E. Duco Jansen, Ph.D.

Professor

duco.jansen@vanderbilt.edu

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Faculty Appointments
Associate Dean for Graduate Studies Professor of Biomedical Engineering Professor of Neurological Surgery
Education
Ph.D., Biomedical Engineering, University of Texas, Austin, TexasM.S., Biomedical Engineering, University of Texas, Austin, TexasM.S., Biomedical Engineering, Utrecht University, Utrecht
Office Address
VU Station B 351631
5824 Stevenson Center
Nashville, AL 37235
Research Description
Dr. Jansen joined the faculty of the Biomedical Engineering Department in January of 1997 and is currently in the process of building up a Biomedical Optics research and educational program. He has been working in the area of laser-tissue interaction and biomedical optics and specifically on pulsed laser ablation of biological tissue for the last eight years. Dr. Jansen?s research effort is split between research related to the Vanderbilt Free Electron Laser (FEL) and Biomedical Optics in the BME Department. The research at the FEL is centered around the implementation of a beam transport and delivery system to allow safe and convenient use by physicians for human clinical care (i.e. tissue removal or ablation). The research program that will be implemented in the Biomedical Engineering Department will include both therapeutic and diagnostic applications of lasers and light in medicine. The BME Department has designated Biomedical Optics as one of the main focus areas of research and a second faculty member in this area will join the department this fall ('98). Starting in the summer of 1997, approximately 2000 ft2 of lab space will become available which is dedicated to the Biomedical Optics research area. Research in the therapeutic area will be focused on 1) clinical applications of lasers and 2) the biological response on a cellular and subcellular level to laser-induced stimuli such as thermal effects, compressive and tensile stresses and shockwaves. In the diagnostic area we will use optical spectroscopic techniques such as fluorescence and near-IR Raman spectroscopy for non-invasive diagnosis of tissue. It is anticipated that most of these projects will develop in strong collaboration with medical faculty.

Current Projects Include:

1. Design, development, and implementation of a beam delivery system in order to facilitate human clinical care with the Vanderbilt Free Electron Laser.

2. Cellular response to laser-induced insult of biological tissues.

3. Mechanisms of pulsed laser-tissue interaction, correlating tissue effects to physical, laser-induced stimuli.

4. Transmyocardial Laser Revascularization (TMR).

5. Development optical tools for use in cellular and molecular biology.
Research Keywords
Biomedical Optics
Publications
Wells J, Kao C, Konrad P, Milner T, Kim J, Mahadevan-Jansen A, Jansen ED. Biophysical mechanisms of transient optical stimulation of peripheral nerve. Biophys. J [print-electronic]. 2007 Oct 10/1/2007; 93(7): 2567-80. PMID: 17526565, PMCID: PMC1965456, PII: S0006-3495(07)71511-4, DOI: 10.1529/biophysj.107.104786, ISSN: 0006-3495.

Faley SL, Takahashi K, Crooke CE, Beckham JT, Tomemori T, Shappell SB, Jansen ED, Takahashi T. Bioluminescence imaging of vascular endothelial growth factor promoter activity in murine mammary tumorigenesis. Mol Imaging. 2007 Sep; 6(5): 331-9. PMID: 18092518, ISSN: 1535-3508.

Wells J, Konrad P, Kao C, Jansen ED, Mahadevan-Jansen A. Pulsed laser versus electrical energy for peripheral nerve stimulation. J. Neurosci. Methods [print-electronic]. 2007 Jul 7/30/2007; 163(2): 326-37. PMID: 17537515, PMCID: PMC2993156, PII: S0165-0270(07)00146-X, DOI: 10.1016/j.jneumeth.2007.03.016, ISSN: 0165-0270.

Wells JD, Thomsen S, Whitaker P, Jansen ED, Kao CC, Konrad PE, Mahadevan-Jansen A. Optically mediated nerve stimulation: Identification of injury thresholds. Lasers Surg Med. 2007 Jul; 39(6): 513-26. PMID: 17659590, DOI: 10.1002/lsm.20522, ISSN: 0196-8092.

Virostko J, Powers AC, Jansen ED. Validation of luminescent source reconstruction using single-view spectrally resolved bioluminescence images. Appl Opt. 2007 May 5/1/2007; 46(13): 2540-7. PMID: 17429468, PII: 131902, ISSN: 0003-6935.

Mackanos MA, Simanovskii D, Joos KM, Schwettman HA, Jansen ED. Mid infrared optical parametric oscillator (OPO) as a viable alternative to tissue ablation with the free electron laser (FEL). Lasers Surg Med. 2007 Mar; 39(3): 230-6. PMID: 17304561, DOI: 10.1002/lsm.20461, ISSN: 0196-8092.

Toms SA, Lin WC, Weil R, Johnson MD, Jansen ED, Mahadevan-Jansen A. Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity. Neurosurgery. 2007; 61((1)): 327-35.

Virostko J, Jansen ED, Powers AC. Current status of imaging pancreatic islets. Curr. Diab. Rep. 2006 Aug; 6(4): 328-32. PMID: 16879787, ISSN: 1534-4827.

Jansen ED, Pickett PM, Mackanos MA, Virostko J. Effect of optical tissue clearing on spatial resolution and sensitivity of bioluminescence imaging. J Biomed Opt. 2006 Jul; 11(4): 41119. PMID: 16965147, DOI: 10.1117/1.2337651, ISSN: 1083-3668.

Wilmink GJ, Opalenik SR, Beckham JT, Davidson JM, Jansen ED. Assessing laser-tissue damage with bioluminescent imaging. J Biomed Opt. 2006 Jul; 11(4): 41114. PMID: 16965142, DOI: 10.1117/1.2339012, ISSN: 1083-3668.

Roth DJ, Jansen ED, Powers AC, Wang TG. A novel method of monitoring response to islet transplantation: bioluminescent imaging of an NF-kB transgenic mouse model. Transplantation. 2006 Apr 4/27/2006; 81(8): 1185-90. PMID: 16641606, PII: 00007890-200604270-00017, DOI: 10.1097/01.tp.0000203808.84963.13, ISSN: 0041-1337.

Jansen ED, Rastegar S. Pioneers in Biomedical Optics: Special Section Honoring Professor Ashley J. Welch, University of Texas at Austin. J Biomed Optics. 2006; 11: 41101.

Izzo AD, Richter CP, Jansen ED, Walsh JT. Laser Stimulation of the Auditory Nerve. Lasers Surg Med. 2006; 38((7)): 745-53.

Wells JD, Mahadevan-Jansen A, Bendett M, Webb J, Ralph H, Kao C, Konrad P, Jansen ED. Lasers stimulate new techniques in nerve studies. Biophotonics. 2006; 13((10)): 30-5.

Moulton K, Lovell F, Williams E, Ryan P, Lay DC, Jansen ED, Willard S. Use of glycerol as an optical clearing agent for enhancing photonic transference and detection of Salmonella typhimurium through porcine skin. J Biomed Optics. 2006; 11((5)): 5427.

Wells J, Kao C, Jansen ED, Konrad P, Mahadevan-Jansen A. Application of infrared light for in vivo neural stimulation. J Biomed Opt. 2005 Nov; 10(6): 64003. PMID: 16409069, DOI: 10.1117/1.2121772, ISSN: 1083-3668.

Mackanos MA, Kozub JA, Hachey DL, Joos KM, Ellis DL, Jansen ED. The effect of free-electron laser pulse structure on mid-infrared soft-tissue ablation: biological effects. Phys Med Biol [print-electronic]. 2005 Apr 4/21/2005; 50(8): 1885-99. PMID: 15815102, PII: S0031-9155(05)90784-7, DOI: 10.1088/0031-9155/50/8/017, ISSN: 0031-9155.

Mackanos MA, Kozub JA, Jansen ED. The effect of free-electron laser pulse structure on mid-infrared soft-tissue ablation: ablation metrics. Phys Med Biol [print-electronic]. 2005 Apr 4/21/2005; 50(8): 1871-83. PMID: 15815101, PII: S0031-9155(05)89655-1, DOI: 10.1088/0031-9155/50/8/016, ISSN: 0031-9155.

Fowler M, Virostko J, Chen Z, Poffenberger G, Radhika A, Brissova M, Shiota M, Nicholson WE, Shi Y, Hirshberg B, Harlan DM, Jansen ED, Powers AC. Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging. Transplantation. 2005 Apr 4/15/2005; 79(7): 768-76. PMID: 15818318, PII: 00007890-200504150-00005, ISSN: 0041-1337.

Wells J, Kao C, Mariappan K, Albea J, Jansen ED, Konrad P, Mahadevan-Jansen A. Optical stimulation of neural tissue in vivo. Opt Lett. 2005 Mar 3/1/2005; 30(5): 504-6. PMID: 15789717, ISSN: 0146-9592.

Gebhart SC, Jansen ED, Galloway RL. Dynamic, three-dimensional optical tracking of an ablative laser beam. Med Phys. 2005 Jan; 32(1): 209-20. PMID: 15719972, ISSN: 0094-2405.

Teichman JM, Glickman RD, Chan KF, Jansen ED, Welch AJ. Plasma bubble formation induced by holmium laser. Urology. 2005; 65((3)): 627-8.

Patil C, Jansen ED. Novel optical technologies to aid diagnosis and guide therapy in colorectal medicine. Sem in Colon Rectal Surgery. 2005; 16((2)): 82-90.

Toms SA, Lin WC, Weil RJ, Johnson MD, Jansen ED, Mahadevan-Jansen A. Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity. Neurosurgery. 2005; 57((4)): 382-91.

Virostko J, Chen Z, Fowler M, Poffenberger G, Powers AC, Jansen ED. Factors influencing quantification of in vivo bioluminescence imaging: application to assessment of pancreatic islet transplants. Mol Imaging. 2004 Oct; 3(4): 333-42. PMID: 15802050, DOI: 10.1162/1535350042973508, ISSN: 1535-3508.

Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW. P47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J. Immunol. 2004 Feb 2/1/2004; 172(3): 1801-8. PMID: 14734763, ISSN: 0022-1767.

Beckham JT, Mackanos MA, Crooke C, Takahashi T, O'Connell-Rodwell C, Contag CH, Jansen ED. Assessment of cellular response to thermal laser injury through bioluminescence imaging of heat shock protein 70. Photochem. Photobiol. 2004 Jan; 79(1): 76-85. PMID: 14974719, ISSN: 0031-8655.

O’Connell-Rodwell CE, Shriver D, Simanovskii DM, McClure C, Cao Y, Zhang W, Bachmann MH, Beckham JT, Jansen ED, Palanker D, Schwettman HA, Contag CH. A genetic reporter of thermal stress defines physiologic zones over a defined temperature range. FASEB Journal. 2004; 18: 264-71.

Powers AC, Jansen ED. In Vivo Bioluminescence Imaging to Assess Pancreatic Islets. Curr Med Chem. 2004; 4((4)): 339-48.

Wu N, Jansen ED, Davidson JM. Comparison of mouse matrix metalloproteinase 13 expression in free-electron laser and scalpel incisions during wound healing. J. Invest. Dermatol. 2003 Oct; 121(4): 926-32. PMID: 14632214, DOI: 10.1046/j.1523-1747.2003.12497.x, ISSN: 0022-202X.

Mackanos MA, Jansen ED, Shaw BL, Sanghera JS, Aggarwal I, Katzir A. Delivery of midinfrared (6 to 7-microm) laser radiation in a liquid environment using infrared-transmitting optical fibers. J Biomed Opt. 2003 Oct; 8(4): 583-93. PMID: 14563195, DOI: 10.1117/1.1606460, ISSN: 1083-3668.

Wu L, Nicholson W, Wu CY, Xu M, McGaha A, Shiota M, Powers AC. Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor. Gene Ther. 2003 Sep; 10(19): 1712-20. PMID: 12923570, PII: 3302055, DOI: 10.1038/sj.gt.3302055, ISSN: 0969-7128.

Yull FE, Han W, Jansen ED, Everhart MB, Sadikot RT, Christman JW, Blackwell TS. Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo. J. Histochem. Cytochem. 2003 Jun; 51(6): 741-9. PMID: 12754285, ISSN: 0022-1554.

Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, Washington MK, Yull FE, Jaffal N, Jansen ED, Gautman S, Stain SC. Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis. J. Surg. Res. 2003 Mar; 110(1): 310-4. PMID: 12697416, PII: S0022480403000246, ISSN: 0022-4804.

Sadikot RT, Han W, Everhart MB, Zoia O, Peebles RS, Jansen ED, Yull FE, Christman JW, Blackwell TS. Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. J. Immunol. 2003 Jan 1/15/2003; 170(2): 1091-8. PMID: 12517978, ISSN: 0022-1767.

Viehoever AR, Anderson D, Jansen ED, Mahadevan-Jansen A. Organotypic raft cultures as an effective tool for understanding Raman spectral analysis of tissue. Photochemistry and Photobiology. 2003; 78((5)): 517-24.

Edwards GS, Austin RH, Carroll FE, Copeland ML, Couprie ME, Gabella WE, Haglund RF, Hooper BA, Hutson MS, Jansen ED, Joos KM, Kiehart DP, Lindau I, Miao J, Pratisto HS, Shen JH, Tokutake Y, van der Meer L, Xie A. FEL-based biophysical and biomedical instrumentation (invited review paper) [editorial]. Rev Sci Instr. 2003; 74((7)): 3207-45.

Choi B, Jansen ED, Welch AJ. Acoustic-based measurements of material absorption coefficients: Relationship between laser pulse duration and stress confinement time. J Appl Phys. 2003; 94((12)): 7826-31.

Wu N, Opalenik S, Liu J, Jansen ED, Giro MG, Davidson JM. Real-time visualization of MMP-13 promoter activity in transgenic mice. Matrix Biol. 2002 Mar; 21(2): 149-61. PMID: 11852231, PII: S0945053X01001925, ISSN: 0945-053X.

Lin WC, Toms SA, Jansen ED, Mahadevan-Jansen A. Elimination of blood contamination effect on optical spectroscopic guidance of surgeries. IEEE J Sp Top Quant Electr. 2002; 7((6)): 996-1003.

Chan KF, Choi B, Vargas G, Hammer DX, Sorg B, Pfefer TJ, Teichman JMH, Welch AJ, Jansen ED. Free electron laser ablation of urinary calculi: An experimental study. IEEE J Sp Top Quant Electr. 2002; 7((6)): 1022-33.

Sadikot RT, Debelak JP, Jansen ED, Wudel LJ, Morris DS, Christman JW, Blackwell TS, Chapman WC. Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kB activation in a transgenic mouse model. J Gastrointestinal Surg. 2002; 6: 264-70.

Sadikot RT, Jansen ED, Blackwell TR, Zoia O, Yull F, Christman JW, Blackwell TS. High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice. Am. J. Respir. Crit. Care Med. 2001 Sep 9/1/2001; 164(5): 873-8. PMID: 11549548, DOI: 10.1164/ajrccm.164.5.2008059, ISSN: 1073-449X.

Lin WC, Toms SA, Johnson M, Jansen ED, Mahadevan-Jansen A. In vivo brain tumor demarcation using optical spectroscopy. Photochem. Photobiol. 2001 Apr; 73(4): 396-402. PMID: 11332035, ISSN: 0031-8655.

Izzo AD, Mackanos MA, Beckham JT, Jansen ED. In vivo optical imaging of expression of vascular endothelial growth factor following laser incision in skin. Lasers Surg Med. 2001; 29(4): 343-50. PMID: 11746112, PII: 10.1002/lsm.1127, ISSN: 0196-8092.

Jansen ED. Laser-tissue interaction during transmyocardial laser revascularization. Current topics in transmyocardial laser revascularization, M. Okada (ed), Medical Tribune Inc., Japan. 2001; Chapter 10: 133-54.

Beckham JT, Baran JA, Izzo AD, Jansen ED. Optical imaging of Hsp70 and VEGF gene expression following laser thermal injury. Laser-Tissue Interaction XI, Jacques SL, (ed), SPIE. 2001; 4257: 377-85.

Lin WC, Toms SA, Motamedi M, Jansen ED, Mahadevan-Jansen A. Brain tumor demarcation using optical spectroscopy; an in vitro study. J Biomed Opt. 2000 Apr; 5(2): 214-20. PMID: 10938786, PII: S1083-3668(00)00602-X, DOI: 10.1117/1.429989, ISSN: 1083-3668.

Chan KF, Hammer DX, Choi B, Teichman JM, McGuff HS, Pratisto HS, Jansen ED, Welch AJ. Free Electron Laser lithotripsy: Threshold radiant exposures. Journal of EndoUrology. 2000; 14((2)): 161-7.

Pratisto HS, Uhlhorn SR, Jansen ED. Beam delivery of the Vanderbilt Free Electron Laser with hollow wave guides: effect on temporal and spatial pulse propagation. Fiber and Integrated Optics. 2000; 20((1)): 83-94.

Jansen ED, Frenz M, Kadipasaoglu KA, Pfefer TJ, Altermatt HJ, Motamedi M, Welch AJ. Laser-tissue interaction during transmyocardial laser revascularization. Ann. Thorac. Surg. 1997 Mar; 63(3): 640-7. PMID: 9066377, PII: S0003497596011435, ISSN: 0003-4975.

Asshauer T., Delacretaz, G., Jansen, E.D., Welch, A.J., Frenz, M. Pulsed holmium laser ablation of tissue phantoms: correlation of bubble formation and acoustic transients. 1997.

Hammer, D.X., Jansen, E.D., Frenz, M., Noojin, G.D., Thomas, R.J., Noack, J., Vogel, A., Rockwell, B.A., Welch, A.J. Shielding properties of laser-induced breakdown in water for pulse durations from 5 ns to 125 fs. 1997.

Fritz JD, Utz AL, Hale NM, Wu L, Powers AC, Verdoorn TA, Robertson D. Gene-based neurotransmitter modulation in cerebellar granule neurons. J. Neurochem. 1997 Jan; 68(1): 204-12. PMID: 8978727, ISSN: 0022-3042.

Frenz, M., Pratisto, H., Konz, F., Jansen, E.D., Welch, A.J., Weber, H.P. Comparison of the effects of absorption coefficient and pulse duration of 2. 12 pm and 2.79 pm radiation on laser ablation. 1996.

Pratisto, H., Frenz, M., Ith, M., Altermatt, H.J., Jansen, E.D., Weber, H.P. Combination of fiberguided pulsed erbium and holmium laser radiation for tissue ablation under water. 1996.

Jansen ED, Asshauer T, Frenz M, Motamedi M, Delacretaz G, Welch AJ. The effect of pulse duration on bubble formation and laser induced pressure waves during holmium laser ablation. Lasers Surg Med. 1996; 18: 278-93.

Welch AJ, Lin WC, Cilesiz I, Jansen ED, Frenz M, Motamedi M. Dynamics of optical properties. Verga-Scheggi AM, Martellucci S, Chester AN, Pratesi R (eds): Biomedical optical instrumentation and laser-assisted biotechnology, NATO A.S.I. Series: E325, Kluwer. 1996; Chapter 1: 33-44.

Van Leeuwen TG, Jansen ED, Welch AJ, Borst C. Excimer laser induced bubbles: dimensions, theory and implications for laser angioplasty. Lasers Surg Med. 1996; 18: 381-90.