John P. Wikswo, Jr., Ph.D.

University Professor

john.p.wikswo@vanderbilt.edu

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Faculty Appointments
Gordon A. Cain University Professor A. B. Learned Professor of Living State PhysicsProfessor of Biomedical EngineeringProfessor of Molecular Physiology and Biophysics
Education
Ph.D., Physics, Stanford University, Stanford, CaliforniaM.S., Physics, Stanford University, Stanford, CaliforniaB.A., Physics, University of Virginia, Charlottesville, Virginia
Office Address
VU Station B 351807
6301 Stevenson Center
Nashville, TN
Research Description
John Wikswo and his group are at present working in three areas: the study of the linear and non-linear electrical properties of cardiac tissue during stimulation, propagation, and recovery for threshold- and defibrillation-strength shocks; the magnetic measurement of cellular action currents in cardiac and intestinal tissue, as can be observed using SQUID magnetometry; and the development and application of micro- and nano-scale devices for instrumenting and controlling the single biological cell and small populations of cells. His long-term program to understand the effects of defibrillation-strength shocks on cardiac tissue now includes studies of charge and electroporation and molecular diffusion. The magnetic studies of action currents range from determining the information content of the magnetocardiogram in isolated rabbit hearts to the non-invasive diagnosis of intestinal ischemia in humans. The project to instrument and control single cells is addressing issues as varied as the use of cells to identify and discriminate chemical and biological warfare agents by metabolic phenotype; the development and application of BioMEMS (BioMicroElectroMechanical Systems) devices to understand the molecular signaling associated with chemotaxis, cellular motility, angiogenesis, and metastasis; and the nature of the signaling and metabolic activity associated with the immune response.
Research Keywords
Development and application of microdevices for instrumenting and controlling single living cells
Publications
J.P. Wikswo and A.P. Porter. "Biology Coming Full Circle: Joining the Whole and the Parts". 2015.

Dukes AD, Samson PC, Keene JD, Davis LM, Wikswo JP, Rosenthal SJ. Single-nanocrystal spectroscopy of white-light-emitting CdSe nanocrystals. J Phys Chem A [print-electronic]. 2011 Apr 4/28/2011; 115(16): 4076-81. PMID: 21338163, DOI: 10.1021/jp1109509, ISSN: 1520-5215.

R.A. Gray and J.P. Wikswo. "Several Small Shocks Beat One Large One". Nature. 2011; 475: 181-2.

J.R. Enders, C.R. Goodwin, C.C. Marasco, K.T. Seale, J.P. Wikswo, and J.A. McLean. "Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles From Haystacks". Current Trends in Mass Spectrometry. 2011.

D.A. Markov, E.M. Lillie, P.C. Samson, J.P. Wikswo, and L.J. McCawley. "Chips & Tips: A Method for Periodic Sterile Sample Collection During Continuous Cell Culture in Microfluidic Devices". Lab Chip. 2010; Published online August 17.

K.T. Seale, S.L. Faley, J. Chamberlain, and J. Wikswo. "Macro to Nano: A Simple Method for Transporting Cultured Cells From Milliliter Scale to Nanoliter Scale". Experimental Biology and Medicine. 2010; 235: 777-83.

J. Greene, J.W. Henderson, Jr., and J.P. Wikswo. "Rapid and Precise Determination of Cellular Amino Acid Flux Rates Using HPLC with Automated Derivatization with Absorbance Detection". 2009.

J.P. Wikswo and B.J. Roth. "Virtual Electrode Theory of Pacing". In Cardiac Bioelectric Therapy: Mechanisms and Practical Implications, I. Efimov, M. Kroll, and P. Tchou, Eds., (Springer). 2009; Chapter 4.3.

K.T. Seale, C. Janetopoulos, and J.P. Wikswo. "Micro-Mirrors for Nanoscale Three-Dimensional Microscopy". ACS Nano. 2009; 3((3)): 493-7.

Holcomb MR, Bekele RY, Lima EA, Wikswo JP. Universal serial bus powered and controlled isolated constant-current physiological stimulator. Rev Sci Instrum. 2008 Dec; 79(12): 126103. PMID: 19123594, PMCID: PMC2736648, DOI: 10.1063/1.3030861, ISSN: 1089-7623.

Sidorov VY, Holcomb MR, Woods MC, Gray RA, Wikswo JP. Effects of unipolar stimulation on voltage and calcium distributions in the isolated rabbit heart. Basic Res. Cardiol [print-electronic]. 2008 Nov; 103(6): 537-51. PMID: 18642125, PMCID: PMC2742888, DOI: 10.1007/s00395-008-0740-1, ISSN: 1435-1803.

Seale KT, Reiserer RS, Markov DA, Ges IA, Wright C, Janetopoulos C, Wikswo JP. Mirrored pyramidal wells for simultaneous multiple vantage point microscopy. J Microsc. 2008 Oct; 232(1): 1-6. PMID: 19017196, PMCID: PMC3789065, PII: JMI2110, DOI: 10.1111/j.1365-2818.2008.02110.x, ISSN: 1365-2818.

Faley S, Seale K, Hughey J, Schaffer DK, VanCompernolle S, McKinney B, Baudenbacher F, Unutmaz D, Wikswo JP. Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Lab Chip [print-electronic]. 2008 Oct; 8(10): 1700-12. PMID: 18813394, PMCID: PMC4160168, DOI: 10.1039/b719799c, ISSN: 1473-0197.

Gruver JS, Wikswo JP, Chung CY. 3'-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis. Biophys. J [print-electronic]. 2008 Oct; 95(8): 4057-67. PMID: 18676656, PMCID: PMC2553113, PII: S0006-3495(08)78543-6, DOI: 10.1529/biophysj.108.130179, ISSN: 1542-0086.

Addae-Mensah KA, Wikswo JP. Measurement techniques for cellular biomechanics in vitro. Exp. Biol. Med. (Maywood) [print-electronic]. 2008 Jul; 233(7): 792-809. PMID: 18445766, PMCID: PMC4156015, PII: 0710-MR-278, DOI: 10.3181/0710-MR-278, ISSN: 1535-3702.

Irimia A, Wikswo JP. Gastrointestinal arrhythmias are associated with statistically significant fluctuations in systemic information dimension. Physiol Meas [print-electronic]. 2008 May; 29(5): N33-40. PMID: 18427160, PII: S0967-3334(08)65429-5, DOI: 10.1088/0967-3334/29/5/N01, ISSN: 0967-3334.

Xu J, Reiserer R, Tellinghuisen J, Wikswo JP, Baudenbacher FJ. A microfabricated nanocalorimeter: design, characterization, and chemical calibration. Anal. Chem [print-electronic]. 2008 Apr 4/15/2008; 80(8): 2728-33. PMID: 18351750, PMCID: PMC4155943, DOI: 10.1021/ac702213d, ISSN: 1520-6882.

Harris MP, Kim E, Weidow B, Wikswo JP, Quaranta V. Migration of isogenic cell lines quantified by dynamic multivariate analysis of single-cell motility. Cell Adh Migr. 2008 Apr; 2(2): 127-36. PMID: 19271355, PMCID: PMC2634586, ISSN: 1933-6926.

Evertson DW, Holcomb MR, Eames MC, Bray MA, Sidorov VY, Xu J, Wingard H, Dobrovolny HM, Woods MC, Gauthier DJ, Wikswo JP. High-resolution high-speed panoramic cardiac imaging system. IEEE Trans Biomed Eng. 2008 Mar; 55(3): 1241-3. PMID: 18334422, PMCID: PMC2561274, DOI: 10.1109/TBME.2007.912417, ISSN: 0018-9294.

Abbas RA, Lin SF, Mashburn D, Xu J, Wikswo JP. A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. IEEE Trans Biomed Eng. 2008 Jan; 55(1): 222-9. PMID: 18232365, PMCID: PMC2742885, DOI: 10.1109/TBME.2007.901039, ISSN: 0018-9294.

B.R. Gorman and J.P. Wikswo. "Characterization of Transport in Microfluidic Gradient Generators". Microfluid Nanofluid. 2008; 4((4)): 273-85.

W. Georgescu, J. Jourquin, L. Estrada, A.R.A. Anderson, V. Quaranta, and J.P. Wikswo. "Model-Controlled Hydrodynamic Focusing to Generate Multiple Overlapping Gradients of Surface-Immobilized Proteins in Microfluidic Devices". Lab Chip. 2008; 8: 238-44.

Y. Liu, J. Sai, A. Richmond, and J. Wikswo. "Microfluidic Switching System for Analyzing Chemotaxis Responses of Wortmannin-Inhibited HL-60 Cells". Biomedical Microdevices. 2008; 10: 499-507.

W. Wang, L.M. Shor, E.J. LeBoeuf, J.P. Wikswo, G.L. Taghon, and D.S. Kosson. "Protozoan Migration in Bent Microfluidic Channels". Applied and Environmental Microbiology. 2008; 74((6)): 1945-9.

J. Sai, D. Raman, Y. Liu, J. Wikswo, and A. Richmond. "Parallel PI3K-Dependent and Src-Dependent Pathways Lead to CXCL8-Mediated Rac2-Activation and Chemotaxis". J. Biological Chemistry. 2008; 283((39)): 26538-47.

S. Huang and J. Wikswo. "Dimensions of Systems Biology". Reviews of Physiology, Biochemistry, and Pharmacology. 2007; 157: 81-104.

K.A. Addae-Mensah, R.S. Reiserer, and J.P. Wikswo. "Poly(Vinyl Alcohol) as a Structure Release Layer for Microfabrication of Polymer Composite Structures". J. Micromech. Microeng. 2007; 17: N41-N46.

K.A. Addae-Mensah, N.J. Kassenbaum, M.J. Bowers II, R.S. Reiserer, S.J. Rosenthal, P.E. Moore, and J.P. Wikswo. "A Flexible, Quantum Dot-Labeled Cantilever Post Array for Studying Cellular Microforces". Sensors and Actuators. 2007; 136: 385-97.

D.N. Mashburn, S.J. Hinkson, M.C. Woods, J.M. Gilligan, M.R. Holcomb, and J.P. Wikswo. "A High Voltage Cardiac Stimulator for Field Shocks of a Whole Heart in a Bath". Rev. Sci. Instrum. 2007; 78: 104302.

S.K. Vajandar, D. Xu, D.A. Markov, J.P. Wikswo, W. Hofmeister, and D. Li. "SiO2-Coated Porous Anodic Alumina Membranes for High Flow Rate Electroosmotic Pumping". Nanotechnology. 2007; 18: 275705.

D.F. Salisbury, A. Price, R.D. Collins, and J.P. Wikswo. "Max at Vanderbilt". Max Delbruck and the New Perception of Biology, 1906-1981: A Centenary Celebration. 2007; University of Salamanca, October 9-10, 2006, W. Shropshire, Jr., Ed. (AuthorHouse, Bloomington, IN).

Woods MC, Sidorov VY, Holcomb MR, Beaudoin DL, Roth BJ, Wikswo JP. Virtual electrode effects around an artificial heterogeneity during field stimulation of cardiac tissue. Heart Rhythm [print-electronic]. 2006 Jun; 3(6): 751-2. PMID: 16731485, PII: S1547-5271(05)02337-4, DOI: 10.1016/j.hrthm.2005.11.003, ISSN: 1547-5271.

S.E. Eklund, J. Wikswo, F. Baudenbacher, A. Prokop, and D.E. Cliffel. "Multianalyte Microphysiometry as a Tool in Metabolomics and Systems Biology". J. Electroanalytical Chemistry. 2006; 587: 333-9.

R.A. Gray, A. Iyer, M.-A. Bray, and J.P. Wikswo. "Voltage-Calcium State-Space Dynamics During Initiation of Reentry". Heart Rhythm. 2006; 3((2)): 247-8.

E. Juzeliunas, Y.P. Ma, and J.P. Wikswo. "Magnetometric Corrosion Sensing Under Hydrodynamic Conditions". J. Solid State Electrochemistry. 2006; 10: 700-7.

R.A. Malkin, D.X. Guan, and J.P. Wikswo. "Experimental Evidence of Improved Transthoracic Defibrillation with Electroporation-Type Pulses". IEEE Trans. BME. 2006; 53(10): 1901-10.

E.A. Lima, A. Irimia, and J.P. Wikswo, Jr. "The Magnetic Inverse Problem". The SQUID Handbook, J. Clarke and A. Braginski, Eds., (Wiley-VCH, Verlag, Berlin). 2006; Vol. 2, Chap. 10.

J. Sai, G. Walker, J. Wikswo, and A. Richmond. "The IL Sequence in the LLKIL Motif in CXCR2 is Required for Full Ligand Induced Activation of Erk, Akt and Chemotaxis in HL60 Cells". J. Biol. Chem. 2006; 281(47): 35931-42.

M.R. Warnement, S.L. Faley, J.P. Wikswo, and S.J. Rosenthal. "Quantum Dot Probes for Monitoring Dynamic Cellular Response: Reporters of T Cell Activation". IEEE Trans. NanoBioscience. 2006; 5(4): 268-72.

Bradshaw LA, Roy OP, O'Mahony GP, Myers AG, McDowell JG, Wikswo JP, Richards WO. Biomagnetic detection of injury currents in rabbit ischemic intestine. Dig. Dis. Sci. 2005 Sep; 50(9): 1561-8. PMID: 16133952, DOI: 10.1007/s10620-005-2898-9, ISSN: 0163-2116.

Wang W, Shor LM, LeBoeuf EJ, Wikswo JP, Kosson DS. Mobility of protozoa through narrow channels. Appl. Environ. Microbiol. 2005 Aug; 71(8): 4628-37. PMID: 16085857, PMCID: PMC1183301, PII: 71/8/4628, DOI: 10.1128/AEM.71.8.4628-4637.2005, ISSN: 0099-2240.

Walker GM, Sai J, Richmond A, Stremler M, Chung CY, Wikswo JP. Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator. Lab Chip [print-electronic]. 2005 Jun; 5(6): 611-8. PMID: 15915253, PMCID: PMC2665276, DOI: 10.1039/b417245k, ISSN: 1473-0197.

Yang Z, Shen W, Rottman JN, Wikswo JP, Murray KT. Rapid stimulation causes electrical remodeling in cultured atrial myocytes. J. Mol. Cell. Cardiol [print-electronic]. 2005 Feb; 38(2): 299-308. PMID: 15698836, PII: S0022-2828(04)00336-0, DOI: 10.1016/j.yjmcc.2004.11.015, ISSN: 0022-2828.

Bradshaw LA, Myers A, Richards WO, Drake W, Wikswo JP. Vector projection of biomagnetic fields. Med Biol Eng Comput. 2005 Jan; 43(1): 85-93. PMID: 15742724, ISSN: 0140-0118.

Holzer JR, Fong LE, Sidorov VY, Wikswo JP, Baudenbacher F. High resolution magnetic images of planar wave fronts reveal bidomain properties of cardiac tissue. Biophys. J [print-electronic]. 2004 Dec; 87(6): 4326-32. PMID: 15377521, PMCID: PMC1304939, PII: S0006-3495(04)73894-1, DOI: 10.1529/biophysj.104.049163, ISSN: 0006-3495.

E. Juzeliũnas, Y.P. Ma, and J.P. Wikswo. "Remote Sensing of Aluminum Alloy Corrosion by SQUID Magnetometry". J. Solid State Electrochem. 2004; 8: 435-41.

E.B. Chancellor, J.P. Wikswo, F. Baudenbacher, M. Radparvar, and D. Osterman. "Heat Conduction Calorimeter for Massively Parallel High Throughput Measurements with Picoliter Sample Volumes". Applied Physics Letters. 2004; 85((12)): 2408-10.

A. Prokop, Z. Prokop, D. Schaffer, E. Kozlov, J.P. Wikswo, D. Cliffel, and F. Baudenbacher. "NanoLiterBioReactor: Monitoring of Long-Term Mammalian Cell Physiology at Nanofabricated Scale". Biomedical Microdevices. 2004; 6((4)): 325-39.

K.R. Cooper, Y. Ma, J.P. Wikswo, and R.G. Kelly. "Simultaneous Monitoring of the Corrosion Activity and Moisture Inside Aircraft Lap Joints". Corrosion Engineering, Science and Technology. 2004; 39((4)): 339-45.

J.P. Wikswo. "SQUIDs Remain Best Tools for Measuring Brains Magnetic Field". Physics Today. 2004; 52((2)): 15-7.

Bray MA, Wikswo JP. Examination of optical depth effects on fluorescence imaging of cardiac propagation. Biophys. J. 2003 Dec; 85(6): 4134-45. PMID: 14645100, PMCID: PMC1303712, PII: S0006-3495(03)74825-5, DOI: 10.1016/S0006-3495(03)74825-5, ISSN: 0006-3495.

Sidorov VY, Aliev RR, Woods MC, Baudenbacher F, Baudenbacher P, Wikswo JP. Spatiotemporal dynamics of damped propagation in excitable cardiac tissue. Phys. Rev. Lett [print-electronic]. 2003 Nov 11/14/2003; 91(20): 208104. PMID: 14683402, DOI: 10.1103/PhysRevLett.91.208104, ISSN: 0031-9007.

Bradshaw LA, Myers AG, Redmond A, Wikswo JP, Richards WO. Biomagnetic detection of gastric electrical activity in normal and vagotomized rabbits. Neurogastroenterol. Motil. 2003 Oct; 15(5): 475-82. PMID: 14507349, PII: 432, ISSN: 1350-1925.

Bray MA, Wikswo JP. Interaction dynamics of a pair of vortex filament rings. Phys. Rev. Lett [print-electronic]. 2003 Jun 6/13/2003; 90(23): 238303. PMID: 12857294, DOI: 10.1103/PhysRevLett.90.238303, ISSN: 0031-9007.

Sidorov VY, Woods MC, Wikswo JP. Effects of elevated extracellular potassium on the stimulation mechanism of diastolic cardiac tissue. Biophys. J. 2003 May; 84(5): 3470-9. PMID: 12719272, PMCID: PMC1302903, PII: S0006-3495(03)70067-8, DOI: 10.1016/S0006-3495(03)70067-8, ISSN: 0006-3495.

Ladipo JK, Seidel SA, Bradshaw LA, Halter S, Wikswo JP, Richards WO. Histopathologic changes during mesenteric ischaemia and reperfusion. West Afr J Med. 2003 Jan; 22(1): 59-62. PMID: 12769310, ISSN: 0189-160X.

L.A. Bradshaw, A.G. Myers, J.P. Wikswo, Jr., and W.O. Richards. "A SpatioTemporal Dipole Simulation of Gastriointestinal Magnetic Fields". IEEE Trans. Biomed. Engr. 2003; 50((7)): 836-47.

S.E. Eklund, D.E. Cliffel, E. Kozlov, A. Prokop, J. Wikswo, and F. Baudenbacher. "Modification of the CytosensorTM Microphysiometer to Simultaneously Measure Extracellular Acidification and Oxygen Consumption Rates". Analytica Chimica Acta. 2003; 496: 93-101.

Bray MA, Wikswo JP. Considerations in phase plane analysis for nonstationary reentrant cardiac behavior. Phys Rev E Stat Nonlin Soft Matter Phys [print-electronic]. 2002 May; 65(5 Pt 1): 51902. PMID: 12059588, DOI: 10.1103/PhysRevE.65.051902, ISSN: 1539-3755.

F. Baudenbacher, N.T. Peters, P. Baudenbacher, and J.P. Wikswo. "High Resolution Imaging of Biomagnetic Fields Generated by Action Currents in Cardiac Tissue Using a LTS-SQUID Microscope". Physica C. 2002; 368: 24-31.

F. Baudenbacher, N.T. Peters, and J.P. Wikswo, Jr. "High Resolution Low-Temperature Superconductivity SQUID Microscopes for Imaging Magnetic Fields of Samples at Room Temperature". Rev. Sci. Instrum. 2002; 73((3)): 1247-54.

M.-A. Bray and J.P. Wikswo. "Use of Topological Charge to Determine Singularity and Filament Location in a Numerical Model of Scroll Wave Activity". IEEE Trans. BME. 2002; 49((10)): 1086-93.

Y.P. Ma, J.P. Wikswo, M. Samuleviiene, K. Leinartas, and E. Juzeliunas. "Magnetic Fields Induced by Electrochemical Reactions: Aluminum Alloy Corrosion Sensing by SQUID Magnetometry on a Macroscopic Scale". J. Phys. Chem. B. 2002; 106((48)): 12549-55.

M.-A. Bray and J.P. Wikswo, Jr. "Three-Dimensional Visualization of Phase Singularities on the Isolated Rabbit Heart". J. Cardiovas. Electrophysiol. 2002; 13((12)): 1311.

G. Choudhury, W.G. Jenks, J.P. Wikswo, Jr., and C.G. Bublitz. "Effects of Parasite Attributes and Injected Current Parameters on Electromagnetic Detection of Parasites in Fish Muscle". J. Food Science: Food Engineering and Physical Properties. 2002; 67((9)): 3381-7.

L.A. Bradshaw, W.O. Richards, and J.P. Wikswo, Jr. "Volume Conductor Effects on the Spatial Resolution of Magnetic Fields and Electric Potentials from Gastrointestinal Electrical Activity". Med. Biol. Eng. Comput. 2001; 39: 35-43.

L.A. Bradshaw and J.P. Wikswo, Jr. "Spatial Filter Approach for Evaluation of the Surface Laplacian of the Electroencephalogram and Magnetoencephalogram". Annals of Biomed. Eng. 2001; 29: 202-13.

L.A. Bradshaw, R.S. Wijesinghe, and J.P. Wikswo, Jr. "Spatial Filter Approach for Comparison of the Forward and Inverse Problems of Electroencephalography and Magnetoencephalography". Annals of Biomed. Eng. 2001; 29: 214-26.

K.K. Parker, L.K. Taylor, J.B. Atkinson, D.E. Hansen, and J.P. Wikswo, Jr. "The Effects of Tubulin-Binding Agents on Stretch-Induced Ventricular Arrhythmias". European Journal of Pharmacology. 2001; 417: 131-40.

M.-A. Bray, S.-F.Lin, R.R. Aliev, B.J. Roth, and J.P. Wikswo, Jr. "Experimental and Theoretical Analysis of Phase Singularity Dynamics in Cardiac Tissue". J. Cardiovasc. Electrophysiol. 2001; 12: 716-22.

B.P. Weiss, F.J. Baudenbacher, J.P. Wikswo, and J.L. Kirschvink. "Magnetic Microscopy Promises a Leap in Sensitivity and Resolution". EoS. 2001; 82: 513-8.

S.-F. Lin and J.P. Wikswo, Jr. "New Perspectives in Electrophysiology from the Cardiac Bidomain". In: Optical Mapping of Cardiac Excitation and Arrhythmias. 2001; D.S. Rosenbaum and J. Jalife, Eds.,((Futura Publishing Co., Inc., New York, Chapter 19)).

R.R. Aliev, W.O. Richards, and J.P. Wikswo, Jr. "A Simple Non-Linear Model of Electrical Activity in the Intestine". J. Theor. Biology. 2000; 204: 21-8.

M.-A. Bray, S.-F. Lin, and J.P. Wikswo, Jr. "Three-Dimensional Surface Reconstruction and Fluorescent Visualization of Cardiac Activation". IEEE Trans. BME. 2000; 47((10)): 1382-91.

B.P. Weiss, J.L. Kirschvink F.J. Baudenbacher, H. Vali, N.T. Peters, F.A. Macdonald, and J.P. Wikswo, Jr. "A Low-Temperature Transfer of ALH84001 from Mars to Earth". Science. 2000; 290((5492)): 791-5.

G. Skennerton, A. Abedi, R.G. Kelly, and J.P. Wikswo, Jr. "Magnetic Measurements of the Response of Corrosion Activity within Aircraft Lap Joints to Accelerated Corrosion Testing". J. Corrosion Science and Engr., on http:// www.cp.umist.ac.uk/jcse/vol3/paper2/v3p2.html. 2000.

J. Wu, D.M. Roden, and J.P. Wikswo, Jr. "Delayed Activation and Retrograde Propagation in Cardiac Muscle: Implication of Virtual Electrode Effects". Annals of Biomed. Eng. 2000; 28: 1318-25.

J.P. Wikswo. "Applications of SQUID Magnetometers to Biomagnetism and Nondestructive Evaluation". In: Applications of Superconductivity. 2000; H. Weinstock, Ed.,((Kluwer Academic Publishers, The Netherlands)).

Bradshaw LA, Ladipo JK, Staton DJ, Wikswo JP, Richards WO. The human vector magnetogastrogram and magnetoenterogram. IEEE Trans Biomed Eng. 1999 Aug; 46(8): 959-70. PMID: 10431461, ISSN: 0018-9294.

S.F. Lin, B.J. Roth, and J.P. Wikswo, Jr. "Quatrefoil Reentry in Myocardium: An Optical Imaging Study of the Induction Mechanism". J. Cardiovasc. Electrophysiol. 1999; 10: 574-86.

S.F. Lin and J.P. Wikswo, J. "Panoramic Optical Imaging of Electrical Propagation in Isolated Heart". J. Biomed. Opt. 1999; 4((2)): 200-7.

T.A. Cruse, A.P. Ewing, and J.P. Wikswo, Jr. "Green's Function Formulation of Laplace's Equation for Electromagnetic Crack Detection". Computational Mechanics. 1999; 23((5/6)): 420-9.

S.A. Seidel, L.A. Bradshaw, J.K. Ladipo, J.P. Wikswo, Jr., and W.O. Richards. "Noninvasive Detection of Ischemic Bowel". J. Vascular Surgery. 1999; 30((2)): 309-19.

A. Abedi, J.J. Fellenstein, A.J. Lucas, and J.P. Wikswo, Jr. "A SQUID Magnetometer System for Quantitative Analysis and Imaging of Hidden Corrosion Activity in Aircraft Aluminum Structures". Rev. Sci. Instrum. 1999; 70((12)): 4640-51.

J.R. Kirtley and J.P. Wikswo, Jr. "Scanning SQUID Microscopy". Annu. Rev. Mater. Sci. 1999; 29: 117-48.

B.J. Roth, S.-F. Lin, and J.P. Wikswo, Jr. "Unipolar Stimulation of Cardiac Tissue". J. Electrocardiol. 1998; 31: 6-12.

B.J. Roth and J.P. Wikswo. "Comments on 'Hall-Effect Imaging'". IEEE Trans. BME. 1998; 45((10)): 1294-6.

S.H. Allos, D.J. Staton, L.A. Bradshaw, S. Halter, J.P. Wikswo, Jr., and W.O. Richards. "Superconducting Quantum Interference Device Magnetometer for Diagnosis of Ischemia Caused by Mesenteric Venous Thrombosis". World J. Surg. 1997; 21: 173-8.

S.F. Lin, R.A. Abbas, and J.P. Wikswo, Jr. "High-Resolution High-Speed Synchronous Epifluorescence Imaging of Cardiac Activation". Rev. Sci. Instr. 1997; 68((1)): 213-7.

D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Detection of Hidden Corrosion of Aircraft Aluminum Alloys by Magnetometry Using a Superconducting Quantum Interference Device". Corrosion. 1997; 53((2)): 93-8.

L.A. Bradshaw, S.H. Allos, J.P. Wikswo, Jr., and W.O. Richards. "Correlation and Comparison of Magnetic and Electric Detection of Small Intestinal Electrical Activity". Am. J. Physiol. 1997; 272: G1159-G1167.

K.K. Parker and J.P. Wikswo, Jr. "A Model of the Magnetic Fields Created by Single Motor Unit Compound Action Potentials in Skeletal Muscle". IEEE Trans. Biomed. Eng. 1997; 44((10)): 948-57.

J. Wu and J.P. Wikswo. "Effects of Bath Resistance on Action Potentials in the Squid Giant Axon: Myocardial Implications". Biophys. J. 1997; 73: 2347-58.

W.G. Jenks, I.M. Thomas, and J.P. Wikswo, Jr. "SQUIDs". Encyclopedia of Applied Physics. 1997; G.L. Trigg, E.S. Vera, and W. Greulich, Eds.,((VCH Publishers, Inc., New York, NY)).

W.G. Jenks, S.S.H. Sadeghi, and J.P. Wikswo, Jr. "SQUIDs for Non-Destructive Evaluation". J. Physics D: Applied Physics. 1997; 30((3)): 293-323.

S. Tan, Y.P. Ma, I.M. Thomas, and J.P. Wikswo, Jr. "Reconstruction of Two-Dimensional Magnetization and Susceptibility Distributions from the Magnetic Field of Soft Magnetic Materials". IEEE Trans. Mag. 1996; 32((1)): 230-4.

N.G. Sepulveda and J.P. Wikswo, Jr. "A Numerical Study of the Use of Magnetometers to Detect Hidden Flaws in Conducting Objects". J. Applied Physics. 1996; 79((4)): 2122-35.

D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Application of Superconducting Magnetometry in the Study of Aircraft Aluminum Alloy Corrosion". Corrosion. 1996; 52((3)): 219-31.

P.H. Bunton, W.P. Henry, and J.P. Wikswo, Jr. "A Simple Integrated Circuit Model of Propagation Along an Excitable Axon". Am. J. Phys. 1996; 64((5)): 602-6.

W.G. Jenks, C.G. Bublitz, G.S. Choudhury, Y.P. Ma, and J.P. Wikswo, Jr. "Detection of Parasites in Fish by Superconducting Quantum Interference Device Magnetometry". Journal of Food Science. 1996; 61((5)): 865-9.

W.O. Richards, L.A. Bradshaw, D.J. Staton, C.L. Garrard, F. Liu, S. Buchanan, and J.P. Wikswo, Jr. "Magnetoenterography (MENG): Noninvasive Measurement of Bioelectric Activity in Human Small Intestine". Digestive Diseases and Sciences. 1996; 41((12)): 2293-301.

B.J. Roth and J.P. Wikswo, Jr. "The Effect of Externally Applied Electrical Fields on Myocardial Tissue". Proceedings of the IEEE. 1996; 84: 379-91.

J.P. Wikswo, Jr. "High-Resolution Magnetic Imaging: Cellular Action Currents and Other Applications". In: SQUID Sensors: Fundamentals, Fabrication and Applications. 1996; H. Weinstock, Ed.,((Kluwer Academic Publishers, The Netherlands)).

J.P. Wikswo, Jr. "The Magnetic Inverse Problem". In: SQUID Sensors: Fundamentals, Fabrication and Applications. 1996; H. Weinstock, Ed.,((Kluwer Academic Publishers, The Netherlands)).

W.O. Richards, C.L. Garrard, S.H. Allos, L.A. Bradshaw, D.J. Staton, and J.P. Wikswo, Jr. "Noninvasive Diagnosis of Mesenteric Ischemia Using a SQUID Magnetometer". Annals of Surgery. 1995; 221((6)): 696-705.

D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Detecting In-Situ Active Corrosion by a SQUID Magnetometer". Journal of Minerals, Metals, and Materials. 1995; 47((9)): 36-9.

S. Tan, N.G. Sepulveda, and J.P. Wikswo, Jr. "A New Finite-Element Approach to Reconstruct a Bounded and Discontinuous Two-Dimensional Current Image From a Magnetic Field Map". J. Comp. Phys. 1995; 122: 150-64.

Y.P. Ma and J.P. Wikswo, Jr. "Techniques for Depth-Selective, Low-Frequency Eddy Current Analysis for SQUID-Based Non-Destructive Testing". J. Nondestr. Eval. 1995; 14((3)): 149-67.

J.P. Wikswo, Jr., S.F. Lin, and R.A. Abbas. "Virtual Electrodes in Cardiac Tissue: A Common Mechanism for Anodal and Cathodal Stimulation". Biophys. J. 1995; 69: 2195-210.

N.G. Sepulveda and J.P. Wikswo, Jr. "Line Follower for Finite Element Post-Processing and Current Imaging". Communications in Numerical Methods and Engineering. 1995; 11: 1025-32.

J.P. Wikswo, Jr. "SQUID Magnetometers for Biomagnetism and Non-Destructive Testing: Important Questions and Initial Answers". IEEE Trans. on Applied Supercond. 1995; 5((2)): 74-120.

J.P. Wikswo, Jr. "Tissue Anisotropy, the Cardiac Bidomain and the Virtual Cathode Effect". In: Cardiac Electrophysiology: From Cell to Bedside, Second Edition, D.P. Zipes and J. Jalife, Eds. 1995; ((W.B. Sauders, Orlando)): 348-61.

Wikswo JP. The complexities of cardiac cables: virtual electrode effects. Biophys. J. 1994 Mar; 66(3 Pt 1): 551-3. PMID: 8011888, PMCID: PMC1275753, ISSN: 0006-3495.

B.J. Roth, P.J. Basser and J.P. Wikswo, Jr. "A Theoretical Model of Magneto-Acoustic Imaging of Bioelectric Currents". IEEE Trans. Biomed. Eng. 1994; 41((8)): 723-8.

B.J. Roth and J.P. Wikswo, Jr. "Electrical Stimulation of Cardiac Tissue: A Bidomain Model With Active Membrane Properties". IEEE Trans. Biomed. Eng. 1994; 41((3)): 232-40.

N.G. Sepulveda and J.P. Wikswo, Jr. "Bipolar Stimulation of Cardiac Tissue Using an Anisotropic Bidomain Model". J. Cardiovasc. Electrophys. 1994; 5((3)): 258-67.

J.P. Barach and J.P. Wikswo, Jr. "Magnetic Fields From Simulated Cardiac Action Currents". IEEE Trans. Biomed. Eng. 1994; 41: 969-74.

J. Golzarian, D.J. Staton, J.P. Wikswo, Jr., R.N. Friedman, and W.O. Richards. "Diagnosing Intestinal Ischemia Using a Noncontact Superconducting Quantum Interference Device". Am. J. Surgery. 1994; 167: 586-92.

N.G. Sepulveda, I.M. Thomas, and J.P. Wikswo, Jr. "Magnetic Susceptibility Tomography for Three-Dimensional Imaging of Diamagnetic and Paramagnetic Objects". IEEE Trans. Mag. 1994; 30((6)): 5062-9.

J.P. Wikswo, Jr. and S.J. Williamson. "Biomagnetism". 1994 McGraw-Hill Yearbook of Science & Technology. 1994; ((McGraw-Hill, Inc., New York)).

Wikswo JP, Gevins A, Williamson SJ. The future of the EEG and MEG. Electroencephalogr Clin Neurophysiol. 1993 Jul; 87(1): 1-9. PMID: 7687949, ISSN: 0013-4694.

J.P. Wikswo, Jr., D.B. Crum, W.P. Henry, Y.P. Ma, N.G. Sepulveda, and D.J. Staton. "An Improved Method for Magnetic Identification and Localization of Cracks in Conductors". J. Nondestr. Eval. 1993; 12((2)): 109-19.

J.M. van Egeraat and J.P. Wikswo, Jr. "A Model for Axonal Propagation Incorporating Both Radial and Axial Ionic Transport". Biophys. J. 1993; 64: 1287-98.

J.M. van Egeraat, R. Stasaski, J.P. Barach, R.N. Friedman, and J.P. Wikswo, Jr. "The Biomagnetic Signature of a Crushed Axon: A Comparison of Theory and Experiment". Biophys. J. 1993; 64: 1299-305.

D.C. Hurley, Y.P. Ma, S. Tan, and J.P. Wikswo, Jr. "Imaging of Small Defects in Nonmagnetic Tubing Using a SQUID Magnetometer". Res. Nondestr. Eval. 1993; 5: 1-29.

I.M. Thomas, S.M. Freake, S.J. Swithenby, and J.P. Wikswo, Jr.. "A Distributed Quasi-static Ionic Current Source in the 3-4 Day Old Chicken Embryo". Phys. Med. Biol. 1993; 38: 1311-28.

S.F. Lin, R.A. Abbas, and J.P. Wikswo. "Magnetic Locailization of the Origin of Self-Sustained Oscillation in SQUID Giant Axons". Biol. Bull. 1993; 185: 300-1.

J.P. Barach and J.P. Wikswo, Jr. "A Numerical Reconstruction of the Effects of Late Stimulation on a Cardiac Ventricular Action Potential". Comp. & Biomed. Res. 1992; 25: 212-7.

J. Turgeon, T.A. Wisialowski, W. Wong, W.A. Altemeier, J.P. Wikswo, Jr., and D.M. Roden. "Suppression of Longitudinal Versus Transverse Conduction by Sodium Channel Block: Effects of Sodium Bolus". Circulation. 1992; 85: 2221-6.

N.G. Sepulveda, D.J. Staton, and J.P. Wikswo, Jr. "A Mathematical Analysis of the Magnetic Field Produced By Flaws in Two-Dimensional Current-Carrying Conductors". J. Nondestr. Eval. 1992; 11((2)): 89-101.

I.M. Thomas, T.C. Moyer, and J.P. Wikswo, Jr. "High Resolution Magnetic Susceptibility Imaging of Geological Thin Sections: Pilot Study of a Pyroclastic Sample from the Bishop Tuff". Geophys. Res. Letters. 1992; 19((21)): 2139-42.

J.P. Wikswo, Jr. and S.J. Williamson. "Magnetic Source Imaging: Cell, Tissue, and Brain". In: Physics News in 1991, P.F. Schewe, Ed. 1992; ((American Institute of Physics, New York)).

D.J. Staton, Y.P. Ma, N.G. Sepulveda, and J.P. Wikswo, Jr. "High-Resolution Magnetic Mapping Using a SQUID Magnetometer Array". IEEE Trans. Mag. 1991; MAG-27((2)): 3237-40.

R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle I: The Forward Calculation". Annals of Biomed. Eng. 1991; 19: 43-72.

R.S. Wijesinghe and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle II: A Sensitivity Analysis of Model Parameters for the Forward and Inverse Calculations". Annals of Biomed. Eng. 1991; 19: 73-96.

J.P. Wikswo, Jr., W. Altemeier, J.R. Balser, H.A. Kopelman, T. Wisialowski, and D.M. Roden. "Virtual Cathode Effects During Stimulation of Cardiac Muscle: Two-Dimensional In Vivo Measurements". Circ. Res. 1991; 68: 513-30.

J.P. Barach and J.P. Wikswo, Jr. "The Effect of Action Potential Propagation on a Numerical Simulation of a Cardiac Fiber Subjected to Secondary External Stimulus". Comp. & Biomed. Res. 1991; 24: 435-52.

Y.P. Ma and J.P. Wikswo, Jr. "Magnetic Shield for Wide-Bandwidth Magnetic Measurements for Nondestructive Testing and Biomagnetism". Rev. Sci. Instr. 1991; 62((11)): 2654-61.

F.L.H. Gielen, R.N. Friedman, and J.P. Wikswo, Jr. "In Vivo Magnetic and Electric Recordings from Nerve Bundles and Single Motor Units in Mammalian Skeletal Muscle: Correlations with Muscle Force". J. Gen. Physiol. 1991; 98: 1043-61.

J.P. Wikswo, Jr. and J.M. vanEgeraat. "Cellular Magnetic Fields: Fundamental and Applied Measurements on Nerve Axons, Peripheral Nerve Bundles, and Skeletal Muscle". J. Clin. Neurophysiology. 1991; 8((2)): 170-88.

R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle III: A Comparison of the Conduction Velocity Distributions Calculated from Compound Action Currents and Potentials". Annals of Biomed. Eng. 1991; 19: 97-121.

J.M. van Egeraat, R.N. Friedman, and J.P. Wikswo, Jr. "Magnetic Field of a Single Muscle Fiber: First Measurements and a Core Conductor Model". Biophys. J. 1990; 57: 663-7.

N.G. Sepulveda, J.P. Wikswo, Jr., and D.S. Echt. "Finite Element Analysis of Cardiac Defibrillation Current Distributions". IEEE Trans. Biomed. Eng. 1990; 37: 354-65.

B.J. Roth and J.P. Wikswo, Jr. "Apodized Pickup Coils for Improved Spatial Resolution of SQUID Magnetometers". Rev. Sci. Instr. 1990; 61: 2439-48.

J.P. Wikswo, Jr. "Biomagnetic Sources and Their Models". 1990; S.J. Williamson, M. Hoke, G. Stroink, and M. Kotani, Eds.,((Plenum, New York)).

S. Tan, B.J. Roth, and J.P. Wikswo, Jr. "The Magnetic Field of Cortical Current Sources: The Application of a Spatial Filtering Model to the Forward and Inverse Problem". Electroencep. and Clin. Neurophys. 1990; 76: 73-85.

B.J. Roth, N.G. Sepulveda, and J.P. Wikswo, Jr. "Using a Magnetometer to Image a Two-dimensional Current Distribution". J. Appl. Phys. 1989; 65: 361-72.

N.G. Sepulveda, B.J. Roth, and J.P. Wikswo, Jr. "Current Injection into a Two-Dimensional Anisotropic Bidomain". Biophys. J. 1989; 55: 987-99.

J.P. Wikswo, Jr. "A Review of Intermediate Physics for Medicine and Biology by R.K. Hobbie". Physics Today. 1989; ((42)): 75-6.

B.J. Roth and J.P. Wikswo, Jr. "Longitudinal Resistance in Cardiac Muscle and its Effects on Propagation". Cell Interactions and Gap Junctions. 1989; N. Sperelakis and W.C. Cole, Eds.,((CRC Press, Boca Raton)).

J.P. Wikswo, Jr. and B.J. Roth. "Magnetic Determination of the Spatial Extent of a Single Cortical Current Source: A Theoretical Analysis". Electroenceph. and Clin. Neurophys. 1988; 69: 266-76.

B.J. Roth, F.L.H. Gielen, and J.P. Wikswo, Jr. "Spatial and Temporal Frequency-Dependent Conductivities in Volume Conduction Calculations of Skeletal Muscle". Mathematical Biosciences. 1988; 88: 159-89.

B.J. Roth, W.-Q. Guo, and J.P. Wikswo, Jr. "The Effects of Spiral Anisotropy on the Electric Potential and the Magnetic Field at the Apex of the Heart". Mathematical Biosciences. 1988; 88: 191-221.

R. Maniewski, T. Katila, T. Poutanen, P. Siltanen, T. Varpula, and J.P. Wikswo, Jr. "Magnetic Measurements of Cardiac Mechanical Activity". IEEE Trans. Biomed. Eng. 1988; 35: 662-70.

J.P. Barach and J.P. Wikswo, Jr. "Computer Simulation of Action Potential Propagation in Septated Nerve Fibers". Biophys. J. 1987; 51: 177-83.

N.G. Sepulveda and J.P. Wikswo, Jr. "Electric and Magnetic Fields from Two-Dimensional Anisotropic Bisyncytia". Biophys. J. 1987; 51: 557-68.

A.K. Bajaj, H.A. Kopelman, J.P. Wikswo, Jr., F. Cassidy, R.L. Woosley, and D.M. Roden. "Frequency- and Orientation-Dependent Effects of Mexiletine and Quinidine on Conduction in the Intact Dog Heart". Circulation. 1987; 75: 1065-73.

M.C. Leifer, J.P. Wikswo, Jr., J. Griffin, W.M. Barry, and D.C. Harrison. "The Effects of the Heart-Lung Boundary on the Magnetocardiogram". J. Electrocard. 1986; 19: 23-32.

B.J. Roth and J.P. Wikswo, Jr. "A Bi-Domain Model for the Extracellular Potential and Magnetic Field of Cardiac Tissue". IEEE Trans. Biomed. Eng. 1986; BME-33: 467-9.

F.L.H. Gielen, B.J. Roth, and J.P. Wikswo, Jr. "Capabilities of a Toroid-Amplifier System for Magnetic Measurement of Current in Biological Tissue". IEEE Trans. Biomed. Eng. 1986; BME-33: 910-21.

B.J. Roth and J.P. Wikswo, Jr. "Electrically-Silent Magnetic Fields". Biophys. J. 1986; 50: 739-45.

V.R. Hentz, J.P. Wikswo, Jr., and G.S. Abraham. "Magnetic Measurements of Nerve Action Current: A New Intraoperative Technique". Peripheral Nerve Repair and Regeneration. 1986; 1: 27-36.

J.P. Barach, B.J. Roth, and J.P. Wikswo, Jr. "Magnetic Measurement of Action Currents in a Single Nerve Axon: A Core Conductor Model". IEEE Trans. Biomed. Eng. 1985; BME-32: 136-40.

J.P. Wikswo, Jr. and K.R. Swinney. "Scalar Multipole Expansions and Their Dipole Equivalents". J. Appl. Phys. 1985; 57: 4301-8.

J.E. Barnhill, J.P. Wikswo, Jr., A.K. Dawson, S. Gundersen, R.M.S. Robertson, D. Robertson, R. Virmani, and R.F. Smith. "The QRS Complex During Transient Myocardial Ischemia: Studies in Patients with Variant Angina Pectoris and in a Canine Preparation". Circulation. 1985; 71((5)): 901-11.

B.J. Roth and J.P. Wikswo, Jr. "The Magnetic Field of a Single Axon: A Comparison of Theory and Experiment". Biophys. J. 1985; 48: 93-109.

D.P. Russell and J.P. Wikswo, Jr. "Optimisation of State Selection and Focusing of a Neutral Atomic Hydrogen Beam by a Hexapole Magnet". J. Physics. 1985; 18: 933-40.

J.K. Woosley, B.J. Roth, and J.P. Wikswo, Jr. "The Magnetic Field of a Single Nerve Axon: A Volume Conductor Model". Mathematical Biosciences. 1985; 76: 1-36.

B.J. Roth and J.P. Wikswo, Jr. "The Electrical Potential and the Magnetic Field of an Axon in a Nerve Bundle". Mathematical Biosciences. 1985; 76: 37-57.

J.A. Freeman, P.B. Manis, G.J. Snipes, B.N. Mayes, P.C. Samson, J.P. Wikswo, Jr., and D.B. Freeman. "Steady Growth Cone Currents Revealed by a Novel Circularly Vibrating Probe: A Possible Mechanism Underlying Neurite Growth". In: Biology of the Nerve Growth Cone. S.B. Kater and P. Letourneau, Eds., J. Neuroscience Res. 1985; (Special Monongraph), pp. 26-38 (1984).

J.P. Wikswo, Jr. and K.R. Swinney. "A Comparison of Scalar Multipole Expansions". J. Appl. Phys. 1984; 56: 3039-49.

R.F. Smith, J.E. Barnhill, and J.P. Wikswo, Jr. "Early Use of Timolol in Acute Myocardial Infarction". N. England J. Med. 1984; 310: 1667.

J.P. Wikswo, Jr., P.C. Samson, and R.P. Giffard. "A Low-Noise, Low Input Impedance Amplifier for Magnetic Measurements of Nerve Action Currents". IEEE Trans. Biomed. Eng. 1983; BME-30: 215-21.

M.C. Leifer and J.P. Wikswo, Jr. "Optimization of a SQUID Clip-On Current Probe". Rev. Sci. Instr. 1983; 54: 1017-22.

J.P. Wikswo, Jr. "Theoretical Aspects of the ECG-MCG Relationship". In: Biomagnetism, An Interdisciplinary Approach. 1983; S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds.,((Plenum, New York)).

J.P. Wikswo, Jr. "Cellular Action Currents". In: Biomagnetism, An Interdisciplinary Approach. 1983; S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds.,((Plenum, New York)).

J.P. Wikswo, Jr. and J.P. Barach. "Possible Sources of New Information in the Magnetocardiogram". J. Theoretical Biol. 1982; 95: 721-9.

J.P. Wikswo, Jr. "Improved Instrumentation for Measuring the Magnetic Field of Cellular Action Currents". Rev. Sci. Instr. 1982; 53: 1846-50.

L.J. Schaad, B.A. Hess, J.P. Wikswo, Jr., and W.M. Fairbank. "Quark Chemistry". Phys. Rev. A. 1981; 23: 1600-7.

J.P. Wikswo, Jr., S.C. Gundersen, W. Murphy, A.K. Dawson, and R.F. Smith. "Sequential QRS Vector Subtractions in Acute Myocardial Infarction in Humans". Circ. Res. 1981; 49: 1055-62.

J.P. Wikswo, Jr., J.E. Opfer, and W.M. Fairbank. "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Experiment". Medical Physics. 1980; 7: 307-14.

J.P. Wikswo, Jr., J.P. Barach, and J.A. Freeman. "Magnetic Field of a Nerve Impulse: First Measurements". Science. 1980; 208: 53-5.

J.P. Wikswo, Jr. and J.P. Barach. "An Estimate of the Steady Magnetic Field Strength Required to Influence Nerve Conduction". IEEE Trans. Biomed. Eng. 1980; BME-27: 722-3.

J.P. Barach, J.A. Freeman and J.P. Wikswo, Jr. "Experiments on the Magnetic Field of Nerve Action Potentials". J. Appl. Phys. 1980; 51: 4532-8.

K.R. Swinney and J.P. Wikswo, Jr. "A Calculation of the Magnetic Field of a Nerve Action Potential". Biophys. J. 1980; 32: 719-32.

J.P. Wikswo, Jr. "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Theory". Medical Physics. 1980; 7: 297-306.

J.P. Wikswo, Jr., J.A.V. Malmivuo, W.H. Barry, M.C. Leifer, and W.M. Fairbank. "Theory and Application of Magnetocardiography". In: Cardiovascular Physics. 1979; D.N. Ghista, E. Van Vollenhoven, and W. Yang, Eds.,((Karger, Basil)).

J.P. Wikswo, Jr. "The Calculation of the Magnetic Field from a Current Distribution: Application to Finite Element Techniques". IEEE Trans. Mag. 1978; MAG-14: 1076-7.

J.A.V. Malmivuo, J.P. Wikswo, Jr., W.H. Barry, D.C. Harrison, and W.M. Fairbank. "Consistent System of Rectangular and Spherical Co-ordinates for Electrocardiography and Magnetocardiography". Med. Biol. Eng. and Comput. 1977; 15: 413-5.

J.A.V. Malmivuo and J.P. Wikswo, Jr. "A New Practical Lead System for Vector Magnetocardiography". Proc. IEEE. 1977; 65: 809-11.

W.H. Barry, D.C. Harrison, W.M. Fairbank, K. Lehrman, J.A.V. Malmivuo, and J.P. Wikswo, Jr. "Measurement of the Human Magnetic Heart Vector". Science. 1977; 198: 1159-62.

R.D. Sandell, J.P. Wikswo, Jr., J.M. Pickler, and B.S. Deaver, Jr. "Quantized Fluctuations in the Josephson Oscillations of a Shunted Superconducting Point Contact". J. Appl. Phys. 1973; 44: 3312-8.

S. Chowdhury, P. Svec, C. Wang, K. Seale, J.P. Wikswo, W. Losert, and S.K. Gupta. "Automated Cell Transport in Optical Tweezers-Assisted Microfluidic Chambers".

R.A. Gray, D.N. Mashburn, V.Y. Sidorov, and J.P. Wikswo. "Quantification of Transmembrane Currents During Action Potential Propagation in the Heart".

J.P. Wikswo, F.E. Block III, D.E. Cliffel, C.R. Goodwin, C.C. Marasco, D.A. Markov, D.L. McLean, J.A. McLean, J.R. McKenzie, R.S. Reiserer, P.C. Samson, D.K. Schaffer, K.T. Seale, and S.D. Sherrod. "Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems".

B. He, R. Baird, R. Butera, A. Datta, S. George, B. Hecht, A. Hero, G. Lazzi, R.C. Lee, J. Liang, M. Neuman, G. Peng, E. Perreault, M. Ramasubramanian, M. Wang, J. Wikswo, G.-Z. Yang, and Y.-T. Zhang. "Grand Challenges in Interfacing Engineering with Life Sciences and Medicine".

K. Hines, S. Ashfaq, J. Davidson, S. Opalenik, J. Wikswo, and J. McLean. "Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry".

J. Deng, A. Dhummakupt, P. Samson, J. Wikswo, and L. Shor. "Dynamic Dosing Assay Relating Real-Time Respiration Responses of Staphylococcus aureus Biofilms to Changing Micro-Chemical Conditions".

J.P. Wikswo, E.L. Curtis, Z.E. Eagleton, B.C. Evans, A. Kole, L.H. Hofmeister, and W.J. Matloff. "Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip".

R.A. Gray, D.N. Mashburn, V.Y. Sidorov, B.J. Roth, P. Pathmanathan, and J.P. Wikswo. "Transmembrane Current Imaging in the Heart During Pacing and Fibrillation".

Y. Yan, L. Jiang, K.J. Aufderheide, G.A. Wright, A. Terekhov, L. Costa, K. Qin, W.T. McCleery, J.J. Fellenstein, A. Ustione, J.B. Robertson, C.H. Johnson, D.W. Piston, M.S. Hutson, J.P. Wikswo, W. Hofmeister, and C. Janetopoulos. "A Microfluidic-Enabled Mechanical Microcompressor for the Immobilization of Live Single- and Multi-Cellular Specimens".

M.S. Shotwell, K.J. Drake, V.Y. Sidorov, and J.P. Wikswo. "Mechanistic Analysis of Challenge-Response Experiments".

M.C. Woods. I. Uzelac, M.R. Holcomb, J.P. Wikswo, and V.Y. Sidorov. "Diagnostic Field Stimulation: The Role of Shock Duration in Epicardial Activation and Propagation".

D.J. Alcendor, F.E. Block III, D.E. Cliffel, J.S. Daniels, K.L.J. Ellacott, C.R. Goodwin, L.H. Hofmeister, D. Li, D.A. Markov, J. May, L.J. McCawley, B.A. McLaughlin, J.A. McLean, K.D. Niswender, V. Pensabene, K.T. Seale, S.D. Sherrod, H-J. Sung, D.L. Tabb. D.J. Webb, and J.P. Wikswo. "Neurovascular Unit on a Chip: Implications for Translational Applications".

S. Hummel, V. Quaranta, and J. Wikswo. "The Biohacker: A Threat to National Security".

C.C. Marasco, C.R. Goodwin, D.G. Winder, N.L. Schramm-Sapyta, J.A. McLean, and J.P. Wikswo. "Systems-Level View of Cocaine Addiction: The Interconnect of the Human and Nervous Systems".

T.F. Byrd, L.T. Hoang, M.E. Pfister, E.M. Werner, S.E. Arndt, J.W. Chamberlain, J.J. Hughey, B.A. Nguyen, E.J. Schneibel, L.L. Wertz, J.S. Whitfield, J.P. Wikswo, and K.T. Seale. "The Microfluidic Multitrap Nanophysiometer for Hematologic Cancer Cell Characterization Reveals Temporal Sensitivity of the Calcein-AM Efflux Assay".

M.W. Irvin, A. Zijlstra, J.P. Wikswo, and A. Pozzi. "Techniques and Assays for the Study of Angiogenesis".

C.R. Goodwin, S.D. Sherrod, C.C. Marasco, B.O. Bachmann, N. Schramm-Sapyta, J.P. Wikswo, and J.A. McLean. "Phenotypic Mapping of Metabolic Profiles Using Self-Organizing Maps of High-Dimensional Mass Spectrometry Data".

K. Hockemeyer, C. Janetopoulous, A. Terekhov, W. Hofmeister, A. Vilgelm, L. Costa, J.P. Wikswo, and A. Richmond. "Engineered Three-Dimensional Microfluidic Device for Interrogating Cell-Cell Interactions in the Tumor Microenvironment".

E.A. Lima, R.M. Snider, R.S. Reiserer, J.R. McKenzie, D.W. Kimmel, S.E. Eklund, D.E. Cliffel, and J.P. Wikswo. "Multichamber Multipotentiostat System for Cellular Microphysiometry".

J.R. McKenzie, D.E. Cliffel, and J.P. Wikswo. "Electrochemical Monitoring of Cellular Metabolism".

J.P. Wikswo. "The Relevance and Potential Roles of Microphysiological Systems in Biology and Medicine".

J.A. Brown, S.D. Sherrod, C.R. Goodwin, B. Brewer, L. Yang, K.A. Garbett, D. Li, J.A. McLean, J.P. Wikswo, and K. Mirnics. "Metabolic Consequences of Interleukin-6 Challenge in Developing Neurons and Astroglia".

C.C. Marasco, J.R. Enders, K.T. Seale, J.A. McLean, and J.P. Wikswo. "Real-Time Cellular Exometabolome Analysis with a Microfluidic-Mass Spectrometry Platform".

D. Patel, R. Naik, R. Boyer, J. Wikswo, and E. Vasilevskis. "Method to Identify Saline-Contaminated Electrolyte Profiles".

C.R. Goodwin, B.C. Covington, D.K. Derewacz, C.R. McNees, J.P. Wikswo, J.A. McLean, and B.O. Bachmann. "Structuring Microbial Metabolic Responses to Multiplexed Stimuli Via Self-Organizing Metabolomics Maps".

K.J. Drake, M.S. Shotwell, J.P. Wikswo, and V.Y. Sidorov. "Glutamine and Glutamate Limit the Shortening of Action Potential Duration in Anoxia-Challenged Rabbit Hearts".

J.R. McKenzie, A.C. Cognata, A.N. Davis, J.P. Wikswo, and D.E. Cliffel. "Real-Time Monitoring of Cellular Bioenergetics with a Multianalyte Screen-Printed Electrode".

J.A. Brown, V. Pensabene, D.A. Markov, V. Allwardt, D.M. Neely, M. Shi, C.M. Britt, O.S. Hoilett, Q. Yang, B.M. Brewer, P.C. Samson, L.J. McCawley, J.M. May, D.J. Webb, D. Li, A.B. Bowman, R.S. Reiserer, and J.P. Wikswo. "Recreating Blood-Brain Barrier Physiology and Structure on Chip: A Novel Neurovascular Microfluidic Bioreactor".

J. Sai, M. Rogers, K. Hockemeyer, J.P. Wikswo, and A. Richmond. "The Study of Chemotaxis and Cell-Cell Interactions in Cancer with Microfluidic Devices".

A.A. Werdich, E.A. Lima, B. Ivanov, I. Ges, J.P. Wikswo, and F.J. Baudenbacher. "A Microfluidic Device to Confine a Single Cardiac Myocyte in a Sub-Nanoliter Volume on a Planar Microelectrode Array for Cellular Activity Detection". Lab Chip. 4: 357-62.

J. Wikswo, A. Prokop, F. Baudenbacher, D. Cliffel, B. Csukas, and M. Velkovsky. "Engineering Challenges of BioNEMS: The Integration of Microfluidics, and Micro- and Nanodevices, Models, and External Control for Systems Biology". IEE Proc. Nanobiotechnology. 153(4): 81-101.

M.M. Maleckar, M.C. Woods, V.Y. Sidorov, M.R. Holcomb, D.N. Mashburn, J.P. Wikswo, and N.A. Trayanova. "Polarity Reversal Lowers Activation Time During Diastolic Field Stimulation of the Rabbit Ventricles: Insights Into Mechanisms". Am. J. Physiol.-Heart Circ. Physiol. 295: H1626-H1633.

S.E. Eklund, R.G. Thompson, R.M. Snider, C.K. Carney, D.W. Wright, J.P. Wikswo, and D.E. Cliffel. "Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer". Sensors. 9((3)): 2117-33.

S.L. Faley, M. Copland, D. Wlodkowic, W. Kolch, K.T. Seale, J.P. Wikswo, and J.M. Cooper. "Microfluidic Single Cell Arrays to Interrogate Signalling Dynamics of Individual, Patient-derived Hematopoietic Stem Cells". Lab Chip. 9((18)): 2659-64.

A. Irimia, K.R. Swinney, and J.P. Wikswo. "Partial Independence of Bioelectric and Biomagentic Fields and Its Implications for Encephalography and Cardiography". Phys. Rev. E. 79: 51908-1.

M.R. Holcomb, M.C. Woods, I. Uzelac, J.P. Wikswo, J.M. Gilligan, and V.Y. Sidorov. "The Potential of Dual Camera Systems for Multimodal Imaging of Cardiac Electrophysiology and Metabolism". Experimental Biology and Medicine. 234((11)): 1355-73.

R.A. Gray, J.P. Wikswo, and N.F. Otani. "Origin Choice and Petal Loss in the Flower Garden of Spiral Wave Tip Trajectories". Chaos. 19((3)): 33118-1.

K.A. Addae-Mensah, S. Retterer, S.R. Opalenik, D. Thomas, N.V. Lavrik, and J.P. Wikswo. "Cryogenic Etching of Silicon: An Alternative Method for Fabrication of Vertical Microcantilever Master Molds". Journal of Microelectromechanical Systems. 19((1)): 64-74.

D.A. Markov, P.C. Samson, D.K. Schaffer, A. Dhummakupt, J.P. Wikswo, and L.M. Shor. "Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media". JoVE. 39: 1-4.

D. Wlodkowic, S. Faley, M. Zagnoni, J.P. Wikswo, and J.M. Cooper. "Microfluidic Single-Cell Array Cytometry for the Analysis of Tumor Apoptosis". Anal. Chem. 13((81)): 5517-23.

R.M. Snider, J.R. McKenzie, L. Kraft, E. Kozlov, J.P. Wikswo, and D.E. Cliffel. "The Effects of Cholera Toxin on Cellular Energy Metabolism Toxins". Toxins. 2((4)): 632-4.

J.R. Enders, C.C. Marasco, A. Kole, B. Nguyen, S. Sundarapandian, K.T. Seale, J.P. Wikswo, and J.A. McLean. "Towards Monitoring Real-Time Cellular Response Using an Integrated MALDI/nESI-Ion Mobility-Mass Spectrometery Platforma". IET Systems Biology. 4((6)): 416-27.

G. Rachakonda, K.R. Sekhar, D. Jowhar, P.C. Samson, J.P. Wikswo, R.D. Beauchamp, P.K. Datta, and M.L. Freeman. "Increased Cell Migration and Plasticity in Nrf2 Deficienct Cancer Cell Lines". Oncogene. 29(25): 3703-14.

K.K. McBride, B.J. Roth, V.Y. Sidorov, J.P. Wikswo, and F.J.Baudenbacher. "Measurements of Transmembrane Potential and Magnetic Field at the Apex of the Heart". Biophys. J. 99: 3113-8.

D. Markov, S. Manuel, L. Shor, S. Opalenik, J. Wikswo, and P. Samson. "Tape Underlayment Rotary-Node (TURN) Valves for Simple On-Chip Microfluidic Flow Control". Biomed. Microdevices. 12: 135-44.

B. Ayati, C. Edwards, G.F. Webb, and J.P. Wikswo. "A Mathematical Model of Bone Remodeling Dynamics for Normal Bone Cell Populations and Myeloma Bone Disease". Biology Direct. 5: 28.

D. Jowhar, G. Wright, P.C. Samson, J.P. Wikswo, and C. Janetopoulos. "Open Access Microfluidic Device for the Study of Cell Migration During Chemotaxis". Integrative Biology. 2: 648-58.

M. Velkovsky, R. Snider, D. Cliffel, and J.P. Wikswo. "Modeling the Measurements of Cellular Fluxes in Microbioreactor Devices Using Thin Enzyme Electrodes". J. Math. Chem. 49: 251-75.

S.G. Darby, M.R. Moore, T.A. Friedlander, D.K. Schaffer, R.S. Reiserer, J.P. Wikswo, and K.T. Seale. "A Metering Rotary Nanopump for Microfluidic Systems". Lab Chip. 10: 3218-26.

P.R. LeDuc, W.C. Messner, and J.P. Wikswo. "How Do Control-Based Approaches Enter into Biology?". Annu. Rev. Biomed. Eng. 13: 369-96.

V.Y. Sidorov, I. Uzelac, and J.P. Wikswo. "Regional Increase of Extracellular Potassium Leads to Electrical Instability and Reentry Occurence Through the Spatial Heterogeneity of APD Restitution". Am. J. Physiol.-Heart Circ. Physiol. 301: H209-H220.

R. Yang, S.C. Lenaghan, J.P. Wikswo, and M. Zhang. "External Control of the GAL Network in S. cerevisiae: A View from Control Theory". PLoS ONE. 6((4)): e19353.

Y. Liu, D.A. Markov, J.P. Wikswo, and L.J. McCawley. "Microfabricated Scaffold-Confined Endothelial Morphogenesis in Three-Dimensional Culture". Biomedical Microdevices. 13: 837-46.

M.D. Schmidt, R.R. Vallabhajosyula, J.W. Jenkins, J.E. Hood, A.S. Soni, J.P. Wikswo, and H. Lipson. "Automated Refinement and Inference of Analytical Models for Metabolic Networks". Physical Biology. 8((5)): 55011.

W. Georgescu, J.P. Wikswo, and V. Quaranta. "CellAnimation: An Open Source MATLAB Framework for Microscopy Assays". Bioinformatics. 28((1)): 138-9.

W.J. Ashby, J.P. Wikswo, and A. Zijlstra. "Magnetically Attachable Stencils and the Non-Destructive Analysis of the Contribution Made by the Underlying Matrix to Cell Migration". Biomaterials. 33((33)): 8189-203.

J.R. Enders, C.C. Marasco, J.P. Wikswo, and J.A. McLean. "A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry". Analytical Chemistry. 84((20)): 8467-74.

D.A. Markov, J.Q. Lu, P.C. Samson, J.P. Wikswo, and L.J. McCawley. "Thick-Tissue Bioreactor as a Platform for Long-Term Organotypic Culture and Drug Delivery". Lab Chip. 12: 4560-8.

K.J. Drake, V.Y. Sidorov, O.P. McGuinness, D.H. Wasserman, and J.P. Wikswo. "Amino Acids as Metabolic Substrates During Cardiac Ischemia". Experimental Biology and Medicine. 237: 1369-78.

Available Postdoctoral Position Details
EMD Millipore Research Associate in Automated Systems Biology With the support of EMD Millipore Bioscience, the Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE) is seeking candidates for a research associate in either of the Departments of Physics & Astronomy, Biomedical Engineering, or Molecular Physiology & Biophysics. The successful candidate will be expected to conduct both experimental and computational research as a part of a long-term project in the automated inference of mathematical models of metabolic and signaling dynamics of small populations of cells. Techniques being used include microfabricated bioreactors with optical, electrochemical, and mass spectrometric sensing, closed-loop control, microfluidics, numerical modeling, and bioinformatics. A doctoral degree in a related field is required. Apply at https://academicjobsonline.org/ajo/jobs/724. Review of applications will begin on 1 July, 2011 and will continue until the position is filled. VIIBRE is a transinstitutional initiative created in 2001 to foster and enhance interdisciplinary research in the biophysical sciences, bioengineering, and medicine at Vanderbilt University, integrated with a strong focus on undergraduate, graduate, and postdoctoral education. VIIBRE’s primary focus is the use of microfluidics and advanced analytical systems to instrument and control single cells and small populations of cells. Founded in 1873, Vanderbilt is a private, coeducational university with approximately 6,000 undergraduates and 5,000 graduate and professional students. Vanderbilt University is an equal-opportunity, affirmative-action employer. Women and minority candidates are particularly encouraged to apply. For more information, please visit our web site http://www.vanderbilt.edu/viibre or contact Prof. John P. Wikswo (please email both john.wikswo@vanderbilt.edu and cheryl.cosby@vanderbilt.edu).