11403205, ISSN: 0360-3997.

Blackwell TS, Christman JW. Defining the lung's response to endotoxin [editorial]. Am. J. Respir. Crit. Care Med. 2001 Jun; 163(7): 1516-7. PMID: 11401864, DOI: 10.1164/ajrccm.163.7.2103055d, ISSN: 1073-449X.

Curran CL, Blackwell TS, Christman JW. NF-kappaB: a therapeutic target in inflammatory diseases. Expert Opin. Ther. Targets. 2001 Apr; 5(2): 197-204. PMID: 15992176, DOI: 10.1517/14728222.5.2.197, ISSN: 1744-7631.

Lancaster LH, Christman JW, Blackwell TR, Koay MA, Blackwell TS. Suppression of lung inflammation in rats by prevention of NF-kappaB activation in the liver. Inflammation. 2001 Feb; 25(1): 25-31. PMID: 11293663, ISSN: 0360-3997.

Sadikot, R.T., Jansen, E.D., Blackwell, T.R., Zoia, O., Yull, F.E., Christman, J.W., Blackwell, T.S. High dose dexamethasone accentuates NF- B activation in endotoxin-treated mice. Am. J. Respir. Crit. Care Med. 2001; ((164)): 873-8.

Koay, A., Christman, J.W., Segal, B.H., Venkatakrishnan, A., Blackwell, T.R., Holland, S.M., Blackwell, T.S. Impaired pulmonary NF- B activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Infection and Immunity. 2001; ((69)): 5991-6.

Sadikot RT, Christman JW, Blackwell TS. Chemokines and chemokine receptors in pulmonary diseases. Curr Opin Investig Drugs. 2000 Nov; 1(3): 314-20. PMID: 11249714, ISSN: 1472-4472.

Blackwell TS, Yull FE, Chen CL, Venkatakrishnan A, Blackwell TR, Hicks DJ, Lancaster LH, Christman JW, Kerr LD. Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation. Am. J. Respir. Crit. Care Med. 2000 Sep; 162(3 Pt 1): 1095-101. PMID: 10988136, DOI: 10.1164/ajrccm.162.3.9906129, ISSN: 1073-449X.

Venkatakrishnan A, Stecenko AA, King G, Blackwell TR, Brigham KL, Christman JW, Blackwell TS. Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 2000 Sep; 23(3): 396-403. PMID: 10970832, DOI: 10.1165/ajrcmb.23.3.3949, ISSN: 1044-1549.

Chapman WC, Debelak JP, Blackwell TS, Gainer KA, Christman JW, Pinson CW, Brigham KL, Parker RE. Hepatic cryoablation-induced acute lung injury: pulmonary hemodynamic and permeability effects in a sheep model. Arch Surg. 2000 Jun; 135(6): 667-72; discussion 672. PMID: 10843362, ISSN: 0004-0010.

Christman JW, Sadikot RT, Blackwell TS. The role of nuclear factor-kappa B in pulmonary diseases. Chest. 2000 May; 117(5): 1482-7. PMID: 10807839, ISSN: 0012-3692.

Chapman WC, Debelak JP, Wright Pinson C, Washington MK, Atkinson JB, Venkatakrishnan A, Blackwell TS, Christman JW. Hepatic cryoablation, but not radiofrequency ablation, results in lung inflammation. Ann. Surg. 2000 May; 231(5): 752-61. PMID: 10767797, PMCID: PMC1421063, ISSN: 0003-4932.

Blackwell, T.S., Yull, F.E., Chen, C-L., Venkatakrishnan, A., Blackwell, T.R., Hicks, D.J., Lancaster, L.H., Christman, J.W., Kerr, L.D. Multi-organ NF- B activation in a transgenic mouse model of systemic inflammation. 2000.

Venkatakrishnan A., King G., Stecenko A.A., Blackwell T.R., Brigham K.L., Christman J.W., and Blackwell T.S. Exaggerated activation of NF- B and altered I B- processing in cystic fibrosis bronchial epithelial cells. 2000.

Blackwell TS, Christman JW, Hagan T, Price P, Edens T, Morris PE, Wolff SN, Goodman SA, Christman BW. Oxidative stress and NF-kappaB activation: correlation in patients following allogeneic bone marrow transplantation. Antioxid. Redox Signal. 2000; 2(1): 93-102. PMID: 11232605, ISSN: 1523-0864.

Christman JW, Blackwell TS, Juurlink BH. Redox regulation of nuclear factor kappa B: therapeutic potential for attenuating inflammatory responses. Brain Pathol. 2000 Jan; 10(1): 153-62. PMID: 10668905, ISSN: 1015-6305.

Blackwell TS, Lancaster LH, Blackwell TR, Venkatakrishnan A, Christman JW. Differential NF-kappaB activation after intratracheal endotoxin. Am. J. Physiol. 1999 Oct; 277(4 Pt 1): L823-30. PMID: 10516225, ISSN: 0002-9513.

Blackwell TS, Debelak JP, Venkatakrishnan A, Schot DJ, Harley DH, Pinson CW, Williams P, Washington K, Christman JW, Chapman WC. Acute lung injury after hepatic cryoablation: correlation with NF-kappa B activation and cytokine production. Surgery. 1999 Sep; 126(3): 518-26. PMID: 10486604, PII: S0039606099002767, ISSN: 0039-6060.

Blackwell TS, Yull FE, Chen CL, Venkatakrishnan A, Blackwell TR, Hicks DJ, Lancaster LH, Christman JW, Kerr LD. Use of genetically altered mice to investigate the role of nuclear factor-kappa B activation and cytokine gene expression in sepsis-induced ARDS. Chest. 1999 Jul; 116(1 Suppl): 73S-74S. PMID: 10424600, ISSN: 0012-3692.

Blackwell TS, Lancaster LH, Blackwell TR, Venkatakrishnan A, Christman JW. Chemotactic gradients predict neutrophilic alveolitis in endotoxin-treated rats. Am. J. Respir. Crit. Care Med. 1999 May; 159(5 Pt 1): 1644-52. PMID: 10228139, DOI: 10.1164/ajrccm.159.5.9806166, ISSN: 1073-449X.

Blackwell, T.S., Lancaster, L.H., Blackwell, T.R., Venkatakrishnan, A., Christman, J.W. Differential NF- B activation after intratracheal endotoxin: correlation with cytokine gene expression and neutrophilic alveolitis. 1999.

Blackwell, T.S., Debelak, J.P., Venkatakrishnan, A., Schot, D.J., Harley, D.H., Pinson, C.W., Williams, P., Washington, K., Christman, J.W., Chapman, W.C. Acute lung injury after hepatic cryoablation: correlation with NF- B activation and cytokine production. 1999.

Blackwell, T.S., Lancaster, L.H., Blackwell, T.R., Venkatakrishnan, A., Christman, J.W. Chemotactic gradients predict neutrophilic alveolitis in endotoxin treated rats. 1999.

Christman JW, Lancaster LH, Blackwell TS. Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med. 1998 Nov; 24(11): 1131-8. PMID: 9876974, ISSN: 0342-4642.

Blackwell TS, Blackwell TR, Christman JW. Induction of endotoxin tolerance depletes nuclear factor-kappaB and suppresses its activation in rat alveolar macrophages. J. Leukoc. Biol. 1997 Dec; 62(6): 885-91. PMID: 9400831, ISSN: 0741-5400.

Blackwell TS, Christman JW. The role of nuclear factor-kappa B in cytokine gene regulation. Am. J. Respir. Cell Mol. Biol. 1997 Jul; 17(1): 3-9. PMID: 9224203, DOI: 10.1165/ajrcmb.17.1.f132, ISSN: 1044-1549.

Blackwell TS, Blackwell TR, Christman JW. Impaired activation of nuclear factor-kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation. J. Immunol. 1997 Jun 6/15/1997; 158(12): 5934-40. PMID: 9190947, ISSN: 0022-1767.

Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J. Immunol. 1996 Aug 8/15/1996; 157(4): 1630-7. PMID: 8759749, ISSN: 0022-1767.

Blackwell TS, Christman JW. Sepsis and cytokines: current status. Br J Anaesth. 1996 Jul; 77(1): 110-7. PMID: 8703620, ISSN: 0007-0912.

Blackwell TS, Gossage JR. Gold pulmonary toxicity in a patient with a normal chest radiograph. South. Med. J. 1995 Jun; 88(6): 644-6. PMID: 7777881, ISSN: 0038-4348.

Christman JW, Holden EP, Blackwell TS. Strategies for blocking the systemic effects of cytokines in the sepsis syndrome. Crit. Care Med. 1995 May; 23(5): 955-63. PMID: 7736757, ISSN: 0090-3493.

Blackwell TS, Holden EP, Blackwell TR, DeLarco JE, Christman JW. Cytokine-induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: association with nuclear factor kappa B activation. Am. J. Respir. Cell Mol. Biol. 1994 Oct; 11(4): 464-72. PMID: 7917314, DOI: 10.1165/ajrcmb.11.4.7917314, ISSN: 1044-1549.