Darryl J. Bornhop, Ph.D.


Faculty Appointments
Professor of Chemistry
Ph.D., Chemistry, Analytical, University of Wyoming, Laramie, WyomingM.A., University of Missouri, Saint Louis, MissouriB.S., University of Missouri, Saint Louis, Missouri
Research Description
Research Keywords
In vivo imaging probes, high throughput chemical screening
D.A. Markov, J.C. Latham, A. Kussrow, H.S. Sørensen, and Darryl J. Bornhop. Label-free, Free Solution Molecular Interaction Determinations by Interferometry. For submission to Science. 2006 Mar.

Latham JC, Markov DA, Sørensen HS, Bornhop DJ. Photobiotin surface chemistry improves label-free interferometric sensing of biochemical interactions. Angew. Chem. Int. Ed. Engl. 2006 Jan 1/30/2006; 45(6): 955-8. PMID: 16385602, DOI: 10.1002/anie.200502418, ISSN: 1433-7851.

J.C. Latham, D.A. Markov, H.S. Sørensen, and D.J. Bornhop. Photobiotin Surface Chemistry Improves Label-Free Interferometric Sensing of Biochemical Interactions. Angewandte Chemie International Edition. 2006; 45((6)): 955-8.

Smentek L, Andes Hess B, Cross JP, Charles Manning H, Bornhop DJ. Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series. J Chem Phys. 2005 Dec 12/22/2005; 123(24): 244302. PMID: 16396532, DOI: 10.1063/1.2139997, ISSN: 0021-9606.

Wang Z, Bornhop DJ. Dual-capillary backscatter interferometry for high-sensitivity nanoliter-volume refractive index detection with density gradient compensation. Anal. Chem. 2005 Dec 12/15/2005; 77(24): 7872-7. PMID: 16351132, DOI: 10.1021/ac050752h, ISSN: 0003-2700.

N.G. Deane, H.C. Manning, C.A. Foutch, M. Kay Washington, B.A. Aronow, D.J. Bornhop and R.J. Coffey. Molecular Imaging of Spontaneous Colonic Tumors in Smad3 Null Mice. Submitted to Cancer Research. 2005 Sep.

H.C. Manning, J.M.M. Griffin, T.S. Goebel, B. Bell, M. Motamedi, G.E. Kiefer and D.J. Bornhop. Lanthanide Chelates for Optical Imaging in Medicine. Submitted to J. American Chemical Society. 2005 Aug.

H.C. Manning, B. Anderson, L. Samuelson, S. Havaland and D.J. Bornhop. Expeditious Synthesis of P-protected Macrocycles In-route to Lanthanide Chelate Metal Complexes. Teterahedron Letters. 2005; 46((28)): 4707-710.

Z. Wang and D.J. Bornhop, “Z. Wang and D.J. Bornhop. Dual-Capillary Backscatter Interferometry for High-Sensitivity Nanoliter Volume Refractive Index Detection with Gradient Compensation. Analytical Chemistry. 2005; 77: 7872-7.

L. Smentek, B. A. Hess, Jr., J. P. Cross, H.C. Manning and D.J. Bornhop. Density Function Theory Structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for Ions Across the Lanthanide Series. J. Chemical Physics. 2005; 123: 244302.

Markov DA, Swinney K, Bornhop DJ. Label-free molecular interaction determinations with nanoscale interferometry. J. Am. Chem. Soc. 2004 Dec 12/22/2004; 126(50): 16659-64. PMID: 15600372, DOI: 10.1021/ja047820m, ISSN: 0002-7863.

Markov DA, Dotson S, Wood S, Bornhop DJ. Noninvasive fluid flow measurements in microfluidic channels with backscatter interferometry. Electrophoresis. 2004 Nov; 25(21-22): 3805-9. PMID: 15565690, DOI: 10.1002/elps.200406139, ISSN: 0173-0835.

Manning HC, Goebel T, Thompson RC, Price RR, Lee H, Bornhop DJ. Targeted molecular imaging agents for cellular-scale bimodal imaging. Bioconjug. Chem. 2004 Nov; 15(6): 1488-95. PMID: 15546219, DOI: 10.1021/bc049904q, ISSN: 1043-1802.

X. Wang, G. Ku, M.A. Wegiel, D.J. Bornhop, G. Stoica and L.V. Wang. Non-invasive Photoacoustic Angiography of Animal Brains In Vivo with NIR Light and an Optical Contrast Agent. Optics Letters. 2004; 29((7)): 730-2.

D.A. Markov, S. Dotson, S. Wood, and D.J. Bornhop. Non-Invasive Fluid Flow Measurements in Microfluidic Channels with Backscatter Interferometry. Electrophoresis. 2004; 25((21-22)): 3805-9.

H.C. Manning, J.M.M. Griffin, T.S. Goebel, M. A. Wegiel, R.C. Thompson, R.R. Price and D.J. Bornhop. A PBR Targeted Molecular Imaging Agent for Cellular-Scale Bi-modal Imaging. Bioconjugate Chemistry. 2004; 15: 1488-95.

D. Markov, K. Swinney, and D.J. Bornhop. Label-Free Molecular Interaction Determinations with Nanoscale Interferometry. J. American Chemical Society. 2004; 126: 16659-64.

Z. Wang, K. Swinney and D.J. Bornhop. Attomole Sensitivity for Proteins and Polypeptides with On-chip CE and Universal Detection by Interferometric Backscatter. Electrophoresis. 2003; 24: 865-73.

H.C. Manning, A.M. Skwierawska, J.N. Marx and D.J. Bornhop. Rapid Removal of Benzyloxycarbonyl Groups from 1,4,7,10-Tetraazacyclodododecance Derivatives by Catalytic Transfer Hydrogenation. Synthetic Communications. 2003; 33((3)): 457-61.

H.S. Sørensen, H Pranov, N.B. Larsen, D.J. Bornhop and P.E. Andersen. Absolute Refractive Index Determination by Micro-Interfermometric Backscatter Detection. Analytical Chemistry. 2003; 75((8)): 1946-53.

T.S. Goebel, J.M.M. Griffin, B. Bell, M. Motamedi, and D.J. Bornhop. Lanthanide Chelate Contrast Agents for the Detection of Malignant Lesions in the Syrian Hamster Cheek Pouch. Applied Spectroscopy. 2003; 57((10)): 1216-22.

K. Swinney and D.J. Bornhop. Quantification and Evaluation of Joule Heating in On-Chip CE. Electrophoresis. 2002; 23((4)): 621-5.

K. Swinney J. Nodorft and D.J. Bornhop. Nanoliter Volume Polarimetry. Applied Spectroscopy. 2002; 56((1)): 134-8.

D. Markov, K. Norville, D. Lu, K. Swinney and D.J. Bornhop. A Fourier Analysis Approach for Capillary Polarimetry. Electrophoresis. 2002; 23((5)): 809-12.

H.C. Manning, T. Goebel, J.N. Marx and D.J. Bornhop. Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Ligand Analogue. Organic Letters. 2002; 4((7)): 1075-8.

D. Markov and D.J. Bornhop. Breaking the 10-7 for RI Measurements in Nanoliter Volumes. Analytical Chemistry. 2002; 74((20)): 5438-41.

K. Swinney J. Nodorft and D.J. Bornhop. Capillary-Scale Polarimetry for Flowing Streams. Analyst. 2001; 126: 673.

D.J. Bornhop, C.H. Contag, K. Licha and C.J. Murphy. Advances in Contrast Agents, Reporters and Detection. J. Biomedical Optics. 2001; 6: 106-10.

J.M.M. Griffin, A.M. Skwierawska, H.C. Manning, J.N. Marx and D.J. Bornhop. Simple, High Yielding Synthesis of Trifunctional Fluorescent Lanthanide Chelates. Tetrahedron Letters. 2001; 42: 3823-8.

K. Swinney and D.J. Bornhop. Non-Invasive Picoliter Volume Thermometry Based on Backscatter Interferometry. Electrophoresis. 2001; 22: 2032-6.

D. Markov and D.J. Bornhop. Nanoliter-scale Non-invasive Flow-Rate Quantification using Micro-Interferometric Backscatter and Phase Detection. Fresenius’ J. Analytical Chemistry. 2001; 371: 234-7.

K. Swinney and D.J. Bornhop. A Review of CE Detection Methodologies. CRC Critical Reviews in Analytical Chemistry. 2000; 30((1)): 1-30.

K. Swinney, D. Markov and D.J. Bornhop. Ultra-Small Volume Refractive Index Detection using Micro-Interferometry. Review of Scientific Instruments. 2000; 71((7)): 2684-93.

D.J. Bornhop and K. Swinney. Detection in Capillary Electrophoresis: A Review. Electrophoresis. 2000; 21: 1239-50.

K. Swinney, D. Markov and D.J. Bornhop. Chip-Scale Universal Detection using Backscattering Interferometry. Analytical Chemistry. 2000; 72: 2690.

K. Swinney and D.J. Bornhop. D- Reaction Kinetics Studied in Nanoliter Volumes using a Capillary Polarimeter. Applied Spectroscopy. 2000; 54: 1458-69.

K. Swinney and D.J. Bornhop. A Chip-Scale Universal Detector for Electrophoresis Based on Backscattering Interferometry. Analyst. 2000; 125: 1713-7.

K. Swinney, J. Pennington and D.J. Bornhop. Universal Detection in Capillary Electrophoresis by Micro-Interferometric Backscatter. Analyst. Accelerated article and Hot Topic paper for The Journal. 1999; 124: 221-6.

K. Swinney, J. Pennington and D.J. Bornhop. Ion Analysis by Capillary Electrophoresis using MIBD. J. Microchemical Society. 1999; 62: 154-63.

33. D.J. Bornhop, D.S. Hubbard, M.P. Houlne, C. Adair, G.E. Kiefer, B.C. Pence and D.L. Morgan. Fluorescent Tissue Site-Selective Lanthanide Chelate, Tb-PTCMB for Enhanced Imaging of Cancer. Analytical Chemistry. 1999; 71: 2607-15.

M.P. Houlne, S.P. O’Briant, T. Goebel and D.J. Bornhop. Some Spectroscopic and Transport Properties of a Rare-Earth Chelate: Tb-PCTMP. Analyta Chimica Acta. 1999; 397: 267.

M.M. Dickens, M.P. Houlne, S. Mitra and D.J. Bornhop. Method of Depixelating Micro-Endoscopic Images. Optical Engineering. 1999; 38: 1836-42.

K. Swinney and D.J. Bornhop. Universal Detection for Capillary Electrophoresis-Using Micro-Interferometric Backscatter Detection. J. MicroColumn Separation. 1999; 11: 596-604.

K. Swinney, D. Markov, J. Hankins and D.J. Bornhop. Micro-Interferometric Backscatter Detection using a Diode Laser. Analytica Chimica Acta. 1999; 400. A contribution to mark the 400th Volume and a result of the Measurement for the next Millennium conference in Egmond aan Zee, The Netherlands.: 265-80.

K. Swinney, J. Hankins and D.J. Bornhop. Laser-Based Capillary Polarimeter. J. Capillary Electrophoresis and Microchip Technology. 1999; 6: 93-6.

D.S. Hubbard, M.P. Houlne, G.E. Kiefer, H.F. Janssen, C. Hacker and D.J. Bornhop. Diagnostic Imaging Using Rare-Earth Chelates. Lasers in Medical Science. 1998; 13: 14-21.

M.P. Houlne, D.S. Hubbard, G.E. Kiefer and D.J. Bornhop. Imaging and Quantitation of Tissue Selective Lanthanide Chelates Using an Endoscopic Fluorometer. J. Biomedical Optics. 1998; 3: 145-53.

D.S. Hubbard, M.P. Houlne, G.E. Kiefer, K. McMillan and D.J. Bornhop. Imaging and Quantitation of Tissue Selective Lanthanide Chelates. Bioimaging. 1998; 6: 63-70.

C.K. Kenmore, S.E. Erskine and D.J. Bornhop. Refractive Index Detection in Packed Capillary HPLC by Interferometric Backscatter. J. Chromatography A. 1997; 762: 219-25.

M.P. Houlne and D.J. Bornhop. Semi-quantitative Two Dimensional Flow Transport Imaging using Micro-Endoscopic Probes. Optical Engineering. 1997; 36: 1982-91.

H. Tarigan, C.K. Kenmore, P. Neill and D.J. Bornhop. Capillary-Scale Refractive Index Detection by Interferometeric Backscatter. Analytical Chemistry. 1996; 68: 1762-70.

D.J. Bornhop and J. Hankins. Polarimetry in Capillary Dimensions. Analytical Chemistry. 1996; 68: 1677-84.

M.P. Houlne, T.S. Agent, G.F. Kiefer, K. McMillan and D.J. Bornhop. Spectroscopy Characterization and Tissue Imaging using Site-Selective Polyazacyclic Terbium (III) Chelates. Applied Spectroscopy. 1996; 10: 225-44.

M. Hackett, H. Wang, G.C. Miller and D.J. Bornhop. Rapid Scanning UV-Vis Detection for Capillary Gas Chromatography Using a Remote Flow Cell. J. Chromatography A. 1995; 695: 243-57.

D.J. Bornhop. Micro-Volume Index of Refraction Detection by Interferometric Backscatter. Applied Optics. 1995; 34: 3234-9.

D.J. Bornhop, L. Hlousek, M. Hackett, H. Wang and G.C. Miller. Remote Scanning Ultraviolet Detection for Capillary Gas Chromatography. Review of Scientific Instruments. 1992; 63: 191.

D.J. Bornhop and G. Verga. Gasoline Analysis by Rapid Scanning Absorbance Detection and Capillary Gas Chromatography. TrAC. 1992; 11: 194-8.

A. Bruno, A. Paluis and D.J. Bornhop. Cross-Beam RI-Absorbance Detection in the UV for Capillary Electrophoresis. Applied Spectroscopy. 1991; 45: 462-7.

D.J. Bornhop and J.G. Wangsgaard. GC-UV: Capillary Gas Chromatography with Rapid Scanning Ultraviolet Detection. HRC & CC. 1991; 14: 344-7.

D.J. Bornhop, B.J. Murphy and L. Krieger-Jones. Chemiluminescence Sulfur Detection in Capillary Supercritical Fluid Chromatography. Analytical Chemistry. 1989; 61: 797-800.

S.R. Weinberger and D.J. Bornhop. Scanning UV Detection in Capillary Supercritical Fluid Chromatography. J. Microcolumn Separations. 1989; 1: 90-5.

B.E. Richter, D.J. Bornhop, J.T. Swanson, J.G. Wangsgaard and M.R. Anderson. Gas Chromatographic Type Detectors in SFC. J. Chromatography. 1989; 27: 303-8.

D.J. Bornhop and J.G. Wangsgaard. Optical Detection Methods in Supercritical Fluid Chromatography. J. Chromatography. 1989; 27: 293-302.

N.J. Dovichim F. Zarrin, T.G. Nolan and D.J. Bornhop. Laser Detector for Capillary Liquid Chromatography. Spectro. Chim. Acta Part B. 1988; 43B: 639-49.

D.J. Bornhop, S.S. Schmidt, and N.L. Porter. Use of Two Stimulaneous Detectors in Capillary Supercritical SFC. J. Chromatography. 1988; 459: 193-200.

F Zarrin, DJ Bornhop and NJ Dovichi. Laser Doppler Velocimetry for Particle Size Determination by Light Scatter within the Sheath Flow Cuvette. Analytical Chemistry. 1987; 59: 854-60.

DJ Bornhop and NJ Dovichi. Simultaneous Laser-Based Refractive Index and Absorbance Determinations Within Micrometer Diameter Capillary Tubes. Analytical Chemistry. 1987; 59: 1632-6.

DJ Bornhop and NJ Dovichi. Subnanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Capillary Liquid Chromatography. LC-GC. 1987; 5: 427-9.

DW Later, DJ Bornhop, ED Lee, JD Henion and RC Weibolt. Detection Techniques for Capillary Supercritical Fluid Chromatography: UV, MS and FTIR. Feature Article LC-GC. 1987; 5((9)): 804-16.

NL Porter, BE Richter, DJ Bornhop, DW Later adn FH Beyerlein. Fill Gas Effects on Reproducibility in Capillary SFC. HRC & CC. 1987; 10: 477-8.

DJ Bornhop and NJ Dovichi. Simple Nanoliter Refractive Index Detector. Analytical Chemistry. 1986; 58: 504-5.

DJ Bornhop, TG Nolan and NJ Dovichi. Sub-Nanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Microbore Liquid Chromatography: Reversed-Phase Separation of Nanogram Amounts of Sugars. J. Chromatography. 1986; 384: 181-7.

TG Nolan, DJ Bornhop and NJ Dovichi. Crossed Beam Thermal-Lens detection for 0.25-mm ID Microbore Liquid Chromatography: Separation of 2,4-Dinitrophenylhydrzones. J. Chromatography. 1986; 384: 189-95.

S Kapila, DJ Bornhop, SE Manahan and GL Nickell. Design of a Combined Photoionization Detector and Photoionization-Based Electron Capture Detector. J. Chromatography. 1983; 259: 205-10.

DJ Bornhop and SE Manahan. Isotope Dilution Analysis of Exchangeable Water in Coal, Coal Char and Activated Coal Char. Analytical Letters. 1980; 13((A12)): 1041-61.

M.P. Houlne, F. Koch, T.S. Goebel and D.J. Bornhop. Structure Dependent Spectroscopic Properties of Europium and Terbium Chelate Complexes Used in Biomedical Imaging and Analysis. For submission to J. American Chemical Society.

S. Robertson, P.J. Sattu, D.L. Morgan, B.C. Pence and D.J. Bornhop. Staging of Colon Cancer in the DMH Sprague Dawley Rat Model using Micro-Endoscopy. In Preparation for Gastroenterology.