Chin Chiang, M.D., Ph.D.

Professor

chin.chiang@vanderbilt.edu

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Faculty Appointments
Professor of Cell and Developmental Biology
Education
Ph.D., Genetics and Cell biology, Washington State University, Pullman, WashingtonM.D., Chemical engineering, Washington State University, Pullman, WashingtonB.S., Chemical engineering, State University of New York, Buffalo, New York
Office Address
4114, MRB3
Nashville, TN 37232-8240
Research Description
The functional neural circuit of the adult brain, including that of the cerebellar system, is comprised of a defined number of inhibitory and excitatory neurons. Developmental studies indicate that these functionally distinct neurons are generated during early development from spatially separate mitotic progenitors that transiently expand in response to extrinsic signals. Imbalance of excitation and inhibition as a result of alterations in these early developmental events has been implicated in several debilitating neurodevelopmental disorders, including ataxia and autism spectrum disorder, where cerebellar dysfunctions have been widely noted. Our laboratory is interested in how defined numbers of functionally and neurochemically different neurons are established and later incorporated into a functional cerebellar circuit, and how defined perturbations of this circuitry affects the ability of animals to integrate and process sensory information.

The cerebellar neurons are generated from their dividing precursors, and dysregulated proliferation of these precursors is associated with medulloblastoma, the most common pediatric malignant brain tumors. We are interested in identifying potential therapeutic target proteins of medulloblastoma.
Research Keywords
Hedgehog signaling, neurogenesis, brain circuitry, sensory processing, animal behaviors, brain tumors
Publications
Loganathan SN, Tang N, Fleming JT, Ma Y, Guo Y, Borinstein SC, Chiang C, Wang J. BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma. Oncotarget [print-electronic]. 2016 Jun 6/1/2016; PMID: 27259270, PII: 9762, DOI: 10.18632/oncotarget.9762, ISSN: 1949-2553.

Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerkov√° G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R. Consensus Paper: Cerebellar Development. Cerebellum [print-electronic]. 2015 Oct 10/6/2015; PMID: 26439486, PMCID: PMC4846577, PII: 10.1007/s12311-015-0724-2, DOI: 10.1007/s12311-015-0724-2, ISSN: 1473-4230.

Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep [print-electronic]. 2015 Apr 4/7/2015; 11(1): 43-50. PMID: 25818300, PMCID: PMC4394042, PII: S2211-1247(15)00243-0, DOI: 10.1016/j.celrep.2015.03.001, ISSN: 2211-1247.

Chiang C, Ihrie RA. Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression. Cancer Cell. 2014 Dec 12/8/2014; 26(6): 773-4. PMID: 25490438, PII: S1535-6108(14)00471-1, DOI: 10.1016/j.ccell.2014.11.020, ISSN: 1878-3686.

Fleming JT, He W, Hao C, Ketova T, Pan FC, Wright CC, Litingtung Y, Chiang C. The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Dev. Cell. 2013 Nov 11/11/2013; 27(3): 278-92. PMID: 24229643, PMCID: PMC3860749, PII: S1534-5807(13)00605-9, DOI: 10.1016/j.devcel.2013.10.008, ISSN: 1878-1551.

Liu J, Li Q, Kuehn MR, Litingtung Y, Vokes SA, Chiang C. Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning. Dev. Biol [print-electronic]. 2013 Mar 3/15/2013; 375(2): 160-71. PMID: 23313125, PMCID: PMC3820152, PII: S0012-1606(13)00004-3, DOI: 10.1016/j.ydbio.2012.12.018, ISSN: 1095-564X.

Ryan KE, Chiang C. Hedgehog secretion and signal transduction in vertebrates. J. Biol. Chem [print-electronic]. 2012 May 5/25/2012; 287(22): 17905-13. PMID: 22474285, PMCID: PMC3365689, PII: R112.356006, DOI: 10.1074/jbc.R112.356006, ISSN: 1083-351X.

Murphy AJ, Li Y, Pietsch JB, Chiang C, Lovvorn HN. Mutational analysis of NOG in esophageal atresia and tracheoesophageal fistula patients. Pediatr. Surg. Int [print-electronic]. 2012 Apr; 28(4): 335-40. PMID: 22083168, PMCID: PMC4148071, DOI: 10.1007/s00383-011-3022-1, ISSN: 1437-9813.

Benesh AE, Fleming JT, Chiang C, Carter BD, Tyska MJ. Expression and localization of myosin-1d in the developing nervous system. Brain Res [print-electronic]. 2012 Feb 2/27/2012; 1440: 9-22. PMID: 22284616, PMCID: PMC3278530, PII: S0006-8993(11)02323-7, DOI: 10.1016/j.brainres.2011.12.054, ISSN: 1872-6240.

Cheng, F.Y., Huang, X., Sarangi, A., Ketova, T., Cooper, M.K., Litingtung, Y. and Chiang, C.. Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for Hedgehog-driven medulloblastoma formation. Plos One. 2012; 7: 35541.

Huang, X., Dubuc, A.M., Hashizume, R., Berg, J., He, Y., Chiang, C. Cooper, M.K., Northcott, P.A., Yatlor, M.D., Barnes, M.J., Tijan, T., Chen, J., Hackett, C.S., Weiss, W.A., David James, C., Rowitch, D.H., Shuman, M.A., Jan, Y.H. and Jan L.Y.. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012; 26: 1780.

Ryan K.E. and Chiang, C.. Hedgehog Secretion and Signal Transduction in Vertebrates. J. Biol. Chem. 2012; 287: 179015.

Bebesh, A.E., Fleming, J.T., Chiang, C., Carter, B.D. and Tyska, M.J.. Expression and localization of myosin-1d in the developing nervous system. Brain Res. 2012; 1440: 9.

Cheng FY, Huang X, Sarangi A, Ketova T, Cooper MK, Litingtung Y, Chiang C. Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for hedgehog-driven medulloblastoma formation. PLoS ONE [print-electronic]. 2012; 7(4): e35541. PMID: 22539980, PMCID: PMC3335071, PII: PONE-D-12-03506, DOI: 10.1371/journal.pone.0035541, ISSN: 1932-6203.

Mason, T.A., Kolobova, E., Liu, J., Roland, J.T., Chiang, C.. Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. Plos One. 2011; 6((11)): 27699.

Mason TA, Kolobova E, Liu J, Roland JT, Chiang C, Goldenring JR. Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. PLoS ONE [print-electronic]. 2011; 6(11): e27699. PMID: 22110729, PMCID: PMC3216988, PII: PONE-D-11-15023, DOI: 10.1371/journal.pone.0027699, ISSN: 1932-6203.

Huang X, Liu J, Ketova T, Fleming JT, Grover VK, Cooper MK, Litingtung Y, Chiang C. Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 May 5/4/2010; 107(18): 8422-7. PMID: 20400693, PMCID: PMC2889567, PII: 0911838107, DOI: 10.1073/pnas.0911838107, ISSN: 1091-6490.

Huang, X., Ketova, T., Litingtung, Y. and Chiang, C. Isolation, Enrichment and Maintenance of Medulloblastoma Stem Cells. J. Vis. Exp. 2010; 43: 2086.

Huang, X., Sarangi, A., Ketova, T., Cooper, M. K., Litingtung, Y. and Chiang, C.. Intracranial Orthotopic Allografting of Medulloblastoma. J. Vis. Exp. 2010; 44: 2153.

Huang X, Sarangi A, Ketova T, Litingtung Y, Cooper MK, Chiang C. Intracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice. J Vis Exp. 2010; (44): PMID: 20972404, PMCID: PMC3185618, PII: 2153, DOI: 10.3791/2153, ISSN: 1940-087X.

Huang X, Ketova T, Litingtung Y, Chiang C. Isolation, enrichment, and maintenance of medulloblastoma stem cells. J Vis Exp. 2010; (43): PMID: 20834221, PMCID: PMC3229217, PII: 2086, DOI: 10.3791/2086, ISSN: 1940-087X.

Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development [print-electronic]. 2009 Aug; 136(15): 2535-43. PMID: 19570847, PMCID: PMC2709062, PII: dev.033795, DOI: 10.1242/dev.033795, ISSN: 0950-1991.

Oh S, Huang X, Liu J, Litingtung Y, Chiang C. Shh and Gli3 activities are required for timely generation of motor neuron progenitors. Dev. Biol [print-electronic]. 2009 Jul 7/15/2009; 331(2): 261-9. PMID: 19433083, PMCID: PMC2703695, PII: S0012-1606(09)00563-6, DOI: 10.1016/j.ydbio.2009.05.539, ISSN: 1095-564X.

Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C. Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev. Biol [print-electronic]. 2008 Oct 10/1/2008; 322(1): 145-55. PMID: 18692041, PMCID: PMC3780977, PII: S0012-1606(08)01081-6, DOI: 10.1016/j.ydbio.2008.07.021, ISSN: 1095-564X.

Huang X, Goudy SL, Ketova T, Litingtung Y, Chiang C. Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev. Dyn. 2008 Oct; 237(10): 3079-87. PMID: 18816854, DOI: 10.1002/dvdy.21714, ISSN: 1058-8388.

Fogel JL, Chiang C, Huang X, Agarwala S. Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling. Dev. Dyn. 2008 May; 237(5): 1359-72. PMID: 18429041, PMCID: PMC2586936, DOI: 10.1002/dvdy.21536, ISSN: 1058-8388.

Zhang H, Lawson WE, Polosukhin VV, Pozzi A, Blackwell TS, Litingtung Y, Chiang C. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am. J. Pathol [print-electronic]. 2007 Oct; 171(4): 1113-26. PMID: 17717145, PMCID: PMC1988863, PII: S0002-9440(10)62377-2, DOI: 10.2353/ajpath.2007.070226, ISSN: 0002-9440.

Huang X, Litingtung Y, Chiang C. Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Hum. Mol. Genet [print-electronic]. 2007 Jun 6/15/2007; 16(12): 1454-68. PMID: 17468181, PII: ddm096, DOI: 10.1093/hmg/ddm096, ISSN: 0964-6906.

Huang X, Litingtung Y, Chiang C. Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development. 2007 Jun; 134(11): 2095-105. PMID: 17507410, PII: 134/11/2095, DOI: 10.1242/dev.000729, ISSN: 0950-1991.

Li Y, Litingtung Y, Ten Dijke P, Chiang C. Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Dev. Dyn. 2007 Mar; 236(3): 746-54. PMID: 17260385, DOI: 10.1002/dvdy.21075, ISSN: 1058-8388.

Guerrero, I and Chiang, C.. A conserved mechanism of Hedgehog gradient formation by lipid modifications. Trends in Cell Biology. 2007; 17: 1-5.

Li Y, Zhang H, Litingtung Y, Chiang C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Apr 4/25/2006; 103(17): 6548-53. PMID: 16611729, PMCID: PMC1458921, PII: 0600124103, DOI: 10.1073/pnas.0600124103, ISSN: 0027-8424.

Chiang, C. From Oligodactyly to Polydactyly:role of Shh and Gli3 in limb morphogenesis. In Hedgehog-Gli Signaling and Human Disease, Edited by A. Ruiz I Altaba. 2006; 137-45.

Zhang, H., Litingtung, Y. and Chiang, C.. Sonic Hedgehog signaling in viceral organ development. In Shh and Gli signaling in Development. Edited by S. Howie and C. Fisher. 2006.

Oh S, Huang X, Chiang C. Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev. Dyn. 2005 Nov; 234(3): 489-96. PMID: 15880651, DOI: 10.1002/dvdy.20422, ISSN: 1058-8388.

van Bokhoven H, Celli J, van Reeuwijk J, Rinne T, Glaudemans B, van Beusekom E, Rieu P, Newbury-Ecob RA, Chiang C, Brunner HG. MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. Nat. Genet [print-electronic]. 2005 May; 37(5): 465-7. PMID: 15821734, PII: ng1546, DOI: 10.1038/ng1546, ISSN: 1061-4036.

Li Y, Zhang H, Choi SC, Litingtung Y, Chiang C. Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev. Biol. 2004 Jun 6/1/2004; 270(1): 214-31. PMID: 15136151, PII: S0012160604001691, DOI: 10.1016/j.ydbio.2004.03.009, ISSN: 0012-1606.

Powles N, Marshall H, Economou A, Chiang C, Murakami A, Dickson C, Krumlauf R, Maconochie M. Regulatory analysis of the mouse Fgf3 gene: control of embryonic expression patterns and dependence upon sonic hedgehog (Shh) signalling. Dev. Dyn. 2004 May; 230(1): 44-56. PMID: 15108308, DOI: 10.1002/dvdy.20028, ISSN: 1058-8388.

Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, Yang E. Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol. Cell. Biol. 2003 Sep; 23(18): 6350-62. PMID: 12944463, PMCID: PMC193703, ISSN: 0270-7306.

Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature [print-electronic]. 2002 Aug 8/29/2002; 418(6901): 979-83. PMID: 12198547, PII: nature01033, DOI: 10.1038/nature01033, ISSN: 0028-0836.

Liu W, Li G, Chien JS, Raft S, Zhang H, Chiang C, Frenz DA. Sonic hedgehog regulates otic capsule chondrogenesis and inner ear development in the mouse embryo. Dev. Biol. 2002 Aug 8/15/2002; 248(2): 240-50. PMID: 12167401, PII: S0012160602907335, ISSN: 0012-1606.

Perriton CL, Powles N, Chiang C, Maconochie MK, Cohn MJ. Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev. Biol. 2002 Jul 7/1/2002; 247(1): 26-46. PMID: 12074550, PII: S0012160602906688, DOI: 10.1006/dbio.2002.0668, ISSN: 0012-1606.

Ohkubo Y, Chiang C, Rubenstein JL. Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Neuroscience. 2002; 111(1): 1-17. PMID: 11955708, PII: S0306452201006169, ISSN: 0306-4522.

Chiang C, Litingtung Y, Harris MP, Simandl BK, Li Y, Beachy PA, Fallon JF. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev. Biol. 2001 Aug 8/15/2001; 236(2): 421-35. PMID: 11476582, PII: S0012-1606(01)90346-X, DOI: 10.1006/dbio.2001.0346, ISSN: 0012-1606.

Mo R, Kim JH, Zhang J, Chiang C, Hui CC, Kim PC. Anorectal malformations caused by defects in sonic hedgehog signaling. Am. J. Pathol. 2001 Aug; 159(2): 765-74. PMID: 11485934, PMCID: PMC1850556, PII: S0002-9440(10)61747-6, DOI: 10.1016/S0002-9440(10)61747-6, ISSN: 0002-9440.

Chattopadhyay A, Chiang CW, Yang E. BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest. Oncogene. 2001 Jul 7/27/2001; 20(33): 4507-18. PMID: 11494146, DOI: 10.1038/sj.onc.1204584, ISSN: 0950-9232.

Chiang CW, Harris G, Ellig C, Masters SC, Subramanian R, Shenolikar S, Wadzinski BE, Yang E. Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Blood. 2001 Mar 3/1/2001; 97(5): 1289-97. PMID: 11222372, ISSN: 0006-4971.

Pak JH, Huang FL, Li J, Balschun D, Reymann KG, Chiang C, Westphal H, Huang KP. Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice. Proc. Natl. Acad. Sci. U.S.A. 2000 Oct 10/10/2000; 97(21): 11232-7. PMID: 11016969, PMCID: PMC17183, PII: 210184697, DOI: 10.1073/pnas.210184697, ISSN: 0027-8424.

Litingtung Y, Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 2000 Oct; 3(10): 979-85. PMID: 11017169, DOI: 10.1038/79916, ISSN: 1097-6256.

Litingtung Y, Chiang C. Control of Shh activity and signaling in the neural tube. Dev. Dyn. 2000 Oct; 219(2): 143-54. PMID: 11002335, PII: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1050>3.0.CO;2-Q, DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1050>3.0.CO;2-Q, ISSN: 1058-8388.

Borycki AG, Brunk B, Tajbakhsh S, Buckingham M, Chiang C, Emerson CP. Sonic hedgehog controls epaxial muscle determination through Myf5 activation. Development. 1999 Sep; 126(18): 4053-63. PMID: 10457014, ISSN: 0950-1991.

Pierani A, Brenner-Morton S, Chiang C, Jessell TM. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell. 1999 Jun 6/25/1999; 97(7): 903-15. PMID: 10399918, PII: S0092-8674(00)80802-8, ISSN: 0092-8674.

Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, Cooper MK, Gaffield W, Westphal H, Beachy PA, Dlugosz AA. Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev. Biol. 1999 Jan 1/1/1999; 205(1): 1-9. PMID: 9882493, PII: S0012-1606(98)99103-5, DOI: 10.1006/dbio.1998.9103, ISSN: 0012-1606.

Litingtung Y, Lei L, Westphal H, Chiang C. Sonic hedgehog is essential to foregut development. Nat. Genet. 1998 Sep; 20(1): 58-61. PMID: 9731532, DOI: 10.1038/1717, ISSN: 1061-4036.

Kos L, Chiang C, Mahon KA. Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression. Mech. Dev. 1998 Jan; 70(1-2): 25-34. PMID: 9510022, ISSN: 0925-4773.

Knezevic, V., De Santo, R., Schughart, K., Huffstadt, U., Chiang, C., Mahon, K.A. and Mackem, S. Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates sonic hedgehog in a positive feedback loop. Development. 1997; 124: 4523-36.

Yuryev A, Patturajan M, Litingtung Y, Joshi RV, Gentile C, Gebara M, Corden JL. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. Proc. Natl. Acad. Sci. U.S.A. 1996 Jul 7/9/1996; 93(14): 6975-80. PMID: 8692929, PMCID: PMC38919, ISSN: 0027-8424.

Chiang C, Litingtung Y, Lee E, Young K, Corden JL, Westphal H and Beachy PA. Cyclopia and defective axial patterning in mice lacking Sonic Hedgehog gene function. Nature. 1996; 383: 407-13.

Chiang, C., Yong, K.E., and Beachy, P.A.. Controlof drosphila trachael branching by the novel homeodomain gene unplugges, a regulatory target for genes of the bithorax complex. Development. 1995; 121: 3901-12.

Roelink, H., Porter, J., Chiang, C., Tanabe, Y., Chang, D.T., Beachy, P.A., and Jessell, T.M.. Concentration-dependent induction of floor plate and motor neuron differentiation by the amino terminal autoproteolytic fragment of Sonic Hedgehog. Cell. 1995; 81: 445-55.

Fan, C.-M., Porter, J.A., Chiang, C., Chang, D.T., Beachy, P.A., Tessier,-Lavigne, M.. Long range sclerotome induction by Sonic Hedgehog: direct role of the amino-terminal clleavage product and modulation by the cyclic AMP signalling pathway. Cell. 1995; 81: 457-65.

Lopez, A., Chang, D.T., Chiang, C., Porter, J., maria, A.R., Simandl, K., Beachy, P.A., and Fallon, J.F.. Limb patterning activity and restricted posterior localization of the amino terminal product of hedgehog autoproteolysis. Current Biology. 1995; 5: 791-6.

Hynes, M., Porter, J.A., Chiang, C, Chang, D., Tessier-Lavigne, M., Beachy P.A., and Rosenthal, A.. Induction of midbrain dopaminergic neurons product of hedgehog autoproteolysis. Neuron. 1995; 15: 35-44.

Chiang, C., andBeachy, P.A. Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila. Mech. Dev. 1994; 47: 225-39.

Chang, D.T., Lopez, A., von Kessler, D.P., Chiang, C., Simandl, K., Renbin, Z., Seldin, M.F., Fallon, J.F., and Beachy, P.A. Products, genetic linkage, and limb patterning activity of a murine hedgehog gene. Development. 1994; 120: 3339-53.

Chiang, C.,, Patel, N., Young, K., and Beachy, P.A.. The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells. Development. 1994; 120: 3581-93.

Available Postdoctoral Position Details
Posted: 7/27/2016

Highly motivated candidates are sought for postdoctoral fellowship positions in the lab of Dr. Chin Chiang (https://medschool.vanderbilt.edu/chiang-lab/) at Vanderbilt University to study the mechanisms of neurogenesis and tumorigenesis in the brain. The successful candidates are expected to carry out his or her projects independently. Applicants should have a Ph.D. or equivalent degree in biological sciences or related fields. Experience and background in cell/molecular biology techniques and mouse models are desired. In addition, the applicants should have good communication and written skills.

Qualified applicants should submit a cover letter describing previous research experience and current interests, curriculum vitae and contact details of three references to Dr. Chin Chiang by email at chin.chiang@vanderbilt.edu.