Shirley Brody Russell, Ph.D.

Research Assistant Professor
Faculty Appointments
Research Assistant Professor of Medicine
Ph.D., Medical Genetics, University of Wisconsin, Madison, WisconsinB.A., Biology, University of Rochester, Rochester, New York
Office Address
3793 TVC
TN 5227
Research Description
Dr. Russell's research is focused on hormonal and cytokine regulation of growth and matrix synthesis in human fibroblasts and characterization of the wound healing response in dermis and gingiva. A long-term goal is to elucidate the molecular basis for the formation of keloids, which are benign dermal tumors that develop during wound healing in genetically predisposed persons. Because the regulators involved in wound healing and their signal transduction pathways are relevant to so many major questions in biology and medicine, these studies may help elucidate the pathogenesis of other diseases involved in abnormal tissue repair, including atherosclerosis, rheumatoid arthritis, uterine fibroma, and gingival hyperplasia. Dr. Russell is Associate Dean for Research, School of Dentistry and the Director of the Regional Research Center for Minority Oral Health.
Research Keywords
The pathogenesis of keloids and the genetic basis of this connective tissue disorder
Russell SB, Smith JC, Huang M, Trupin JS, Williams SM. Pleiotropic Effects of Immune Responses Explain Variation in the Prevalence of Fibroproliferative Diseases. PLoS Genet. 2015 Nov; 11(11): e1005568. PMID: 26540410, PMCID: PMC4634921, PII: PGENETICS-D-15-01023, DOI: 10.1371/journal.pgen.1005568, ISSN: 1553-7404.

Velez Edwards DR, Tsosie KS, Williams SM, Edwards TL, Russell SB. Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans. Hum. Genet [print-electronic]. 2014 Dec; 133(12): 1513-23. PMID: 25280642, PMCID: PMC4334317, DOI: 10.1007/s00439-014-1490-9, ISSN: 1432-1203.

Russell SB, Russell JD, Trupin KM, Gayden AE, Opalenik SR, Nanney LB, Broquist AH, Raju L, Williams SM. Epigenetically altered wound healing in keloid fibroblasts. J. Invest. Dermatol [print-electronic]. 2010 Oct; 130(10): 2489-96. PMID: 20555348, PMCID: PMC2939920, PII: S0022-202X(15)34563-2, DOI: 10.1038/jid.2010.162, ISSN: 1523-1747.

Meyer LJ, Russell SB, Russell JD, Trupin JS, Egbert BM, Shuster S, Stern R. Reduced hyaluronan in keloid tissue and cultured keloid fibroblasts. J Invest Dermatol. 2000; 114(5): 953-9.

Russell SB, Trupin JS, Kennedy RZ, Russell JD, Davidson JM. Glucocorticoid regulation of elastin synthesis in human fibroblasts: down-regulation in fibroblasts from normal dermis but not from keloids. J Invest Dermatol. 1995; 104(2): 241-5.

Myles ME, Russell JD, Trupin JS, Smith JC, Russell SB. Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters. Altered response is accompanied by reduced sensitivity to prostaglandin E2 and altered down-regulation of phorbol ester binding sites. J Biol Chem. 1992; 267(13): 9014-20.

Russell SB, Trupin JS, Myers JC, Broquist AH, Smith JC, Myles ME, Russell JD. Differential glucocorticoid regulation of collagen mRNAs in human dermal fibroblasts. Keloid-derived and fetal fibroblasts are refractory to down-regulation. J Biol Chem. 1989; 264(23): 13730-5.

Russell SB, Trupin KM, Rodriguez-Eaton S, Russell JD, Trupin JS. Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth. Proc Natl Acad Sci U S A. 1988; 85(2): 587-91.

Russell SB, Russell JD, Trupin JS. Hydrocortisone induction of system A amino acid transport in human fibroblasts from normal dermis and keloid. J Biol Chem. 1984; 259: 11464-9.

Gadson PF, Russell JD, Russell SB. Glucocorticoid receptors in human fibroblasts derived from normal dermis and keloid tissue. J Biol Chem. 1984; 259: 11236-41.

Trupin JS, Russell SB, Russell JD. Variation in prolyl hydroxylase activity of keloid-derived and normal human fibroblasts in response to hydrocortisone and ascorbic acid. Coll Relat Res. 1983; 3: 13-23.

Russell SB, Russell JD, Trupin JS. Alteration of amino acid transport by hydrocortisone. Different effects in human fibroblasts derived from normal skin and keloid. J Biol Chem. 1982; 257: 9525-31.

Russell JD, Russell SB, Trupin KM. Fibroblast heterogeneity in glucocorticoid regulation of collagen metabolism: genetic or epigenetic?. In Vitro. 1982; 18(6): 557-64.